Koon Teo
YOU?
Author Swipe
View article: Blood pressure lowering in isolated diastolic hypertension and cardiovascular risk: an individual patient data meta-analysis
Blood pressure lowering in isolated diastolic hypertension and cardiovascular risk: an individual patient data meta-analysis Open
Background and Aims Blood pressure (BP) lowering reduces cardiovascular disease (CVD) risk; however, the benefits of treating patients with normal systolic BP but elevated diastolic BP remain uncertain. Methods Data from 51 randomized cont…
View article: The burden of cardiovascular events according to cardiovascular risk profile in adults from high-income, middle-income, and low-income countries (PURE): a cohort study
The burden of cardiovascular events according to cardiovascular risk profile in adults from high-income, middle-income, and low-income countries (PURE): a cohort study Open
The funding bodies are listed in the appendix (p 29).
View article: Embracing doctors as teachers: Evaluating the student-led near-peer teaching at transnational campus
Embracing doctors as teachers: Evaluating the student-led near-peer teaching at transnational campus Open
Introduction: Every medical graduate is expected to fulfil the teaching responsibilities stated by the General Medical Council (GMC). It is beneficial to nurture both teaching motivation and skills early in the undergraduate program. This …
View article: Maternal Profiles Account for Birth Weight Differences Across Ethnicities: Results from Three Canadian Birth Cohorts
Maternal Profiles Account for Birth Weight Differences Across Ethnicities: Results from Three Canadian Birth Cohorts Open
Background Marked differences in birth weight (BW) between South Asian and White European-origin populations are well-documented and pose public health concerns. Methods We analyzed fetal BW, the fat mass (FM), and fat-free mass (FFM) comp…
View article: Blood Pressure Lowering and Risk of Cancer
Blood Pressure Lowering and Risk of Cancer Open
Randomized data analysis provided no evidence to indicate that pharmacologic BP lowering has a substantial impact, either increasing or decreasing, on the risk for incident cancer, cause-specific cancer death, or selected site-specific can…
View article: Validation of the standard assessment of global everyday activities (SAGEA) scale for dementia diagnosis
Validation of the standard assessment of global everyday activities (SAGEA) scale for dementia diagnosis Open
Background Standardised questionnaires of cognitive symptoms and cognitive-related function can assist in diagnosing dementia. The Standardised Assessment of Global Everyday Activities (SAGEA) is a 15-item questionnaire, developed to measu…
View article: Trajectory of Early Life Adiposity Among South Asian Children
Trajectory of Early Life Adiposity Among South Asian Children Open
Importance Measures of childhood adiposity merit investigation, particularly in individuals of South Asian descent. Objective To investigate prenatal and childhood factors associated with the trajectory of adiposity in South Asian children…
View article: Exposure to air pollutants and subclinical carotid atherosclerosis measured by magnetic resonance imaging: A cross-sectional analysis
Exposure to air pollutants and subclinical carotid atherosclerosis measured by magnetic resonance imaging: A cross-sectional analysis Open
Objectives Long-term exposure to air pollution has been associated with higher risk of cardiovascular mortality. Less is known about the association of air pollution with initial development of cardiovascular disease. Herein, the associati…
View article: blood pressure-lowering and risk of cancer: an individual participant-level data meta-analysis and mendelian randomisation studies
blood pressure-lowering and risk of cancer: an individual participant-level data meta-analysis and mendelian randomisation studies Open
Background The current body of randomised evidence concerning the effect of blood pressure lowering on the risk of cancer remains limited. Purpose We leveraged the strengths of both randomised controlled trials (RCTs) and genomic informati…
View article: Effectiveness and risk of ARB and ACEi among different ethnic groups in England: A reference trial (ONTARGET) emulation analysis using UK Clinical Practice Research Datalink Aurum-linked data
Effectiveness and risk of ARB and ACEi among different ethnic groups in England: A reference trial (ONTARGET) emulation analysis using UK Clinical Practice Research Datalink Aurum-linked data Open
Background Guidelines by the National Institute for Health and Care Excellence recommend an angiotensin receptor blocker (ARB) rather than an angiotensin-converting enzyme inhibitor (ACEi) for the treatment of hypertension for people of Af…
View article: Mortality, Cardiovascular Disease, and Their Associations With Risk Factors in Southeast Asia
Mortality, Cardiovascular Disease, and Their Associations With Risk Factors in Southeast Asia Open
CVD and cancer account for one-half of adult mortality in Malaysia and the Philippines. Hypertension was the largest population driver of CVD, whereas low education was associated with the largest burden of overall mortality.
View article: Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry
Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry Open
Background: Maternal smoking has been linked to adverse health outcomes in newborns but the extent to which it impacts newborn health has not been quantified through an aggregated cord blood DNA methylation (DNAm) score. Here, we examine t…
View article: Lipoprotein(a) and Calcific Aortic Valve Stenosis Progression
Lipoprotein(a) and Calcific Aortic Valve Stenosis Progression Open
Importance There are currently no pharmacological treatments available to slow hemodynamic progression of aortic stenosis. Plasma lipoprotein(a) concentrations predict incident aortic stenosis but its association with hemodynamic progressi…
View article: Author response: Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry
Author response: Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry Open
Maternal smoking has been linked to adverse health outcomes in newborns but the extent to which it impacts newborn health has not been quantified through an aggregated cord blood DNA methylation (DNAm) score. Here we examine the feasibilit…
View article: Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry
Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry Open
Maternal smoking has been linked to adverse health outcomes in newborns but the extent to which it impacts newborn health has not been quantified through an aggregated cord blood DNA methylation (DNAm) score. Here we examine the feasibilit…
View article: P-476 Barriers and facilitators to nationwide implementation of fertility screening interventions: a qualitative study
P-476 Barriers and facilitators to nationwide implementation of fertility screening interventions: a qualitative study Open
Study question What are the barriers and facilitators to the potential nationwide implementation of Fertility Health Screening (FHS) and/or Fertility Awareness and Education (FAE) in Singapore? Summary answer The study reveals implementati…
View article: Cardiorenal effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers among people underrepresented in trials: analysis of routinely collected data with emulation of a reference trial (ONTARGET)
Cardiorenal effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers among people underrepresented in trials: analysis of routinely collected data with emulation of a reference trial (ONTARGET) Open
Cardiovascular disease is a leading cause of death globally. Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB), compared in the ONTARGET trial (Ongoing Telmisartan Alone and in Combination with Ramipri…
View article: Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry
Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry Open
Maternal smoking has been linked to adverse health outcomes in newborns but the extent to which it impacts newborn health has not been quantified through an aggregated cord blood DNA methylation (DNAm) score. Here we examine the feasibilit…
View article: Author response: Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry
Author response: Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry Open
Maternal smoking has been linked to adverse health outcomes in newborns but the extent to which it impacts newborn health has not been quantified through an aggregated cord blood DNA methylation (DNAm) score. Here we examine the feasibilit…
View article: Reviewer #2 (Public Review): Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry
Reviewer #2 (Public Review): Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry Open
Maternal smoking has been linked to adverse health outcomes in newborns but the extent to which it impacts newborn health has not been quantified through an aggregated cord blood DNA methylation (DNAm) score. Here we examine the feasibilit…
View article: Reviewer #3 (Public Review): Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry
Reviewer #3 (Public Review): Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry Open
Maternal smoking has been linked to adverse health outcomes in newborns but the extent to which it impacts newborn health has not been quantified through an aggregated cord blood DNA methylation (DNAm) score. Here we examine the feasibilit…
View article: The association of red and processed meat with gestational diabetes mellitus: Results from 2 Canadian birth cohort studies
The association of red and processed meat with gestational diabetes mellitus: Results from 2 Canadian birth cohort studies Open
Objective Red and processed meat is considered risk factors of gestational diabetes mellitus (GDM), but the evidence is inconclusive. We aimed to examine the association between red and processed meat intake and odds of GDM among South Asi…
View article: Cardiorenal effects of dual blockade with Angiotensin-converting enzyme inhibitors and Angiotensin receptor blockers in people with CKD: analysis of routinely collected data with emulation of a reference trial (ONTARGET)
Cardiorenal effects of dual blockade with Angiotensin-converting enzyme inhibitors and Angiotensin receptor blockers in people with CKD: analysis of routinely collected data with emulation of a reference trial (ONTARGET) Open
We aimed to explore whether the ONTARGET trial results, which led to an end of recommendations of dual angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blocker (ARB) use, extended to patients with chronic kidney dise…
View article: Impact of seasonal blood pressure changes on visit-to-visit blood pressure variability and related cardiovascular outcomes
Impact of seasonal blood pressure changes on visit-to-visit blood pressure variability and related cardiovascular outcomes Open
Background: Visit-to-visit blood pressure (BP) variability associates with an increased risk of cardiovascular events. We investigated the role of seasonal BP modifications on the magnitude of BP variability and its impact on cardiovascula…
View article: #530 Cardiorenal effects of dual blockade with ACE inhibitors and ARBs among people with CKD: emulation of a reference trial (ONTARGET) using CPRD
#530 Cardiorenal effects of dual blockade with ACE inhibitors and ARBs among people with CKD: emulation of a reference trial (ONTARGET) using CPRD Open
Background and Aims Cardiovascular disease (CVD) is a leading cause of death globally, and individuals with chronic kidney disease (CKD) are at increased risk. Results from the ONTARGET trial, in conjunction with the ALTITUDE and VA-Nephro…
View article: A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity
A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity Open
Although hundreds of genome-wide association studies-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity and with only a few studies conducted in non-Europe…
View article: Comparative effectiveness of ARB and ACEi for cardiovascular outcomes and risk of angioedema among different ethnic groups in England: an analysis in the UK Clinical Practice Research Datalink with emulation of a reference trial (ONTARGET)
Comparative effectiveness of ARB and ACEi for cardiovascular outcomes and risk of angioedema among different ethnic groups in England: an analysis in the UK Clinical Practice Research Datalink with emulation of a reference trial (ONTARGET) Open
Objective To study the comparative effectiveness of angiotensin receptor blockers (ARB) and angiotensin-converting enzyme inhibitors (ACEi) in ethnic minority groups in the UK. Design Observational cohort study using a reference trial emul…