Korry Hintze
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View article: Cocoa Polyphenols Modulate the Mouse Gut Microbiome in a Site-Specific Manner
Cocoa Polyphenols Modulate the Mouse Gut Microbiome in a Site-Specific Manner Open
Background/Objectives: The dietary modulation of the gut microbiome is a promising strategy for mitigating gastrointestinal diseases, such as inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Cocoa powder is …
View article: Cocoa Polyphenols Alter the Fecal Microbiome Without Mitigating Colitis in Mice Fed Healthy or Western Basal Diets
Cocoa Polyphenols Alter the Fecal Microbiome Without Mitigating Colitis in Mice Fed Healthy or Western Basal Diets Open
Background/Objectives: Chronic inflammation and Western-style diets elevate colorectal cancer (CRC) risk, particularly in individuals with colitis, a feature of inflammatory bowel disease (IBD). Diets rich in polyphenol-containing function…
View article: Dynamic Microbiome Responses to Structurally Diverse Anthocyanin-Rich Foods in a Western Diet Context
Dynamic Microbiome Responses to Structurally Diverse Anthocyanin-Rich Foods in a Western Diet Context Open
Background/Objectives: Anthocyanin (ACN)-rich foods are known to influence the gut microbiota composition, but the temporal dynamics and structural specificity of these effects remain poorly understood. This study investigated how distinct…
View article: Mesobiliverdin IXα-enriched microalgal feed supplement promotes beneficial gut microbiota in rabbits
Mesobiliverdin IXα-enriched microalgal feed supplement promotes beneficial gut microbiota in rabbits Open
Studies were conducted to determine if an antibiotic-free diet supplemented with mesobiliverdin IXα-enriched microalgae extract promotes beneficial gut microbiota in 4- to 6-wk-old New Zealand White rabbits. Mesobiliverdin IXα is a cytopro…
View article: Basal Diet Fed to Recipient Mice Was the Driving Factor for Colitis and Colon Tumorigenesis, despite Fecal Microbiota Transfer from Mice with Severe or Mild Disease
Basal Diet Fed to Recipient Mice Was the Driving Factor for Colitis and Colon Tumorigenesis, despite Fecal Microbiota Transfer from Mice with Severe or Mild Disease Open
Consumption of the total Western diet (TWD) in mice has been shown to increase gut inflammation, promote colon tumorigenesis, and alter fecal microbiome composition when compared to mice fed a healthy diet, i.e., AIN93G (AIN). However, it …
View article: Dietary Supplementation with Black Raspberries Altered the Gut Microbiome Composition in a Mouse Model of Colitis-Associated Colorectal Cancer, although with Differing Effects for a Healthy versus a Western Basal Diet
Dietary Supplementation with Black Raspberries Altered the Gut Microbiome Composition in a Mouse Model of Colitis-Associated Colorectal Cancer, although with Differing Effects for a Healthy versus a Western Basal Diet Open
Black raspberries (BRB) are rich in anthocyanins with purported anti-inflammatory properties. However, it is not known whether dietary supplementation would ameliorate Western-diet enhanced gut inflammation and colon tumorigenesis. We empl…
View article: Effect of Replacing Cellulose With Primarily Insoluble Fiber on the Microbiome and Short Chain Fatty Acids, and Fecal Calprotectin in Mice Fed a High Fat Diet
Effect of Replacing Cellulose With Primarily Insoluble Fiber on the Microbiome and Short Chain Fatty Acids, and Fecal Calprotectin in Mice Fed a High Fat Diet Open
OBJECTIVES: Most semi-purified rodent diets contain only cellulose as the fiber source, and do not provide diverse fermentable substrates for the gut microbiota. The focus of this work was to determine how replacing cellulose with a mix of…
View article: Resistant Potato Starch Alters the Cecal Microbiome and Gene Expression in Mice Fed a Western Diet Based on NHANES Data
Resistant Potato Starch Alters the Cecal Microbiome and Gene Expression in Mice Fed a Western Diet Based on NHANES Data Open
Several studies indicate that the four major types of resistant starch (RS1-4) are fermented in the cecum and colon to produce short-chain fatty acids (SCFAs) and can alter the microbiome and host physiology. However, nearly all these stud…
View article: Excess Vitamins or Imbalance of Folic Acid and Choline in the Gestational Diet Alter the Gut Microbiota and Obesogenic Effects in Wistar Rat Offspring
Excess Vitamins or Imbalance of Folic Acid and Choline in the Gestational Diet Alter the Gut Microbiota and Obesogenic Effects in Wistar Rat Offspring Open
Excess vitamin intake during pregnancy leads to obesogenic phenotypes, and folic acid accounts for many of these effects in male, but not in female, offspring. These outcomes may be modulated by another methyl nutrient choline and attribut…
View article: Increased Vitamin Content or an Imbalance in Methyl Nutrients in the Gestational Diet Shifts the Gut Microbiota of the Offspring in a Sex-Dependent Manner
Increased Vitamin Content or an Imbalance in Methyl Nutrients in the Gestational Diet Shifts the Gut Microbiota of the Offspring in a Sex-Dependent Manner Open
OBJECTIVES: Excess gestational folic acid and insufficient choline intakes as observed in the North American populations may increase the risk of obesity in offspring. It is well-established that adverse health outcomes may arise due to sh…
View article: The Western Dietary Pattern Combined with Vancomycin-Mediated Changes to the Gut Microbiome Exacerbates Colitis Severity and Colon Tumorigenesis
The Western Dietary Pattern Combined with Vancomycin-Mediated Changes to the Gut Microbiome Exacerbates Colitis Severity and Colon Tumorigenesis Open
Previous work by our group using a mouse model of inflammation-associated colorectal cancer (CAC) showed that the total Western diet (TWD) promoted colon tumor development. Others have also shown that vancomycin-mediated changes to the gut…
View article: Dynamics of Cancer- and Immune-Pathway Gene Expression During Colitis and Recovery from Gut Injury in Mice Fed the Total Western Diet
Dynamics of Cancer- and Immune-Pathway Gene Expression During Colitis and Recovery from Gut Injury in Mice Fed the Total Western Diet Open
OBJECTIVES: Consumption of a Western type diet is a known risk factor for colorectal cancer. Our group previously developed the total Western diet (TWD) for rodents with energy and nutrient profiles that emulate a typical Western diet. In …
View article: Effect of a High Flavonoid Supplement on Intestinal Inflammation, Short Chain Fatty Acids, and the Gut Microbiome
Effect of a High Flavonoid Supplement on Intestinal Inflammation, Short Chain Fatty Acids, and the Gut Microbiome Open
OBJECTIVES: Endurance exercise is a known cause of intestinal inflammation. Recent studies suggest that dietary flavonoids may protect the gut from chronic low-grade inflammation and have other effects at the gastrointestinal barrier. As a…
View article: Food matrix and the microbiome: considerations for preclinical chronic disease studies
Food matrix and the microbiome: considerations for preclinical chronic disease studies Open
Animal models of chronic disease are continuously being refined and have evolved with the goal of increasing the translation of results to human populations. Examples of this progress include transgenic models and germ-free animals convent…
View article: Consumption of the Total Western Diet Promotes Colitis and Inflammation-Associated Colorectal Cancer in Mice
Consumption of the Total Western Diet Promotes Colitis and Inflammation-Associated Colorectal Cancer in Mice Open
Consumption of a Western type diet is a known risk factor for colorectal cancer. Our group previously developed the total Western diet (TWD) for rodents with energy and nutrient profiles that emulate a typical Western diet. In this study, …
View article: Basal Diet Determined Long-Term Composition of the Gut Microbiome and Mouse Phenotype to a Greater Extent than Fecal Microbiome Transfer from Lean or Obese Human Donors
Basal Diet Determined Long-Term Composition of the Gut Microbiome and Mouse Phenotype to a Greater Extent than Fecal Microbiome Transfer from Lean or Obese Human Donors Open
The Western dietary pattern can alter the gut microbiome and cause obesity and metabolic disorders. To examine the interactions between diet, the microbiome, and obesity, we transplanted gut microbiota from lean or obese human donors into …
View article: Consumption of Black Raspberries Altered the Composition of the Fecal Microbiome in Mice Fed a Western Type Diet (OR04-01-19)
Consumption of Black Raspberries Altered the Composition of the Fecal Microbiome in Mice Fed a Western Type Diet (OR04-01-19) Open
OBJECTIVES: Dietary strategies to reduce colonic inflammation and promote gut homeostasis may markedly reduce the risk of colitis-associated colorectal cancer. Previously, we showed that dietary supplementation with black raspberries signi…
View article: Impact of the Total Western Diet for Rodents on Colon Mucosal Gene Expression in a Multigenerational Murine Model of Colitis-associated Colorectal Cancer (OR04-03-19)
Impact of the Total Western Diet for Rodents on Colon Mucosal Gene Expression in a Multigenerational Murine Model of Colitis-associated Colorectal Cancer (OR04-03-19) Open
OBJECTIVES: A Western type dietary pattern is a major risk factor for colitis-associated colorectal cancer (CAC). Observations from transgenerational studies suggest that epimutations may be inherited, resulting in persistent aberrant gene…
View article: Impact of the Introduction of Black Raspberries in a Standard Western-Style Diet on Colitis and Colorectal Cancer Risk in Mice
Impact of the Introduction of Black Raspberries in a Standard Western-Style Diet on Colitis and Colorectal Cancer Risk in Mice Open
Approximately 1.4 million people suffer from inflammatory bowel disease, which is major risk factor for developing colitis associated colorectal cancer (CAC). Dietary interventions with the goal to reduce colon inflammation and encourage g…
View article: ASEA Redox Supplement Fails to Improve Aerobic Capacity and Ventilatory Threshold: A Double-Blind, Placebo-Controlled Study
ASEA Redox Supplement Fails to Improve Aerobic Capacity and Ventilatory Threshold: A Double-Blind, Placebo-Controlled Study Open
The ASEA redox cell signaling supplement beverage has been commercially available for the past decade. Despite the market longevity of this supplement, athletic sponsorship, and anecdotal ergogenic claims, there is no independent, peer-rev…