Kosuke Minaga
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View article: Loss of Brg1 and Pten in Pancreatic Ductal Cells Forms Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway
Loss of Brg1 and Pten in Pancreatic Ductal Cells Forms Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway Open
View article: A novel endoscopic lithotripsy technique for a huge common bile duct stone: endoscopic snare lithotripsy
A novel endoscopic lithotripsy technique for a huge common bile duct stone: endoscopic snare lithotripsy Open
View article: Dysregulated Pro-inflammatory and Anti-inflammatory Cytokine Responses to Microbe-associated Molecular Patterns in X-linked Chronic Granulomatous Disease
Dysregulated Pro-inflammatory and Anti-inflammatory Cytokine Responses to Microbe-associated Molecular Patterns in X-linked Chronic Granulomatous Disease Open
A dysregulated balance between pro-inflammatory and anti-inflammatory cytokines may contribute to the manifestations of recurrent infection, autoimmunity, and IBD in patients with X-linked CGD.
View article: Role and Challenges of Endoscopic Ultrasonography‐Guided Tissue Acquisition for Para‐Aortic Lymph Node Staging
Role and Challenges of Endoscopic Ultrasonography‐Guided Tissue Acquisition for Para‐Aortic Lymph Node Staging Open
View article: Development of Diffuse Large B Cell Lymphoma in a Patient with Systemic Lupus Erythematosus within Two Years after the Initiation of Anifrolumab and Mycophenolate Mofetil Treatment
Development of Diffuse Large B Cell Lymphoma in a Patient with Systemic Lupus Erythematosus within Two Years after the Initiation of Anifrolumab and Mycophenolate Mofetil Treatment Open
Anifrolumab is a newly developed biological agent for patients with moderate-to-severe systemic lupus erythematosus (SLE). Anifrolumab neutralizes the signaling pathways mediated by type I interferons (IFNs), which are involved in viral cl…
View article: Shining stars in the sky on the gastric mucosa
Shining stars in the sky on the gastric mucosa Open
We report a rare case of an elderly Japanese man diagnosed with sporadic gastric Burkitt lymphoma. Esophagogastroduodenoscopy showed nodular and ulcerated lesions in the lesser curvature of the stomach. Pathological analysis of showed that…
View article: Gut Microbiota Involved in the Immunopathogenesis of Autoimmune Pancreatitis
Gut Microbiota Involved in the Immunopathogenesis of Autoimmune Pancreatitis Open
Autoimmune pancreatitis (AIP), which is considered the pancreatic expression of a systemic immunoglobulin G4-related disease, is characterized by excessive infiltration of plasmacytes bearing immunoglobulin G4 and a unique form of fibrosis…
View article: Sequential activation of conventional and plasmacytoid dendritic cells in autoimmune pancreatitis and systemic lupus erythematosus: similarities and dissimilarities
Sequential activation of conventional and plasmacytoid dendritic cells in autoimmune pancreatitis and systemic lupus erythematosus: similarities and dissimilarities Open
Type 1 autoimmune pancreatitis (AIP) and systemic lupus erythematosus (SLE) are caused by type I IFNs secreted by plasmacytoid dendritic cells (pDCs). Our understanding of the immune consequences before and after pDC activation in SLE is e…
View article: Complete Remission of Acute-onset Autoimmune Hepatitis Following Transcatheter Splenic Arterial Embolization and Splenectomy for Spontaneous Splenic Rupture
Complete Remission of Acute-onset Autoimmune Hepatitis Following Transcatheter Splenic Arterial Embolization and Splenectomy for Spontaneous Splenic Rupture Open
A 62-year-old woman presented with jaundice and fatigue. A blood examination revealed markedly elevated serum transaminase and bilirubin levels and negative hepatitis virus markers. A radiographic examination revealed no bile duct abnormal…
View article: Methotrexate-Associated Systemic Lymphadenopathy Exhibiting a Marked Elevation of the Serum IgG4 Concentrations
Methotrexate-Associated Systemic Lymphadenopathy Exhibiting a Marked Elevation of the Serum IgG4 Concentrations Open
Methotrexate (MTX) is an established anchor drug used for the treatment of rheumatoid arthritis. Patients receiving MTX are at an increased risk of developing MTX-associated lymphoproliferative disorders (MTX-LPDs). A diagnosis of MTX-LPD …
View article: Enlargement of Gastric Hyperplastic Polyps Arising from <i>Helicobacter heilmannii</i> sensu stricto-infected Mucosa after the Successful Eradication of <i>Helicobacter pylori</i> and the Long-Term Use of a Proton Pump Inhibitor
Enlargement of Gastric Hyperplastic Polyps Arising from <i>Helicobacter heilmannii</i> sensu stricto-infected Mucosa after the Successful Eradication of <i>Helicobacter pylori</i> and the Long-Term Use of a Proton Pump Inhibitor Open
Helicobacter pylori eradication is effective for the regression of gastric hyperplastic polyps (GHPs). We report a case which demonstrated an enlargement of GHPs after H. pylori eradication. The patient, who received long-term proton-pump …
View article: Cronkhite–Canada syndrome tends to be accompanied by colorectal cancer: Report of seven cases
Cronkhite–Canada syndrome tends to be accompanied by colorectal cancer: Report of seven cases Open
Cronkhite–Canada syndrome (CCS) can be difficult to diagnose. To diagnose CCS, it is important to perform endoscopic examination for patients with chronic diarrhea, check for the presence or absence of polyposis, and evaluate inflammation …
View article: Clinical practice guidelines for acute pancreatitis in the United States and Japan: similarities and differences
Clinical practice guidelines for acute pancreatitis in the United States and Japan: similarities and differences Open
View article: A positive cytokine/chemokine feedback loop establishes plasmacytoid DC–driven autoimmune pancreatitis in IgG4-related disease
A positive cytokine/chemokine feedback loop establishes plasmacytoid DC–driven autoimmune pancreatitis in IgG4-related disease Open
The pathogenesis of the murine model of autoimmune pancreatitis associated with IgG4-related disease (AIP/IgG4-RD) induced by administration of polyinosinic-polycytidylic acid (poly[I:C]) is incompletely understood. While it is known that …
View article: Detective flow imaging endoscopic ultrasound for locating optimal puncture site for a poorly vascularized pancreatic mass
Detective flow imaging endoscopic ultrasound for locating optimal puncture site for a poorly vascularized pancreatic mass Open
View article: Early detection of pancreatic cancer by comprehensive serum miRNA sequencing with automated machine learning
Early detection of pancreatic cancer by comprehensive serum miRNA sequencing with automated machine learning Open
View article: Comparison of bispectral index-guided endoscopic ultrasonography with continuous vs. intermittent infusion of propofol: a retrospective study in Japan
Comparison of bispectral index-guided endoscopic ultrasonography with continuous vs. intermittent infusion of propofol: a retrospective study in Japan Open
Background/Aims: This study aimed to evaluate the safety and efficacy of continuous propofol infusion for anesthesia during endoscopic ultrasonography (EUS).Methods: A total of 427 consecutive patients who underwent EUS between May 2018 an…
View article: High-mobility group box 1: friend or foe in pancreatitis
High-mobility group box 1: friend or foe in pancreatitis Open
View article: Early diagnosis of pancreatic cancer via pancreatic juice cytology with a cell-block method in a patient with altered anatomy
Early diagnosis of pancreatic cancer via pancreatic juice cytology with a cell-block method in a patient with altered anatomy Open
Received: 26 February 2024 Accepted after revision: 25 March 2024 Article published online:06 June 2024
View article: Efficacy of texture and color enhancement imaging for short‐type single‐balloon enteroscopy‐assisted biliary cannulation in patients with Roux‐en‐Y gastrectomy: Multicenter study (with video)
Efficacy of texture and color enhancement imaging for short‐type single‐balloon enteroscopy‐assisted biliary cannulation in patients with Roux‐en‐Y gastrectomy: Multicenter study (with video) Open
Objectives Texture and color enhancement imaging (TXI) reportedly improves the identification of the papilla of Vater for selective biliary cannulation compared with white light imaging (WLI). This multicenter study evaluated the efficacy …
View article: Role of leucine-rich repeat kinase 2 in severe acute pancreatitis
Role of leucine-rich repeat kinase 2 in severe acute pancreatitis Open
Introduction Intrapancreatic activation of trypsinogen caused by alcohol or high-fat intake and the subsequent autodigestion of the pancreas tissues by trypsin are indispensable events in the development of acute pancreatitis. In addition …
View article: Emergency digital cholangioscopy-assisted electrohydraulic lithotripsy for basket impaction with an entrapped bile duct stone
Emergency digital cholangioscopy-assisted electrohydraulic lithotripsy for basket impaction with an entrapped bile duct stone Open
Basket impaction with an entrapped common bile duct stone (CBDS) is among the most challenging complications occasionally encountered by endoscopists during endoscopic lithotripsy [1] [2]. Even with the availability of various devices incl…
View article: An autopsy case of gas gangrene, massive intravascular hemolysis, and cytokine storm due to Clostridium perfringens type A infection
An autopsy case of gas gangrene, massive intravascular hemolysis, and cytokine storm due to Clostridium perfringens type A infection Open
Clostridium perfringens bacteremia is a rare but rapidly fatal condition, especially in patients exhibiting massive intravascular hemolysis (MIH), gas gangrene, and septic shock. Herein, we present an autopsy case of C. perfringe…
View article: Reciprocal regulation of protein arginine deiminase 2 and 4 expression in the colonic mucosa of ulcerative colitis
Reciprocal regulation of protein arginine deiminase 2 and 4 expression in the colonic mucosa of ulcerative colitis Open
Neutrophils express protein arginine deiminase 2 and PAD4, both of which mediate the citrullination of target proteins to induce production of neutrophil extracellular traps. Although PAD-dependent NETs trigger inflammatory bowel disease, …
View article: Crosstalk between NOD2 and TLR2 suppresses the development of TLR2-mediated experimental colitis
Crosstalk between NOD2 and TLR2 suppresses the development of TLR2-mediated experimental colitis Open
Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular sensor for muramyl dipeptide (MDP), a degradation product of bacterial cell wall peptidoglycan (PGN). PGN stimulates cell-surface Toll-like receptor 2 (TLR2) independen…
View article: Unresectable hepatocellular carcinoma after Fontan surgery: A case report
Unresectable hepatocellular carcinoma after Fontan surgery: A case report Open
症例は30代男性．幼少期に完全大血管転位III型に対してFontan手術が施行され，近医に定期的に通院していた．20XX年7月腹部USで多発肝腫瘤を指摘され当院紹介受診となった．造影CTにて最大13 cmの多発肝細胞癌と判明した（BCLC stage B）．画像上は門脈圧亢進所見や明らかな肝形態異常を認めなかったが，肝生検でCongestive Hepatic Fibrosis Score 3であり，実際には線維化の進展を認めていた．肝内多発のため外科手術やRFAの適応外で…
View article: Leucine-rich repeat kinase 2 promotes the development of experimental severe acute pancreatitis
Leucine-rich repeat kinase 2 promotes the development of experimental severe acute pancreatitis Open
Translocation of gut bacteria into the pancreas promotes the development of severe acute pancreatitis (SAP). Recent clinical studies have also highlighted the association between fungal infections and SAP. The sensing of gut bacteria by pa…
View article: Cytokine and chemokine profiles in ulcerative colitis relapse after coronavirus disease 2019 vaccination
Cytokine and chemokine profiles in ulcerative colitis relapse after coronavirus disease 2019 vaccination Open
Coronavirus disease 2019 (COVID-19) vaccines are highly effective; however, vaccine-related adverse events, including autoimmunity, have been reported. Case reports describing relapse or new-onset of ulcerative colitis (UC) after COVID-19 …
View article: Piercing technique for mucosal hyperplasia at an uncovered part of a partially covered stent after endoscopic ultrasound-guided hepaticogastrostomy
Piercing technique for mucosal hyperplasia at an uncovered part of a partially covered stent after endoscopic ultrasound-guided hepaticogastrostomy Open
A partially covered self-expandable metal stent (PCSEMS) is preferred in endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) to prevent stent dislocation and branch duct occlusion [1] [2]. A PCSEMS with a 10-mm uncovered part on the…
View article: Low‐dose gemcitabine plus nab‐paclitaxel <i>versus</i> standard‐dose gemcitabine plus nab‐paclitaxel in elderly patients with metastatic pancreatic cancer: A randomized Phase <scp>II</scp> trial
Low‐dose gemcitabine plus nab‐paclitaxel <i>versus</i> standard‐dose gemcitabine plus nab‐paclitaxel in elderly patients with metastatic pancreatic cancer: A randomized Phase <span>II</span> trial Open
Background and Aim A multicenter, open‐label randomized Phase II trial was conducted to determine whether low‐dose gemcitabine plus nab‐paclitaxel (GnP) could improve tolerability and show equivalent efficacy to the standard‐dose GnP for e…