Kouichi Itoh
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View article: Long-term exposure to urban particulate matter exacerbates mortality after ischemic stroke in mice
Long-term exposure to urban particulate matter exacerbates mortality after ischemic stroke in mice Open
Exposure to fine particulate matter (PM2.5) has been epidemiologically reported to worsen the prognosis of ischemic stroke; however, the details have not been investigated. One of the major toxic mechanisms of PM2.5 inhalation is oxidative…
View article: Suppressive Effects of Docosahexaenoic Acid Intake on Increased Seizure Susceptibility after Growth Due to Febrile Seizures in Infancy
Suppressive Effects of Docosahexaenoic Acid Intake on Increased Seizure Susceptibility after Growth Due to Febrile Seizures in Infancy Open
Febrile seizures are seizures accompanied by a fever and frequently occur in children six months to five years of age. Febrile seizures are classified as simple or complex, and complex febrile seizures increase the risk of temporal lobe ep…
View article: Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation
Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation Open
Background A recent epidemiological study showed that air pollution is closely involved in the prognosis of ischemic stroke. We and others have reported that microglial activation in ischemic stroke plays an important role in neuronal dama…
View article: Microglial inflammatory reactions regulated by oxidative stress
Microglial inflammatory reactions regulated by oxidative stress Open
Microglia are immune cells in the brain that can respond to endogenous and exogenous substrates to elicit inflammatory reactions. The transcription factor nuclear factor kappa-light-chain-enhancer of activated B induces proinflammatory gen…
View article: A CCR5 antagonist, maraviroc, alleviates neural circuit dysfunction and behavioral disorders induced by prenatal valproate exposure
A CCR5 antagonist, maraviroc, alleviates neural circuit dysfunction and behavioral disorders induced by prenatal valproate exposure Open
Background Valproic acid (VPA) is a clinically used antiepileptic drug, but it is associated with a significant risk of a low verbal intelligence quotient (IQ) score, attention-deficit hyperactivity disorder and autism spectrum disorder in…
View article: Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice
Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice Open
Acute brain inflammation after status epilepticus (SE) is involved in blood–brain barrier (BBB) dysfunction and brain edema, which cause the development of post-SE symptomatic epilepsy. Using pilocarpine-induced SE mice, we previously repo…
View article: Regulation of Inflammation-Related Genes through Fosl1 Suppression in a Levetiracetam-Treated Pilocarpine-Induced Status Epilepticus Mouse Model
Regulation of Inflammation-Related Genes through Fosl1 Suppression in a Levetiracetam-Treated Pilocarpine-Induced Status Epilepticus Mouse Model Open
Levetiracetam (LEV) suppresses the upregulation of proinflammatory molecules that occurs during epileptogenesis after status epilepticus (SE). Based on previous studies, LEV likely helps prevent the onset of epilepsy after insults to the b…
View article: Involvement of polycyclic aromatic hydrocarbons and endotoxin in macrophage expression of interleukin-33 induced by exposure to particulate matter
Involvement of polycyclic aromatic hydrocarbons and endotoxin in macrophage expression of interleukin-33 induced by exposure to particulate matter Open
Air pollutants are important factors that contribute to the development and/or exacerbation of allergic inflammation accompanied by asthma, but experimental evidence still needs to be collected. Interleukin 33 (IL-33) is closely involved i…
View article: <i>Fosl1</i> gene expression in the mouse hippocampus of earlier stages of epileptogenic processes
<i>Fosl1</i> gene expression in the mouse hippocampus of earlier stages of epileptogenic processes Open
We recently reported that LPS markedly increased Fosl1 (Fra1, one of Fos family) expression, and knockdown of Fosl1 significantly suppressed the expression of inflammatory cytokines in murine BV-2 microglial cell lines. These observations …
View article: Photothrombotic Cerebral Stroke as a Model of Post-Stroke Seizures/Epilepsy in aged mice.
Photothrombotic Cerebral Stroke as a Model of Post-Stroke Seizures/Epilepsy in aged mice. Open
Stroke is a prevalent medical condition, a leading cause of disability and the third most common cause of death. Post-stroke seizure/epilepsy (PSS/E) is a common complication, accounting for 30–40% of epilepsy cases in older adults. In thi…
View article: FosL1 Is a Novel Target of Levetiracetam for Suppressing the Microglial Inflammatory Reaction
FosL1 Is a Novel Target of Levetiracetam for Suppressing the Microglial Inflammatory Reaction Open
We previously showed that the antiepileptic drug levetiracetam (LEV) inhibits microglial activation, but the mechanism remains unclear. The purpose of this study was to identify the target of LEV in microglial activity suppression. The mou…
View article: Involvement of the Microglial Aryl Hydrocarbon Receptor in Neuroinflammation and Vasogenic Edema after Ischemic Stroke
Involvement of the Microglial Aryl Hydrocarbon Receptor in Neuroinflammation and Vasogenic Edema after Ischemic Stroke Open
Microglia are activated after ischemic stroke and induce neuroinflammation. The expression of the aryl hydrocarbon receptor (AhR) has recently been reported to elicit cytokine expression. We previously reported that microglial activation m…
View article: Measurement of the Estradiol Concentration in Cerebrospinal Fluid from Infants and Its Correlation with Serum Estradiol and Exosomal MicroRNA-126-5p
Measurement of the Estradiol Concentration in Cerebrospinal Fluid from Infants and Its Correlation with Serum Estradiol and Exosomal MicroRNA-126-5p Open
Estradiol has an important role in the brain, such as in neuronal development and protection, but estradiol levels in the human brain have not been well investigated. In this study, we measured the estradiol concentration in the cerebrospi…
View article: Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus
Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus Open
Methylmercury (MeHg) is well known to induce auditory disorders such as dysarthria. When we performed a global analysis on the brains of mice exposed to MeHg by magnetic resonance imaging, an increase in the T1 signal in the inferior colli…
View article: The pilocarpine seizure sensitivity test is capable of detecting masked late posttraumatic epilepsy after controlled cortical impact in mice
The pilocarpine seizure sensitivity test is capable of detecting masked late posttraumatic epilepsy after controlled cortical impact in mice Open
Late posttraumatic epilepsy (PTE) following traumatic brain injury (TBI) is characterized by long and unexpected latencies until the onset of seizure. Interventions with antiepileptic drugs before seizure onset have not been found to preve…
View article: Two non-cytotoxic type 2 ribosome-inactivating proteins (Sambucus Sieboldiana lectin and Sambucus Nigra lectin) lead neurosphere cells to caspase-independent apoptosis
Two non-cytotoxic type 2 ribosome-inactivating proteins (Sambucus Sieboldiana lectin and Sambucus Nigra lectin) lead neurosphere cells to caspase-independent apoptosis Open
We found a new phenomenon of cell damage and/or cell death of almost all types of neurosphere cells derived from telencephalons of mouse embryos.The cell damage/death was induced by non-cytotoxic type 2 ribosome-inactivating proteins: Samb…