Péter Kovács
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View article: Inhibition of adipocyte lipolysis by vaspin impairs thermoregulation in vivo
Inhibition of adipocyte lipolysis by vaspin impairs thermoregulation in vivo Open
Altered activity of brown adipose tissue (BAT) contributes to obesity, insulin resistance, and cardiovascular disease. BAT secretes endocrine factors (“batokines”) that regulate thermogenesis. We identify the serpin vaspin as a batokine th…
View article: Salivary extracellular vesicle-derived microRNAs are related to variances in parameters of obesity, taste and eating behaviour
Salivary extracellular vesicle-derived microRNAs are related to variances in parameters of obesity, taste and eating behaviour Open
This study, one of the largest on salivary EVs, supports an interrelation of EV's microRNA load with metabolism, eating behaviour and taste recognition offering potential targets for obesity intervention.
View article: Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus
Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus Open
Although genome-wide association studies have provided valuable insights into the genetic basis of complex traits and diseases, translating these findings to causal genes and their downstream mechanisms remains challenging. We performed tr…
View article: Diet and temperature interactively impact brown adipose tissue gene regulation controlled by DNA methylation
Diet and temperature interactively impact brown adipose tissue gene regulation controlled by DNA methylation Open
Controlling brown adipose tissue (BAT) plasticity in adulthood holds promising potential for effective new obesity therapies by targeting the mechanisms of adaptive thermogenesis. Recent studies have shown that BAT development and function…
View article: HOOK1 Gene Expression and DNA Methylation in Obesity and Related Cardiometabolic Traits
HOOK1 Gene Expression and DNA Methylation in Obesity and Related Cardiometabolic Traits Open
Introduction: Accumulation of fat in omental visceral adipose tissue (OVAT) is strongly linked to metabolic diseases. Our recent findings show a distinct and more accessible chromatin landscape of the visceral depot compared to its subcuta…
View article: The Double-Edged Nature of the Gonadotropin-Releasing Hormone Agonist (GnRHa) Long Protocol: A Case of Paradoxical Ovarian Hyperstimulation During the Expected Downregulation Phase
The Double-Edged Nature of the Gonadotropin-Releasing Hormone Agonist (GnRHa) Long Protocol: A Case of Paradoxical Ovarian Hyperstimulation During the Expected Downregulation Phase Open
Objectives: Our aim is to report an uncommon pituitary activation occurring during the desensitization phase of the gonadotropin-releasing hormone agonist (GnRHa) long protocol, a cornerstone of medically assisted reproduction (MAR) therap…
View article: Chronic Lyme Disease or Post-Treatment Lyme Disease Syndrome (PTLDS) Is a Misnomer for Focal Infection?
Chronic Lyme Disease or Post-Treatment Lyme Disease Syndrome (PTLDS) Is a Misnomer for Focal Infection? Open
The complete clinical spectrum of Lyme borreliosis has been known for nearly 50 years. However, this long period has not been sufficient to clarify the diagnosis of the disease. Lyme foundations have emerged, publishing and disseminating g…
View article: Sarcospan, a candidate gene of fat distribution, may affect lipid storage in adipocytes
Sarcospan, a candidate gene of fat distribution, may affect lipid storage in adipocytes Open
Although the epigenetic downregulation of Sspn showed only marginal effects on adipogenesis, associations of SSPN expression in human adipose tissue with parameters of fat distribution and glucose homeostasis make it a promising candidate …
View article: Individual response to lifestyle interventions: a pooled analysis of three long-term weight loss trials
Individual response to lifestyle interventions: a pooled analysis of three long-term weight loss trials Open
Aims We explored the manifestations of individual weight loss (WL) response to long-term lifestyle interventions on cardiometabolic risk. Methods and results We pooled data from three large long-term lifestyle WL-intervention trials: 24-mo…
View article: Epigenetics of childhood obesity
Epigenetics of childhood obesity Open
Background: Childhood obesity has become a global pandemic and is one of the strongest risk factors for cardiovascular disease later in life. The correlation of epigenetic marks with obesity and related traits is being elucidated. This rev…
View article: Circulating Cell-Free DNA in Metabolic Diseases
Circulating Cell-Free DNA in Metabolic Diseases Open
Metabolic diseases affect a consistent part of the human population, leading to rising mortality rates. This raises the need for diagnostic tools to monitor the progress of these diseases. Lately, circulating cell-free DNA (cfDNA) has emer…
View article: FGF21 and its underlying adipose tissue-liver axis inform cardiometabolic burden and improvement in obesity after metabolic surgery
FGF21 and its underlying adipose tissue-liver axis inform cardiometabolic burden and improvement in obesity after metabolic surgery Open
This work was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) through CRC 1052, project number 209933838, CRC1382 and a Walther-Benjamin Fellowship and by a junior research grant by the Medical Faculty, U…
View article: Working memory gating in obesity is moderated by striatal dopaminergic gene variants
Working memory gating in obesity is moderated by striatal dopaminergic gene variants Open
Everyday life requires an adaptive balance between distraction-resistant maintenance of information and the flexibility to update this information when needed. These opposing mechanisms are proposed to be balanced through a working memory …
View article: Working Memory Gating in Obesity is Moderated by Striatal Dopaminergic Gene Variants
Working Memory Gating in Obesity is Moderated by Striatal Dopaminergic Gene Variants Open
Everyday life requires an adaptive balance between distraction-resistant maintenance of information and the flexibility to update this information when needed. These opposing mechanisms are proposed to be balanced through a working memory …
View article: Glycemic control contributes to the neuroprotective effects of Mediterranean and green-Mediterranean diets on brain age: the DIRECT PLUS brain-magnetic resonance imaging randomized controlled trial
Glycemic control contributes to the neuroprotective effects of Mediterranean and green-Mediterranean diets on brain age: the DIRECT PLUS brain-magnetic resonance imaging randomized controlled trial Open
Glycemic control contributes to the neuroprotective effects of the MED and green-MED diets on brain age. Polyphenols-rich diet components as Mankai and green tea may contribute to a more youthful brain age. This trial was registered at cli…
View article: The Concentration of Salivary Extracellular Vesicles Is Related to Obesity
The Concentration of Salivary Extracellular Vesicles Is Related to Obesity Open
Background and aims: Saliva is essential for the proper dilution and distribution of taste molecules on the tongue. It harbors extracellular vesicles (EVs), which mediate cell–cell communication. Changes in the composition of salivary EVs …
View article: FGF21 reflects a responsive adipose tissue-liver axis in both cardiometabolic burden and following metabolic surgery
FGF21 reflects a responsive adipose tissue-liver axis in both cardiometabolic burden and following metabolic surgery Open
Objective This research aims to uncover the factors associated with circulating FGF21 levels in a cohort mimicking metabolic disease progression, examining its relationship with adipose tissue (AT) morphology and function. It also investig…
View article: Blood methylation pattern reflects epigenetic remodelling in adipose tissue after bariatric surgery
Blood methylation pattern reflects epigenetic remodelling in adipose tissue after bariatric surgery Open
Background Studies on DNA methylation following bariatric surgery have primarily focused on blood cells, while it is unclear to which extend it may reflect DNA methylation profiles in specific metabolically relevant organs such as adipose …
View article: Reviewer #2 (Public Review): Impaired updating of working memory representations in individuals with high BMI: evidence for dopaminergic mechanisms
Reviewer #2 (Public Review): Impaired updating of working memory representations in individuals with high BMI: evidence for dopaminergic mechanisms Open
Everyday life requires an adaptive balance between distraction-resistant maintenance of information and the flexibility to update this information when needed. These opposing mechanisms are proposed to be balanced through a working memory …
View article: Reviewer #1 (Public Review): Impaired updating of working memory representations in individuals with high BMI: evidence for dopaminergic mechanisms
Reviewer #1 (Public Review): Impaired updating of working memory representations in individuals with high BMI: evidence for dopaminergic mechanisms Open
Everyday life requires an adaptive balance between distraction-resistant maintenance of information and the flexibility to update this information when needed. These opposing mechanisms are proposed to be balanced through a working memory …
View article: Impaired updating of working memory representations in individuals with high BMI: evidence for dopaminergic mechanisms
Impaired updating of working memory representations in individuals with high BMI: evidence for dopaminergic mechanisms Open
Everyday life requires an adaptive balance between distraction-resistant maintenance of information and the flexibility to update this information when needed. These opposing mechanisms are proposed to be balanced through a working memory …
View article: Working memory gating in obesity is moderated by striatal dopaminergic gene variants
Working memory gating in obesity is moderated by striatal dopaminergic gene variants Open
Everyday life requires an adaptive balance between distraction-resistant maintenance of information and the flexibility to update this information when needed. These opposing mechanisms are proposed to be balanced through a working memory …