Kozo Nagai
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View article: Successful resection of large subependymal giant cell astrocytoma using presurgical mammalian target of rapamycin inhibitor
Successful resection of large subependymal giant cell astrocytoma using presurgical mammalian target of rapamycin inhibitor Open
Background: A subependymal giant cell astrocytoma (SEGA) grows slowly near the foramen of Monro and develops in tuberous sclerosis complex patients. Large SEGA resection has a high risk of hemorrhage, resulting in irreversible sequelae. Ma…
View article: Rapid Identification of <i>DUX4::IGH</i> Fusion in Acute Lymphoblastic Leukemia
Rapid Identification of <i>DUX4::IGH</i> Fusion in Acute Lymphoblastic Leukemia Open
Introduction DUX4 is rearranged and overexpressed in a subgroup of acute lymphoblastic leukemia (ALL) with B‐precursor phenotype, with a favorable outcome. Even though characteristic gene expression signature as well as surface expression …
View article: Neonatal Sepsis Caused by Human Parechovirus Type A3 With Marked Hyperferritinemia: A Case Report
Neonatal Sepsis Caused by Human Parechovirus Type A3 With Marked Hyperferritinemia: A Case Report Open
Background: In neonates and young infants, human parechovirus A3 (PeV‐A3) is associated with severe infections, such as sepsis and encephalomyelitis. However, the mechanisms behind severe illness and the proper indications and methods for …
View article: A Catheter‐Related Bloodstream Infection by <i>Brevibacterium casei</i> in a Child with Acute Myeloid Leukemia: Case Report and Literature Review
A Catheter‐Related Bloodstream Infection by <i>Brevibacterium casei</i> in a Child with Acute Myeloid Leukemia: Case Report and Literature Review Open
The most common organisms isolated from pediatric catheter‐related bloodstream infections (CRBSIs) are Gram‐positive cocci, such as coagulase‐negative staphylococci and Staphylococcus aureus . There are few formal reports of Brevibacterium…
View article: Malignant Ovarian Steroid Cell Tumor, Not Otherwise Specified, Causes Virilization in a 4-Year-Old Girl: A Case Report and Literature Review
Malignant Ovarian Steroid Cell Tumor, Not Otherwise Specified, Causes Virilization in a 4-Year-Old Girl: A Case Report and Literature Review Open
We report a case of a 4-year-old girl with an ovarian steroid cell tumor, not otherwise specified (SCT-NOS). She was admitted to the hospital with progressing virilization and Cushing’s syndrome, which included abnormality of the perineum,…
View article: Brain Abscess Associated with Polymicrobial Infection after Intraoral Laceration: A Pediatric Case Report
Brain Abscess Associated with Polymicrobial Infection after Intraoral Laceration: A Pediatric Case Report Open
Brain abscesses, infections within the brain parenchyma, can arise as complications of various conditions including infections, trauma, and surgery. However, brain abscesses due to polymicrobial organisms have rarely been reported in child…
View article: Mesenchymal Stem Cell Therapy Overcomes Steroid Resistance in Severe Gastrointestinal Acute Graft-Versus-Host Disease
Mesenchymal Stem Cell Therapy Overcomes Steroid Resistance in Severe Gastrointestinal Acute Graft-Versus-Host Disease Open
The authors describe the high effectiveness of human mesenchymal stem cell (hMSC) therapy to treat steroid-refractory gastrointestinal acute graft-versus-host Disease (aGVHD) in a 15-year-old boy with acute lymphoblastic leukemia (ALL). He…
View article: Combination of ATO with FLT3 TKIs eliminates FLT3/ITD+ leukemia cells through reduced expression of FLT3
Combination of ATO with FLT3 TKIs eliminates FLT3/ITD+ leukemia cells through reduced expression of FLT3 Open
Acute myeloid leukemia (AML) patients with FLT3/ITD mutations have a poor prognosis. Monotherapy with selective FLT3 tyrosine kinase inhibitors (TKIs) have shown transient and limited efficacy due to the development of resistance. Arsenic …
View article: Sepsis and Pleural Empyema Caused by <i>Streptococcus pyogenes</i> after Influenza A Virus Infection
Sepsis and Pleural Empyema Caused by <i>Streptococcus pyogenes</i> after Influenza A Virus Infection Open
Streptococcus pyogenes (also referred to as group A streptococci, GAS) causes severe invasive diseases such as bacteremia, necrotizing fasciitis, pneumonia, osteomyelitis, septic arthritis, and toxic shock syndrome in children. However, th…
View article: <i>Dnmt3a</i> deletion cooperates with the <i>Flt3/ITD</i> mutation to drive leukemogenesis in a murine model
<i>Dnmt3a</i> deletion cooperates with the <i>Flt3/ITD</i> mutation to drive leukemogenesis in a murine model Open
Internal tandem duplications of the juxtamembrane domain of FLT3 (FLT3/ITD) are among the most common mutations in Acute Myeloid Leukemia (AML). Resulting in constitutive activation of the kinase, FLT3/ITD portends a particularly poor prog…
View article: Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma with Cardiac Metastasis and Arterial Tumor Embolisms during First-Course Chemotherapy
Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma with Cardiac Metastasis and Arterial Tumor Embolisms during First-Course Chemotherapy Open
We described an 11-year-old boy suffering from pediatric anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with heart metastasis at diagnosis and arterial tumor embolisms during chemotherapy. Both the heart metastasis and …