Kozue Murata
YOU?
Author Swipe
View article: Hepatic vein-derived factors may affect pulmonary arteriovenous malformations after single ventricle palliation by modulating vascular cell behavior
Hepatic vein-derived factors may affect pulmonary arteriovenous malformations after single ventricle palliation by modulating vascular cell behavior Open
Pulmonary arteriovenous malformations (PAVM) are a major surgical complication of univentricular heart therapy, significantly limiting patient survival. Interruption of hepatic venous drainage into the lungs has been long hypothesized to p…
View article: Recellularization of decellularized vascular grafts via aligned seeding of endothelial cells derived from human iPS cells
Recellularization of decellularized vascular grafts via aligned seeding of endothelial cells derived from human iPS cells Open
The development of decellularized vascular tissues for tissue engineering and vascular implants presents a promising approach to creating functional blood vessels. However, effective endothelialization with human endothelial cells remains …
View article: Takayasu Arteritis with Multivessel Occlusion: Staged Revascularization and Cerebral Perfusion Management: A Case Report
Takayasu Arteritis with Multivessel Occlusion: Staged Revascularization and Cerebral Perfusion Management: A Case Report Open
Background: Takayasu arteritis is a rare large-vessel vasculitis that typically affects young women, but it is also diagnosed in older patients with severe vascular occlusions. Case Presentation: We report a case of a 67-year-old female wi…
View article: Production of bioactive cytokines using plant expression system for cardiovascular cell differentiation from human pluripotent stem cells
Production of bioactive cytokines using plant expression system for cardiovascular cell differentiation from human pluripotent stem cells Open
Bioactive cytokines such as vascular endothelial growth factor (VEGF) and Activin A are critical for the differentiation of stem cells into vascular endothelial cells and cardiomyocytes. However, production of the cytokines using conventio…
View article: Retention of locally injected human iPS cell-derived cardiomyocytes into the myocardium using hydrolyzed gelatin
Retention of locally injected human iPS cell-derived cardiomyocytes into the myocardium using hydrolyzed gelatin Open
This study explored the impact of hydrolyzed gelatin (HG) concentration on the retention and therapeutic efficacy of human iPS cell-derived cardiomyocytes (hiPSC-CMs) when injected into the myocardium. The solubility of HG allows precise c…
View article: Investigation of the usefulness of collagen peptide in intramyocardial injection of human iPS cell-derived cardiomyocytes
Investigation of the usefulness of collagen peptide in intramyocardial injection of human iPS cell-derived cardiomyocytes Open
Background Injecting human induced pluripotent stem (iPS) cell-derived cardiomyocytes directly into the heart muscle holds promise as a treatment for heart failure. Achieving better engraftment is crucial for maximizing therapeutic effecti…
View article: Developing endoscopic cell sheet delivery device using a beating human heart simulator and a pig model for minimally invasive cardiac regenerative therapy
Developing endoscopic cell sheet delivery device using a beating human heart simulator and a pig model for minimally invasive cardiac regenerative therapy Open
Introduction Recently, clinical trials have commenced for cardiac regenerative therapy utilizing stem cells in patients with heart failure. Among the various transplantation approaches, there is a growing demand for less invasive methods t…
View article: Simultaneous electro-dynamic stimulation accelerates maturation of engineered cardiac tissues generated by human iPS cells
Simultaneous electro-dynamic stimulation accelerates maturation of engineered cardiac tissues generated by human iPS cells Open
Electrical and dynamic stimulation are commonly employed to enhance the maturation of engineered cardiac tissue (ECT) derived from human induced pluripotent stem cells (iPSCs), reflecting the physiological environment of the heart. While e…
View article: miR-124-3p downregulates EGR1 to suppress ischemia-hypoxia reperfusion injury in human iPS cell-derived cardiomyocytes
miR-124-3p downregulates EGR1 to suppress ischemia-hypoxia reperfusion injury in human iPS cell-derived cardiomyocytes Open
Ischemic heart diseases are a major global cause of death, and despite timely revascularization, heart failure due to ischemia-hypoxia reperfusion (IH/R) injury remains a concern. The study focused on the role of Early Growth Response 1 (E…
View article: Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model
Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model Open
Patients with chronic cardiomyopathy may have persistent viral infections in their hearts, particularly with SARS-CoV-2, which targets the ACE2 receptor highly expressed in human hearts. This raises concerns about a potential global heart …
View article: A novel approach for the endothelialization of xenogeneic decellularized vascular tissues by human cells utilizing surface modification and dynamic culture
A novel approach for the endothelialization of xenogeneic decellularized vascular tissues by human cells utilizing surface modification and dynamic culture Open
Decellularized xenogeneic vascular grafts can be used in revascularization surgeries. We have developed decellularization methods using high hydrostatic pressure (HHP), which preserves the extracellular structure. Here, we attempted ex viv…
View article: A novel approach for the endothelialization of xenogeneic decellularized vascular tissues by human cells utilizing surface modification and dynamic culture
A novel approach for the endothelialization of xenogeneic decellularized vascular tissues by human cells utilizing surface modification and dynamic culture Open
Decellularized xenogeneic vascular grafts can be used in revascularization surgeries. We have developed decellularization methods using high hydrostatic pressure (HHP), which preserves the extracellular structure. Here, we attempted ex viv…
View article: Pioglitazone-incorporated microspheres targeting macrophage polarization alleviates cardiac dysfunction after myocardial infarction
Pioglitazone-incorporated microspheres targeting macrophage polarization alleviates cardiac dysfunction after myocardial infarction Open
OBJECTIVES Excessive and chronic inflammation after a myocardial infarction (MI) is associated with left ventricular remodelling and impaired cardiac function. Among inflammatory cells, macrophages play a critical role in polarizing proinf…
View article: Large Animal Models in Cardiovascular Research
Large Animal Models in Cardiovascular Research Open
Studies of not only preclinical cardiovascular research but also those of life science, medical, and pharmacological fields commonly utilize small animal models. However, for the advancement of cardiovascular medicine, researches using lar…
View article: Systems for the Functional Evaluation of Human Heart Tissues Derived from Pluripotent Stem Cells
Systems for the Functional Evaluation of Human Heart Tissues Derived from Pluripotent Stem Cells Open
Human pluripotent stem cells (hPSCs) are expected to be a promising cell source in regenerative medicine and drug discovery for the treatment of various intractable diseases. An approach for creating a 3-dimensional (3D) structure from hPS…
View article: Benzyl isothiocyanate induces cardiomyocyte proliferation and heart regeneration
Benzyl isothiocyanate induces cardiomyocyte proliferation and heart regeneration Open
Cardiomyocyte proliferation is an evolutionarily conserved mechanism that supports cardiac regeneration in vertebrates. Mammalian cardiomyocytes are arrested from the cell cycle shortly after birth, and therefore mammals lose the ability t…
View article: In vivo recellularization of xenogeneic vascular grafts decellularized with high hydrostatic pressure method in a porcine carotid arterial interpose model
In vivo recellularization of xenogeneic vascular grafts decellularized with high hydrostatic pressure method in a porcine carotid arterial interpose model Open
Autologous vascular grafts are widely used in revascularization surgeries for small caliber targets. However, the availability of autologous conduits might be limited due to prior surgeries or the quality of vessels. Xenogeneic decellulari…
View article: Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function
Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function Open
Human iPS cell (iPSC)-derived cardiomyocytes (CMs) hold promise for drug discovery for heart diseases and cardiac toxicity tests. To utilize human iPSC-derived CMs, the establishment of three-dimensional (3D) heart tissues from iPSC-derive…
View article: Strategies for immune regulation in iPS cell-based cardiac regenerative medicine
Strategies for immune regulation in iPS cell-based cardiac regenerative medicine Open
Cardiac regenerative therapy is expected to be a promising therapeutic option for the treatment of severe cardiovascular diseases. Artificial tissues or organoids made from cardiovascular cell lineages differentiated from human induced plu…