Ruth E. Krasnow
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View article: G.3.2 is a novel allele of the gene connector enhancer of ksr (cnk) in Drosophila melanogaster
G.3.2 is a novel allele of the gene connector enhancer of ksr (cnk) in Drosophila melanogaster Open
Genetic screens in Drosophila melanogaster have long been used to identify genes found in a variety of developmental, cellular, and behavioral processes. Here we describe the characterization and mapping of a mutation identified in a condi…
View article: Supplementary Table 1 from Nicotine Withdrawal Sensitivity, Linkage to chr6q26, and Association of <i>OPRM1</i> SNPs in the SMOking in FAMilies (SMOFAM) Sample
Supplementary Table 1 from Nicotine Withdrawal Sensitivity, Linkage to chr6q26, and Association of <i>OPRM1</i> SNPs in the SMOking in FAMilies (SMOFAM) Sample Open
Supplementary Table 1 from Nicotine Withdrawal Sensitivity, Linkage to chr6q26, and Association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) Sample
View article: Supplementary Table 2 from Nicotine Withdrawal Sensitivity, Linkage to chr6q26, and Association of <i>OPRM1</i> SNPs in the SMOking in FAMilies (SMOFAM) Sample
Supplementary Table 2 from Nicotine Withdrawal Sensitivity, Linkage to chr6q26, and Association of <i>OPRM1</i> SNPs in the SMOking in FAMilies (SMOFAM) Sample Open
Supplementary Table 2 from Nicotine Withdrawal Sensitivity, Linkage to chr6q26, and Association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) Sample
View article: Supplementary Table 1 from Nicotine Withdrawal Sensitivity, Linkage to chr6q26, and Association of <i>OPRM1</i> SNPs in the SMOking in FAMilies (SMOFAM) Sample
Supplementary Table 1 from Nicotine Withdrawal Sensitivity, Linkage to chr6q26, and Association of <i>OPRM1</i> SNPs in the SMOking in FAMilies (SMOFAM) Sample Open
Supplementary Table 1 from Nicotine Withdrawal Sensitivity, Linkage to chr6q26, and Association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) Sample
View article: Data from Nicotine Withdrawal Sensitivity, Linkage to chr6q26, and Association of <i>OPRM1</i> SNPs in the SMOking in FAMilies (SMOFAM) Sample
Data from Nicotine Withdrawal Sensitivity, Linkage to chr6q26, and Association of <i>OPRM1</i> SNPs in the SMOking in FAMilies (SMOFAM) Sample Open
Background: Nicotine withdrawal symptoms are related to smoking cessation. A Rasch model has been used to develop a unidimensional sensitivity score representing multiple correlated measures of nicotine withdrawal. A previous autosome-wide…
View article: Supplementary Table 2 from Nicotine Withdrawal Sensitivity, Linkage to chr6q26, and Association of <i>OPRM1</i> SNPs in the SMOking in FAMilies (SMOFAM) Sample
Supplementary Table 2 from Nicotine Withdrawal Sensitivity, Linkage to chr6q26, and Association of <i>OPRM1</i> SNPs in the SMOking in FAMilies (SMOFAM) Sample Open
Supplementary Table 2 from Nicotine Withdrawal Sensitivity, Linkage to chr6q26, and Association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) Sample
View article: Data from Nicotine Withdrawal Sensitivity, Linkage to chr6q26, and Association of <i>OPRM1</i> SNPs in the SMOking in FAMilies (SMOFAM) Sample
Data from Nicotine Withdrawal Sensitivity, Linkage to chr6q26, and Association of <i>OPRM1</i> SNPs in the SMOking in FAMilies (SMOFAM) Sample Open
Background: Nicotine withdrawal symptoms are related to smoking cessation. A Rasch model has been used to develop a unidimensional sensitivity score representing multiple correlated measures of nicotine withdrawal. A previous autosome-wide…
View article: Whole-Genome Differentially Hydroxymethylated DNA Regions among Twins Discordant for Cardiovascular Death
Whole-Genome Differentially Hydroxymethylated DNA Regions among Twins Discordant for Cardiovascular Death Open
Epigenetics is a mechanism underlying cardiovascular disease. It is unknown whether DNA hydroxymethylation is prospectively associated with the risk for cardiovascular death independent of germline and common environment. Male twin pairs m…
View article: Pharmacogenetics of Nicotine Metabolism in Twins: Methods and Procedures
Pharmacogenetics of Nicotine Metabolism in Twins: Methods and Procedures Open
This article describes a pharmacogenetic investigation of nicotine metabolism in twins. One hundred and thirty-nine twin pairs (110 monozygotic and 29 dizygotic) were recruited and assessed for smoking status, zygosity, and health conditio…
View article: The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins
The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins Open
The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different envir…
View article: Midlife moderation-quantified healthy diet and 40-year mortality risk from CHD: the prospective National Heart, Lung, and Blood Institute Twin Study − ERRATUM
Midlife moderation-quantified healthy diet and 40-year mortality risk from CHD: the prospective National Heart, Lung, and Blood Institute Twin Study − ERRATUM Open
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View article: Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994
Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994 Open
Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,…
View article: Author response: Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994
Author response: Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994 Open
Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts.We conducted an individual-based pooled analysis of 40 twin cohorts including 143,3…
View article: Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study
Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study Open
Background: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking.
View article: Circulating MicroRNAs and Life Expectancy Among Identical Twins
Circulating MicroRNAs and Life Expectancy Among Identical Twins Open
Summary Human life expectancy is influenced not only by longevity assurance mechanisms and disease susceptibility loci but also by the environment, gene–environment interactions, and chance. MicroRNAs (miRNAs) are a class of small noncodin…
View article: Genetic and environmental influences on height from infancy to early adulthood:An individual-based pooled analysis of 45 twin cohorts
Genetic and environmental influences on height from infancy to early adulthood:An individual-based pooled analysis of 45 twin cohorts Open
Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis o…
View article: Midlife moderation-quantified healthy diet and 40-year mortality risk from CHD: the prospective National Heart, Lung, and Blood Institute Twin Study
Midlife moderation-quantified healthy diet and 40-year mortality risk from CHD: the prospective National Heart, Lung, and Blood Institute Twin Study Open
It is unknown whether influences of midlife whole diet on the long-term CHD mortality risk are independent of genetic and common environmental factors or familial predisposition. We addressed this question prospectively using data from the…
View article: Genome-Wide Association of the Laboratory-Based Nicotine Metabolite Ratio in Three Ancestries
Genome-Wide Association of the Laboratory-Based Nicotine Metabolite Ratio in Three Ancestries Open
This multiple ancestry meta-GWAS of the laboratory study-based NMR provides novel evidence and replication for genome-wide association of CYP2A6 single nucleotide and insertion-deletion polymorphisms. We identify three regions of genome-wi…