Kris Johnson
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View article: Surface-based morphometry reveals divergent aging trajectories in veterans with and without traumatic brain injury
Surface-based morphometry reveals divergent aging trajectories in veterans with and without traumatic brain injury Open
This study investigates how traumatic brain injury (TBI) alters cortical aging by comparing cortical thickness (CT) and surface area (SA) in 34 brain regions between TBI survivors and age-matched controls. Using a cross-sectional retrospec…
View article: Complementary value of molecular, phenotypic, and functional aging biomarkers in dementia prediction
Complementary value of molecular, phenotypic, and functional aging biomarkers in dementia prediction Open
DNA methylation age (MA), brain age (BA), and frailty index (FI) are putative aging biomarkers linked to dementia risk. We investigated their relationship and combined potential for prediction of cognitive impairment and future dementia ri…
View article: Greenhouse gas emissions in US beef production can be reduced by up to 30% with the adoption of selected mitigation measures
Greenhouse gas emissions in US beef production can be reduced by up to 30% with the adoption of selected mitigation measures Open
Greenhouse gas (GHG) emissions from beef production in the United States are unevenly distributed across the supply chain and production regions, complicating where and how to reduce emissions most effectively. Using spatially explicit lif…
View article: A novel spatiotemporal graph convolutional network framework for functional connectivity biomarkers identification of Alzheimer’s disease
A novel spatiotemporal graph convolutional network framework for functional connectivity biomarkers identification of Alzheimer’s disease Open
Background Functional connectivity (FC) biomarkers play a crucial role in the early diagnosis and mechanistic study of Alzheimer’s disease (AD). However, the identification of effective FC biomarkers remains challenging. In this study, we …
View article: Polygenic effects on the risk of Alzheimer’s disease in the Japanese population
Polygenic effects on the risk of Alzheimer’s disease in the Japanese population Open
Background Polygenic effects have been proposed to account for some disease phenotypes; these effects are calculated as a polygenic risk score (PRS). This score is correlated with Alzheimer’s disease (AD)-related phenotypes, such as biomar…
View article: Silvopasture offers climate change mitigation and profit potential for farmers in the eastern United States
Silvopasture offers climate change mitigation and profit potential for farmers in the eastern United States Open
Silvopasture—integrating trees, forage, and grazing livestock on the same piece of land—is increasingly popular, given its potential to store carbon (C) and improve farmers’ livelihoods. We examined the C and economic implications of addin…
View article: Prevalence and Clinical Implications of a β-Amyloid–Negative, Tau-Positive Cerebrospinal Fluid Biomarker Profile in Alzheimer Disease
Prevalence and Clinical Implications of a β-Amyloid–Negative, Tau-Positive Cerebrospinal Fluid Biomarker Profile in Alzheimer Disease Open
Importance Knowledge is lacking on the prevalence and prognosis of individuals with a β-amyloid–negative, tau-positive (A−T+) cerebrospinal fluid (CSF) biomarker profile. Objective To estimate the prevalence of a CSF A−T+ biomarker profile…
View article: Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer’s disease
Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer’s disease Open
For optimal design of anti-amyloid-β (Aβ) and anti-tau clinical trials, we need to better understand the pathophysiological cascade of Aβ- and tau-related processes. Therefore, we set out to investigate how Aβ and soluble phosphorylated ta…
View article: The trend of disruption in the functional brain network topology of Alzheimer’s disease
The trend of disruption in the functional brain network topology of Alzheimer’s disease Open
Alzheimer’s disease (AD) is a progressive disorder associated with cognitive dysfunction that alters the brain’s functional connectivity. Assessing these alterations has become a topic of increasing interest. However, a few studies have ex…
View article: Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume Open
The concept of age acceleration, the difference between biological age and chronological age, is of growing interest, particularly with respect to age-related disorders, such as Alzheimer’s Disease (AD). Whilst studies have reported associ…
View article: In vivo staging of regional amyloid deposition
In vivo staging of regional amyloid deposition Open
To estimate a regional progression pattern of amyloid deposition from cross-sectional amyloid-sensitive PET data and evaluate its potential for in vivo staging of an individual's amyloid pathology.
View article: Author Correction: Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease
Author Correction: Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease Open
The original version of the Supplementary information associated with this Article inadvertently omitted Supplementary Table S1. The HTML has been updated to include a corrected version of the Supplementary information.
View article: Environmental Impact Bonds: a common framework and looking ahead
Environmental Impact Bonds: a common framework and looking ahead Open
A frequent barrier to addressing some of our world’s most pressing environmental challenges is a lack of funding. Currently, environmental project funding largely comes from philanthropic and public sources, but this does not meet current …
View article: Leading at the edge: A roadmap to advance edge of field practices in agriculture
Leading at the edge: A roadmap to advance edge of field practices in agriculture Open
Anyone who has driven cross-country knows one thing: America’s landscape is as diverse as it is beautiful. From the sandy shores of the Atlantic Ocean, rich soils of the Midwest, and flat expanse of the Mississippi River Delta, to the arid…