Chandan Krishna
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View article: IMG-140. A network-based approach links novel patterns of multiparametric MRI to clinically relevant molecular signatures in high-grade glioma
IMG-140. A network-based approach links novel patterns of multiparametric MRI to clinically relevant molecular signatures in high-grade glioma Open
High-grade gliomas (HGG) have significant spatial heterogeneity, complicating therapeutic approaches. While multiparametric MRI (mpMRI) enables noninvasive assessment of this heterogeneity, most predictive models lack biological interpreta…
View article: POS0069 SYNOVIAL IMMUNE CELLS EXHIBIT A TYPE I IFN GENE SIGNATURE IN ACPA-NEGATIVE RHEUMATOID ARTHRITIS
POS0069 SYNOVIAL IMMUNE CELLS EXHIBIT A TYPE I IFN GENE SIGNATURE IN ACPA-NEGATIVE RHEUMATOID ARTHRITIS Open
View article: Point-of-Care Testing and Integrated Digital Health Technology for CKD Screening in High-Risk Populations of India
Point-of-Care Testing and Integrated Digital Health Technology for CKD Screening in High-Risk Populations of India Open
CKD screening using POCT and digital health technology allowed diagnosis of CKD in patients of high-risk groups and should be scaled up with the final goal to ensure early diagnosis, decrease costs, and improve patients' clinical managemen…
View article: Outpatient Endocrine Protocol and Testing Coincides with Reduced Length of Postpituitary Surgery Admission
Outpatient Endocrine Protocol and Testing Coincides with Reduced Length of Postpituitary Surgery Admission Open
The study objective was to compare the length of stay (LOS) and the proportion of one-night admissions before and after the implementation of an endocrine monitoring protocol following endoscopic transsphenoidal surgery (ETSS) for pituitar…
View article: Evaluating osteoporosis and bone quality in the aging spine: modern considerations for surgical management in the geriatric population
Evaluating osteoporosis and bone quality in the aging spine: modern considerations for surgical management in the geriatric population Open
View article: Optimizing radiotherapy strategies for skull base chordoma: a comprehensive meta-analysis and systematic review of treatment modalities and outcomes
Optimizing radiotherapy strategies for skull base chordoma: a comprehensive meta-analysis and systematic review of treatment modalities and outcomes Open
OBJECTIVE In the treatment of skull base chordoma (SBC) surgery is considered the mainstay approach, and gross-total resection has an established relationship with progression-free survival (PFS) and overall survival (OS). However, the tum…
View article: Quantifying intra-tumoral genetic heterogeneity of glioblastoma toward precision medicine using MRI and a data-inclusive machine learning algorithm
Quantifying intra-tumoral genetic heterogeneity of glioblastoma toward precision medicine using MRI and a data-inclusive machine learning algorithm Open
Background and objective Glioblastoma (GBM) is one of the most aggressive and lethal human cancers. Intra-tumoral genetic heterogeneity poses a significant challenge for treatment. Biopsy is invasive, which motivates the development of non…
View article: Quantifying intra-tumoral genetic heterogeneity of glioblastoma toward precision medicine using MRI and a data-inclusive machine learning algorithm
Quantifying intra-tumoral genetic heterogeneity of glioblastoma toward precision medicine using MRI and a data-inclusive machine learning algorithm Open
Glioblastoma (GBM) is one of the most aggressive and lethal human cancers. Intra-tumoral genetic heterogeneity poses a significant challenge for treatment. Biopsy is invasive, which motivates the development of non-invasive, MRI-based mach…
View article: Image-localized biopsy mapping of brain tumor heterogeneity: A single-center study protocol
Image-localized biopsy mapping of brain tumor heterogeneity: A single-center study protocol Open
Brain cancers pose a novel set of difficulties due to the limited accessibility of human brain tumor tissue. For this reason, clinical decision-making relies heavily on MR imaging interpretation, yet the mapping between MRI features and un…
View article: EPCO-31. THE PROGNOSTIC IMPLICATIONS OF THE RELATIVE ABUNDANCE OF DECONVOLVED TUMOR AND NON-TUMORAL SUBPOPULATIONS IN MULTI-REGIONAL BIOPSIES OF HIGH GRADE GLIOMA WITH BULK RNA-SEQ
EPCO-31. THE PROGNOSTIC IMPLICATIONS OF THE RELATIVE ABUNDANCE OF DECONVOLVED TUMOR AND NON-TUMORAL SUBPOPULATIONS IN MULTI-REGIONAL BIOPSIES OF HIGH GRADE GLIOMA WITH BULK RNA-SEQ Open
High-grade glioma continues to have dismal survival owing in part to its intra- and inter-patient heterogeneity. Standard clinical protocol collects tumor samples with the aim of providing or confirming a diagnosis and determining the stat…
View article: INNV-01. ASSESSMENT OF SURVIVAL AND SAFETY FOLLOWING INTRATHECAL CHEMOTHERAPY VIA OMMAYA RESERVOIR FOR PATIENTS WITH LEPTOMENINGEAL DISEASE
INNV-01. ASSESSMENT OF SURVIVAL AND SAFETY FOLLOWING INTRATHECAL CHEMOTHERAPY VIA OMMAYA RESERVOIR FOR PATIENTS WITH LEPTOMENINGEAL DISEASE Open
BACKGROUND Leptomeningeal disease (LMD) carries poor prognosis with an average survival of 3-6 months after diagnosis. Ommaya reservoirs (OR) are an accessible alternative to serial lumbar punctures for delivery of intrathecal chemotherapy…
View article: Integrated molecular and multiparametric MRI mapping of high-grade glioma identifies regional biologic signatures
Integrated molecular and multiparametric MRI mapping of high-grade glioma identifies regional biologic signatures Open
Sampling restrictions have hindered the comprehensive study of invasive non-enhancing (NE) high-grade glioma (HGG) cell populations driving tumor progression. Here, we present an integrated multi-omic analysis of spatially matched molecula…
View article: BULK RNA-SEQ DECONVOLUTION OF IMAGE-LOCALIZED HIGGRADE GLIOMA BIOPSIES REVEALS MEANINGFUL CELLULAR STATES
BULK RNA-SEQ DECONVOLUTION OF IMAGE-LOCALIZED HIGGRADE GLIOMA BIOPSIES REVEALS MEANINGFUL CELLULAR STATES Open
AIMS High-grade glioma continues to have dismal survival with current standard-of-care treatment, owing in part to its intra- and inter-patient heterogeneity. Typical diagnostic biopsies are taken from the dense tumor core to determine the…
View article: Image-localized biopsy mapping of brain tumor heterogeneity: A single-center study protocol
Image-localized biopsy mapping of brain tumor heterogeneity: A single-center study protocol Open
Brain cancers pose a novel set of difficulties due to the limited accessibility of human brain tumor tissue. For this reason, clinical decision-making relies heavily on MR imaging interpretation, yet the mapping between MRI features and un…
View article: TMIC-58. PATTERNS OF CELLULAR SUBPOPULATION COHABITATION DEFINE GLIOBLASTOMA STATES
TMIC-58. PATTERNS OF CELLULAR SUBPOPULATION COHABITATION DEFINE GLIOBLASTOMA STATES Open
Characterizing intra- and inter-tumoral heterogeneity of glioblastoma has historically relied on discrete classifications of malignant cell populations leaving immune and other cell populations, known to exist admixed with the malignant tu…
View article: Optimizing Door-to-Groin Puncture Time: The Mayo Clinic Experience
Optimizing Door-to-Groin Puncture Time: The Mayo Clinic Experience Open
Computed tomography flow modifications produced the largest and most consistent reduction in the DTP time. However, the reduction in the DTP time across all the studies suggests that any systematic protocol aimed at reducing the DTP time c…
View article: Glioblastoma states are defined by cohabitating cellular populations with progression-, imaging- and sex-distinct patterns
Glioblastoma states are defined by cohabitating cellular populations with progression-, imaging- and sex-distinct patterns Open
Glioblastomas (GBMs) are biologically heterogeneous within and between patients. Many previous attempts to characterize this heterogeneity have classified tumors according to their omics similarities. These discrete classifications have pr…
View article: Uncertainty quantification in the radiogenomics modeling of EGFR amplification in glioblastoma
Uncertainty quantification in the radiogenomics modeling of EGFR amplification in glioblastoma Open
View article: Uncertainty Quantification in Radiogenomics: EGFR Amplification in Glioblastoma
Uncertainty Quantification in Radiogenomics: EGFR Amplification in Glioblastoma Open
BACKGROUND Radiogenomics uses machine-learning (ML) to directly connect the morphologic and physiological appearance of tumors on clinical imaging with underlying genomic features. Despite extensive growth in the area of radiogenomics acro…
View article: Troubleshooting an unusual complication following intrathecal chemotherapy delivered via Ommaya catheter: A case report
Troubleshooting an unusual complication following intrathecal chemotherapy delivered via Ommaya catheter: A case report Open
The authors report the case of a 39-year-old woman with leukemic meningitis. A right frontal Ommaya reservoir was placed for intrathecal chemotherapy. During and immediately following the first injection of chemotherapy, the patient develo…
View article: Oral Presentations from the 2020 AANS Annual Scientific Meeting
Oral Presentations from the 2020 AANS Annual Scientific Meeting Open
Introduction:Anterior lumbar interbody fusion (ALIF) is used to treat lumbar spondylosis and spondylolisthesis.The operation involves an anterior, retroperitoneal approach to the spine.Patients frequently experience a slow return of bowel …
View article: Performance of Standardized Relative CBV for Quantifying Regional Histologic Tumor Burden in Recurrent High-Grade Glioma: Comparison against Normalized Relative CBV Using Image-Localized Stereotactic Biopsies
Performance of Standardized Relative CBV for Quantifying Regional Histologic Tumor Burden in Recurrent High-Grade Glioma: Comparison against Normalized Relative CBV Using Image-Localized Stereotactic Biopsies Open
Standardization of relative CBV achieves similar performance compared with normalized relative CBV and offers an important step toward workflow optimization and consensus methodology.
View article: NIMG-52. UNCERTAINTY QUANTIFICATION IN RADIOMICS
NIMG-52. UNCERTAINTY QUANTIFICATION IN RADIOMICS Open
INTRODUCTION The quantification of intratumoral heterogeneity – through radiomics-based approaches - can help resolve the regionally distinct genetic drug targets that may co-exist within a single Glioblastoma (GBM) tumor. While this offer…
View article: A Multicenter Pilot Study on the Clinical Utility of Computational Modeling for Flow-Diverter Treatment Planning
A Multicenter Pilot Study on the Clinical Utility of Computational Modeling for Flow-Diverter Treatment Planning Open
Physicians found computational modeling to be an impactful and useful tool for flow-diverter treatment planning. Validation results showed good agreement between simulated and clinical flow-diverter diameters and lengths.
View article: Accurate Patient-Specific Machine Learning Models of Glioblastoma Invasion Using Transfer Learning
Accurate Patient-Specific Machine Learning Models of Glioblastoma Invasion Using Transfer Learning Open
Transfer learning significantly improves predictive modeling performance for quantifying tumor cell density in glioblastoma.
View article: Extended Lateral Orbital Craniotomy: Anatomic Study and Initial Clinical Series of a Novel Minimally Invasive Pterional Approach
Extended Lateral Orbital Craniotomy: Anatomic Study and Initial Clinical Series of a Novel Minimally Invasive Pterional Approach Open
Background Of the minimally invasive “keyhole” alternatives to the pterional region, the supraorbital eyebrow approach is the most widely adopted. Yet it can prove disadvantageous when a more direct lateral microsurgical trajectory of atta…
View article: Use of 4D Computer Tomographic Angiography to Accurately Identify Distal Internal Carotid Artery Occlusions and Pseudo-Occlusions: Technical Note.
Use of 4D Computer Tomographic Angiography to Accurately Identify Distal Internal Carotid Artery Occlusions and Pseudo-Occlusions: Technical Note. Open
4D CTA may be a more effective noninvasive imaging technique than traditional CTA to detect intracranial carotid artery occlusions and carotid artery pseudo-occlusions. Accurate, rapid, and noninvasive diagnosis of carotid artery lesions m…
View article: Spontaneous resolution of ruptured intracranial pial arteriovenous fistula following spinal surgery
Spontaneous resolution of ruptured intracranial pial arteriovenous fistula following spinal surgery Open
Pial arteriovenous fistulae (AVFs) are rare vascular abnormalities that are distinct from arteriovenous malformations and dural AVFs. These vascular lesions have been linked with trauma, ischemic syndromes, venous thrombotic diseases, and …
View article: Assessment of the Interrater Reliability of the Congress of Neurological Surgeons Microanastomosis Assessment Scale
Assessment of the Interrater Reliability of the Congress of Neurological Surgeons Microanastomosis Assessment Scale Open
BACKGROUND: The potential for simulation-based learning in neurosurgical training has led the Congress of Neurosurgical Surgeons to develop a series of simulation modules. The Northwestern Objective Microanastomosis Assessment Tool (NOMAT)…
View article: Patency of anterior circulation branch vessels after Pipeline embolization: longer-term results from 82 aneurysm cases
Patency of anterior circulation branch vessels after Pipeline embolization: longer-term results from 82 aneurysm cases Open
OBJECTIVE The Pipeline Embolization Device (PED) has become increasingly used for the treatment of intracranial aneurysms. Given its high metal surface area coverage, there is concern for the patency of branch vessels that become covered b…