Krishna Kumar Ojha
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View article: Evaluating the Relative Efficacy of Synthetic and Natural Drugs in Endometriosis Adopting Molecular Modelling Approach
Evaluating the Relative Efficacy of Synthetic and Natural Drugs in Endometriosis Adopting Molecular Modelling Approach Open
Background: Endometriosis is a chronic inflammatory condition of high incidence and with serious consequences. Several synthetic compounds proved to be useful in treating its symptoms by inhibiting aromatase, which is responsible for the p…
View article: Identification of possible SARS-CoV-2 main protease inhibitors: in silico molecular docking and dynamic simulation studies
Identification of possible SARS-CoV-2 main protease inhibitors: in silico molecular docking and dynamic simulation studies Open
Background COVID-19 was declared a pandemic by the World Health Organisation in 2020 after its outbreak in December 2019 in Wuhan, China. Since researchers have been working to develop specific drugs to cure COVID-19. COVID-19 is caused by…
View article: WITHDRAWN: In-silico discovery of novel microtubule inhibitors targeting colchicine binding site; A combined Group-based QSAR approach
WITHDRAWN: In-silico discovery of novel microtubule inhibitors targeting colchicine binding site; A combined Group-based QSAR approach Open
Microtubules are a potential target for the design and development of novel anti-mitotic drugs for cancer therapy Focusing on their mechanisms of action, Microtubuletargeting agents are classified into stabilizers and destabilizers, among …
View article: In silico ADMET, molecular docking and molecular simulation-based study of glabridin’s natural and semisynthetic derivatives as potential tyrosinase inhibitors
In silico ADMET, molecular docking and molecular simulation-based study of glabridin’s natural and semisynthetic derivatives as potential tyrosinase inhibitors Open
Objective Hyper-pigmentation conditions may develop due to erroneous melanogenesis cascade which leads to excess melanin production. Recently, inhibition of tyrosinase is the main focus of investigation as it majorly contributes to melanin…
View article: <i>In silico</i> analysis of comparative affinity of phytosiderophore and bacillibactin for iron uptake by YSL15 and YSL18 receptors of <i>Oryza sativa</i>
<i>In silico</i> analysis of comparative affinity of phytosiderophore and bacillibactin for iron uptake by YSL15 and YSL18 receptors of <i>Oryza sativa</i> Open
Iron is an important micronutrient for plant growth and development. In the case of Oryza sativa, iron is made available primarily with the help of iron chelators called phytosiderophores i.e. variants of deoxymugineic acid (DMA). They bin…
View article: Development of predictive in silico cytotoxic activity model to predict the cytotoxicity of a diverse set of colchicine binding site inhibitors
Development of predictive in silico cytotoxic activity model to predict the cytotoxicity of a diverse set of colchicine binding site inhibitors Open
Microtubule targeting agents often have limitations to the development of resistance. Colchicine binding site agents have several advantages as compared to other tubulin inhibitors. Numerous medications in this class are less susceptible t…
View article: A Drug Repurposing Approach to Identify Therapeutics by Screening Medicines for Malaria Ventures Exploiting SARS-CoV-2 Main Protease
A Drug Repurposing Approach to Identify Therapeutics by Screening Medicines for Malaria Ventures Exploiting SARS-CoV-2 Main Protease Open
COVID-19 pandemic makes the human-kind standstill and results in high morbidity and mortality cases worldwide. Still, there are no approved antiviral drugs with proven efficacy nor any therapeutic vaccines to combat the disease as per the …
View article: A Drug Repurposing Approach to Identify Therapeutics by Screening Medicines for Malaria Ventures Exploiting SARS-CoV-2 Main Protease
A Drug Repurposing Approach to Identify Therapeutics by Screening Medicines for Malaria Ventures Exploiting SARS-CoV-2 Main Protease Open
COVID-19 pandemic makes the human-kind standstill and results in high morbidity and mortality cases worldwide. Still, there are no approved antiviral drugs with proven efficacy nor any therapeutic vaccines to combat the disease as per the …
View article: Deciphering foot-and-mouth disease (FMD) virus–host tropism
Deciphering foot-and-mouth disease (FMD) virus–host tropism Open
The pattern of interactions between foot and mouth disease (FMD) viral protein 1 (VP1) with susceptible and resistant host integrins were deciphered. The putative effect of site-directed mutation on alteration of interaction is illustrated…
View article: Deciphering foot-and-mouth disease (FMD) virus–host tropism
Deciphering foot-and-mouth disease (FMD) virus–host tropism Open
The pattern of interactions between foot and mouth disease (FMD) viral protein 1 (VP1) with susceptible and resistant host integrins were deciphered. The putative effect of site-directed mutation on alteration of interaction is illustrated…
View article: In silico Studies for Potential Natural Inhibitors for Isocitrate Dehydrogenase Type II of Mycobacterium tuberculosis (H37Rv)
In silico Studies for Potential Natural Inhibitors for Isocitrate Dehydrogenase Type II of Mycobacterium tuberculosis (H37Rv) Open
Background and Objective: Tuberculosis is a life threatening bacterial disease caused by Mycobacterium tuberculosis (M.tuberculosis) which has affected the population of almost all parts of the world since time immemorial.Although remarkab…
View article: ArchaeVir: A Comprehensive Genometrics Database of Archaeal Viruses
ArchaeVir: A Comprehensive Genometrics Database of Archaeal Viruses Open
Background and Objective: The era of high throughput sequencing technology has poured thousands of full genomes sequences in public databases.A remarkable portion of these genomic sequences belongs to the viruses of which viruses infecting…
View article: In Silico Studies of M. Tuberculosis L-Lysine 6- Monooxygenase (Mbtg) as Potential Target and an Approach for Repurposing First Line Antitubercular Oral Drugs
In Silico Studies of M. Tuberculosis L-Lysine 6- Monooxygenase (Mbtg) as Potential Target and an Approach for Repurposing First Line Antitubercular Oral Drugs Open
Tuberculosis deadly bacterial disease caused by Mycobacterium tuberculosis which has affected the almost all part of the world population. A exhaustive work has been done for defending this bacteria but due to emergence of resistant strain…