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View article: Effect of Particulate Matter Pollution on Global Lung Cancer Burden: A Systematic Analysis for the Global Burden of Disease Study 1990–2021
Effect of Particulate Matter Pollution on Global Lung Cancer Burden: A Systematic Analysis for the Global Burden of Disease Study 1990–2021 Open
Background Lung cancer remains a leading cause of cancer mortality globally, with particulate matter pollution (PMP) identified as a critical environmental risk. This study analyzes long‐term trends in age‐standardized mortality (ASMR) and…
View article: Machine learning‑based model identifies a novel cuproptosis‑related mitochondrial gene signature with a key role in the prognosis and treatment of lung adenocarcinoma
Machine learning‑based model identifies a novel cuproptosis‑related mitochondrial gene signature with a key role in the prognosis and treatment of lung adenocarcinoma Open
Lung adenocarcinoma (LUAD) remains one of the most prevalent and lethal cancers globally, making it critical to understand the mechanisms driving its progression and improve prognosis. Moreover, cuproptosis and mitochondrial dysfunction ma…
View article: Mediating role of thyroid dysfunction in the relationship between insomnia and osteoporosis: A Mendelian randomization analysis
Mediating role of thyroid dysfunction in the relationship between insomnia and osteoporosis: A Mendelian randomization analysis Open
This study supports a causal link between insomnia and osteoporosis. Hypothyroidism plays a mediating role in this pathway. Targeting hypothyroidism may lower the risk of osteoporosis associated with insomnia.
View article: Exploring the causal relationship between serum uric acid and gastrointestinal cancer based on Mendelian randomization studies and bioinformatics approaches
Exploring the causal relationship between serum uric acid and gastrointestinal cancer based on Mendelian randomization studies and bioinformatics approaches Open
Recent observational studies show a correlation between serum uric acid (SUA) levels and colorectal and gastric cancers (CRC and GC). It is unclear, nevertheless, what the biological mechanisms and causation of these connections are. Using…
View article: Anlotinib Plus Osimertinib in Osimertinib‐Resistant Nonsquamous Nonsmall Cell Lung Cancer With Gradual Progression: A Retrospective Study
Anlotinib Plus Osimertinib in Osimertinib‐Resistant Nonsquamous Nonsmall Cell Lung Cancer With Gradual Progression: A Retrospective Study Open
Background Previous studies have shown that anlotinib plus third‐generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) overcome acquired resistance to EGFR‐TKIs in patients with advanced EGFR‐mutant nonsmall ce…
View article: Unexpected outcomes of tislelizumab treatment in thoracic metastasis of malignant phyllodes tumors: a case report and literature review
Unexpected outcomes of tislelizumab treatment in thoracic metastasis of malignant phyllodes tumors: a case report and literature review Open
Phyllodes tumo (PT) of the breast are classified into benign, borderline, and malignant types. Malignant phyllodes tumor (MPT) with metastasis, particularly those containing sarcomatous components, have a notably poor prognosis. The most c…
View article: Is intraperitoneal isoperistaltic side-to-side anastomosis a safe surgical procedure in radical colon cancer surgery
Is intraperitoneal isoperistaltic side-to-side anastomosis a safe surgical procedure in radical colon cancer surgery Open
BACKGROUND Colorectal cancer, one of the most common malignancies, is primarily treated through surgery. With the widespread use of laparoscopy, gastrointestinal reconstruction remains a key area of research. The choice between intraperito…
View article: [The combined regimen based on obinutuzumab plus glucocorticoid for 4 cases of relapsed iTTP].
[The combined regimen based on obinutuzumab plus glucocorticoid for 4 cases of relapsed iTTP]. Open
Objective: To evaluate the efficacy and safety of obinutuzumab combined with glucocorticoid-based therapy in patients with relapsed immune thrombotic thrombocytopenic purpura (iTTP). Methods: This study analyzed the efficacy and adverse re…
View article: Unravelling the prognostic and operative role of intratumoural microbiota in non‐small cell lung cancer: Insights from <i>16S rRNA</i> and RNA sequencing
Unravelling the prognostic and operative role of intratumoural microbiota in non‐small cell lung cancer: Insights from <i>16S rRNA</i> and RNA sequencing Open
Background Complex interrelationships between the microbiota and cancer have been identified by several studies. However, despite delineating microbial composition in non‐small cell lung cancer (NSCLC), key pathogenic microbiota and their …
View article: Myofibroblasts derived type V collagen promoting tissue mechanical stress and facilitating metastasis and therapy resistance of lung adenocarcinoma cells
Myofibroblasts derived type V collagen promoting tissue mechanical stress and facilitating metastasis and therapy resistance of lung adenocarcinoma cells Open
Lung cancer is a leading cause of cancer-related mortality globally, with a dismal 5-year survival rate, particularly for Lung Adenocarcinoma (LUAD). Mechanical changes within the tumor microenvironment, such as extracellular matrix (ECM) …
View article: Pan-cancer analysis combined with experiments predicts NNMT as a therapeutic target for human cancers
Pan-cancer analysis combined with experiments predicts NNMT as a therapeutic target for human cancers Open
The identification of effective therapeutic targets plays a pivotal role in advancing cancer treatment outcomes. We employed a comprehensive pan-cancer analysis, complemented by experimental validation, to explore the potential of Nicotina…
View article: Pan-cancer analysis predict that FAT1 is a therapeutic target and immunotherapy biomarker for multiple cancer types including non-small cell lung cancer
Pan-cancer analysis predict that FAT1 is a therapeutic target and immunotherapy biomarker for multiple cancer types including non-small cell lung cancer Open
FAT1, a substantial transmembrane protein, plays a pivotal role in cellular adhesion and cell signaling. Numerous studies have documented frequent alterations in FAT1 across various cancer types, with its aberrant expression being linked t…
View article: Corrigendum: ITGAL expression in non-small-cell lung cancer tissue and its association with immune infiltrates
Corrigendum: ITGAL expression in non-small-cell lung cancer tissue and its association with immune infiltrates Open
[This corrects the article DOI: 10.3389/fimmu.2024.1382231.].
View article: Myofibroblasts Derived Type V Collagen Promoting Tissue Mechanical Stress and Facilitating Metastasis and Therapy Resistance of Lung Adenocarcinoma Cells
Myofibroblasts Derived Type V Collagen Promoting Tissue Mechanical Stress and Facilitating Metastasis and Therapy Resistance of Lung Adenocarcinoma Cells Open
Background Lung cancer accounts for 11.6% of new diagnosed malignancy cases and stands as a major cause of global cancer-related deaths, with a 5-year survival rate of 5% for Lung Adenocarcinoma (LUAD), which is one of the major histology …
View article: ITGAL expression in non-small-cell lung cancer tissue and its association with immune infiltrates
ITGAL expression in non-small-cell lung cancer tissue and its association with immune infiltrates Open
Background Integrin subunit alpha L (ITGAL) encodes an integrin component of LFA-1 and is a membrane receptor molecule widely expressed on leukocytes. It plays a key role in the interaction between white blood cells and other cells. There …
View article: Construction of a Prognostic Model for Lung Adenocarcinoma Based on Nucleotide Metabolism-Related Genes and Bioinformatics Analysis
Construction of a Prognostic Model for Lung Adenocarcinoma Based on Nucleotide Metabolism-Related Genes and Bioinformatics Analysis Open
Background: Metabolic reprogramming is an important hallmark of cancer. However, it is still uncertain how nucleotide metabolism-related genes (NMRGs) may affect the prognosis of Lung adenocarcinoma (LUAD). Methods: In our study, the LUAD …
View article: [Expression of FAT1 in Lung Adenocarcinoma and Its Relationship
with Immune Cell Infiltration].
[Expression of FAT1 in Lung Adenocarcinoma and Its Relationship
with Immune Cell Infiltration]. Open
FAT1 mRNA is highly expressed in lung adenocarcinoma tissues, and elevated FAT1 mRNA expression is associated with poor prognosis in lung adenocarcinoma patients. FAT1 may serve as a potential biomarker for lung cancer.
View article: [Identification and Analysis of SND1 as an Oncogene and Prognostic Biomarker
for Lung Adenocarcinoma].
[Identification and Analysis of SND1 as an Oncogene and Prognostic Biomarker
for Lung Adenocarcinoma]. Open
SND1 might be an important prognostic biomarker of LUAD and may promote LUAD cells proliferation and migration.
View article: ARID1B Deficiency Leads to Impaired DNA Damage Response and Activated cGAS-STING Pathway in Non-Small Cell Lung Cancer
ARID1B Deficiency Leads to Impaired DNA Damage Response and Activated cGAS-STING Pathway in Non-Small Cell Lung Cancer Open
Purpose: Lung cancer is a major cause of morbidity and mortality globally, necessitating the identification of predictive markers for effective immunotherapy. Mutations in SWI/SNF chromatin remodeling complex genes were reported sensitized…
View article: Identification of Hypoxia and Mitochondrial-related Gene Signature and Prediction of Prognostic Model in Lung Adenocarcinoma
Identification of Hypoxia and Mitochondrial-related Gene Signature and Prediction of Prognostic Model in Lung Adenocarcinoma Open
Background: The correlation between hypoxia and tumor development is widely acknowledged. Meanwhile, the foremost organelle affected by hypoxia is mitochondria. This study aims to determine whether they possess prognostic characteristics i…
View article: Identification and Validation of a Hypoxia and Glycolysis Prognostic Signatures in Lung Adenocarcinoma
Identification and Validation of a Hypoxia and Glycolysis Prognostic Signatures in Lung Adenocarcinoma Open
Background: Lung adenocarcinoma (LUAD) represents a prevalent subtype of non-small cell lung cancer with a complex molecular landscape. Dysregulated cellular energetics, notably the interplay between hypoxia and glycolysis, has emerged as …
View article: Apatinib added when <scp>NSCLC</scp> patients get slow progression with <scp>EGFR‐TKI</scp>: A prospective, single‐arm study
Apatinib added when <span>NSCLC</span> patients get slow progression with <span>EGFR‐TKI</span>: A prospective, single‐arm study Open
Background Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKI) acquired resistance was an inevitably events in NSCLC treatment. Aims Intending to overcome the acquired resistance of EGFR‐TKI. Materials & Methods A clinic…
View article: Pan-cancer analysis combined with experiments predicts NNMT as a therapeutic target for human cancers
Pan-cancer analysis combined with experiments predicts NNMT as a therapeutic target for human cancers Open
The identification of effective therapeutic targets plays a pivotal role in advancing cancer treatment outcomes. We employed a comprehensive pan-cancer analysis, complemented by experimental validation, to explore the potential of Nicotina…
View article: Exploring the therapeutic potential of targeting polycomb repressive complex 2 in lung cancer
Exploring the therapeutic potential of targeting polycomb repressive complex 2 in lung cancer Open
The pathogenesis of lung cancer (LC) is a multifaceted process that is influenced by a variety of factors. Alongside genetic mutations and environmental influences, there is increasing evidence that epigenetic mechanisms play a significant…
View article: ARID1B Deficiency Leads to Impaired DNA Damage Response and Activated cGAS- STING Pathway in Non-Small Cell Lung Cancer
ARID1B Deficiency Leads to Impaired DNA Damage Response and Activated cGAS- STING Pathway in Non-Small Cell Lung Cancer Open
Purpose Lung cancer is a major cause of morbidity and mortality globally, necessitating the identification of predictive markers for effective immunotherapy. Mutations in SWI/SNF chromatin remodeling complex genes were reported sensitized …
View article: Case Report: ALK rearranged locally advanced lung adenocarcinoma showing inconsistent radiographic findings and pathological responses during neoadjuvant alectinib therapy
Case Report: ALK rearranged locally advanced lung adenocarcinoma showing inconsistent radiographic findings and pathological responses during neoadjuvant alectinib therapy Open
Alectinib has been approved as first-line treatment for anaplastic lymphoma kinase (ALK)-positive non-small cell lung carcinoma. Oncologists are also exploring the possibility of applying alectinib in the perioperative period. Here, we pre…
View article: Exploring the Association Between PRC2 Genes Variants and Lung Cancer Risk in Chinese Han Population
Exploring the Association Between PRC2 Genes Variants and Lung Cancer Risk in Chinese Han Population Open
This study provides evidence that allelic variants in EZH2, EED, and RBBP4 may act as protective factors against LC development and could serve as genetic markers associated with susceptibility to LC.