Krishnan Venkataraman
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View article: Signs and symptoms of oral candidiasis associated with health factors and resistant Candida infections in a Northern Ontario patient cohort
Signs and symptoms of oral candidiasis associated with health factors and resistant Candida infections in a Northern Ontario patient cohort Open
Background Oral candidiasis is a common fungal infection that disproportionately affects older adults, immunosuppressed individuals, and patients undergoing cancer treatment. Despite its prevalence, diagnosis and treatment remain challengi…
View article: Pre-infection cerebral cortex structure predicts murine sepsis outcome
Pre-infection cerebral cortex structure predicts murine sepsis outcome Open
Sepsis is a life-threatening condition caused by an inappropriate host response to an infection that can lead to multi-organ failure and death. Predictive markers that can inform the trajectory and outcome for a septic patient are necessar…
View article: The use of Bacillus subtilis as a cost-effective expression system for production of Cholera Toxin B fused factor VIII epitope regions applicable for inducing oral immune tolerance
The use of Bacillus subtilis as a cost-effective expression system for production of Cholera Toxin B fused factor VIII epitope regions applicable for inducing oral immune tolerance Open
View article: Cholesterol transport and beyond: Illuminating the versatile functions of <scp>HDL</scp> apolipoproteins through structural insights and functional implications
Cholesterol transport and beyond: Illuminating the versatile functions of <span>HDL</span> apolipoproteins through structural insights and functional implications Open
High‐density lipoproteins (HDLs) play a vital role in lipid metabolism and cardiovascular health, as they are intricately involved in cholesterol transport and inflammation modulation. The proteome of HDL particles is indeed complex and di…
View article: High factor VIII concentrations interfere with glycoprotein VI-mediated platelet activation in vitro
High factor VIII concentrations interfere with glycoprotein VI-mediated platelet activation in vitro Open
We showed that VWF-free FVIII binding to, or close to, GPVI modulates platelet activation in vitro. This may represent an uncharacterized negative feedback loop to control overt platelet activation. Whether locally activated FVIII concentr…
View article: GPR56 signaling pathway network and its dynamics in the mesenchymal transition of glioblastoma
GPR56 signaling pathway network and its dynamics in the mesenchymal transition of glioblastoma Open
G protein-coupled receptor 56 (GPR56/ADGRG1) is a multifunctional adhesion GPCR involved in diverse biological processes ranging from development to cancer. In our earlier study, we reported that GPR56 is expressed heterogeneously in gliob…
View article: Molecular Mechanisms Associated with Antifungal Resistance in Pathogenic Candida Species
Molecular Mechanisms Associated with Antifungal Resistance in Pathogenic Candida Species Open
Candidiasis is a highly pervasive infection posing major health risks, especially for immunocompromised populations. Pathogenic Candida species have evolved intrinsic and acquired resistance to a variety of antifungal medications. The prim…
View article: The Effects of Oral Probiotics on Type 2 Diabetes Mellitus (T2DM): A Clinical Trial Systematic Literature Review
The Effects of Oral Probiotics on Type 2 Diabetes Mellitus (T2DM): A Clinical Trial Systematic Literature Review Open
Type 2 diabetes mellitus (T2DM) remains a global health concern. Emerging clinical trial (CT) evidence suggests that probiotic intervention may promote a healthy gut microbiome in individuals with T2DM, thereby improving management of the …
View article: A commentary on the paper, ‘Development and validation of a novel automatable assay for cholesterol efflux capacity’
A commentary on the paper, ‘Development and validation of a novel automatable assay for cholesterol efflux capacity’ Open
The determination of functionality or quality of high-density lipoproteins (HDL) is assuming a central stage in the prediction of cardiovascular diseases (CVD). To assess HDL quality, several attempts have been made to develop an automated…
View article: Oxidized Lipoproteins as the Diagnostic Target for Cardiovascular Diseases
Oxidized Lipoproteins as the Diagnostic Target for Cardiovascular Diseases Open
Low HDL-cholesterol and high LDL-cholesterol in plasma have long been associated with cardiovascular disease (CVD) risk.The quantity of cholesterol associated with these lipoproteins is being traditionally used to predict CVD risk.However,…
View article: Diagnostic potential of monoclonal antibodies developed against C-terminal polypeptide of <i>P. falciparum</i> Histidine Rich Protein2 (P<i>f</i>HRP2) in malaria infected patients from India
Diagnostic potential of monoclonal antibodies developed against C-terminal polypeptide of <i>P. falciparum</i> Histidine Rich Protein2 (P<i>f</i>HRP2) in malaria infected patients from India Open
Malaria, caused by Plasmodium falciparum has become a major health burden in most tropical and developing countries. P. falciparum Histidine Rich Protein2 (PfHRP2), which exhibits polymorphism, is being widely used as a diagnostic marker. …
View article: Serovar prevalence of Leptospira in semirural India and the development of an IgM-based indirect ELISA
Serovar prevalence of Leptospira in semirural India and the development of an IgM-based indirect ELISA Open
Introduction: Leptospirosis is a major public health problem in India. However, it has been underreported and under-diagnosed due to a lack of awareness of the disease, a functional surveillance system, and appropriate laboratory diagnosti…
View article: Exercise and Antioxidant Intake in Aging Normotensive and Hypertensive Individuals
Exercise and Antioxidant Intake in Aging Normotensive and Hypertensive Individuals Open
Cardiovascular Disease (CVD) is a leading cause of
View article: Issue Information
Issue Information Open
Isolation and
View article: Expression of anti‐tumor necrosis factor alpha (TNFα) single‐chain variable fragment (scFv) in <i>Spirodela punctata</i> plants transformed with <i>Agrobacterium tumefaciens</i>
Expression of anti‐tumor necrosis factor alpha (TNFα) single‐chain variable fragment (scFv) in <i>Spirodela punctata</i> plants transformed with <i>Agrobacterium tumefaciens</i> Open
Therapeutic antibodies against tumor necrosis factor alpha (TNFα) have been considered effective for some of the autoimmune diseases such as rheumatoid arthritis, Crohn's diseases, and so on. But associated limitations of the current thera…