Krishnananda Chattopadhyay
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View article: Spatio-temporal regulation of ligand trafficking and TLR9 activation involves PIEZO1 mechanosensing in human plasmacytoid dendritic cells
Spatio-temporal regulation of ligand trafficking and TLR9 activation involves PIEZO1 mechanosensing in human plasmacytoid dendritic cells Open
Plasmacytoid dendritic cells (pDCs) are specialized innate immune cells which play a pivotal role in antiviral immunity by producing large quantities of type I interferons (IFNs) upon sensing nucleic acids via Toll-like receptor 9 (TLR9). …
View article: One of these things is not like the others: Theta, beta, & ERP dynamics of mismatch detection
One of these things is not like the others: Theta, beta, & ERP dynamics of mismatch detection Open
Working memory (WM) enables the detection of mistakes by permitting one to notice when sensory input is mismatched to their internal prediction. Prior studies support the role of frontal midline theta activity, with an overlapping N200 eve…
View article: Heterotypic Protein Interactions Modulate the Condensate Dynamics and Aggregation of α-Synuclein
Heterotypic Protein Interactions Modulate the Condensate Dynamics and Aggregation of α-Synuclein Open
Multicomponent biomolecular condensates formed by diverse multivalent proteins underlie numerous cellular processes, from ribosome biogenesis to stress response regulation, and have recently been implicated in disease-related protein aggre…
View article: Multivalent interaction induces phase separation and formation of more toxic aggregates of α-syn in a yeast model of Parkinson’s disease
Multivalent interaction induces phase separation and formation of more toxic aggregates of α-syn in a yeast model of Parkinson’s disease Open
The process of protein phase separation, particularly in the context of intrinsically disordered proteins, has been extensively studied for its implications in several neuro-degenerative diseases. Although the mechanism of protein phase se…
View article: Mapping DHPS Evolvability: Identification of Novel Evolutionarily Critical Sub-Structure through Evolutionary and Structural Analyses of DHPS
Mapping DHPS Evolvability: Identification of Novel Evolutionarily Critical Sub-Structure through Evolutionary and Structural Analyses of DHPS Open
Protein evolution shapes pathogen adaptation-landscape, particularly in developing drug resistance. The rapid evolution of target proteins under antibiotic pressure leads to escape mutations leading to the problem of antibiotic resistance.…
View article: Crowder induced conformational fluctuations modulate the phase separation of yeast SUP35 NM domain
Crowder induced conformational fluctuations modulate the phase separation of yeast SUP35 NM domain Open
Intrinsically disordered proteins (IDPs) like Sup35NM can undergo liquid-liquid phase separation (LLPS) to form biomolecular condensates, a process influenced by their conformational flexibility and the crowded intracellular environment. T…
View article: Mechanism of host cell invasion by<i>Leishmania</i>through KMP-11 mediated cholesterol-transport and membrane phase transition
Mechanism of host cell invasion by<i>Leishmania</i>through KMP-11 mediated cholesterol-transport and membrane phase transition Open
The first step of successful infection by any intracellular pathogen relies on its ability to invade its host cell membrane. However, the detailed structural and molecular understanding underlying lipid membrane modification during pathoge…
View article: Amyloid Beta Oligomers Accelerate ATP-Dependent Phase Separation of miRNA-Bound Ago2 to RNA Processing Bodies<i>in vitro</i>
Amyloid Beta Oligomers Accelerate ATP-Dependent Phase Separation of miRNA-Bound Ago2 to RNA Processing Bodies<i>in vitro</i> Open
Phase separation to insoluble membrane-less organelles is a major way of activity regulation of specific proteins in eukaryotic cells. miRNA-repressed mRNAs and Ago proteins are known to be localized to RNA-processing bodies, the subcellul…
View article: Conformational switch of a peptide provides a novel strategy to design peptide loaded porous organic polymer for Pyroptosis pathway mediated cancer therapy
Conformational switch of a peptide provides a novel strategy to design peptide loaded porous organic polymer for Pyroptosis pathway mediated cancer therapy Open
While peptide-based drug development is now extensively explored, this strategy does have limitations, which come from their rapid excretion from the body (or shorter half-life in the body), and vulnerability to protease-mediated degradati…
View article: A tale of (disordered) tail
A tale of (disordered) tail Open
Although liquid-liquid phase separation (LLPS) has been extensively studied in various cellular and organismal contexts, the link between functional influence of a genetic mutation and LLPS with respect to human diseases is poorly understo…
View article: Interplay of lipid head group and packing defects in driving amyloid-beta–mediated myelin-like model membrane deformation
Interplay of lipid head group and packing defects in driving amyloid-beta–mediated myelin-like model membrane deformation Open
Accumulating evidence suggests that amyloid plaque-associated myelin lipid loss as a result of elevated amyloid burden might also contribute to Alzheimer's disease. The amyloid fibrils are closely associated with lipids under physiological…
View article: Zn-dependent structural transition of SOD1 modulates its ability to undergo liquid-liquid phase separation
Zn-dependent structural transition of SOD1 modulates its ability to undergo liquid-liquid phase separation Open
The toxic gain of function of Cu/Zn superoxide dismutase (SOD1) associated with the neurodegenerative disease - Amyotrophic lateral sclerosis (ALS), is believed to occur via misfolding and/or aggregation. SOD1 is also associated with stres…
View article: In vitro reconstitution demonstrates the amyloid-beta mediated myelin membrane deformation
In vitro reconstitution demonstrates the amyloid-beta mediated myelin membrane deformation Open
Amyloid-beta (Aβ) aggregation mediated neuronal membrane deformation, although poorly understood, is implicated in Alzheimer’s Disease (AD). Particularly, whether Aβ aggregation can induce neuronal demyelination remains unknown. Here we sh…
View article: IMMUND: an Early Stage Diagnostic and Therapeutic Frame for Neurodegenerative Diseases and Multiple Sclerosis based on Immunological Markers
IMMUND: an Early Stage Diagnostic and Therapeutic Frame for Neurodegenerative Diseases and Multiple Sclerosis based on Immunological Markers Open
For neurodegenerative diseases, the impact of immunological markers is one of the modern research areas. It has been observed that neuroinflammation increases the cellular precipitation of some of the key proteins associated with neurodege…
View article: The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS model
The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS model Open
Aggregation of Cu–Zn superoxide dismutase (SOD1) is implicated in the motor neuron disease, amyotrophic lateral sclerosis (ALS). Although more than 140 disease mutations of SOD1 are available, their stability or aggregation behaviors in me…
View article: Author response: The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS model
Author response: The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS model Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Aggregation of Cu–Zn superoxi…
View article: Membrane composition and lipid to protein ratio modulate amyloid kinetics of yeast prion protein
Membrane composition and lipid to protein ratio modulate amyloid kinetics of yeast prion protein Open
This study provides a mechanistic description of how the membrane composition and lipid to protein ratio modulate amyloid kinetics of yeast prion protein.
View article: Lipid Droplets Promote Phase Separation of Ago2 to Accelerate Dicer1 Loss and Decelerate miRNA Activity in Lipid Exposed Hepatic Cells
Lipid Droplets Promote Phase Separation of Ago2 to Accelerate Dicer1 Loss and Decelerate miRNA Activity in Lipid Exposed Hepatic Cells Open
miR-122 is a liver specific miRNA that plays an important role in controlling metabolic homeostasis in mammalian liver cells. Interestingly, miR-122 on exposure to lipotoxic stress is reduced in liver cells. To fight stress, miRNA processo…
View article: Membrane composition and lipid to protein ratio modulate amyloid kinetics of yeast prion protein
Membrane composition and lipid to protein ratio modulate amyloid kinetics of yeast prion protein Open
Understanding of prion aggregation in membrane environment may help to ameliorate neurodegenerative complications caused by the amyloid forms of prions. Here, we investigated the membrane binding induced aggregation of yeast prion protein …
View article: The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an<i>in vitro</i>ALS Model
The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an<i>in vitro</i>ALS Model Open
Aggregation of Cu-Zn superoxide dismutase (SOD1) is implicated in the motor neuron disease, ALS. Although more than 140 disease mutations of SOD1 are available, their stability or aggregation behaviors in membrane environment are not corre…