Krishnendu Mukherjee
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View article: Trained immunity and immune priming in plants and invertebrates
Trained immunity and immune priming in plants and invertebrates Open
Immune memory has long been thought to be restricted to the adaptive immune system of vertebrates. However, several lines of evidence have changed our understanding of immune memory and have shattered the strict separation between innate a…
View article: Differential perception of virulence factors of uropathogenic Escherichia coli at the level of chromatin dynamics of infected host cells
Differential perception of virulence factors of uropathogenic Escherichia coli at the level of chromatin dynamics of infected host cells Open
Introduction Uropathogenic Escherichia coli (UPEC) evades the innate immune response in the urinary tract through the coordinated action of various virulence factors encoded within distinct pathogenicity islands (PAIs). We have demonstrate…
View article: Less is more: the lack of autoinducer-2-dependent quorum sensing promotes competitive fitness of Escherichia coli strain 83972
Less is more: the lack of autoinducer-2-dependent quorum sensing promotes competitive fitness of Escherichia coli strain 83972 Open
Autoinducer-2 is a signaling molecule involved in quorum sensing in Escherichia coli . Quorum sensing enables coordinated behavior based on cell density and helps bacteria adapt to their environment. The luxS gene and the lsr locus are inv…
View article: Efficacy of Sofosbuvir–Velpatasvir–Ribavirin Regimen for Retreatment of Chronic Hepatitis C in Patients With Prior DAA Failure: A Retrospective Study From a National Treatment Center
Efficacy of Sofosbuvir–Velpatasvir–Ribavirin Regimen for Retreatment of Chronic Hepatitis C in Patients With Prior DAA Failure: A Retrospective Study From a National Treatment Center Open
Introduction: Direct‐acting antivirals (DAAs) are highly effective in treating HCV infection, but a small subset of patients may fail to achieve SVR12 and require further intervention. In resource‐limited settings where second‐line DAAs (s…
View article: Efficacy of Sofosbuvir-Velpatasvir-Ribavirin Regimen for Retreatment of Chronic Hepatitis C in Patients with Prior DAA Failure: A Retrospective Study from a National Treatment Center
Efficacy of Sofosbuvir-Velpatasvir-Ribavirin Regimen for Retreatment of Chronic Hepatitis C in Patients with Prior DAA Failure: A Retrospective Study from a National Treatment Center Open
Introduction: Direct-acting antivirals (DAAs) are highly effective in treating HCV infection, but a small subset of patients may fail to achieve SVR12 and require further intervention. In resource-limited settings where second-line DAAs (s…
View article: Metabolism and immune memory in invertebrates: are they dissociated?
Metabolism and immune memory in invertebrates: are they dissociated? Open
Since the discovery of specific immune memory in invertebrates, researchers have investigated its immune response to diverse microbial and environmental stimuli. Nevertheless, the extent of the immune system’s interaction with metabolism, …
View article: Epigenetic remodeling in insect immune memory
Epigenetic remodeling in insect immune memory Open
The innate immune system of insects can respond more swiftly and efficiently to pathogens based on previous experience of encountering antigens. The understanding of molecular mechanisms governing immune priming, a form of immune memory in…
View article: Dealing with blood group discrepancies in donor populations in a resource-poor blood center, practical approach: A single blood center study from Eastern India
Dealing with blood group discrepancies in donor populations in a resource-poor blood center, practical approach: A single blood center study from Eastern India Open
BACKGROUND: ABO and RhD grouping are the most important pretransfusion tests. Discrepancies in blood grouping are one of the major causes of transfusion reactions. Although ABO and RhD blood group discrepancies are not a very frequent phen…
View article: Managing Complications
Managing Complications Open
Complications are neither entirely predictable nor preventable in the practice of spinal surgery. Communications, particularly the pre-operative consent, play an important role in the management of complications. Patient dissatisfaction le…
View article: Reprograming of epigenetic mechanisms controlling host insect immunity and development in response to egg-laying by a parasitoid wasp
Reprograming of epigenetic mechanisms controlling host insect immunity and development in response to egg-laying by a parasitoid wasp Open
Parasitoids are insects that use other insects as hosts. They sabotage host cellular and humoral defences to promote the survival of their offspring by injecting viruses and venoms along with their eggs. Many pathogens and parasites disrup…
View article: MicroRNAs regulate innate immunity against uropathogenic and commensal-like Escherichia coli infections in the surrogate insect model Galleria mellonella
MicroRNAs regulate innate immunity against uropathogenic and commensal-like Escherichia coli infections in the surrogate insect model Galleria mellonella Open
View article: The insect antimicrobial peptide cecropin A disrupts uropathogenic Escherichia coli biofilms
The insect antimicrobial peptide cecropin A disrupts uropathogenic Escherichia coli biofilms Open
View article: Seasonal phenotype‐specific expression of microRNAs during metamorphosis in the European map butterfly <i>Araschnia levana</i>
Seasonal phenotype‐specific expression of microRNAs during metamorphosis in the European map butterfly <i>Araschnia levana</i> Open
The European map butterfly ( Araschnia levana ) is a well‐known example of seasonal polyphenism because the spring and summer imagoes exhibit distinct morphological phenotypes. The day length and temperature during larval and prepupal deve…
View article: Distribution of antenatal alloimmunization in the southern districts of West Bengal and its significant associated factor
Distribution of antenatal alloimmunization in the southern districts of West Bengal and its significant associated factor Open
OBJECTIVES: Detection of maternal irregular antibodies against red blood cell antigen is vital in the management of hemolytic disease of fetus and newborn. There are no uniform guidelines related to antenatal antibody screening and identif…
View article: Epigenetic Mechanisms Are Involved in Sex-Specific Trans-Generational Immune Priming in the Lepidopteran Model Host Manduca sexta
Epigenetic Mechanisms Are Involved in Sex-Specific Trans-Generational Immune Priming in the Lepidopteran Model Host Manduca sexta Open
Parents invest in their offspring by transmitting acquired resistance against pathogens that only the parents have encountered, a phenomenon known as trans-generational immune priming (TGIP). Examples of TGIP are widespread in the a…
View article: Epigenetic mechanisms mediate the experimental evolution of resistance against parasitic fungi in the greater wax moth Galleria mellonella
Epigenetic mechanisms mediate the experimental evolution of resistance against parasitic fungi in the greater wax moth Galleria mellonella Open
View article: The entomopathogenic fungus <i>Metarhizium robertsii</i> communicates with the insect host <i>Galleria mellonella</i> during infection
The entomopathogenic fungus <i>Metarhizium robertsii</i> communicates with the insect host <i>Galleria mellonella</i> during infection Open
Parasitic fungi are the only pathogens that can infect insect hosts directly through their proteinaceous exoskeleton. Penetration of the cuticle requires the release of fungal enzymes, including proteinases, which act as virulence factors.…
View article: ABO, Rhesus, and Kell Antigens, Alleles, and Haplotypes in West Bengal, India
ABO, Rhesus, and Kell Antigens, Alleles, and Haplotypes in West Bengal, India Open
Background: Few studies have documented the blood group antigens in the population of eastern India. Frequencies of some common alleles and haplotypes were unknown. We describe phenotype, allele, and haplotype frequencies in the sta…
View article: Epigenetic Mechanisms Regulate Innate Immunity against Uropathogenic and Commensal-Like Escherichia coli in the Surrogate Insect Model Galleria mellonella
Epigenetic Mechanisms Regulate Innate Immunity against Uropathogenic and Commensal-Like Escherichia coli in the Surrogate Insect Model Galleria mellonella Open
Innate-immunity-related genes in humans are activated during urinary tract infections (UTIs) caused by pathogenic strains of Escherichia coli but are suppressed by commensals. Epigenetic mechanisms play a pivotal role in the regulation of …
View article: Experimental evolution of resistance against <i>Bacillus thuringiensis</i> in the insect model host <i>Galleria mellonella</i> results in epigenetic modifications
Experimental evolution of resistance against <i>Bacillus thuringiensis</i> in the insect model host <i>Galleria mellonella</i> results in epigenetic modifications Open
Epigenetic mechanisms have been proposed to translate environmental stimuli into heritable transgenerational phenotypic variations that can significantly influence natural selection. An intriguing example is exposure to pathogens, which im…
View article: Recurrent arsenic induced cancers over 20 years: a surgeon's nightmare!
Recurrent arsenic induced cancers over 20 years: a surgeon's nightmare! Open
The journal is the official publication of the College of Surgeons of Sri Lanka. Its mission is to reach the highest standard of scientific surgical practice by dissemination of high quality scientific information and to foster and promote…
View article: A differently managed Spleen Injury
A differently managed Spleen Injury Open
Introduction: Treatment of symptomatic splenic injury after more than 1 month of the trauma is not very specific. Moreover, here, we are reporting such a case where the patient was treated laparoscopically salvaging the spleen. Case report…
View article: Immuno-physiological adaptations confer wax moth<i>Galleria mellonella</i>resistance to<i>Bacillus thuringiensis</i>
Immuno-physiological adaptations confer wax moth<i>Galleria mellonella</i>resistance to<i>Bacillus thuringiensis</i> Open
Microevolutionary mechanisms of resistance to a bacterial pathogen were explored in a population of the Greater wax moth, Galleria mellonella, selected for an 8.8-fold increased resistance against the entomopathogenic bacterium Bacillus th…
View article: Insects as models to study the epigenetic basis of disease
Insects as models to study the epigenetic basis of disease Open
Epigenetic inheritance refers to changes in gene expression that are heritable across generations but are not caused by changes in the DNA sequence. Many environmental factors are now known to cause epigenetic changes, including the presen…
View article: A <i>Photorhabdus</i> Natural Product Inhibits Insect Juvenile Hormone Epoxide Hydrolase
A <i>Photorhabdus</i> Natural Product Inhibits Insect Juvenile Hormone Epoxide Hydrolase Open
Simple urea compounds (“phurealipids”) have been identified from the entomopathogenic bacterium Photorhabdus luminescens , and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as i…
View article: Renal Tumours in Adults with Correlation between Fuhrman Grading and Proliferative Marker.
Renal Tumours in Adults with Correlation between Fuhrman Grading and Proliferative Marker. Open
Malignant Kidney tumours, especially, grade I RCC were commonest tumour. Fuhrman grading correlated well with Ki-67 labeling index. A 2-tier system for grading is proposed for better correlation with proliferation.
View article: Frequency of Red Cell Alloimmunization and Autoimmunization in Thalassemia Patients: A Report from Eastern India
Frequency of Red Cell Alloimmunization and Autoimmunization in Thalassemia Patients: A Report from Eastern India Open
Introduction . Red blood cell (RBC) alloimmunization and autoimmunization remain a major problem in transfusion dependent thalassemic patients. There is a paucity of data on the incidence of RBC alloimmunization and autoimmunization in tha…
View article: Expression of CDX-2 and Ki-67 in different grades of colorectal adenocarcinomas
Expression of CDX-2 and Ki-67 in different grades of colorectal adenocarcinomas Open
Expression of CDX2 does not significantly change with the grade of colorectal adenocarcinomas. However, it is an important diagnostic marker in metastatic colonic lesions. The Ki-67 LI, on the other hand, showed a strong correlation with h…