Krista D. Stackley
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View article: Zebrafish lacking functional DNA polymerase gamma survive to juvenile stage, despite rapid and sustained mitochondrial DNA depletion, altered energetics and growth
Zebrafish lacking functional DNA polymerase gamma survive to juvenile stage, despite rapid and sustained mitochondrial DNA depletion, altered energetics and growth Open
DNA polymerase gamma (POLG) is essential for replication and repair of mitochondrial DNA (mtDNA). Mutations in POLG cause mtDNA instability and a diverse range of poorly understood human diseases. Here, we created a unique Polg animal mode…
View article: Metalloprotease OMA1 Fine-tunesMitochondrial BioenergeticFunction and RespiratorySupercomplex Stability
Metalloprotease OMA1 Fine-tunesMitochondrial BioenergeticFunction and RespiratorySupercomplex Stability Open
Mitochondria are involved in key cellular functions including energy production, metabolic homeostasis, and apoptosis. Normal mitochondrial function is preserved by several interrelated mechanisms. One mechanism – intramitochondrial qualit…
View article: Opa1 Is Required for Proper Mitochondrial Metabolism in Early Development
Opa1 Is Required for Proper Mitochondrial Metabolism in Early Development Open
Opa1 catalyzes fusion of inner mitochondrial membranes and formation of the cristae. OPA1 mutations in humans lead to autosomal dominant optic atrophy. OPA1 knockout mice lose viability around embryonic day 9 from unknown reasons, indicati…
View article: Bioenergetic Profiling of Zebrafish Embryonic Development
Bioenergetic Profiling of Zebrafish Embryonic Development Open
Many debilitating conditions are linked to bioenergetic defects. Developing screens to probe the genetic and/or chemical basis for such links has proved intractable. Furthermore, there is a need for a physiologically relevant assay of bioe…