Krista M. D. La Perle
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View article: Supplementary Figure Legends from NK Cell–Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines
Supplementary Figure Legends from NK Cell–Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines Open
Supplementary Figure Legends
View article: Data from NK Cell–Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines
Data from NK Cell–Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines Open
Optimally effective antitumor therapies would not only activate immune effector cells but also engage them at the tumor. Folate conjugated to immunoglobulin (F-IgG) could direct innate immune cells with Fc receptors to folate receptor–expr…
View article: Data from NK Cell–Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines
Data from NK Cell–Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines Open
Optimally effective antitumor therapies would not only activate immune effector cells but also engage them at the tumor. Folate conjugated to immunoglobulin (F-IgG) could direct innate immune cells with Fc receptors to folate receptor–expr…
View article: Supplemental Figures 1-3 from NK Cell–Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines
Supplemental Figures 1-3 from NK Cell–Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines Open
Supplemental Figure 1.F‑IgG and IL-12 mediated NK cell lysis is dependent on the folate receptor availability and does not correlate with FcR genotype. Supplemental Figure 2. MDSC inhibit NK cell lytic activity and IFN-y production. Supp…
View article: Supplemental Figures 1-3 from NK Cell–Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines
Supplemental Figures 1-3 from NK Cell–Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines Open
Supplemental Figure 1.F‑IgG and IL-12 mediated NK cell lysis is dependent on the folate receptor availability and does not correlate with FcR genotype. Supplemental Figure 2. MDSC inhibit NK cell lytic activity and IFN-y production. Supp…
View article: Supplementary Figure Legends from NK Cell–Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines
Supplementary Figure Legends from NK Cell–Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines Open
Supplementary Figure Legends
View article: Data from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Data from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Our group and others have determined that immune effector cells from patients with advanced cancers exhibit reduced activation of IFN signaling pathways. We hypothesized that increases in immune regulatory cells termed myeloid-derived supp…
View article: Supplementary Figure Legends 1-6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure Legends 1-6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure Legends 1-6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 5 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 5 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 5 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 1 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 1 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 1 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 2 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 2 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 2 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 4 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 4 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 4 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 3 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 3 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 3 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 4 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 4 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 4 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 2 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 2 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 2 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Data from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Data from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Our group and others have determined that immune effector cells from patients with advanced cancers exhibit reduced activation of IFN signaling pathways. We hypothesized that increases in immune regulatory cells termed myeloid-derived supp…
View article: Supplementary Figure 1 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 1 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 1 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure Legends 1-6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure Legends 1-6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure Legends 1-6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 3 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 3 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 3 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 5 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 5 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 5 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: UVB mutagenesis differs in <i>Nras</i>- and <i>Braf</i>-mutant mouse models of melanoma
UVB mutagenesis differs in <i>Nras</i>- and <i>Braf</i>-mutant mouse models of melanoma Open
BRAF -mutant melanomas are more likely than NRAS -mutant melanomas to arise in anatomical locations protected from chronic sun damage. We hypothesized that this discrepancy in tumor location is a consequence of the differential sensitivity…
View article: Cotton Rat Placenta Anatomy and Fc Receptor Expression and Their Roles in Maternal Antibody Transfer
Cotton Rat Placenta Anatomy and Fc Receptor Expression and Their Roles in Maternal Antibody Transfer Open
Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral pneumonia in infants and young children worldwide. Currently no vaccine is available to prevent RSV infection, but virus-neutralizing monoclonal antibodies c…
View article: Cause and Treatment of Exophthalmos in Aged Cotton Rats (<i>Sigmodon hispidus</i>)
Cause and Treatment of Exophthalmos in Aged Cotton Rats (<i>Sigmodon hispidus</i>) Open
Aged cotton rats ( Sigmodon hispidus ) from an established breeding colony displayed signs of spontaneous exophthalmos. Of a total of 118 colony animals that were older than 6 mo of age, 37 (31%) displayed signs of exophthalmos. These rats…
View article: Tagging enhances histochemical and biochemical detection of Ran Binding Protein 9 in vivo and reveals its interaction with Nucleolin
Tagging enhances histochemical and biochemical detection of Ran Binding Protein 9 in vivo and reveals its interaction with Nucleolin Open
View article: UVB mutagenesis differs in <i>NRAS</i>- and <i>BRAF</i>-mutant mouse models of melanoma
UVB mutagenesis differs in <i>NRAS</i>- and <i>BRAF</i>-mutant mouse models of melanoma Open
BRAF -mutant melanomas are more likely than NRAS -mutant melanomas to arise in anatomical locations protected from chronic sun damage. We hypothesized that this discrepancy in tumor location is a consequence of the differential sensitivity…
View article: Machine Learning and Veterinary Pathology: Be Not Afraid!
Machine Learning and Veterinary Pathology: Be Not Afraid! Open
View article: MAPK- and AKT-activated thyroid cancers are sensitive to group I PAK inhibition
MAPK- and AKT-activated thyroid cancers are sensitive to group I PAK inhibition Open
The number of individuals who succumb to thyroid cancer has been increasing and those who are refractory to standard care have limited therapeutic options, highlighting the importance of developing new treatments for patients with aggressi…
View article: Pathology of wild Norway rats in Vancouver, Canada
Pathology of wild Norway rats in Vancouver, Canada Open
To achieve a contemporary understanding of the common and rare lesions that affect wild, urban Norway rats ( Rattus norvegicus), we conducted a detailed pathology analysis of 672 rats from Vancouver, British Columbia, Canada. Grossly evide…