Krista Y. Chen
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View article: Primary resistance to ICI-based regimens is associated with early longitudinal changes in the fecal microbiome and loss of microbial stability
Primary resistance to ICI-based regimens is associated with early longitudinal changes in the fecal microbiome and loss of microbial stability Open
While immune checkpoint inhibitors (ICI)-based regimens and chemo-immunotherapy combinations (chemo-ICI) are now first-line therapy for patients with metastatic non-small cell lung cancer (NSCLC), the number of patients who experience a su…
View article: TRLS-14 CLINICOPATHOLOGIC CHARACTERISTICS AND OUTCOMES OF PATIENTS WITH KRAS G12C MUTANT NSCLC WITH BRAIN METASTASES
TRLS-14 CLINICOPATHOLOGIC CHARACTERISTICS AND OUTCOMES OF PATIENTS WITH KRAS G12C MUTANT NSCLC WITH BRAIN METASTASES Open
INTRODUCTION KRAS G12C-mutated non-small cell lung cancer (NSCLC) is linked to higher risk of brain metastases (BM). However, clinicopathologic and genomic characteristics associated with BM in this population are poorly understood. METHOD…
View article: Response to: Local social vulnerability as a predictor for cancer-related mortality among US counties.
Response to: Local social vulnerability as a predictor for cancer-related mortality among US counties. Open
View article: Transparency and Representation in Clinical Research Utilizing Artificial Intelligence in Oncology: A Scoping Review
Transparency and Representation in Clinical Research Utilizing Artificial Intelligence in Oncology: A Scoping Review Open
Introduction Artificial intelligence (AI) has significant potential to improve health outcomes in oncology. However, as AI utility increases, it is imperative to ensure that these models do not systematize racial and ethnic bias and furthe…
View article: Patient perspectives on cancer care during COVID-19: A qualitative study
Patient perspectives on cancer care during COVID-19: A qualitative study Open
Purpose The COVID-19 pandemic posed unique challenges to cancer-related care as health systems balanced competing risks of timely delivery of care and minimizing exposure to infection in a high-risk, immunocompromised patient population. T…
View article: Characterization of long COVID temporal sub-phenotypes by distributed representation learning from electronic health record data: a cohort study
Characterization of long COVID temporal sub-phenotypes by distributed representation learning from electronic health record data: a cohort study Open
Authors are supported by National Institute of Allergy and Infectious Diseases, National Institute on Aging, National Center for Advancing Translational Sciences, National Medical Research Council, National Institute of Neurological Disord…
View article: Local Social Vulnerability as a Predictor for Cancer-Related Mortality Among US Counties
Local Social Vulnerability as a Predictor for Cancer-Related Mortality Among US Counties Open
Substantial gaps in national healthcare spending and disparities in cancer mortality rates are noted across counties in the US. In this cross-sectional analysis, we investigated whether differences in local county-level social vulnerabilit…
View article: Hospitalizations Associated With Mental Health Conditions Among Adolescents in the US and France During the COVID-19 Pandemic
Hospitalizations Associated With Mental Health Conditions Among Adolescents in the US and France During the COVID-19 Pandemic Open
Importance The COVID-19 pandemic has been associated with an increase in mental health diagnoses among adolescents, though the extent of the increase, particularly for severe cases requiring hospitalization, has not been well characterized…
View article: Clinical Outcomes in Fibrolamellar Hepatocellular Carcinoma Treated with Immune Checkpoint Inhibitors
Clinical Outcomes in Fibrolamellar Hepatocellular Carcinoma Treated with Immune Checkpoint Inhibitors Open
Background: Fibrolamellar hepatocellular carcinoma (FLC) is a rare form of liver cancer primarily affecting children and young adults. Although considered a subset of hepatocellular carcinoma (HCC), FLC has unique molecular and pathologic …
View article: Trends in Dispensing of Controlled Medications for US Adolescents and Young Adults, 2008 to 2019
Trends in Dispensing of Controlled Medications for US Adolescents and Young Adults, 2008 to 2019 Open
This cohort study examines trends from 2008 to 2019 in dispensations of controlled medications to US adolescents and young adults.
View article: Reporting of clinical trial safety results in ClinicalTrials.gov for FDA-approved drugs: A cross-sectional analysis
Reporting of clinical trial safety results in ClinicalTrials.gov for FDA-approved drugs: A cross-sectional analysis Open
Background Adverse events identified during clinical trials can be important early indicators of drug safety, but complete and timely data on safety results have historically been difficult to access. The aim was to compare the availabilit…
View article: Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells
Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells Open