Explanipedia

Higher colorectal tissue HIV infectivity in cisgender women compared with MSM before and during oral preexposure prophylaxis Open

Rogers Sekabira, Krista Yuhas, Rhonda M. Brand, Yukari C. Manabe, Joseph J. Eron , et al. · 2025

OBJECTIVE: The objective of this study was to compare HIV-negative cisgender women (CGW) with MSM for mucosal tissue differences in pharmacokinetics, HIV infectivity and cell phenotype. DESIGN: A substudy of HPTN 069/ACTG A5305, 48-week st…

Prevalence of SARS-CoV-2 Infection among Children and Adults in 15 US Communities, 20211 Open

Jessica Justman, Timothy Skalland, Ayana Moore, Christopher I. Amos, Mark A. Marzinke , et al. · 2024

During January-August 2021, the Community Prevalence of SARS-CoV-2 Study used time/location sampling to recruit a cross-sectional, population-based cohort to estimate SARS-CoV-2 seroprevalence and nasal swab sample PCR positivity across 15…

Adaptive Time–Location Sampling for COMPASS: A SARS-CoV-2 Prevalence Study in Fifteen Diverse Communities in the United States Open

Sahar Z. Zangeneh, Timothy Skalland, Krista Yuhas, Lynda Emel, Jean de Dieu Tapsoba , et al. · 2023

Background: COVID-19 has placed a disproportionate burden on underserved racial and ethnic groups, community members working in essential industries, those living in areas of high population density, and those reliant on in-person services…

Demographics of sources of HIV-1 transmission in Zambia: a molecular epidemiology analysis in the HPTN 071 PopART study Open

Matthew Hall, Tanya Golubchik, David Bonsall, Lucie Abeler‐Dörner, Mohammed Limbada , et al. · 2023

ADAPTIVE TIME LOCATION SAMPLING FOR COMPASS, A SARS-COV-2 PREVALENCE STUDY IN FIFTEEN DIVERSE COMMUNITIES IN THE UNITED STATES Open

Sahar Z. Zangeneh, Timothy Skalland, Krista Yuhas, Lynda Emel, Jean de Dieu Tapsoba , et al. · 2023

The COVPN 5002 (COMPASS) study aimed to estimate the prevalence of SARS-CoV-2 (active SARS-CoV-2 or prior SARS-CoV-2 infection) in children and adults attending public venues in 15 socio-demographically diverse communities in the United St…

Projected outcomes of universal testing and treatment in a generalised HIV epidemic in Zambia and South Africa (the HPTN 071 [PopART] trial): a modelling study Open

William J. M. Probert, Rafael Sauter, Michael Pickles, Anne Cori, Nomtha Bell‐Mandla , et al. · 2022

Sexual behavior and medication adherence in men who have sex with men participating in a pre-exposure prophylaxis study of combinations of Maraviroc, Tenofovir Disoproxil Fumarate and/or Emtricitabine (HPTN 069/ACTG 5305) Open

Kenneth H. Mayer, Krista Yuhas, K. Rivet Amico, Timothy Wilkin, Raphael J. Landovitz , et al. · 2022

Bone changes with candidate PrEP regimens containing tenofovir disoproxil fumarate and/or maraviroc and/or emtricitabine in US men and women: HPTN 069/ACTG A5305 Open

Todd T. Brown, Krista Yuhas, Kenneth H. Mayer, Raphael J. Landovitz, Mark A. Marzinke , et al. · 2021

Background Tenofovir disoproxil fumarate-containing pre-exposure prophylaxis (PrEP) has been associated with decreases in bone mineral density (BMD), but the bone effects of other non-tenofovir disoproxil fumarate candidate PrEP regimens a…

Higher colorectal tissue HIV infectivity in cisgender women compared with MSM before and during oral preexposure prophylaxis Open

Rogers Sekabira, Ian McGowan, Krista Yuhas, Rhonda M. Brand, Mark A. Marzinke , et al. · 2021

Objective: The objective of this study was to compare HIV-negative cisgender women (CGW) with MSM for mucosal tissue differences in pharmacokinetics, HIV infectivity and cell phenotype. Design: A substudy of HPTN 069/ACTG A5305, 48-week st…

Mycoplasma genitalium infection among HIV-infected pregnant African women and implications for mother-to-child transmission of HIV Open

Alison C. Roxby, Krista Yuhas, Carey Farquhar, Rose Bosire, Dorothy Mbori‐Ngacha , et al. · 2019

Vaginal M. genitalium infection was frequently detected among Kenyan HIV-infected pregnant women and was associated with higher plasma HIV levels, but was not associated with perinatal transmission of HIV.

Prevalence and predictors of unmet contraceptive need in HIV-positive female sex workers in Mombasa, Kenya Open

Jessica E. Long, Gladys Waruguru, Krista Yuhas, Kate Wilson, Linnet N. Masese , et al. · 2019

Unmet need for modern non-barrier contraception was found in two-thirds of HIV-positive FSWs who reported that they were not currently trying to become pregnant, and was higher in women with the lowest number of prior pregnancies (0-1 prio…

The prevalence and antifolate drug resistance profiles of Plasmodium falciparum in study participants randomized to discontinue or continue cotrimoxazole prophylaxis Open

Dennis W. Juma, Peninah Muiruri, Krista Yuhas, Grace John‐Stewart, Ronald K. Ottichilo , et al. · 2019

ClinicalTrials.gov NCT01425073.

Diarrheal Etiology and Impact of Coinfections on Rotavirus Vaccine Efficacy Estimates in a Clinical Trial of a Monovalent Human–Bovine (116E) Oral Rotavirus Vaccine, Rotavac, India Open

Ira Praharaj, James A Platts-Mills, Sunita Taneja, Kalpana Antony, Krista Yuhas , et al. · 2018

Background Rotavirus vaccine efficacy (VE) estimates in low-resource settings are lower than in developed countries. We detected coinfections in cases of severe rotavirus diarrhea in a rotavirus VE trial to determine whether these negative…

Evaluation of the association between the concentrations of key vaginal bacteria and the increased risk of HIV acquisition in African women from five cohorts: a nested case-control study Open

R. Scott McClelland, Jairam R. Lingappa, Sujatha Srinivasan, John Kinuthia, Grace John‐Stewart , et al. · 2018

Combined effectiveness of anthelmintic chemotherapy and WASH among HIV-infected adults Open

Arianna Rubin Means, Lisette van Lieshout, Eric A. T. Brienen, Krista Yuhas, James P. Hughes , et al. · 2018

ClinicalTrials.gov, NCT00507221.

ART Attrition across Health Facilities Implementing Option B+ in Haiti Open

Martine Pamphile Myrtil, Nancy Puttkammer, Stephen Gloyd, Julia Robinson, Krista Yuhas , et al. · 2018

Background: Describing factors related to high attrition is important in order to improve the implementation of the Option B+ strategy in Haiti. Methods: We conducted a retrospective cohort study to describe the variability of antiretrovir…

Association between non-barrier modern contraceptive use and condomless sex among HIV-positive female sex workers in Mombasa, Kenya: A prospective cohort analysis Open

Diya Surie, Krista Yuhas, Kate Wilson, Linnet N. Masese, Juma Shafi , et al. · 2017

Non-barrier methods of modern contraception were not associated with increased risk of objective evidence of condomless sex.

O11.3 Extreme heterogeneity in vaginal microbial kinetics within and across women Open

Joshua T. Schiffer, Sujatha Srinivasan, Anthony Lopez, L Wang, Sean Proll , et al. · 2017

Introduction Incident bacterial vaginosis (BV) is associated with a shift in the vaginal microbiota from lactobacillus predominant to a diverse community of anaerobic bacteria The kinetics of this shift are poorly described. We sought to i…

P2.11 Association between genital herpes simpex virus type-2 shedding and presence of bacterial vaginosis-associated bacteria Open

Christine Johnston, Amalia Magaret, Krista Yuhas, Sujatha Srinivasan, Sean Proll , et al. · 2017

Introduction Herpes simplex virus type 2 (HSV-2) infection increases the risk of bacterial vaginosis (BV). We hypothesised that the biologic mechanism of this association is that genital HSV-2 shedding increases inflammation, resulting in …

O06.6 The urethral microbiota in nongonococcal urethritis Open

Sujatha Srinivasan, Laura C. Chambers, Noah G. Hoffman, Jennifer L. L. Morgan, Matthew M Munch , et al. · 2017

Introduction There is no known aetiology for up to half of all nongonococcal urethritis (NGU) cases. We sought to characterise the bacterial communities in men with (NGU+) and without (NGU-) NGU among men who have sex with men (MSM) and me…

ART attrition and risk factors among Option B+ patients in Haiti: A retrospective cohort study Open

Nancy Puttkammer, Jean Wysler Domerçant, Michelle Adler, Krista Yuhas, Martine Pamphile Myrtil , et al. · 2017

Our study demonstrates early ART attrition among Option B+ patients and contributes evidence on the characteristics of women who are most at risk of attrition in Haiti. Our findings highlight the importance of targeted strategies to suppor…

Attrition from antiretroviral treatment services among pregnant and non-pregnant patients following adoption of Option B+ in Haiti Open

Jean Wysler Domerçant, Nancy Puttkammer, Paul R. Young, Krista Yuhas, Kesner François , et al. · 2017

ART attrition in Haiti is high among adults, especially among Option B+ patients. Identifying newly initiated patients most at risk for attrition and providing appropriate interventions could help reduce ART attrition.

Malaria Parasitemia and Parasite Density in Antiretroviral-Treated HIV-Infected Adults Following Discontinuation of Cotrimoxazole Prophylaxis Open

Ronald K. Ottichilo, Christina S. Polyak, Bernard Guyah, Benson Singa, Josphat Nyataya , et al. · 2016

NCT01425073.

A Prospective Cohort Study of Intimate Partner Violence and Unprotected Sex in HIV-Positive Female Sex Workers in Mombasa, Kenya Open

Kate Wilson, Ruth Deya, Krista Yuhas, Jane M. Simoni, Ann Vander Stoep , et al. · 2016

Cotrimoxazole Prophylaxis Discontinuation among Antiretroviral-Treated HIV-1-Infected Adults in Kenya: A Randomized Non-inferiority Trial Open

Christina S. Polyak, Krista Yuhas, Benson Singa, Monica Khaemba, Judd L. Walson , et al. · 2016

ClinicalTrials.gov NCT01425073.

An assessment of data quality in Haiti's multi-site electronic medical record system Open

Nancy Puttkammer, Janet Baseman, Beth Devine, Nathaelf Hyppolite, G France , et al. · 2015

Welcome to Annals of Global Health,Annals of Global Health is a peer-reviewed, fully open access, online journal dedicated to publishing high quality articles dedicated to all aspects of global health. The journal's mission is to advance g…

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