Kristen E. Funk
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View article: Novel <i>In Vitro</i> Culture of Microglia from Aged Mice: Implications for the Future of Aging Neurobiology Research
Novel <i>In Vitro</i> Culture of Microglia from Aged Mice: Implications for the Future of Aging Neurobiology Research Open
Aging is associated with elevated levels of inflammation across tissues, a status recognized as “inflammaging.” Within the brain, microglia are the resident phagocytic immune cells that are important in both homeostatic and disease states.…
View article: Exploring the role of T cells in Alzheimer's and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium
Exploring the role of T cells in Alzheimer's and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium Open
This proceedings article summarizes the inaugural “T Cells in the Brain” symposium held at Columbia University. Experts gathered to explore the role of T cells in neurodegenerative diseases. Key topics included characterization of antigen‐…
View article: Compromised CD8+ T cell immunity in the aged brain increases severity of neurotropic coronavirus infection and postinfectious cognitive impairment
Compromised CD8+ T cell immunity in the aged brain increases severity of neurotropic coronavirus infection and postinfectious cognitive impairment Open
Advanced age increases the risk of severe disease from SARS‐CoV‐2 infection, as well as incidence of long COVID and SARS‐CoV‐2 reinfection. We hypothesized that perturbations in the aged antiviral CD8 + T cell response predisposes elderly …
View article: Author Correction: Viral pathogens increase risk of neurodegenerative disease
Author Correction: Viral pathogens increase risk of neurodegenerative disease Open
View article: Editorial: Cellular and molecular mechanisms of neurotropic viral infection
Editorial: Cellular and molecular mechanisms of neurotropic viral infection Open
International audience
View article: Antigen non-specific CD8<sup>+</sup>T cells accelerate cognitive decline in aged mice following respiratory coronavirus infection
Antigen non-specific CD8<sup>+</sup>T cells accelerate cognitive decline in aged mice following respiratory coronavirus infection Open
Primarily a respiratory infection, numerous patients infected with SARS-CoV-2 present with neurologic symptoms, some continuing long after viral clearance as a persistent symptomatic phase termed “long COVID”. Advanced age increases the ri…
View article: Molecular and Cellular Mechanisms Underlying Neurologic Manifestations of Mosquito-Borne Flavivirus Infections
Molecular and Cellular Mechanisms Underlying Neurologic Manifestations of Mosquito-Borne Flavivirus Infections Open
Flaviviruses are a family of enveloped viruses with a positive-sense RNA genome, transmitted by arthropod vectors. These viruses are known for their broad cellular tropism leading to infection of multiple body systems, which can include th…
View article: Imaging blood–brain barrier disruption in neuroinflammation and Alzheimer’s disease
Imaging blood–brain barrier disruption in neuroinflammation and Alzheimer’s disease Open
The blood–brain barrier (BBB) is the neurovascular structure that regulates the passage of cells and molecules to and from the central nervous system (CNS). Alzheimer’s disease (AD) is a neurodegenerative disorder that is associated with g…
View article: Viral pathogens increase risk of neurodegenerative disease
Viral pathogens increase risk of neurodegenerative disease Open
View article: The role of antiviral CD8+ T cells in cognitive impairment
The role of antiviral CD8+ T cells in cognitive impairment Open
The impact of the immune system on the etiopathogenesis of neurodegenerative diseases, including Alzheimer's disease, is a rapidly growing area of investigation. Evidence from human patients and animal models implicates neurotropic viral i…
View article: Editorial: Multifaceted Interactions Between Immunity and the Diseased Brain
Editorial: Multifaceted Interactions Between Immunity and the Diseased Brain Open
EDITORIAL article Front. Cell. Neurosci., 08 June 2022Sec. Cellular Neuropathology Volume 16 - 2022 | https://doi.org/10.3389/fncel.2022.941590
View article: Levels of Circulating NS1 Impact West Nile Virus Spread to the Brain
Levels of Circulating NS1 Impact West Nile Virus Spread to the Brain Open
Flavivirus NS1 serves as an essential scaffolding molecule during virus replication but also is expressed on the cell surface and is secreted as a soluble glycoprotein that circulates in the blood of infected individuals. Although extracel…
View article: Decreased antiviral immune response within the central nervous system of aged mice is associated with increased lethality of West Nile virus encephalitis
Decreased antiviral immune response within the central nervous system of aged mice is associated with increased lethality of West Nile virus encephalitis Open
West Nile virus (WNV) is an emerging pathogen that causes disease syndromes ranging from a mild flu‐like illness to encephalitis. While the incidence of WNV infection is fairly uniform across age groups, the risk of lethal encephalitis inc…
View article: Microbial Infections Are a Risk Factor for Neurodegenerative Diseases
Microbial Infections Are a Risk Factor for Neurodegenerative Diseases Open
Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, comprise a family of disorders characterized by progressive loss of nervous system function. Neuroinflammation is increasingly…
View article: Assessing the Expression of Major Histocompatibility Complex Class I on Primary Murine Hippocampal Neurons by Flow Cytometry
Assessing the Expression of Major Histocompatibility Complex Class I on Primary Murine Hippocampal Neurons by Flow Cytometry Open
Increasing evidence supports the hypothesis that neuro-immune interactions impact nervous system function in both homeostatic and pathologic conditions. A well-studied function of major histocompatibility complex class I (MHCI) is the pres…
View article: Neuroinflammation During RNA Viral Infections
Neuroinflammation During RNA Viral Infections Open
Neurotropic RNA viruses continue to emerge and are increasingly linked to diseases of the central nervous system (CNS) despite viral clearance. Indeed, the overall mortality of viral encephalitis in immunocompetent individuals is low, sugg…
View article: CSF1R antagonism limits local restimulation of antiviral CD8+ T cells during viral encephalitis
CSF1R antagonism limits local restimulation of antiviral CD8+ T cells during viral encephalitis Open
View article: A complement–microglial axis drives synapse loss during virus-induced memory impairment
A complement–microglial axis drives synapse loss during virus-induced memory impairment Open
View article: Distinct Therapeutic Mechanisms of Tau Antibodies
Distinct Therapeutic Mechanisms of Tau Antibodies Open