Kristen R. Maynard
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View article: <i>APOE</i> E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex
<i>APOE</i> E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex Open
The entorhinal cortex (ERC) is implicated in early progression of Alzheimer’s disease (AD). Here we investigated the impact of established biological risk factors for AD, including APOE genotype (E2 versus E4 alleles), sex, and ancestry, o…
View article: Impact of Alzheimer’s disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus
Impact of Alzheimer’s disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus Open
The locus coeruleus (LC) is a small noradrenergic nucleus in the dorsal pons that sends projections across the brain regulating sleep, arousal, attention, stress responses, and some forms of cognition. LC neurons show pathology in the earl…
View article: Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens
Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens Open
The nucleus accumbens (NAc) is a key component of the mesolimbic dopamine system that critically regulates many behaviors related to reward and motivation. The NAc is implicated in several neuropsychiatric disorders, including major depres…
View article: An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus
An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus Open
View article: Spatio-molecular gene expression reflects dorsal anterior cingulate cortex structure and function in the human brain
Spatio-molecular gene expression reflects dorsal anterior cingulate cortex structure and function in the human brain Open
In the human brain, the dorsal anterior cingulate cortex (dACC) plays key roles in various components of cognitive control, and is particularly relevant for reward processing and conflict monitoring. The dACC regulates expression of fear a…
View article: <i>BDNF-DT and BDNF-AS-DT</i>: Novel Genes in the <i>BDNF</i> locus
<i>BDNF-DT and BDNF-AS-DT</i>: Novel Genes in the <i>BDNF</i> locus Open
Divergent transcription from bidirectional promoters is frequently observed in eukaryotic genomes, but the biological relevance of divergent RNA transcripts (DT) is unknown. We identified and characterized BDNF-DT , a novel DT gene, and BD…
View article: lute: estimating the cell composition of heterogeneous tissue with varying cell sizes using gene expression
lute: estimating the cell composition of heterogeneous tissue with varying cell sizes using gene expression Open
Background Relative cell type fraction estimates in bulk RNA-sequencing data are important to control for cell composition differences across heterogenous tissue samples. While there exist algorithms to estimate the cell type proportions i…
View article: Benchmark of cellular deconvolution methods using a multi-assay dataset from postmortem human prefrontal cortex
Benchmark of cellular deconvolution methods using a multi-assay dataset from postmortem human prefrontal cortex Open
Cellular deconvolution of bulk RNA-sequencing data using single cell/nuclei RNA-seq reference data is an important strategy for estimating cell type composition in heterogeneous tissues, such as the human brain. Here, we generate a multi-a…
View article: Reelin marks cocaine-activated striatal neurons, promotes neuronal excitability, and regulates cocaine reward
Reelin marks cocaine-activated striatal neurons, promotes neuronal excitability, and regulates cocaine reward Open
Drugs of abuse activate defined neuronal populations in reward structures such as the nucleus accumbens (NAc), which promote the enduring synaptic, circuit, and behavioral consequences of drug exposure. While the molecular and cellular eff…
View article: Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation
Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation Open
View article: Author Correction: Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery
Author Correction: Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery Open
View article: Spatially-resolved molecular sex differences at single cell resolution in the adult human ventromedial and arcuate hypothalamus
Spatially-resolved molecular sex differences at single cell resolution in the adult human ventromedial and arcuate hypothalamus Open
The hypothalamus contains multiple regions, including the ventromedial hypothalamus (VMH) and arcuate (ARC), which are responsible for sex-differentiated functions such as endocrine signaling, metabolism, and reproductive behaviors. While …
View article: Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery
Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery Open
View article: Molecular impact of nicotine and smoking exposure on the developing and adult mouse brain
Molecular impact of nicotine and smoking exposure on the developing and adult mouse brain Open
Maternal smoking during pregnancy (MSDP) is associated with significant cognitive and behavioral effects on offspring. While neurodevelopmental outcomes have been studied for prenatal exposure to nicotine, the main psychoactive component o…
View article: Reelin marks cocaine-activated striatal ensembles, promotes neuronal excitability, and regulates cocaine reward
Reelin marks cocaine-activated striatal ensembles, promotes neuronal excitability, and regulates cocaine reward Open
Summary Drugs of abuse activate defined neuronal ensembles in brain reward structures such as the nucleus accumbens (NAc), which are thought to promote the enduring synaptic, circuit, and behavioral consequences of drug exposure. While the…
View article: Network nature of ligand-receptor interactions underlies disease comorbidity in the brain
Network nature of ligand-receptor interactions underlies disease comorbidity in the brain Open
Neurodegenerative disorders have overlapping symptoms and have high comorbidity rates, but this is not reflected in overlaps of risk genes. We have investigated whether ligand-receptor interactions (LRIs) are a mechanism by which distinct …
View article: A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex
A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex Open
The molecular organization of the human neocortex historically has been studied in the context of its histological layers. However, emerging spatial transcriptomic technologies have enabled unbiased identification of transcriptionally defi…
View article: An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus
An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus Open
The hippocampus contains many unique cell types, which serve the structure’s specialized functions, including learning, memory and cognition. These cells have distinct spatial organization, morphology, physiology, and connectivity, highlig…
View article: lute: estimating the cell composition of heterogeneous tissue with varying cell sizes using gene expression
lute: estimating the cell composition of heterogeneous tissue with varying cell sizes using gene expression Open
Relative cell type fraction estimates in bulk RNA-sequencing data are important to control for cell composition differences across heterogenous tissue samples. Current computational tools estimate relative RNA abundances rather than cell t…
View article: Transcriptomic analysis of the human habenula in schizophrenia
Transcriptomic analysis of the human habenula in schizophrenia Open
Pathophysiology of many neuropsychiatric disorders, including schizophrenia (SCZD), is linked to habenula (Hb) function. While pharmacotherapies and deep brain stimulation targeting the Hb are emerging as promising therapeutic treatments, …
View article: Benchmark of cellular deconvolution methods using a multi-assay reference dataset from postmortem human prefrontal cortex
Benchmark of cellular deconvolution methods using a multi-assay reference dataset from postmortem human prefrontal cortex Open
Background Cellular deconvolution of bulk RNA-sequencing (RNA-seq) data using single cell or nuclei RNA-seq (sc/snRNA-seq) reference data is an important strategy for estimating cell type composition in heterogeneous tissues, such as human…
View article: Author Response: The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics
Author Response: The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Peer review Author response Article and author information Metrics Abstract Norepinephrine…
View article: The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics
The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics Open
Norepinephrine (NE) neurons in the locus coeruleus (LC) make long-range projections throughout the central nervous system, playing critical roles in arousal and mood, as well as various components of cognition including attention, learning…
View article: Challenges and opportunities to computationally deconvolve heterogeneous tissue with varying cell sizes using single-cell RNA-sequencing datasets
Challenges and opportunities to computationally deconvolve heterogeneous tissue with varying cell sizes using single-cell RNA-sequencing datasets Open
View article: Reviewer #2 (Public Review): The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics
Reviewer #2 (Public Review): The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics Open
Norepinephrine (NE) neurons in the locus coeruleus (LC) make long-range projections throughout the central nervous system, playing critical roles in arousal and mood, as well as various components of cognition including attention, learning…
View article: The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics
The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics Open
Norepinephrine (NE) neurons in the locus coeruleus (LC) make long-range projections throughout the central nervous system, playing critical roles in arousal and mood, as well as various components of cognition including attention, learning…
View article: Reviewer #1 (Public Review): The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics
Reviewer #1 (Public Review): The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics Open
Norepinephrine (NE) neurons in the locus coeruleus (LC) make long-range projections throughout the central nervous system, playing critical roles in arousal and mood, as well as various components of cognition including attention, learning…
View article: Author Response: The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics
Author Response: The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics Open
Norepinephrine (NE) neurons in the locus coeruleus (LC) make long-range projections throughout the central nervous system, playing critical roles in arousal and mood, as well as various components of cognition including attention, learning…
View article: Reviewer #3 (Public Review): The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics
Reviewer #3 (Public Review): The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics Open
Norepinephrine (NE) neurons in the locus coeruleus (LC) make long-range projections throughout the central nervous system, playing critical roles in arousal and mood, as well as various components of cognition including attention, learning…
View article: Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation
Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation Open
The dentate gyrus of the hippocampus is important for many cognitive functions, including learning, memory, and mood. Here, we investigated age-associated changes in transcriptome-wide spatial gene expression in the human dentate gyrus acr…