Kristian Lynch
YOU?
Author Swipe
View article: Microbial associations and viruses on the risk of celiac disease (MAVRiC): a longitudinal post-hoc case-cohort study
Microbial associations and viruses on the risk of celiac disease (MAVRiC): a longitudinal post-hoc case-cohort study Open
Celiac disease etiopathogenesis requires genetic predisposition and exposure to gluten, yet these factors alone are not sufficient. Larger longitudinal studies are needed to determine the role of time-varying infections and gut microorgani…
View article: The Contribution of BMI to a young child’s risk of islet autoimmunity is dependent on HLA-DR4-DQ8 without HLA-DR3-DQ2
The Contribution of BMI to a young child’s risk of islet autoimmunity is dependent on HLA-DR4-DQ8 without HLA-DR3-DQ2 Open
ObjectiveChildhood obesity may impact the risk of islet autoimmunity (IA). The trajectory of BMI through childhood resembles the early peak incidence of first-appearing autoantibodies against insulin (IAA-first) but not GAD65 (GADA-first).…
View article: The Contribution of BMI to a young child’s risk of islet autoimmunity is dependent on HLA-DR4-DQ8 without HLA-DR3-DQ2
The Contribution of BMI to a young child’s risk of islet autoimmunity is dependent on HLA-DR4-DQ8 without HLA-DR3-DQ2 Open
ObjectiveChildhood obesity may impact the risk of islet autoimmunity (IA). The trajectory of BMI through childhood resembles the early peak incidence of first-appearing autoantibodies against insulin (IAA-first) but not GAD65 (GADA-first).…
View article: Association of fever and infections with the subsequent risk of atopic diseases in children with genetic susceptibility for T1D: Results from the TEDDY cohort study
Association of fever and infections with the subsequent risk of atopic diseases in children with genetic susceptibility for T1D: Results from the TEDDY cohort study Open
Background The increased prevalence of atopic diseases may be due to lifestyle changes affecting our exposure to microbes. We investigated the association between infections, fever, and atopic diseases in a large international birth cohort…
View article: Subspecialty neurology genetic counselors—A cost effective solution to substantial time costs associated with genomic testing in the neurology clinic
Subspecialty neurology genetic counselors—A cost effective solution to substantial time costs associated with genomic testing in the neurology clinic Open
To understand the modality and results of genetic testing in a tertiary pediatric neurology center, we undertook a review of testing to provide insights into both direct and indirect costs of testing within the department. The financial co…
View article: A case-cohort longitudinal study for the analysis of microbial associations and viruses on the risk of celiac disease (MAVRiC)
A case-cohort longitudinal study for the analysis of microbial associations and viruses on the risk of celiac disease (MAVRiC) Open
Celiac disease etiopathogenesis requires genetic predisposition and exposure to gluten before a child can develop the chronic autoimmune disorder. However, these factors alone are not sufficient. Even a child with persistent tissue transgl…
View article: Unfolding the Mystery of Autoimmunity: The Environmental Determinants of Diabetes in the Young (TEDDY) Study
Unfolding the Mystery of Autoimmunity: The Environmental Determinants of Diabetes in the Young (TEDDY) Study Open
In 2025, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health celebrates 75 years of leadership in diabetes research. The NIDDK serves people of the U.S. affected by or at risk f…
View article: Unfolding the Mystery of Autoimmunity: The Environmental Determinants of Diabetes in the Young (TEDDY) Study
Unfolding the Mystery of Autoimmunity: The Environmental Determinants of Diabetes in the Young (TEDDY) Study Open
In 2025, the National Institute for Diabetes, Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health celebrates 75 years of leadership in diabetes research. The NIDDK serves people of the United States affected by or at…
View article: Unfolding the Mystery of Autoimmunity: The Environmental Determinants of Diabetes in the Young (TEDDY) Study
Unfolding the Mystery of Autoimmunity: The Environmental Determinants of Diabetes in the Young (TEDDY) Study Open
In 2025, the National Institute for Diabetes, Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health celebrates 75 years of leadership in diabetes research. The NIDDK serves people of the United States affected by or at…
View article: Detecting potential outliers in longitudinal data with time-dependent covariates
Detecting potential outliers in longitudinal data with time-dependent covariates Open
View article: Factors assessed in the first year of a longitudinal study predict subsequent study visit compliance: the TEDDY study
Factors assessed in the first year of a longitudinal study predict subsequent study visit compliance: the TEDDY study Open
View article: SAI-CH-6: Development of a Short Form of the State Anxiety Inventory for Children At-Risk for Type 1 Diabetes
SAI-CH-6: Development of a Short Form of the State Anxiety Inventory for Children At-Risk for Type 1 Diabetes Open
Objective To develop a reliable and valid short form of the State Anxiety Subscale of the State-Trait Anxiety Inventory for Children (STAI-CH) in the Environmental Determinants of Diabetes in the Young (TEDDY) study. Methods A Development …
View article: Gastrointestinal infections modulate the risk for insulin autoantibodies as the first-appearing autoantibody in the TEDDY Study
Gastrointestinal infections modulate the risk for insulin autoantibodies as the first-appearing autoantibody in the TEDDY Study Open
Objective: To investigate gastrointestinal infection episodes (GIE) in relation to the appearance of islet autoantibodies in The Environmental Determinants of Diabetes in the Young (TEDDY) cohort.Research Design and Methods: …
View article: Gastrointestinal Infections Modulate the Risk for Insulin Autoantibodies as the First-Appearing Autoantibody in the TEDDY Study
Gastrointestinal Infections Modulate the Risk for Insulin Autoantibodies as the First-Appearing Autoantibody in the TEDDY Study Open
OBJECTIVE To investigate gastrointestinal infection episodes (GIEs) in relation to the appearance of islet autoantibodies in The Environmental Determinants of Diabetes in the Young (TEDDY) cohort. RESEARCH DESIGN AND METHODS GIEs on risk o…
View article: Gastrointestinal infections modulate the risk for insulin autoantibodies as the first-appearing autoantibody in the TEDDY Study
Gastrointestinal infections modulate the risk for insulin autoantibodies as the first-appearing autoantibody in the TEDDY Study Open
Objective: To investigate gastrointestinal infection episodes (GIE) in relation to the appearance of islet autoantibodies in The Environmental Determinants of Diabetes in the Young (TEDDY) cohort.Research Design and Methods: …
View article: Detecting Potential Outliers in Longitudinal Data with Time-Dependent Covariates
Detecting Potential Outliers in Longitudinal Data with Time-Dependent Covariates Open
Outliers can influence regression model parameters and change the direction of the estimated effect, over-estimating or under-estimating the strength of the association between a response variable and an exposure of interest. Identifying v…
View article: Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5-15 Year Old Children Followed in the TEDDY Study
Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5-15 Year Old Children Followed in the TEDDY Study Open
Objective: This study investigated physical activity and its association with the development of islet autoimmunity (IA) and type 1 diabetes in genetically at-risk 5-15 year old children. Research Design and Meth…
View article: Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5- to 15-Year-Old Children Followed in the TEDDY Study
Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5- to 15-Year-Old Children Followed in the TEDDY Study Open
OBJECTIVE This study investigated physical activity and its association with the development of islet autoimmunity and type 1 diabetes in genetically at-risk children aged 5–15 years. RESEARCH DESIGN AND METHODS As part of the longitudinal…
View article: Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5-15 Year Old Children Followed in the TEDDY Study
Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5-15 Year Old Children Followed in the TEDDY Study Open
Objective: This study investigated physical activity and its association with the development of islet autoimmunity (IA) and type 1 diabetes in genetically at-risk 5-15 year old children. Research Design and Meth…
View article: Incidence of Pediatric Celiac Disease Varies by Region
Incidence of Pediatric Celiac Disease Varies by Region Open
INTRODUCTION: The Environmental Determinants of Diabetes in the Young study follows an HLA risk selected birth cohort for celiac disease (CD) development using a uniform protocol. Children under investigation come from 6 different regions …
View article: Is staff consistency important to parents’ satisfaction in a longitudinal study of children at risk for type 1 diabetes: the TEDDY study
Is staff consistency important to parents’ satisfaction in a longitudinal study of children at risk for type 1 diabetes: the TEDDY study Open
View article: Is Staff Consistency Important to Parents’ Satisfaction in a Longitudinal Study of Children at Risk for Type 1 Diabetes: The TEDDY Study
Is Staff Consistency Important to Parents’ Satisfaction in a Longitudinal Study of Children at Risk for Type 1 Diabetes: The TEDDY Study Open
Background: Participants’ study satisfaction is important for both study compliance and retention, but research on parental study satisfaction is rare. The aim of the study was to identify factors associated with parent study satisfaction …
View article: Parental monitoring for type 1 diabetes in genetically at‐risk young children: The TEDDY study
Parental monitoring for type 1 diabetes in genetically at‐risk young children: The TEDDY study Open
Many parents view TEDDY participation as a way to monitor for type 1 diabetes, a benefit of enrollment in a longitudinal study with no prevention offered. IA+ notification increases short- and long-term monitoring behaviors. For IA- and IA…
View article: Associations of breastfeeding with childhood autoimmunity, allergies, and overweight: The Environmental Determinants of Diabetes in the Young (TEDDY) study
Associations of breastfeeding with childhood autoimmunity, allergies, and overweight: The Environmental Determinants of Diabetes in the Young (TEDDY) study Open
View article: Utilization, Timing, and Outcomes of BRCA Genetic Testing Among Women With Newly Diagnosed Breast Cancer From a National Commercially Insured Population: The ABOARD Study
Utilization, Timing, and Outcomes of BRCA Genetic Testing Among Women With Newly Diagnosed Breast Cancer From a National Commercially Insured Population: The ABOARD Study Open
PURPOSE: To evaluate timing and outcomes of BRCA testing and definitive surgical treatment among patients with newly diagnosed breast cancer. METHODS: Patient-reported (n = 1,381) and deidentified health-plan (n = 2,369) data were analyzed…
View article: First-appearing islet autoantibodies for type 1 diabetes in young children: maternal life events during pregnancy and the child’s genetic risk
First-appearing islet autoantibodies for type 1 diabetes in young children: maternal life events during pregnancy and the child’s genetic risk Open
View article: Prospective virome analyses in young children at increased genetic risk for type 1 diabetes
Prospective virome analyses in young children at increased genetic risk for type 1 diabetes Open
View article: The relationship between breastfeeding and reported respiratory and gastrointestinal infection rates in young children
The relationship between breastfeeding and reported respiratory and gastrointestinal infection rates in young children Open
View article: Nested case‐control data analysis using weighted conditional logistic regression in The Environmental Determinants of Diabetes in the Young (TEDDY) study: A novel approach
Nested case‐control data analysis using weighted conditional logistic regression in The Environmental Determinants of Diabetes in the Young (TEDDY) study: A novel approach Open
Background A nested case‐control (NCC) design within a prospective cohort study can realize substantial benefits for biomarker studies. In this context, it is natural to consider the sample availability in the selection of controls to mini…
View article: The association between stressful life events and respiratory infections during the first 4 years of life: <scp>The Environmental Determinants of Diabetes in the Young</scp> study
The association between stressful life events and respiratory infections during the first 4 years of life: <span>The Environmental Determinants of Diabetes in the Young</span> study Open
The aim of this study was to conduct a prospective analysis of the association between negative life events (NLEs) and respiratory infections in children genetically at risk for islet autoimmunity (IA) and type 1 diabetes (T1D). Long‐ and …