Kristian Hellenkamp
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View article: Finerenone in diabetic chronic kidney disease—Real‐world insights including patients with HFpEF or HFmrEF
Finerenone in diabetic chronic kidney disease—Real‐world insights including patients with HFpEF or HFmrEF Open
Purpose Finerenone, a highly selective non‐steroidal mineralocorticoid receptor antagonist, was approved for the treatment of patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (diabetic kidney disease, DKD). Finerenon…
View article: Reaching the SUMMIT? Benefits and potential risks associated with the use of tirzepatide in heart failure with preserved ejection fraction
Reaching the SUMMIT? Benefits and potential risks associated with the use of tirzepatide in heart failure with preserved ejection fraction Open
The SUMMIT trial1 showed that the dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist tirzepatide improves quality of life and reduces worsening heart failure (HF) events in patients with HF with preserved ej…
View article: Engineered heart muscle allografts for heart repair in primates and humans
Engineered heart muscle allografts for heart repair in primates and humans Open
Cardiomyocytes can be implanted to remuscularize the failing heart 1–7 . Challenges include sufficient cardiomyocyte retention for a sustainable therapeutic impact without intolerable side effects, such as arrhythmia and tumour growth. We …
View article: Prognostic and diagnostic implications of impaired rest and exercise-stress left atrial compliance in heart failure with preserved ejection fraction: Insights from the HFpEF Stress Trial
Prognostic and diagnostic implications of impaired rest and exercise-stress left atrial compliance in heart failure with preserved ejection fraction: Insights from the HFpEF Stress Trial Open
Background With emerging therapies, early diagnosis of heart failure with preserved ejection fraction (HFpEF) comes to the fore. Whilst the reference standard of exercise-stress right heart catheterisation is well established, the clinical…
View article: Estimated annual healthcare costs after acute pulmonary embolism: results from a prospective multicentre cohort study
Estimated annual healthcare costs after acute pulmonary embolism: results from a prospective multicentre cohort study Open
Aims Patients surviving acute pulmonary embolism (PE) necessitate long-term treatment and follow-up. We estimated, the chronic economic impact of PE on the German healthcare system. Methods and results We calculated the direct cost of illn…
View article: Prognostic and diagnostic implications of impaired rest and exercise-stress left atrial compliance in heart failure with preserved ejection fraction: Insights from the HFpEF stress trial
Prognostic and diagnostic implications of impaired rest and exercise-stress left atrial compliance in heart failure with preserved ejection fraction: Insights from the HFpEF stress trial Open
LA compliance at rest can be obtained from clinical routine imaging and bears strong diagnostic and prognostic accuracy. Addition of LA compliance can improve the role of echocardiography as the primary test and gatekeeper.
View article: Repurposing the β<sub>3</sub>-Adrenergic Receptor Agonist Mirabegron in Patients With Structural Cardiac Disease
Repurposing the β<sub>3</sub>-Adrenergic Receptor Agonist Mirabegron in Patients With Structural Cardiac Disease Open
Importance Left ventricular (LV) hypertrophy contributes to the onset and progression of heart failure (HF), particularly for patients with pre-HF (stage B) for whom no treatment has yet proven effective to prevent transition to overt HF (…
View article: Concomitant latent pulmonary vascular disease leads to impaired global cardiac performance in heart failure with preserved ejection fraction
Concomitant latent pulmonary vascular disease leads to impaired global cardiac performance in heart failure with preserved ejection fraction Open
Aims The REDUCE‐LAP II trial demonstrated adverse outcomes after interatrial shunt device (IASD) placement in heart failure with preserved ejection fraction (HFpEF) attributed to latent pulmonary vascular disease (PVD). We hypothesized tha…
View article: Structured, Harmonized, and Interoperable Integration of Clinical Routine Data to Compute Heart Failure Risk Scores
Structured, Harmonized, and Interoperable Integration of Clinical Routine Data to Compute Heart Failure Risk Scores Open
Risk prediction in patients with heart failure (HF) is essential to improve the tailoring of preventive, diagnostic, and therapeutic strategies for the individual patient, and effectively use health care resources. Risk scores derived from…
View article: Chronic thromboembolic pulmonary hypertension and impairment after pulmonary embolism: the FOCUS study
Chronic thromboembolic pulmonary hypertension and impairment after pulmonary embolism: the FOCUS study Open
Aims To systematically assess late outcomes of acute pulmonary embolism (PE) and to investigate the clinical implications of post-PE impairment (PPEI) fulfilling prospectively defined criteria. Methods and results A prospective multicentre…
View article: Travelling with heart failure: risk assessment and practical recommendations
Travelling with heart failure: risk assessment and practical recommendations Open
Patients with heart failure are at a higher risk of cardiovascular events compared with the general population, particularly during domestic or international travel. Patients with heart failure should adhere to specific recommendations dur…
View article: Exercise Stress Real-Time Cardiac Magnetic Resonance Imaging for Noninvasive Characterization of Heart Failure With Preserved Ejection Fraction
Exercise Stress Real-Time Cardiac Magnetic Resonance Imaging for Noninvasive Characterization of Heart Failure With Preserved Ejection Fraction Open
Background: Right heart catheterization using exercise stress is the reference standard for the diagnosis of heart failure with preserved ejection fraction (HFpEF) but carries the risk of the invasive procedure. We hypothesized that real-t…
View article: A machine learning approach for the prediction of pulmonary hypertension
A machine learning approach for the prediction of pulmonary hypertension Open
Using ML, we were able to predict pulmonary hypertension based on a broader set of echocardiographic data with little reliance on estimated RAP compared to an existing formula with non-inferior performance. With the conceptual advantages o…
View article: A MACHINE LEARNING APPROACH FOR THE PREDICTION OF PULMONARY HYPERTENSION
A MACHINE LEARNING APPROACH FOR THE PREDICTION OF PULMONARY HYPERTENSION Open
Machine learning (ML) is ideal for identifying and structuring informative variables for predictive tasks. Here, we investigated how ML algorithms may advance decision making in PH prediction.
In our database of 90 patients with invasivel…
View article: Prognostic impact of copeptin in pulmonary embolism: a multicentre validation study
Prognostic impact of copeptin in pulmonary embolism: a multicentre validation study Open
To externally validate the prognostic impact of copeptin, either alone or integrated in risk stratification models, in pulmonary embolism (PE), we performed a post hoc analysis of 843 normotensive PE patients prospectively included in thre…
View article: Echocardiographic Estimation of Mean Pulmonary Artery Pressure: A Comparison of Different Approaches to Assign the Likelihood of Pulmonary Hypertension
Echocardiographic Estimation of Mean Pulmonary Artery Pressure: A Comparison of Different Approaches to Assign the Likelihood of Pulmonary Hypertension Open
Although all methods are associated with inaccuracies, echocardiographically determined PAPm was superior to the current guideline recommendation of using TR Vmax with regard to its correlation with invasively determined PAPm and the prese…
View article: P4922Validation of the prognostic impact of copeptin in normotensive pulmonary embolism in a European multicentre study
P4922Validation of the prognostic impact of copeptin in normotensive pulmonary embolism in a European multicentre study Open
Background: Patients with unprovoked venous thromboembolism (VTE) are at an increased risk of mortality, but whether their cardiovascular risks also increase remains to be determined.We aimed to investigate the factors associated with over…
View article: Enhanced cardiac TBC1D10C expression lowers heart rate and enhances exercise capacity and survival
Enhanced cardiac TBC1D10C expression lowers heart rate and enhances exercise capacity and survival Open
TBC1D10C is a protein previously demonstrated to bind and inhibit Ras and Calcineurin. In cardiomyocytes, also CaMKII is inhibited and all three targeted enzymes are known to promote maladaptive cardiomyocyte hypertrophy. Here, in accordan…
View article: Early pneumonia and timing of antibiotic therapy in patients after nontraumatic out-of-hospital cardiac arrest
Early pneumonia and timing of antibiotic therapy in patients after nontraumatic out-of-hospital cardiac arrest Open
Background While early pneumonia is common in patients after out-of-hospital cardiac arrest (OHCA), little is known about the impact of pneumonia and the optimal timing of antibiotic therapy after OHCA. Methods We conducted a 5-year retros…