Kristian Savstrup Kastberg
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View article: Display of clustered antigen by follicular dendritic cells tunes B-cell receptor activation
Display of clustered antigen by follicular dendritic cells tunes B-cell receptor activation Open
To generate high-affinity antibodies against pathogens, B cells engage antigens displayed on the surface of follicular dendritic cells (FDCs) in secondary lymphoid tissues. Binding of cognate antigen by the B-cell receptor (BCR) causes Src…
View article: Maternal imprinting of autoreactivity in a murine model of systemic lupus erythematosus
Maternal imprinting of autoreactivity in a murine model of systemic lupus erythematosus Open
View article: Serial intravital microscopy reveals temporal dynamics of autoreactive germinal centers in the spleen
Serial intravital microscopy reveals temporal dynamics of autoreactive germinal centers in the spleen Open
The spleen plays a key role in clearing blood-borne infections and is involved in autoimmune and hematological disorders. It undergoes extensive remodeling during inflammation and immune reactions, but its localization in the peritoneal ca…
View article: Antigen presentation by B cells enables epitope spreading across an MHC barrier
Antigen presentation by B cells enables epitope spreading across an MHC barrier Open
View article: The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus
The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus Open
Introduction Many autoimmune diseases are characterized by germinal center (GC)-derived, affinity-matured, class-switched autoantibodies, and strategies to block GC formation and progression are currently being explored clinically. However…
View article: Extrafollicular responses are sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus
Extrafollicular responses are sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus Open
Many autoimmune diseases are characterized by germinal center (GC) derived affinity-matured, class-switched autoantibodies. Strategies to block GC formation and progression are currently being explored clinically, however, extrafollicular …