Kristien J. Ledeganck
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View article: Metabolic dysfunction‐associated steatotic liver disease is associated with worse time in ranges in type 1 diabetes
Metabolic dysfunction‐associated steatotic liver disease is associated with worse time in ranges in type 1 diabetes Open
Aim To investigate the relationship between continuous glucose monitoring (CGM)‐derived glucometrics and metabolic dysfunction‐associated steatotic liver disease (MASLD) in type 1 diabetes (T1D). Methods A cross‐sectional study collecting …
View article: Early feasibility study with an implantable near-infrared spectroscopy sensor for glucose, ketones, lactate and ethanol
Early feasibility study with an implantable near-infrared spectroscopy sensor for glucose, ketones, lactate and ethanol Open
Objective To evaluate the safety and performance of an implantable near-infrared (NIR) spectroscopy sensor for multi-metabolite monitoring of glucose, ketones, lactate, and ethanol. Research design and methods This is an early feasibility …
View article: Urinary epidermal growth factor reflects vascular health in boys with either obesity or type 1 diabetes. A role for renin, or beyond?
Urinary epidermal growth factor reflects vascular health in boys with either obesity or type 1 diabetes. A role for renin, or beyond? Open
An increased blood pressure is a known comorbidity of both type 1 diabetes (T1DM) and obesity in children. Increasing evidence suggests a subtle interplay between epidermal growth factor (EGF) and renin along the juxtaglomerular system, re…
View article: Effect of nationwide reimbursement of real-time continuous glucose monitoring on HbA1c, hypoglycemia and quality of life in a pediatric type 1 diabetes population: The RESCUE-pediatrics study
Effect of nationwide reimbursement of real-time continuous glucose monitoring on HbA1c, hypoglycemia and quality of life in a pediatric type 1 diabetes population: The RESCUE-pediatrics study Open
Objective Real-time continuous glucose monitoring (RT-CGM) can improve metabolic control and quality of life (QoL), but long-term real-world data in children with type 1 diabetes (T1D) are scarce. Over a period of 24 months, we assessed th…
View article: Screening for an Underlying Tubulopathy in Children With Growth Failure, Simply Maths?
Screening for an Underlying Tubulopathy in Children With Growth Failure, Simply Maths? Open
Background Involving pediatric nephrological input in the clinical diagnostic work-up of children with short stature, gave rise to the hypothesis that the presence of an underlying renal tubular disorder in children with short stature is p…
View article: Seroconversion rate after primary vaccination with two doses of BNT162b2 versus mRNA-1273 in solid organ transplant recipients: a systematic review and meta-analysis
Seroconversion rate after primary vaccination with two doses of BNT162b2 versus mRNA-1273 in solid organ transplant recipients: a systematic review and meta-analysis Open
Background In the general population, the seroconversion rate after primary vaccination with two doses of an anti-severe acute respiratory syndrome coronavirus 2 messenger RNA (mRNA) vaccine reaches nearly 100%, with significantly higher a…
View article: MO1010: Seroconversion Rate After Primary Vaccination with Two Doses of BNT162B2 versus MRNA-1273 in Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis
MO1010: Seroconversion Rate After Primary Vaccination with Two Doses of BNT162B2 versus MRNA-1273 in Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis Open
BACKGROUND AND AIMS In the general population, the seroconversion rate after primary vaccination with two doses of anti-SARS-CoV-2 mRNA vaccine reaches nearly 100%, with significantly higher antibody titers after mRNA-1273 vaccination comp…
View article: Seroconversion rate after primary vaccination with two doses of BNT162b2 versus mRNA-1273 in solid organ transplant recipients: a systematic review and meta-analysis
Seroconversion rate after primary vaccination with two doses of BNT162b2 versus mRNA-1273 in solid organ transplant recipients: a systematic review and meta-analysis Open
In the general population, the seroconversion rate after primary vaccination with two doses of anti-SARS-CoV-2 mRNA vaccine reaches nearly 100%, with significantly higher antibody titers after mRNA-1273 vaccination compared to BNT162b2 vac…
View article: mRNA-1273 vaccine (Moderna): a better option than BNT162b2 (Pfizer) in kidney transplant recipients and dialysis patients?
mRNA-1273 vaccine (Moderna): a better option than BNT162b2 (Pfizer) in kidney transplant recipients and dialysis patients? Open
The authors received no specific funding for this work. The authors would like to thank the study nurses E. Meersman, S. Verhofstede, N. Marmitte and T. Bogaerts for their excellent and efficient help. We also thank E. Snelders, S. Van Hee…
View article: Biopsy or Biomarker? Children With Minimal Change Disease Have a Distinct Profile of Urinary Epidermal Growth Factor
Biopsy or Biomarker? Children With Minimal Change Disease Have a Distinct Profile of Urinary Epidermal Growth Factor Open
Background: In this study, the profile of urinary EGF excretion (uEGF/uCreat) was mapped in children presenting with prolonged proteinuria or with nephrotic syndrome refractory to or dependent of steroids. We investigated whether uEGF/uCre…
View article: mRNA-1273 vaccine (Moderna): a better option than BNT162b2 (Pfizer) in kidney transplant recipients and dialysis patients?
mRNA-1273 vaccine (Moderna): a better option than BNT162b2 (Pfizer) in kidney transplant recipients and dialysis patients? Open
In this study of the humoral immune response after the SARS-CoV-2 mRNA vaccination, low seroconversion rates were noted in both kidney transplant recipients and dialysis patients after first dose administration. While in DP the seroconvers…
View article: Relationship Between Time in Range, Glycemic Variability, HbA1c, and Complications in Adults With Type 1 Diabetes Mellitus
Relationship Between Time in Range, Glycemic Variability, HbA1c, and Complications in Adults With Type 1 Diabetes Mellitus Open
Purpose Real-time continuous glucose monitoring (RT-CGM) provides information on glycemic variability (GV), time in range (TIR), and guidance to avoid hypoglycemia, thereby complimenting HbA1c for diabetes management. We investigated wheth…
View article: The next generation: Urinary epidermal growth factor is associated with an early decline in kidney function in children and adolescents with type 1 diabetes mellitus
The next generation: Urinary epidermal growth factor is associated with an early decline in kidney function in children and adolescents with type 1 diabetes mellitus Open
This study provides evidence that uEGF can serve as an early marker of diabetes nephropathy in children and adolescents.
View article: Epidermal growth factor as a potential prognostic and predictive biomarker of response to platinum-based chemotherapy
Epidermal growth factor as a potential prognostic and predictive biomarker of response to platinum-based chemotherapy Open
In this study, we investigated serum epidermal growth factor (EGF) in an oncological population of head- and neck and pulmonary neoplasms and whether serum EGF could serve as a prognostic marker of survival and as a predictive marker for t…
View article: A Combined microRNA and Chemokine Profile in Urine to Identify Rejection After Kidney Transplantation
A Combined microRNA and Chemokine Profile in Urine to Identify Rejection After Kidney Transplantation Open
Background. There is an unmet need for noninvasive tools for diagnosis of rejection after kidney transplantation. The aim of this study was to determine the discriminative value of a combined cellular and molecular biomarker platform in ur…
View article: Body composition measurement percentiles for boys and girls aged 2 to 17 years
Body composition measurement percentiles for boys and girls aged 2 to 17 years Open
Detailed body composition percentile tables from children aged 2 to 17 years. A full publication describing detailed methodology is available: Van Eyck, A., Eerens, S., Trouet, D. et al. Body composition monitoring in children and adolesce…
View article: Body composition measurement percentiles for boys and girls aged 2 to 17 years
Body composition measurement percentiles for boys and girls aged 2 to 17 years Open
Detailed body composition percentile tables from children aged 2 to 17 years. A full publication describing detailed methodology is available: Van Eyck, A., Eerens, S., Trouet, D. et al. Body composition monitoring in children and adolesce…
View article: Chronic complications versus glycaemic variability, time in range and HbA<sub>1c</sub> in people with type 1 diabetes: sub study of the RESCUE-trial
Chronic complications versus glycaemic variability, time in range and HbA<sub>1c</sub> in people with type 1 diabetes: sub study of the RESCUE-trial Open
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
View article: A Literature Review of the Potential Diagnostic Biomarkers of Head and Neck Neoplasms
A Literature Review of the Potential Diagnostic Biomarkers of Head and Neck Neoplasms Open
Head and neck neoplasms have a poor prognosis because of their late diagnosis. Finding a biomarker to detect these tumors in an early phase could improve the prognosis and survival rate. This literature review provides an overview of bioma…
View article: P1611PRE-ANALYTICAL CONSIDERATIONS IN STUDYING CIRCULATING MICRORNA EXPRESSION: COMPARISON BETWEEN PAIRED EDTA PLASMA, EDTA WHOLE BLOOD AND PAXGENE BLOOD RNA TUBES
P1611PRE-ANALYTICAL CONSIDERATIONS IN STUDYING CIRCULATING MICRORNA EXPRESSION: COMPARISON BETWEEN PAIRED EDTA PLASMA, EDTA WHOLE BLOOD AND PAXGENE BLOOD RNA TUBES Open
Background and Aims microRNA (miRNA) dysregulations have been related to pathological processes, including kidney disease. Relative stability in blood makes miRNAs attractive biomarkers. The current recommendation is to use fresh EDTA plas…
View article: TO009THE POTENTIAL OF DONOR-DERIVED CELL-FREE DNA AS A BIOMARKER FOR REJECTION IN KIDNEY TRANSPLANTATION: A SYSTEMATIC REVIEW AND META-ANALYSIS
TO009THE POTENTIAL OF DONOR-DERIVED CELL-FREE DNA AS A BIOMARKER FOR REJECTION IN KIDNEY TRANSPLANTATION: A SYSTEMATIC REVIEW AND META-ANALYSIS Open
Background and Aims Donor-derived cell-free DNA (dd-cfDNA) is actively studied as a non-invasive biomarker for the diagnosis of kidney allograft rejection, with conflicting results being reported. Therefore, we conducted a systematic revie…
View article: The use of plasma donor-derived, cell-free DNA to monitor acute rejection after kidney transplantation
The use of plasma donor-derived, cell-free DNA to monitor acute rejection after kidney transplantation Open
Background After transplantation, cell-free deoxyribonucleic acid (DNA) derived from the donor organ (ddcfDNA) can be detected in the recipient’s circulation. We aimed to investigate the role of plasma ddcfDNA as biomarker for acute kidney…
View article: Epidermal growth factor and its influencing variables in healthy children and adults
Epidermal growth factor and its influencing variables in healthy children and adults Open
This study provides valuable insights in urinary and serum EGF patterns in healthy subjects. By systematically correcting EGF for body surface, significant correlations with age, gender and magnesium were observed.
View article: Non-invasive Biomarkers of Acute Rejection in Kidney Transplantation: Novel Targets and Strategies
Non-invasive Biomarkers of Acute Rejection in Kidney Transplantation: Novel Targets and Strategies Open
Kidney transplantation is considered the favored treatment for patients suffering from end-stage renal disease, since successful transplantation is associated with longer survival and improved quality of life compared to dialysis. Alloreac…