Kristin M. Burkart
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View article: A Genome-Wide Association Study in Hispanics/Latinos Identifies Novel Signals for Lung Function. The Hispanic Community Health Study/Study of Latinos
A Genome-Wide Association Study in Hispanics/Latinos Identifies Novel Signals for Lung Function. The Hispanic Community Health Study/Study of Latinos Open
RATIONALE: Lung function and chronic obstructive pulmonary disease (COPD) are heritable traits. Genome-wide association studies (GWAS) have identified numerous pulmonary function and COPD loci, primarily in cohorts of European ancestry. OB…
View article: Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants
Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants Open
Chronic obstructive pulmonary disease (COPD), diagnosed by reduced lung function, is a leading cause of morbidity and mortality. We performed whole genome sequence (WGS) analysis of lung function and COPD in a multi-ethnic sample of 11,497…
View article: Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function Open
Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in …
View article: The Virtual Interview Experience: Perspectives of Pulmonary and Critical Care Fellowship Applicants
The Virtual Interview Experience: Perspectives of Pulmonary and Critical Care Fellowship Applicants Open
Most pulmonary and critical care medicine applicants preferred future interviews to include both VIs and the option of an in-person visit or interview. This study can assist programs in designing their future interview formats in a trainee…
View article: Latent Class Analysis Reveals COVID-19–related Acute Respiratory Distress Syndrome Subgroups with Differential Responses to Corticosteroids
Latent Class Analysis Reveals COVID-19–related Acute Respiratory Distress Syndrome Subgroups with Differential Responses to Corticosteroids Open
Rationale: Two distinct subphenotypes have been identified in acute respiratory distress syndrome (ARDS), but the presence of subgroups in ARDS associated with coronavirus disease (COVID-19) is unknown. Objectives: To identify clinically r…
View article: Supervised Machine Learning Approach to Identify Early Predictors of Poor Outcome in Patients with COVID-19 Presenting to a Large Quaternary Care Hospital in New York City
Supervised Machine Learning Approach to Identify Early Predictors of Poor Outcome in Patients with COVID-19 Presenting to a Large Quaternary Care Hospital in New York City Open
Background: The progression of clinical manifestations in patients with coronavirus disease 2019 (COVID-19) highlights the need to account for symptom duration at the time of hospital presentation in decision-making algorithms. Methods: We…
View article: Balancing Demands: Determinants of Burnout Reported by Fellows in Pulmonary and Critical Care Medicine
Balancing Demands: Determinants of Burnout Reported by Fellows in Pulmonary and Critical Care Medicine Open
Background: Burnout is common among physicians who care for critically ill patients and is known to contribute to worse patient outcomes. Fellows training in pulmonary and critical care medicine (PCCM) have risk factors that make them susc…
View article: Development of a National Academic Boot Camp to Improve Fellowship Readiness
Development of a National Academic Boot Camp to Improve Fellowship Readiness Open
Conclusion: RBC participation improved PCCM-bound trainee knowledge, procedural familiarity, and confidence. Refinement of the RBC curriculum over the past 7 years has been guided by educator and course evaluations, with the ongoing goal o…
View article: APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema
APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema Open
Chronic obstructive pulmonary disease (COPD) is linked to cardiovascular disease; however, there are few studies on the associations of cardiovascular genes with COPD.
View article: Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function
Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function Open
Genome-wide association studies have identified numerous genetic loci for spirometic measures of pulmonary function, forced expiratory volume in one second (FEV1), and its ratio to forced vital capacity (FEV1/FVC). Given that cigarette smo…
View article: Replication and fine mapping of asthma-associated loci in individuals of African ancestry
Replication and fine mapping of asthma-associated loci in individuals of African ancestry Open
Asthma originates from genetic and environmental factors with about half the risk of disease attributable to heritable causes. Genome-wide association studies, mostly in populations of European ancestry, have identified numerous asthma-ass…
View article: Randomization to Omega-3 Fatty Acid Supplementation and Endothelial Function in COPD: The COD-Fish Randomized Controlled Trial
Randomization to Omega-3 Fatty Acid Supplementation and Endothelial Function in COPD: The COD-Fish Randomized Controlled Trial Open
Randomization to n-3 PUFAs for 6 months did not change systemic endothelial function in COPD. Changes in EMPs and SGRQ suggest n-3 PUFAs might have biologic and clinical effects that warrant further investigation.
View article: Breaking Silos: The Team-Based Approach to Coronavirus Disease 2019 Pandemic Staffing
Breaking Silos: The Team-Based Approach to Coronavirus Disease 2019 Pandemic Staffing Open
To the Editor: As coronavirus disease 2019 (COVID-19) spreads across New York, it became apparent that there were not enough ICU beds, ventilators, or staff to accommodate patients flowing in through our emergency rooms. NewYork-Presbyteri…
View article: Genome-Wide Association Studies Identify CHRNA5/3 and HTR4 in the Development of Airflow Obstruction
Genome-Wide Association Studies Identify CHRNA5/3 and HTR4 in the Development of Airflow Obstruction Open
Rationale: Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are known.
View article: Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants
Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants Open
Chronic obstructive pulmonary disease (COPD), diagnosed by reduced lung function, is a leading cause of morbidity and mortality. We performed whole genome sequence (WGS) analysis of lung function and COPD in a multi-ethnic sample of 11,497…
View article: Virtually Hosting a National Medical Society Conference. Lessons Learned from the 2020 Association of Pulmonary and Critical Care Medicine Program Directors Conference
Virtually Hosting a National Medical Society Conference. Lessons Learned from the 2020 Association of Pulmonary and Critical Care Medicine Program Directors Conference Open
The coronavirus pandemic forced the Association of Pulmonary and Critical Care Medicine Program Directors to change the 2020 annual conference to a virtual format with relatively short notice. Using the experience of the planning committee…
View article: What Do Program Directors Value in Personal Statements? A Qualitative Analysis
What Do Program Directors Value in Personal Statements? A Qualitative Analysis Open
Background: All applicants to accredited training programs must write a personal statement as part of the application process. This may provoke anxiety on the part of the applicant and can result in an impersonal product that does not enha…
View article: Albuminuria, Lung Function Decline, and Risk of Incident Chronic Obstructive Pulmonary Disease. The NHLBI Pooled Cohorts Study
Albuminuria, Lung Function Decline, and Risk of Incident Chronic Obstructive Pulmonary Disease. The NHLBI Pooled Cohorts Study Open
Albuminuria was associated with greater lung function decline, incident spirometry-defined COPD, and incident COPD-related events in a U.S. population-based sample.
View article: Meta-analysis of exome array data identifies six novel genetic loci for lung function
Meta-analysis of exome array data identifies six novel genetic loci for lung function Open
Background: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease. Methods: We carried out meta-analyses of exome array data and thre…
View article: Meta-analysis of exome array data identifies six novel genetic loci for lung function
Meta-analysis of exome array data identifies six novel genetic loci for lung function Open
Background: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease. Methods: We carried out meta-analyses of exome array data and thre…