Kristin M. Long
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View article: Using SHAPE-MaP To Model RNA Secondary Structure and Identify 3'UTR Variation in Chikungunya Virus.
Using SHAPE-MaP To Model RNA Secondary Structure and Identify 3'UTR Variation in Chikungunya Virus. Open
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus associated with debilitating arthralgia in humans. RNA secondary structure in the viral genome plays an important role in the lifecycle of alphaviruses; however, the specific role of…
View article: Novel modulators of p53-signaling encoded by unknown genes of emerging viruses
Novel modulators of p53-signaling encoded by unknown genes of emerging viruses Open
The p53 transcription factor plays a key role both in cancer and in the cell-intrinsic response to infections. The ORFEOME project hypothesized that novel p53-virus interactions reside in hitherto uncharacterized, unknown, or hypothetical …
View article: Gamma-delta T cells play a protective role in chikungunya virus-induced disease.
Gamma-delta T cells play a protective role in chikungunya virus-induced disease. Open
Chikungunya virus (CHIKV) is an alphavirus responsible for causing epidemic outbreaks of polyarthralgia in humans. As CHIKV is initially introduced into the skin where γδ T cells are prevalent, we evaluated their response to CHIKV infectio…
View article: Using SHAPE-MaP To Model RNA Secondary Structure and Identify 3′UTR Variation in Chikungunya Virus
Using SHAPE-MaP To Model RNA Secondary Structure and Identify 3′UTR Variation in Chikungunya Virus Open
Chikungunya virus (CHIKV) is a mosquito-borne RNA virus that causes febrile illness and debilitating arthralgia in humans. CHIKV causes explosive outbreaks but there are no approved therapies to treat or prevent CHIKV infection. The CHIKV …
View article: Laboratory-Acquired Dengue Virus Infection, United States, 2018
Laboratory-Acquired Dengue Virus Infection, United States, 2018 Open
Investigation of a dengue case in a laboratory worker in North Carolina, USA, revealed that the case-patient prepared high-titer dengue virus stocks soon before illness onset. Improper doffing of gloves with an open finger wound likely res…
View article: Structural divergence creates new functional features in alphavirus genomes
Structural divergence creates new functional features in alphavirus genomes Open
Alphaviruses are mosquito-borne pathogens that cause human diseases ranging from debilitating arthritis to lethal encephalitis. Studies with Sindbis virus (SINV), which causes fever, rash, and arthralgia in humans, and Venezuelan equine en…
View article: γδ T cells play a protective role in Chikungunya virus-induced disease
γδ T cells play a protective role in Chikungunya virus-induced disease Open
Chikungunya virus (CHIKV) is an alphavirus responsible for causing epidemic outbreaks of polyarthralgia in humans. Because CHIKV is initially introduced via the skin, where γδ T cells are prevalent, we evaluated the response of these cells…
View article: Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology
Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology Open
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for several significant outbreaks of debilitating acute and chronic arthritis and arthralgia over the past decade. These include a recent outbreak in the Caribbean island…
View article: Structural divergence creates new functional features in alphavirus genomes
Structural divergence creates new functional features in alphavirus genomes Open
Alphaviruses are mosquito-borne pathogens that cause human diseases ranging from debilitating arthritis to lethal encephalitis. Studies with Sindbis virus (SINV), which causes fever, rash, and arthralgia in humans, and Venezuelan equine en…
View article: Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology
Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology Open
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for several significant outbreaks of debilitating acute and chronic arthritis and arthralgia over the past decade. These include a recent outbreak in the Caribbean island…
View article: Complete Genome Sequences of 15 Chikungunya Virus Isolates from Puerto Rico
Complete Genome Sequences of 15 Chikungunya Virus Isolates from Puerto Rico Open
Here, we report the complete genome sequences of 15 chikungunya virus strains isolated from human plasma from infected patients in Puerto Rico. The results show that currently circulating chikungunya strains in Puerto Rico are closely rela…
View article: γδ T Cells Play a Protective Role in Chikungunya Virus-Induced Disease
γδ T Cells Play a Protective Role in Chikungunya Virus-Induced Disease Open
Chikungunya virus (CHIKV) is an alphavirus responsible for causing epidemic outbreaks of polyarthralgia in humans. Because CHIKV is initially introduced via the skin, where γδ T cells are prevalent, we evaluated the response of these cells…
View article: High Rates of O’Nyong Nyong and Chikungunya Virus Transmission in Coastal Kenya
High Rates of O’Nyong Nyong and Chikungunya Virus Transmission in Coastal Kenya Open
Alphavirus exposure, particularly ONNV exposure, is common in coastal Kenya with ongoing interepidemic transmission of both ONNV and CHIKV. Women and adults were more likely to be seropositive. Household location may be a defining factor f…
View article: Protective and Pathogenic Responses to Chikungunya Virus Infection
Protective and Pathogenic Responses to Chikungunya Virus Infection Open