Kristin M. Sheffield
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View article: Intentional Weight Loss and Associated Cancer Incidence Among People With Overweight or Obesity: A Systematic Literature Review
Intentional Weight Loss and Associated Cancer Incidence Among People With Overweight or Obesity: A Systematic Literature Review Open
Aims While obesity is linked to increased cancer risk, evidence on the impact of intentional weight loss on obesity‐associated cancers (OACs) is limited. A systematic literature review (SLR) was conducted to assess the association between …
View article: Applying Bias Correction Methods to Build Hybrid Controls Using Real‐World Patients for a Phase <scp>IIb</scp> Randomized Controlled Trial of Baricitinib for Rheumatoid Arthritis
Applying Bias Correction Methods to Build Hybrid Controls Using Real‐World Patients for a Phase <span>IIb</span> Randomized Controlled Trial of Baricitinib for Rheumatoid Arthritis Open
Studies incorporating randomized controlled trial (RCT) controls with real‐world (RW) patients face concerns of selection bias and unmeasured confounding. To evaluate two methods (Match, Test‐then‐Pool [MTP] and Matching and Bias Adjustmen…
View article: Understanding motivations of older women to continue or discontinue breast cancer screening
Understanding motivations of older women to continue or discontinue breast cancer screening Open
Breast cancer screening guidelines indicate screening in women over 75 years of age is optional, depending upon patient health and preferences. To better understand the preferences and decision-making of older women, their experiences and …
View article: Understanding motivations of older women to continue or discontinue breast cancer screening
Understanding motivations of older women to continue or discontinue breast cancer screening Open
Background Breast cancer screening guidelines indicate screening in women over 75 years of age is optional, depending upon patient health and preferences. Objectives To link experiences and perceptions of older women concerning screening t…
View article: Real-world outcomes in patients with brain metastases secondary to HR+/HER2− MBC treated with abemaciclib and local intracranial therapy
Real-world outcomes in patients with brain metastases secondary to HR+/HER2− MBC treated with abemaciclib and local intracranial therapy Open
Background Real-world data are limited for patients with brain metastases secondary to metastatic breast cancer (MBC) and treated with cyclin-dependent kinase 4/6 inhibitors (CDK4/6i). This study describes real-world outcomes in patients w…
View article: Real-World Analysis of Clinical and Demographic Characteristics, Treatment Patterns, and Outcomes in Predominantly Older Patients with HR+/HER2− Metastatic Breast Cancer Receiving Abemaciclib in Routine Clinical Practice
Real-World Analysis of Clinical and Demographic Characteristics, Treatment Patterns, and Outcomes in Predominantly Older Patients with HR+/HER2− Metastatic Breast Cancer Receiving Abemaciclib in Routine Clinical Practice Open
These patients were older than those in the MONARCH studies with substantial visceral disease, and prior chemotherapy and CDK4 & 6i use. Discontinuation rates were higher than in previous real-world studies (11.9%), highlighting the need f…
View article: Real Effect or Bias? Best Practices for Evaluating the Robustness of Real-World Evidence through Quantitative Sensitivity Analysis for Unmeasured Confounding
Real Effect or Bias? Best Practices for Evaluating the Robustness of Real-World Evidence through Quantitative Sensitivity Analysis for Unmeasured Confounding Open
The assumption of no unmeasured confounders is a critical but unverifiable assumption required for causal inference yet quantitative sensitivity analyses to assess robustness of real-world evidence remains underutilized. The lack of use is…
View article: Real Effect or Bias? Best Practices for Evaluating the Robustness of Real-World Evidence through Quantitative Sensitivity Analysis for Unmeasured Confounding
Real Effect or Bias? Best Practices for Evaluating the Robustness of Real-World Evidence through Quantitative Sensitivity Analysis for Unmeasured Confounding Open
The assumption of ‘no unmeasured confounders’ is a critical but unverifiable assumption required for causal inference yet quantitative sensitivity analyses to assess robustness of real-world evidence remains underutilized. The lack of use …
View article: Clinicogenomic factors and treatment patterns among patients with advanced non–small cell lung cancer with or without brain metastases in the United States
Clinicogenomic factors and treatment patterns among patients with advanced non–small cell lung cancer with or without brain metastases in the United States Open
Background This retrospective, real-world study evaluated the prevalence of brain metastases, clinicodemographic characteristics, systemic treatments, and factors associated with overall survival among patients with advanced non–small cell…
View article: Characteristics and Outcomes in Cases of US Male Patients with Metastatic Breast Cancer Receiving Abemaciclib in Routine Clinical Practice
Characteristics and Outcomes in Cases of US Male Patients with Metastatic Breast Cancer Receiving Abemaciclib in Routine Clinical Practice Open
View article: Real-world comparison between weekly versus biweekly dosing of cetuximab for metastatic colorectal cancer
Real-world comparison between weekly versus biweekly dosing of cetuximab for metastatic colorectal cancer Open
Aim: This real-world study aims to compare overall survival (OS) associated with biweekly (Q2W) versus weekly (Q1W) cetuximab dosing regimens for metastatic colorectal cancer (mCRC) treatment in the US. Methods: Adult patients with KRAS wi…
View article: Development and Validation of Coding Algorithms to Identify Patients with Incident Non-Small Cell Lung Cancer in United States Healthcare Claims Data
Development and Validation of Coding Algorithms to Identify Patients with Incident Non-Small Cell Lung Cancer in United States Healthcare Claims Data Open
Our study developed and validated a practical, 10-variable, point-based algorithm for identifying incident NSCLC cases in a US claims database based on a previously validated incident lung cancer algorithm.
View article: The Burden of Metastatic Cancer–Induced Bone Pain: A Narrative Review
The Burden of Metastatic Cancer–Induced Bone Pain: A Narrative Review Open
Bone pain is one of the most common forms of pain reported by cancer patients with metastatic disease. We conducted a review of oncology literature to further understand the epidemiology of and treatment approaches for metastatic cancer-in…
View article: A Real-World US Study of Recurrence Risks using Combined Clinicopathological Features in HR-Positive, HER2-Negative Early Breast Cancer
A Real-World US Study of Recurrence Risks using Combined Clinicopathological Features in HR-Positive, HER2-Negative Early Breast Cancer Open
Aim: To assess invasive disease-free survival (IDFS) and distant relapse-free survival (DRFS) in hormone receptor-positive, HER2-negative early breast cancer with combined clinicopathological criteria from monarchE, a phase III stud…
View article: Machine readable code lists for an algorithm to identify incident non-small cell lung cancer (NSCLC) in United States healthcare claims data
Machine readable code lists for an algorithm to identify incident non-small cell lung cancer (NSCLC) in United States healthcare claims data Open
Machine readable code lists for an algorithm to identify incident non-small cell lung cancer (NSCLC) in United States healthcare claims data
View article: Machine readable code lists for an algorithm to identify incident non-small cell lung cancer (NSCLC) in United States healthcare claims data
Machine readable code lists for an algorithm to identify incident non-small cell lung cancer (NSCLC) in United States healthcare claims data Open
Machine readable code lists for an algorithm to identify incident non-small cell lung cancer (NSCLC) in United States healthcare claims data
View article: Predicting optimal treatment regimens for patients with HR+/HER2- breast cancer using machine learning based on electronic health records
Predicting optimal treatment regimens for patients with HR+/HER2- breast cancer using machine learning based on electronic health records Open
Aim: To predict optimal treatments maximizing overall survival (OS) and time to treatment discontinuation (TTD) for patients with metastatic breast cancer (MBC) using machine learning methods on electronic health records. Patients/methods:…
View article: Study of patient characteristics, treatment patterns, <i>EGFR</i> testing patterns and outcomes in real-world patients with <i>EGFR</i>m<sup>+</sup> non-small cell lung cancer
Study of patient characteristics, treatment patterns, <i>EGFR</i> testing patterns and outcomes in real-world patients with <i>EGFR</i>m<sup>+</sup> non-small cell lung cancer Open
This retrospective, observational study examined patient characteristics, treatment patterns, testing patterns and outcomes of US patients receiving first-/second- or third-generation epidermal growth factor receptor (EGFR) tyrosine kinase…
View article: Study of patient characteristics, treatment patterns, <i>EGFR</i> testing patterns and outcomes in real-world patients with <i>EGFR</i>m<sup>+</sup> non-small cell lung cancer
Study of patient characteristics, treatment patterns, <i>EGFR</i> testing patterns and outcomes in real-world patients with <i>EGFR</i>m<sup>+</sup> non-small cell lung cancer Open
This retrospective, observational study examined patient characteristics, treatment patterns, testing patterns, and outcomes of US patients receiving first-/second- or third-generation epidermal growth factor receptor (EGFR) tyrosine kinas…
View article: Real-world treatment patterns and outcomes of abemaciclib for the treatment of HR+, HER2− metastatic breast cancer
Real-world treatment patterns and outcomes of abemaciclib for the treatment of HR+, HER2− metastatic breast cancer Open
This retrospective observational study described baseline characteristics, real-world treatment patterns, and outcomes among patients with metastatic breast cancer treated with abemaciclib in the United States. De-identified electronic hea…
View article: Real-world treatment patterns and outcomes of abemaciclib for the treatment of HR+, HER2- metastatic breast cancer
Real-world treatment patterns and outcomes of abemaciclib for the treatment of HR+, HER2- metastatic breast cancer Open
Objective This retrospective observational study described baseline characteristics, real-world treatment patterns, and outcomes among patients with metastatic breast cancer treated with abemaciclib in the United States. Methods<…
View article: Replication of randomized clinical trial results using real-world data: paving the way for effectiveness decisions
Replication of randomized clinical trial results using real-world data: paving the way for effectiveness decisions Open
The FDA is preparing guidance about using real-world evidence (RWE) to support decisions about product effectiveness. Several ongoing efforts aim to replicate randomized clinical trial (RCT) results using RWE with the intent of identifying…
View article: Real-world survival outcomes of heavily pretreated patients with refractory HR+, HER2−metastatic breast cancer receiving single-agent chemotherapy—a comparison with MONARCH 1
Real-world survival outcomes of heavily pretreated patients with refractory HR+, HER2−metastatic breast cancer receiving single-agent chemotherapy—a comparison with MONARCH 1 Open
View article: Primary tumor location and survival in colorectal cancer: A retrospective cohort study
Primary tumor location and survival in colorectal cancer: A retrospective cohort study Open
In this real-world mCRC cohort, the prognostic role of primary tumor location was substantiated, but not the predictive role for treatment with cetuximab vs bevacizumab in combination with 5-fluorouracil-based chemotherapy.
View article: Machine readable code lists for an algorithm to identify incident lung cancer in United States healthcare claims data
Machine readable code lists for an algorithm to identify incident lung cancer in United States healthcare claims data Open
Machine readable code lists for an algorithm to identify incident lung cancer in United States healthcare claims data
View article: Machine readable code lists for an algorithm to identify incident lung cancer in United States healthcare claims data
Machine readable code lists for an algorithm to identify incident lung cancer in United States healthcare claims data Open
Machine readable code lists for an algorithm to identify incident lung cancer in United States healthcare claims data
View article: KRAS mutation as a prognostic factor and predictive factor in advanced/metastatic non-small cell lung cancer: A systematic literature review and meta-analysis
KRAS mutation as a prognostic factor and predictive factor in advanced/metastatic non-small cell lung cancer: A systematic literature review and meta-analysis Open
View article: Perceptions of overdetection of breast cancer among women 70 years of age and older in the USA: a mixed-methods analysis
Perceptions of overdetection of breast cancer among women 70 years of age and older in the USA: a mixed-methods analysis Open
Many older women did not understand the concept of overdetection, in addition to being suspicious of or resistant to the concept. Providing older women with descriptions of overdetection may not be sufficient to influence screening intenti…
View article: PS02.19 Systematic Literature Review to Assess Role of KRAS Mutations as Prognostic Factors/Treatment Effect Modifiers in Advanced/Metastatic in NSCLC
PS02.19 Systematic Literature Review to Assess Role of KRAS Mutations as Prognostic Factors/Treatment Effect Modifiers in Advanced/Metastatic in NSCLC Open
View article: CONTINUE OR STOP: A QUALITATIVE ANALYSIS OF MAMMOGRAPHY SCREENING DECISION FOR OLDER WOMEN
CONTINUE OR STOP: A QUALITATIVE ANALYSIS OF MAMMOGRAPHY SCREENING DECISION FOR OLDER WOMEN Open
There is insufficient evidence to determine the benefits and harms of screening mammography for women aged 75 and older. Therefore, guidelines emphasize on shared decision-making. This study aimed to understand older women’s mammography sc…