Kristina V. Orlova
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View article: Immunotherapy Combined with Stereotactic Radiotherapy or Isolated Hepatic Perfusion for Metastatic Uveal Melanoma: Preliminary Study Results
Immunotherapy Combined with Stereotactic Radiotherapy or Isolated Hepatic Perfusion for Metastatic Uveal Melanoma: Preliminary Study Results Open
Введение. Метастатическая увеальная меланома (мУМ) характеризуется неблагоприятным прогнозом и ограниченным числом возможных опций терапии. Одним из основных вариантов лечения лекарственными средствами на сегодняшний день остаются ингибито…
View article: Expert Consensus Statement: Sonidegib for the Treatment of Locally Advanced Basal Cell Carcinoma
Expert Consensus Statement: Sonidegib for the Treatment of Locally Advanced Basal Cell Carcinoma Open
15 мая 2025 г. состоялся экспертный совет «Возможности терапии местнораспространенного базальноклеточного рака препаратом “Сонидегиб”», по итогам которого эксперты подготовили резолюцию. В ней обозначены основные положения, касающиеся совр…
View article: Changes in clinical guidelines of 2023 and 2025 on treatment of cutaneous and mucosal melanoma
Changes in clinical guidelines of 2023 and 2025 on treatment of cutaneous and mucosal melanoma Open
The article presents a comparative analysis of Russian clinical recommendations on treatment of melanoma of the skin and mucous membranes during a period of 2020 and 2023, as well as foreign recommendations of N CCN (National Comprehensive…
View article: 65eP Real-world impact of pembrolizumab plus lenvatinib in metastatic uveal melanoma: A retrospective multicenter study
65eP Real-world impact of pembrolizumab plus lenvatinib in metastatic uveal melanoma: A retrospective multicenter study Open
View article: Comparison of in vivo and ex vivo Elastography and Elastometric in the Diagnosis of Metastasis of Skin Melanoma to Peripheral Lymph Nodes
Comparison of in vivo and ex vivo Elastography and Elastometric in the Diagnosis of Metastasis of Skin Melanoma to Peripheral Lymph Nodes Open
Purpose : To conduct a comparative analysis of the diagnostic effectiveness of elastography and elastometry in detecting melanoma metastases in lymph nodes using histological examination of a macropreparation as a reference method. The dat…
View article: Improvement of Ultrasound Diagnosis of Regional Lymph Nodes in Skin Melanoma: Development of the Russian Classification (RUCL-M) to Reduce Hyperdiagnostics and Unjustified Biopsies.
Improvement of Ultrasound Diagnosis of Regional Lymph Nodes in Skin Melanoma: Development of the Russian Classification (RUCL-M) to Reduce Hyperdiagnostics and Unjustified Biopsies. Open
Purpose : To improve ultrasound diagnostics of regional lymph nodes in skin melanoma: to develop a new Russian ultrasound classification of regional lymph nodes in melanoma (RUCL-M) to reduce hyperdiagnosis and reduce the number of unjusti…
View article: Adjuvant Therapy and Outcomes in Patients with Stage III BRAF-Mutated Cutaneous Melanoma: Real-World Data
Adjuvant Therapy and Outcomes in Patients with Stage III BRAF-Mutated Cutaneous Melanoma: Real-World Data Open
Adjuvant therapy for BRAF-mutated stage III melanoma patients includes targeted therapy (dabrafenib + trametinib) and anti-PD-1 immunotherapy (pembrolizumab or nivolumab). Direct comparative studies are lacking, and data are limited to ret…
View article: Multiparametric Ultrasound Diagnostics in the Preoperative Assessment of Regional Lymph Nodes in Patients with High-Risk Skin Melanoma
Multiparametric Ultrasound Diagnostics in the Preoperative Assessment of Regional Lymph Nodes in Patients with High-Risk Skin Melanoma Open
The article shows the criteria for differential ultrasound diagnosis of changes in regional lymph nodes in patients with high-risk skin melanoma
View article: Neoadjuvant Immunotherapy for Resectable Stage III Skin Melanoma – a New Standard of Treatment
Neoadjuvant Immunotherapy for Resectable Stage III Skin Melanoma – a New Standard of Treatment Open
Modern antitumor drug therapy has significantly improved the treatment outcomes of patients with metastatic and/or inoperable melanoma. The success in metastatic melanoma has led to scientific interest in studying the efficacy and safety o…
View article: The Course of Bullous Pemphigoid Against the Background of Therapy with Immune Response Blockers in Metastatic Melanoma
The Course of Bullous Pemphigoid Against the Background of Therapy with Immune Response Blockers in Metastatic Melanoma Open
Therapy with immune checkpoint blockers significantly affected the survival rates of patients with metastatic melanoma. However, immunotherapy may be accompanied by the development of various immune-mediated complications. Skin adverse eve…
View article: Combined stereotactic radiation therapy and immunotherapy for metastatic uveal melanoma
Combined stereotactic radiation therapy and immunotherapy for metastatic uveal melanoma Open
Aim Uveal melanoma (UM) is a rare primary intraocular malignant tumor with an extremely poor prognosis. Our study evaluated the feasibility to improve metastatic UM treatment outcomes with a combined approach of immunotherapy and radiation…
View article: Basal cell skin carcinoma: Epidemiology of locally advanced and metastatic forms based on the data of the N.N. Blokhin National Medical Research Center of Oncology: A retrospective study
Basal cell skin carcinoma: Epidemiology of locally advanced and metastatic forms based on the data of the N.N. Blokhin National Medical Research Center of Oncology: A retrospective study Open
Background. Basal cell skin carcinoma (BCSC) is the most common skin cancer. Most cases are diagnosed early and successfully treated using local methods. However, a small proportion of patients develop locally advanced or metastatic BCRCs,…
View article: 156P Stereotactic radiotherapy and immunotherapy for metastatic uveal melanoma: A retrospective observational study
156P Stereotactic radiotherapy and immunotherapy for metastatic uveal melanoma: A retrospective observational study Open
View article: Prognostic value of gene expression profiling in melanoma: a systematic literature review
Prognostic value of gene expression profiling in melanoma: a systematic literature review Open
Introduction. Skin melanoma, despite having similar clinical and histological characteristics, can have different prognoses. Gene expression profiling potentially allows for more accurate risk stratification of patients. Aim. To study prog…
View article: Меланома кожи
Меланома кожи Open
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View article: Triple combination of vemurafenib, cobimetinib, and atezolizumab in real clinical practice in the Russian Federation: results of the A1 cohort of the ISABELLA study
Triple combination of vemurafenib, cobimetinib, and atezolizumab in real clinical practice in the Russian Federation: results of the A1 cohort of the ISABELLA study Open
Background Among several treatment options for BRAF-mutant metastatic melanoma, a combination of BRAF inhibitor, MEK inhibitor, and anti-PDL1 antibody seems to be a new emergent approach recently registered in the Russian Federation. It is…
View article: Treatment of Metastatic Uveal Melanoma: Literature Review
Treatment of Metastatic Uveal Melanoma: Literature Review Open
Увеальная меланома редкая внутриглазная опухоль, несмотря на все успехи в лечении первичной опухоли, более чем у 50 % пациентов развивается метастатическая форма заболевания. Увеальная меланома отличается по своим молекулярно-биологическим…
View article: Unclassified carcinoma of the scalp in a child. Clinical case with literature review
Unclassified carcinoma of the scalp in a child. Clinical case with literature review Open
Malignant tumors of the scalp are neoplasms of various morphologies. The most common malignant tumors of this localization are basal cell and squamous cell skin cancer, accounting for 95 % of all neoplasms in adults. Malignant tumors of th…
View article: The Prevalence of Various Subtypes of Mutation in the BRAF Gene in Patients with Metastatic Melanoma in Russia Based on Own Research
The Prevalence of Various Subtypes of Mutation in the BRAF Gene in Patients with Metastatic Melanoma in Russia Based on Own Research Open
A mutation in the BRAF gene is key in skin melanoma. Its prevalence varies depending on the region of residence and other clinical and morphological characteristics. The determination of a mutation in the BRAF gene in patients with metasta…
View article: Treatment of Metastatic Uveal Melanoma. The Experience of a Leading Reference Center
Treatment of Metastatic Uveal Melanoma. The Experience of a Leading Reference Center Open
Uveal melanoma (UM) is the most common primary intraocular tumor. Despite successful treatment of the primary tumor, 50% of patients develop distant metastases. To date, there are no clear standards for choosing the first line of therapy f…
View article: Melanoma and Pregnancy. Own Clinical Experience
Melanoma and Pregnancy. Own Clinical Experience Open
The number of cases of melanoma of the skin is steadily increasing every year, which leads to an increase in cases of melanoma associated with pregnancy. To date, there is no convincing evidence of an increased risk of skin melanoma or dea…
View article: Adjuvant Targeted Therapy Versus Anti-PD-1 Immunotherapy in BRAF-Mutated Stage III Melanoma: a Real-World Data
Adjuvant Targeted Therapy Versus Anti-PD-1 Immunotherapy in BRAF-Mutated Stage III Melanoma: a Real-World Data Open
Targeted therapy and anti-PD1 immunotherapy are standard of adjuvant stage III (or equivalent stage III) melanoma treatment. Both treatments significantly improve relapse-free survival compared with placebo and ipilimumab. The impact of ad…
View article: Detection of mutations in the <i>BRAF</i> in patients with melanoma in routine clinical practice: Survey results
Detection of mutations in the <i>BRAF</i> in patients with melanoma in routine clinical practice: Survey results Open
Background. According to current clinical guidelines, patients with inoperable and/or metastatic melanoma (IMM) should undergo a molecular genetic study for the presence of mutations in the BRAF V600 gene in order to select drug therapy. I…
View article: Final data on the efficacy of the FORA study (FOrteca Real practice Assessment): a multicenter prospective observational study on the real-world efficacy of prolgolimab in patients with metastatic melanoma in Russia
Final data on the efficacy of the FORA study (FOrteca Real practice Assessment): a multicenter prospective observational study on the real-world efficacy of prolgolimab in patients with metastatic melanoma in Russia Open
Background. Prior to the introduction of new agents — immune checkpoint inhibitors — for inoperable and/or metastatic melanoma (IMM), chemotherapy outcomes were generally poor. The median (Me) overall survival (OS) in IMM was no more than …
View article: Clinical and economic analysis of treatment sequences with prolgolimab and BRAF/MEK inhibitors in adult patients with metastatic or unresectable cutaneous melanoma
Clinical and economic analysis of treatment sequences with prolgolimab and BRAF/MEK inhibitors in adult patients with metastatic or unresectable cutaneous melanoma Open
Objective: evaluation of the comparative pharmacoeconomic effectiveness of treatment sequences with prolgolimab as the first line and combination therapy with BRAF/MEK inhibitors as the second line versus a regimen with BRAF/MEK inhibitors…
View article: Меланома кожи
Меланома кожи Open
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View article: Basal Cell Cancer in Patients with Gorlin-Goltz Syndrome: Clinical Features and Therapy Options
Basal Cell Cancer in Patients with Gorlin-Goltz Syndrome: Clinical Features and Therapy Options Open
Gorlin-Goltz syndrome is a rare hereditary disorder characterised by multiple congenital abnormalities and cancer predisposition – basal cell cancer (BCC) and medulloblastoma. BCC develops in most patients throughout their life. The number…
View article: Combined Immunotherapy for Metastatic Uveal Melanoma. Single Centre Experience
Combined Immunotherapy for Metastatic Uveal Melanoma. Single Centre Experience Open
Uveal melanoma (UM) is the most common intraocular tumor. Despite satisfactory results in the treatment of primary uveal melanoma, almost 50% of patients develop a metastatic lesion. Overall one-year survival in patients with metastatic uv…
View article: Rechallenge of Immune Checkpoint Inhibitors in Patients with Metastatic Melanoma of the Skin: Literature Review and a Clinical Case
Rechallenge of Immune Checkpoint Inhibitors in Patients with Metastatic Melanoma of the Skin: Literature Review and a Clinical Case Open
The prognosis of patients with metastatic and/or unresectable melanoma has changed dramatically over the past decade. When using modern medications (immune checkpoint inhibitors and BRAF/MEK inhibitors), more than 50% of patients survive 6…
View article: Repeated Use of BRAF and MEK Inhibitors in Patients with BRAF-Mutated Metastatic Melanoma of the Skin
Repeated Use of BRAF and MEK Inhibitors in Patients with BRAF-Mutated Metastatic Melanoma of the Skin Open
In this paper we review the existing data and our clinical experience of repeated use of combination therapy with BRAF/MEK inhibitors (BRAFi/MEKi) in the treatment of patients with BRAF-mutated metastatic melanoma of the skin. Recent advan…