Kristina Wolf
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View article: Capability Analysis of Earth Observation Data for Integrated Emergency Management
Capability Analysis of Earth Observation Data for Integrated Emergency Management Open
Space is one of the UK’s fastest-growing industry sectors of the last decade. Recognising this, in 2021 the UK Government’s first National Space Strategy established a new vision to make the nation one of the most innovative and attractive…
View article: Building enduring smart city data platforms to provide urban management support: lessons learnt from UK Urban Observatories and the US Smart Columbus Operating System
Building enduring smart city data platforms to provide urban management support: lessons learnt from UK Urban Observatories and the US Smart Columbus Operating System Open
Cities are complicated entities with multiple stakeholders operating data infrastructures complying to different regulations and standards in heterogeneous environments; this can be challenging when developing a smart city data platform to…
View article: Preclinical efficacy and pharmacokinetics of an RNA-encoded T cell–engaging bispecific antibody targeting human claudin 6
Preclinical efficacy and pharmacokinetics of an RNA-encoded T cell–engaging bispecific antibody targeting human claudin 6 Open
We present the preclinical pharmacology of BNT142, a lipid nanoparticle (LNP)–formulated RNA (RNA-LNP) encoding a T cell–engaging bispecific antibody that monovalently binds the T cell marker CD3 and bivalently binds claudin 6 (CLDN6), an …
View article: Assessing the impact of heavy rainfall on the Newcastle upon Tyne transport network using a geospatial data infrastructure
Assessing the impact of heavy rainfall on the Newcastle upon Tyne transport network using a geospatial data infrastructure Open
Extreme weather conditions can adversely impact transport networks and driver behaviour, leading to variations in traffic volumes and travel times and increased accident rates. Emergency services that need to navigate to an accident site i…
View article: Supporting geospatial climate hazard reporting using computer vision and text generation of social media imagery
Supporting geospatial climate hazard reporting using computer vision and text generation of social media imagery Open
Citizen reports and social media images that capture the aftermath of natural disasters contain important information for emergency responders. Currently, these data sources are not fully integrated into existing systems or require labour-…
View article: The morphology, functionality, and longevity of a novel all human hepatic cell-based tri-culture system
The morphology, functionality, and longevity of a novel all human hepatic cell-based tri-culture system Open
There remains a significant need for a convenient, phenotypically stable long-term culture platform for primary human hepatocytes (PHHs) for use in pharmacological and toxicological applications. Conventional in vitro models are often inco…
View article: Beyond conventional hazard maps: Assessing flood impacts using real-time data from smart device
Beyond conventional hazard maps: Assessing flood impacts using real-time data from smart device Open
This paper presents a flood impact assessment following a storm event during early October 2021 in Newcastle upon Tyne, UK. Floods represent one of the most catastrophic natural hazards worldwide. While flood hazard maps help to identify a…
View article: A Mouse Diversity Panel Approach Reveals the Potential for Clinical Kidney Injury Due to DB289 Not Predicted by Classical Rodent Models
A Mouse Diversity Panel Approach Reveals the Potential for Clinical Kidney Injury Due to DB289 Not Predicted by Classical Rodent Models Open
DB289 is the first oral drug shown in clinical trials to have efficacy in treating African trypanosomiasis (African sleeping sickness). Mild liver toxicity was noted but was not treatment limiting. However, development of DB289 was termina…
View article: Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport
Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport Open
Hepatocellular accumulation of bile acids due to inhibition of the canalicular bile salt export pump (BSEP/ABCB11) is one proposed mechanism of drug-induced liver injury (DILI). Some hepatotoxic compounds also are potent inhibitors of bile…
View article: Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys
Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys Open
Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on limited availability of drugs that are safe and efficacious, particularly against the second stage (central nervous system [CN…
View article: Safety, Pharmacokinetic, and Efficacy Studies of Oral DB868 in a First Stage Vervet Monkey Model of Human African Trypanosomiasis
Safety, Pharmacokinetic, and Efficacy Studies of Oral DB868 in a First Stage Vervet Monkey Model of Human African Trypanosomiasis Open
There are no oral drugs for human African trypanosomiasis (HAT, sleeping sickness). A successful oral drug would have the potential to reduce or eliminate the need for patient hospitalization, thus reducing healthcare costs of HAT. The dev…
View article: Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?
Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury? Open
Drug-induced liver injury (DILI) is a significant clinical and economic problem in the United States, yet the mechanisms that underlie DILI remain poorly understood. Recent evidence suggests that signaling molecules released by stressed he…
View article: Hepatocyte-Derived Exosomes Promote Liver Immune Tolerance: Possible Implications for Idiosyncratic Drug-Induced Liver Injury
Hepatocyte-Derived Exosomes Promote Liver Immune Tolerance: Possible Implications for Idiosyncratic Drug-Induced Liver Injury Open
Most idiosyncratic drug-induced liver injury appears to result from an adaptive immune attack on the liver. Recent evidence suggests that the T-cell response may be facilitated by the loss of immune tolerance. In this study, we explored th…
View article: miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model
miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model Open
Idiosyncratic drug-induced liver injury (IDILI) is thought to often result from an adaptive immune attack on the liver. However, it has been proposed that the cascade of events culminating in an adaptive immune response begins with drug-in…
View article: Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?
Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury? Open
Drug-induced liver injury (DILI) is a significant clinical and economic problem in the United States, yet the mechanisms that underlie DILI remain poorly understood. Recent evidence suggests that signaling molecules released by stressed he…