Kristina Y. Aguilera
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View article: USEFULNESS OF ALPHA-FETOPROTEIN AND PIVKA-II DETECTION IN THE DIAGNOSIS OF HEPATOCELLULAR CARCINOMA IN AT-RISK POPULATION
USEFULNESS OF ALPHA-FETOPROTEIN AND PIVKA-II DETECTION IN THE DIAGNOSIS OF HEPATOCELLULAR CARCINOMA IN AT-RISK POPULATION Open
Introduction and Objectives: Despite existing surveillance methods, the diagnosis of hepatocellular carcinoma (HCC) in at-risk populations often occurs in advanced stages of the disease and carries a worse prognosis. AFP and PIVKA-II are t…
View article: INFLUENTIAL VARIABLES FOR THE DIAGNOSIS OF HEPATOCELLULAR CARCINOMA IN HIGH-RISK PATIENTS.
INFLUENTIAL VARIABLES FOR THE DIAGNOSIS OF HEPATOCELLULAR CARCINOMA IN HIGH-RISK PATIENTS. Open
Introduction and Objectives: Hepatocellular carcinoma (HCC) is a fearsome neoplasia with patients at well-identified risk who require surveillance.To identify variables that are influential in the diagnosis of hepatocellular carcinoma in a…
View article: P-123 CLINICAL COURSE OF PATIENTS WITH CHOLESTATIC LIVER DISEASES IN A LIVER TRANSPLANT CENTER
P-123 CLINICAL COURSE OF PATIENTS WITH CHOLESTATIC LIVER DISEASES IN A LIVER TRANSPLANT CENTER Open
Conflict of interest: No Introduction and Objectives: Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are immune-mediated cholestatic liver diseases, in which inflammation and/or fibrosis result in progressive de…
View article: Supplementary Figure from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
Supplementary Figure from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer Open
Supplementary Figure from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
View article: Supplementary Figures 1-5 from Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma
Supplementary Figures 1-5 from Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma Open
Supplementary Figure 1: 7rh reduces collagen-mediated signaling in a concentration-dependent manner in vivo; Supplementary Figure 2: 7rh inhibits Ddr1 activation in Pan02 tumors; Supplementary Figure 3: Inhibition of Ddr1 with 7rh does not…
View article: Data from Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma
Data from Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma Open
The extracellular matrix (ECM), a principal component of pancreatic ductal adenocarcinoma (PDA), is rich in fibrillar collagens that facilitate tumor cell survival and chemoresistance. Discoidin domain receptor 1 (DDR1) is a receptor tyros…
View article: Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer Open
Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
View article: Data from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
Data from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer Open
WNT signaling promotes pancreatic ductal adenocarcinoma (PDAC) through diverse effects on proliferation, differentiation, survival, and stemness. A subset of PDAC with inactivating mutations in ring finger protein 43 (RNF43) show gr…
View article: Data from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
Data from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer Open
WNT signaling promotes pancreatic ductal adenocarcinoma (PDAC) through diverse effects on proliferation, differentiation, survival, and stemness. A subset of PDAC with inactivating mutations in ring finger protein 43 (RNF43) show gr…
View article: Data from Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma
Data from Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma Open
The extracellular matrix (ECM), a principal component of pancreatic ductal adenocarcinoma (PDA), is rich in fibrillar collagens that facilitate tumor cell survival and chemoresistance. Discoidin domain receptor 1 (DDR1) is a receptor tyros…
View article: Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer Open
Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
View article: Supplementary Figure from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
Supplementary Figure from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer Open
Supplementary Figure from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
View article: Supplementary Figures 1-5 from Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma
Supplementary Figures 1-5 from Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma Open
Supplementary Figure 1: 7rh reduces collagen-mediated signaling in a concentration-dependent manner in vivo; Supplementary Figure 2: 7rh inhibits Ddr1 activation in Pan02 tumors; Supplementary Figure 3: Inhibition of Ddr1 with 7rh does not…
View article: Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer Open
Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
View article: Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer Open
Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
View article: Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer Open
Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
View article: Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer Open
Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
View article: Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer Open
Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
View article: Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer Open
Supplementary Table from Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
View article: Data from Collagen Signaling Enhances Tumor Progression after Anti-VEGF Therapy in a Murine Model of Pancreatic Ductal Adenocarcinoma
Data from Collagen Signaling Enhances Tumor Progression after Anti-VEGF Therapy in a Murine Model of Pancreatic Ductal Adenocarcinoma Open
There is growing evidence that antiangiogenic therapy stimulates cancer cell invasion and metastasis. However, the underlying molecular mechanisms responsible for these changes have not been fully defined. Here, we report that anti-VEGF th…
View article: Supplementary Figures 1 - 6 from Collagen Signaling Enhances Tumor Progression after Anti-VEGF Therapy in a Murine Model of Pancreatic Ductal Adenocarcinoma
Supplementary Figures 1 - 6 from Collagen Signaling Enhances Tumor Progression after Anti-VEGF Therapy in a Murine Model of Pancreatic Ductal Adenocarcinoma Open
PDF file - 2694K, Supplementary Figure 1: Characterization of tumor growth in KIC mice (LSL-KrasG12D; Cdkn2alox/lox; p48Cre). Supplementary Figure 2: Liver metastatic burden in KIC mice. Supplementary Figure 3: Level of hypoxia, collagen I…
View article: Data from Collagen Signaling Enhances Tumor Progression after Anti-VEGF Therapy in a Murine Model of Pancreatic Ductal Adenocarcinoma
Data from Collagen Signaling Enhances Tumor Progression after Anti-VEGF Therapy in a Murine Model of Pancreatic Ductal Adenocarcinoma Open
There is growing evidence that antiangiogenic therapy stimulates cancer cell invasion and metastasis. However, the underlying molecular mechanisms responsible for these changes have not been fully defined. Here, we report that anti-VEGF th…
View article: Supplementary Figures 1 - 6 from Collagen Signaling Enhances Tumor Progression after Anti-VEGF Therapy in a Murine Model of Pancreatic Ductal Adenocarcinoma
Supplementary Figures 1 - 6 from Collagen Signaling Enhances Tumor Progression after Anti-VEGF Therapy in a Murine Model of Pancreatic Ductal Adenocarcinoma Open
PDF file - 2694K, Supplementary Figure 1: Characterization of tumor growth in KIC mice (LSL-KrasG12D; Cdkn2alox/lox; p48Cre). Supplementary Figure 2: Liver metastatic burden in KIC mice. Supplementary Figure 3: Level of hypoxia, collagen I…
View article: Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer Open
WNT signaling promotes pancreatic ductal adenocarcinoma (PDAC) through diverse effects on proliferation, differentiation, survival, and stemness. A subset of PDAC with inactivating mutations in ring finger protein 43 (RNF43) show growth de…
View article: AXL-TBK1 driven nuclear AKT3 promotes metastasis
AXL-TBK1 driven nuclear AKT3 promotes metastasis Open
Epithelial-to-mesenchymal transition (EMT) contributes to tumor cell survival, immune evasion, migration, invasion, and therapy resistance. Across human cancer, tumors that are high grade, poorly differentiated, and have undergone EMT carr…
View article: Deep proteome profiling of human mammary epithelia at lineage and age resolution
Deep proteome profiling of human mammary epithelia at lineage and age resolution Open
Age is the major risk factor in most carcinomas, yet little is known about how proteomes change with age in any human epithelium. We present comprehensive proteomes comprised of >9,000 total proteins and >15,000 phosphopeptides from normal…
View article: WNT Ligand Dependencies in Pancreatic Cancer
WNT Ligand Dependencies in Pancreatic Cancer Open
WNT signaling promotes the initiation and progression of pancreatic ductal adenocarcinoma (PDAC) through wide-ranging effects on cellular proliferation, survival, differentiation, stemness, and tumor microenvironment. Of therapeutic intere…
View article: Deep Proteome Profiling of Human Mammary Epithelia at Lineage and Age Resolution
Deep Proteome Profiling of Human Mammary Epithelia at Lineage and Age Resolution Open
SUMMARY Age is the major risk factor in most carcinomas, yet little is known about how proteomes change with age in any human epithelium. We present comprehensive proteomes comprised of >9,000 total proteins, and >15,000 phosphopeptides, f…
View article: Deep Proteome Profiling of Human Mammary Epithelia at Lineage and Age Resolution
Deep Proteome Profiling of Human Mammary Epithelia at Lineage and Age Resolution Open
View article: Internet-based tool for visualizing county and state level COVID-19 trends in the United States
Internet-based tool for visualizing county and state level COVID-19 trends in the United States Open
The novel COVID-19 outbreak started in 2019 in Wuhan China and quickly spread to at least 185 countries. We developed an interactive web application that allows users to visualize the spread of COVID-19 in the Unites States at state and co…