Explanipedia

Farm exposure is associated with human breast milk immune profile and microbiome Open

Mary Hannah Swaney, Olivia Steidl, Anastasia Tackett, Samantha Fye, Kristine E. Lee , et al. · 2024

SUMMARY Prenatal and early life farm exposure, and breastfeeding, are associated with protection from allergic diseases. We hypothesize that farm exposure influences the human breast milk microbiome and immune proteins. The immune protein …

Atopic dermatitis phenotype affects expression of atopic diseases despite similar mononuclear cell cytokine response Open

Mohamed Taki, Kristine E. Lee, Ronald E. Gangnon, James E. Gern, Robert F. Lemanske , et al. · 2024

Farm animal exposure, respiratory illnesses, and nasal cell gene expression Open

Joshua Brownell, Kristine E. Lee, Deborah Chasman, Ronald E. Gangnon, Casper G. Bendixsen , et al. · 2024

Effect of Tibetan herbal formulas on symptom duration among ambulatory patients with native SARS-CoV-2 infection: A retrospective cohort study Open

Tawni Tidwell, Tenzin Namdul, Kristine E. Lee, Kevin M. Riordan, Natalie Skopicki , et al. · 2024

Despite abundant data regarding factors that influence COVID-19 symptom severity and need for hospitalization, few studies examine time to resolution of symptoms and potential complementary and alternative therapies that may expedite outpa…

Comparison of hyperpolarized 3He-MRI, CT based parametric response mapping, and mucus scores in asthmatics Open

K.J. Carey, Peter Hotvedt, David Mummy, Kristine E. Lee, Loren C. Denlinger , et al. · 2023

Purpose: The purpose of this study was to anatomically correlate ventilation defects with regions of air trapping by whole lung, lung lobe, and airway segment in the context of airway mucus plugging in asthma. Methods: A total of 34 asthma…

Development and Dynamic Responsiveness of the Acute Asthma Exacerbation Survey in Patients With Moderate to Severe Disease Open

Scott A. Laurenzo, Elizabeth Townsend, Nicole Lane Starr, Lori Wollet, Mario Castro , et al. · 2023

Skeletal Muscle Adiposity and Lung Function Trajectory in the Severe Asthma Research Program Open

Matthew C. Tattersall, Kristine E. Lee, Nanae Tsuchiya, Fauzia Osman, Claudia E. Korcarz , et al. · 2022

Rationale: Extrapulmonary manifestations of asthma, including fatty infiltration in tissues, may reflect systemic inflammation and influence lung function and disease severity. Objectives: To determine if skeletal muscle adip…

Association of Smoking, Alcohol Consumption, Blood Pressure, Body Mass Index, and Glycemic Risk Factors With Age-Related Macular Degeneration Open

Valerie Kuan, Alasdair Warwick, Aroon D. Hingorani, Adnan Tufail, Valentina Cipriani , et al. · 2021

This study provides genetic evidence that increased alcohol intake may be a causal risk factor for GA. As there are currently no known treatments for GA, this finding has important public health implications. These results also support pre…

Platelet association with leukocytes in active eosinophilic esophagitis Open

Kelly A. Bartig, Kristine E. Lee, Deane F. Mosher, Sameer K. Mathur, Mats W. Johansson · 2021

We previously demonstrated that the percentage of blood eosinophils that are associated with platelets and thus positive for CD41 (integrin α IIb -subunit) correlates with and predicts peak eosinophil count (PEC) in biopsies of eosinophili…

Retinal microvascular signs and risk of diabetic kidney disease in asian and white populations Open

Simon Nusinovici, Charumathi Sabanayagam, Kristine E. Lee, Liang Zhang, Carol Y. Cheung , et al. · 2021

The objective was to examine prospectively the association between retinal microvascular signs and development of diabetic kidney disease (DKD) in Asian and White populations. We analysed two population-based cohorts, composing of 1,221 As…

Ensemble Analysis Identifies Nasal 15-Keto-PGE2 as a Predictor of Recovery in Experimental Rhinovirus Colds Open

Nicole Lane Starr, Michael D. Evans, Kristine E. Lee, James E. Gern, Loren C. Denlinger · 2021

Background Symptom intensity during a common cold is highly variable, particularly after the illness peaks, contributing to delay in recovery. Rhinoviruses frequently cause colds and, during acute infections, generate leukotriene B4 and pr…

Enhanced Neutralizing Antibody Responses to Rhinovirus C and Age-Dependent Patterns of Infection Open

Timothy Choi, Mark Devries, Leonard B. Bacharier, William W. Busse, Carlos A. Camargo , et al. · 2020

Rationale: Rhinovirus (RV) C can cause asymptomatic infection and respiratory illnesses ranging from the common cold to severe wheezing.Objectives: To identify how age and other individual-level factors are associated with su…

Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract Open

Ekaterina Yonova‐Doing, Wanting Zhao, Robert P. Igo, Chaolong Wang, Periasamy Sundaresan , et al. · 2020

Developmental patterns in the nasopharyngeal microbiome during infancy are associated with asthma risk Open

Howard H.F. Tang, Anna Lang, Shu Mei Teo, Louise M. Judd, Ronald E. Gangnon , et al. · 2020

Patterns of farm exposure are associated with reduced incidence of atopic dermatitis in early life Open

Cheryl A. Steiman, Michael D. Evans, Kristine E. Lee, Michael Lasarev, Ronald E. Gangnon , et al. · 2020

A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration Open

Tobias Strunz, Susette Lauwen, Christina Kiel, Lars G. Fritsche, Wilmar Igl , et al. · 2020

αIIb-Integrin (CD41) associated with blood eosinophils is a potential biomarker for disease activity in eosinophilic esophagitis Open

Mats W. Johansson, Elizabeth McKernan, Paul S. Fichtinger, Evelyn L. Angulo, Jennifer Bagley , et al. · 2020

Plasma P-Selectin Is Inversely Associated with Lung Function and Corticosteroid Responsiveness in Asthma Open

Mats W. Johansson, Brandon M. Grill, Karina T. Barretto, Molly C. Favour, Hazel Marie Schira , et al. · 2020

Background: Severe asthma has multiple phenotypes for which biomarkers are still being defined. Plasma P-selectin reports endothelial and/or platelet activation. Objective: To determine if P-selectin is associated with features of asthma i…

Skin Intrinsic Fluorescence and Selected Measures of Visual Function and aging in Older Adults Open

Ronald Klein, Kristine E. Lee, John Maynard, Chris A. Johnson, Lorraine G. Danforth , et al. · 2019

Purpose: Functional, structural and metabolic decline in many systems and in combination contribute to biologic aging and may be manifest as increased risk of morbid events such as neuropathy, albuminuria, and coronary artery diseas…

Correction: A 32 kb Critical Region Excluding Y402H in CFH Mediates Risk for Age-Related Macular Degeneration Open

Theru A. Sivakumaran, Robert P. Igo, Jeffrey M. Kidd, Andy Itsara, Laura J. Kopplin , et al. · 2018

[This corrects the article DOI: 10.1371/journal.pone.0025598.].

Genome-wide association study of diabetic kidney disease highlights biology involved in renal basement membrane collagen Open

Rany M. Salem, Jennifer N. Todd, Niina Sandholm, Joanne B. Cole, Wei‐Min Chen , et al. · 2018

Diabetic kidney disease (DKD) is a heritable but poorly understood complication of diabetes. To identify genetic variants predisposing to DKD, we performed genome-wide association analyses in 19,406 individuals with type 1 diabetes (T1D) u…

Oxidized Low-density Lipoprotein and the Incidence of Age-related Macular Degeneration Open

Ronald Klein, Kristine E. Lee, Michael Y. Tsai, Karen J. Cruickshanks, Ronald E. Gangnon , et al. · 2018

Aldose Reductase Polymorphisms, Fasting Blood Glucose, and Age-Related Cortical Cataract Open

Ava Grace Tan, Annette Kifley, Elizabeth Holliday, Ronald Klein, Sudha K. Iyengar , et al. · 2018

The identified interaction between rs9640883 and FBG in relation to cortical cataract was not replicated but may warrant further investigation.

Refraction and Change in Refraction Over a 20-Year Period in the Beaver Dam Eye Study Open

Samantha Bomotti, Bryan Lau, Ronald Klein, Kristine E. Lee, Ronald Klein , et al. · 2018

Nuclear cataract is the primary contributor to the myopic shift among older individuals. Birth cohort effects on baseline refraction but not change in refraction were observed.

Association of retinal vessel diameters and diabetic retinopathy in pregnancy Open

Barbara E.K. Klein, Kristine E. Lee, Stacy M. Meuer, Anne Mosher, A. F. Ewen , et al. · 2018

The Characteristics of Geographic Atrophy From 25 Years of The Beaver Dam Eye Study (BDES) Open

Stacy M. Meuer, Kristine E. Lee, Ronald Klein, Ronald Klein · 2018

Oxidized LDL and the Incidence of Age-Related Macular Degeneration (AMD) Open

Ronald Klein, Kristine E. Lee, Stacy M. Meuer, Lorraine G. Danforth, Ronald E. Gangnon , et al. · 2018

Skin Intrinsic Fluorescence and Age-Related Macular Degeneration: The Beaver Dam Eye Study Open

Ronald Klein, Kristine E. Lee, John Maynard, Stacy M. Meuer, Ronald E. Gangnon , et al. · 2017

There was a suggestive relationship of two SIF measures, SIF01 and SIF03, using different correction factors from the excitation centered at 375 nm, with the prevalence of geographic atrophy in the BDES. Longitudinal follow-up is indicated…

The relationship of oral bisphosphonates to age-related macular degeneration: The Beaver Dam Eye Study. Open

Stacy M. Meuer, Kristine E. Lee, Ronald Klein, Ronald Klein · 2017

Aspirin, statins and central retinal venular diameter in persons with and without diabetes Open

Christine A. Kiire, Kristine E. Lee, Ronald Klein, Ronald Klein · 2017

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