Kristine Yaffe
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View article: Disentangling the Causal Effects of Education and Participation Bias on Alzheimer Disease Using Mendelian Randomization
Disentangling the Causal Effects of Education and Participation Bias on Alzheimer Disease Using Mendelian Randomization Open
Univariable MR analyses indicated that education and participation reduced the risk of AD. However, MR also suggested that education increased the risk of AD/ADRD, highlighting the inconsistencies between clinical and proxy diagnoses of AD…
View article: Development of a core outcome set for clinical trials of interventions to improve sleep in people with cognitive impairment‐the Sleep in Cognitive Impairment Core Outcome Set (SCICOS)
Development of a core outcome set for clinical trials of interventions to improve sleep in people with cognitive impairment‐the Sleep in Cognitive Impairment Core Outcome Set (SCICOS) Open
INTRODUCTION Sleep disturbances are common in older people with cognitive impairment, potentially contributing to negative outcomes. A core outcome set (COS) is required to reduce heterogeneity in clinical trials and promote the developmen…
View article: Association of Objective Long Sleep Duration and Insomnia with Objective Short Sleep Duration Phenotypes with Mortality in Older Persons
Association of Objective Long Sleep Duration and Insomnia with Objective Short Sleep Duration Phenotypes with Mortality in Older Persons Open
Objective To investigate the association of objective long sleep duration (LS) and insomnia with objective short sleep duration (ISSD) with mortality in older persons. Methods In 3,054 men (average age 76.4±5.5; mean follow-up=12.1 years) …
View article: Cross-Ancestry Polygenic Risk Scores Enhance Alzheimer’s Disease Risk Prediction in Multiethnic Cohorts
Cross-Ancestry Polygenic Risk Scores Enhance Alzheimer’s Disease Risk Prediction in Multiethnic Cohorts Open
INTRODUCTION Genome-wide association studies (GWAS) have identified 80+ genetic loci associated with Alzheimer’s disease (AD), enabling the development of polygenic risk scores (PRS). However, the predictive accuracy of PRS in diverse popu…
View article: Mitochondrial haplogroups, but not heteroplasmy, are associated with midlife cognitive function
Mitochondrial haplogroups, but not heteroplasmy, are associated with midlife cognitive function Open
INTRODUCTION Mitochondrial DNA (mtDNA) variation may influence cognitive performance, but prior findings are inconsistent. METHODS We analyzed data from 2308 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) stu…
View article: Evaluating the causal effect of mitochondrial dysfunction on Alzheimer’s and Parkinson’s disease using Polygenic Risk Scores and Mendelian Randomization
Evaluating the causal effect of mitochondrial dysfunction on Alzheimer’s and Parkinson’s disease using Polygenic Risk Scores and Mendelian Randomization Open
INTRODUCTION Mitochondrial DNA copy number (mtDNAcn), a measure of mitochondrial genomes per nucleated cell, has an unclear causal relationship with AD and PD. We integrate genetic correlation, Polygenic Risk Scores (PRS), and Mendelian Ra…
View article: Dementia Risk and Machine Learning-Derived Brain Age Index from Sleep Electroencephalography: A Pooled Cohort Analysis of Over 7,000 Individuals Across Five Community Cohorts
Dementia Risk and Machine Learning-Derived Brain Age Index from Sleep Electroencephalography: A Pooled Cohort Analysis of Over 7,000 Individuals Across Five Community Cohorts Open
Importance: Sleep electroencephalographic (EEG) microstructures are closely related to cognition and undergo age-dependent changes. However, their multidimensional nature makes them challenging to interpret using conventional approaches. M…
View article: Networks and clusters of immunometabolic biomarkers and depression-associated features in middle-aged and older community-dwelling US adults with and without depression
Networks and clusters of immunometabolic biomarkers and depression-associated features in middle-aged and older community-dwelling US adults with and without depression Open
View article: The return home model: design and implementation of a geriatric home-care model for long-term care eligible older adults
The return home model: design and implementation of a geriatric home-care model for long-term care eligible older adults Open
Background Most older adults prefer to “age in place” within their communities. This preference cannot always be honored and dependent older adults may transfer to a long-term care facility. The Return Home is an Israel Ministry of Health …
View article: Chronic emotional stress and mediating role of Interleukin-6 in the association with cardiometabolic disorders in a multiethnic middle-aged and older US population
Chronic emotional stress and mediating role of Interleukin-6 in the association with cardiometabolic disorders in a multiethnic middle-aged and older US population Open
The study highlights a further aspect of the pathophysiological mechanisms involved in the brain-body communication. While IL-6 partially explains statistical associations between chronic emotional stress and major cardiometabolic disorder…
View article: Neuroimaging markers of dementia across race/ethnicity and sex/gender using an intersectional approach within the HABS‐HD cohort
Neuroimaging markers of dementia across race/ethnicity and sex/gender using an intersectional approach within the HABS‐HD cohort Open
INTRODUCTION Racial/ethnic and sex/gender differences in neuroimaging markers of dementia have been previously explored, but rarely with an intersectional approach. METHODS Using data from the Health and Aging Brain Study–Health Disparitie…
View article: Epigenetic age acceleration and midlife cognition: joint evidence from observational study and Mendelian randomization
Epigenetic age acceleration and midlife cognition: joint evidence from observational study and Mendelian randomization Open
View article: Multidimensional sleep profiles via machine learning and risk of dementia and cardiovascular disease
Multidimensional sleep profiles via machine learning and risk of dementia and cardiovascular disease Open
Background Sleep health comprises several dimensions such as sleep duration and fragmentation, circadian activity, and daytime behavior. Yet, most research has focused on individual sleep characteristics. Studies are needed to identify sle…
View article: Integrative effects of Telomere Length, Epigenetic Age, and Mitochondrial DNA abundance in Alzheimer’s Disease
Integrative effects of Telomere Length, Epigenetic Age, and Mitochondrial DNA abundance in Alzheimer’s Disease Open
Background and Objectives Biological age, reflecting the cumulative molecular and cellular damage such as telomere attrition, epigenetic alterations and mitochondrial dysfunction, may better capture age-related decline and Alzheimer’s dise…
View article: Psychosis in Neurocognitive Disorder Among Ethnoculturally Diverse Older Persons
Psychosis in Neurocognitive Disorder Among Ethnoculturally Diverse Older Persons Open
[This corrects the article DOI: 10.1212/CPJ.0000000000200467.].
View article: An international multi-cohort investigation of self-reported sleep and future depressive symptoms in older adults
An international multi-cohort investigation of self-reported sleep and future depressive symptoms in older adults Open
Poor subjective sleep is associated with future depression in older adults, but there is limited consensus on which sleep features have the strongest associations. Moreover, composite scores incorporating multiple features may better repre…
View article: Objective sleep quality in diverse older adults: a cross-sectional study on the importance of race and ethnicity and sex
Objective sleep quality in diverse older adults: a cross-sectional study on the importance of race and ethnicity and sex Open
Background Research on sleep disparities across different sociodemographic groups is limited and often yields inconsistent findings. We aimed to examine differences in objective sleep measures by race and ethnicity, sex, and age within a d…
View article: Health and Aging Brain Study–Health Disparities (HABS‐HD) methods and partner characteristics
Health and Aging Brain Study–Health Disparities (HABS‐HD) methods and partner characteristics Open
INTRODUCTION The Health and Aging Brain Study–Health Disparities (HABS‐HD) is an ongoing prospective study aimed at understanding brain health and aging. The current work provides a description of the cohort baseline characteristics and ou…
View article: Genetically proxied blood pressure, vascular brain injury, and Alzheimer's disease pathology
Genetically proxied blood pressure, vascular brain injury, and Alzheimer's disease pathology Open
INTRODUCTION Lower blood pressure (BP) is linked to reduced dementia risk, though it is uncertain whether this benefit stems solely from mitigating vascular brain injury (VBI) or also extends to directly influencing Alzheimer's disease (AD…
View article: Associations Between Inflammation and Multisensory Impairment Among Older Adults
Associations Between Inflammation and Multisensory Impairment Among Older Adults Open
Background Impairment in multiple senses (multisensory impairment) is common in older adults but the underlying mechanisms are unclear. We evaluated whether common blood‐based markers of inflammation (e.g., Interleukin 6 (IL‐6), C‐Reactive…
View article: Assessing the Global Impact of Brain Small Vessel Disease on Cognition: The Multi‐Ethnic Study of Atherosclerosis
Assessing the Global Impact of Brain Small Vessel Disease on Cognition: The Multi‐Ethnic Study of Atherosclerosis Open
INTRODUCTION We aimed to examine the global impact of brain small vessel disease (SVD) on cognitive performance. METHODS In 892 participants from the Multi‐Ethnic Study of Atherosclerosis (MESA), we derived perivascular spaces (PVS), white…
View article: Sleep architecture and dementia risk in adults: an analysis of 5 cohorts from the Sleep and Dementia Consortium
Sleep architecture and dementia risk in adults: an analysis of 5 cohorts from the Sleep and Dementia Consortium Open
Study Objectives Poor sleep may play a role in the risk of dementia. However, few studies have investigated the association between polysomnography (PSG)-derived sleep architecture and dementia incidence. We examined the relationship betwe…
View article: Sleep macro‐architecture, nocturnal hypoxemia, and Alzheimer's disease‐related MRI patterns among diverse older adults
Sleep macro‐architecture, nocturnal hypoxemia, and Alzheimer's disease‐related MRI patterns among diverse older adults Open
INTRODUCTION Sleep patterns change with aging, yet their relationship with brain health, particularly Alzheimer's disease (AD)‐related MRI patterns among diverse older adults is not clear. METHODS We cross‐sectionally studied community‐dwe…
View article: Plasma proteomic analysis of intermuscular fat links muscle integrity with processing speed in older adults
Plasma proteomic analysis of intermuscular fat links muscle integrity with processing speed in older adults Open
INTRODUCTION More intermuscular fat (IMF) has been associated with lower cognitive performance through mechanisms that are not fully elucidated. METHODS The associations of 7628 plasma proteins with IMF were assessed in the Baltimore Longi…
View article: 0345 Life Course Sleep Duration Trajectories and Risk and Age at Onset of Parkinson’s Disease
0345 Life Course Sleep Duration Trajectories and Risk and Age at Onset of Parkinson’s Disease Open
Introduction Sleep disturbances may be prodromal signs or risk factors for Parkinson’s disease (PD). This study aims at characterizing life course sleep duration trajectories and examining their associations with PD risk and age at onset (…
View article: Psychosis in Neurocognitive Disorder Among Ethnoculturally Diverse Older Persons
Psychosis in Neurocognitive Disorder Among Ethnoculturally Diverse Older Persons Open
Black-NL, Latino, and AI/AN individuals were more likely to be diagnosed with psychosis in NCDs when compared with White-NL participants. More research is needed to explore sociocultural, psychosocial, and neuropathologic factors involved.
View article: Diabetes and cortical thickness in ethnically diverse cognitively normal older adults
Diabetes and cortical thickness in ethnically diverse cognitively normal older adults Open
INTRODUCTION Mechanisms linking type 2 diabetes mellitus (T2DM) with dementia are poorly understood. We examined T2DM associations with cortical thickness and hippocampal volume in ethnoracially diverse, cognitively unimpaired older adults…
View article: Objective Sleep Quality in Diverse Older Adults: the Importance of Race and Ethnicity and Sex
Objective Sleep Quality in Diverse Older Adults: the Importance of Race and Ethnicity and Sex Open
Background Research on sleep disparities across different sociodemographic groups is limited and often yields inconsistent findings. We aimed to examine differences in objective sleep measures by race and ethnicity, sex, and age within a d…
View article: Difference in Cystatin C-Based and Creatinine-Based eGFR and Cognition in Osteoporotic Fracture in Men Study
Difference in Cystatin C-Based and Creatinine-Based eGFR and Cognition in Osteoporotic Fracture in Men Study Open
View article: Hospice Use Among Medicare Beneficiaries With Parkinson Disease and Dementia With Lewy Bodies
Hospice Use Among Medicare Beneficiaries With Parkinson Disease and Dementia With Lewy Bodies Open
Importance Neurodegenerative disorders are now the most common reason that Medicare beneficiaries enroll in hospice for end-of-life care. People with all-cause dementia have high rates of suboptimal hospice use, but little is known about h…