Kristof Wing
YOU?
Author Swipe
View article: The impact of sex on the immune system explored at the single-cell level
The impact of sex on the immune system explored at the single-cell level Open
Summary Sex has a key role in disease susceptibility, in particular autoimmunity. Sex differences of the immune system stems from genes and their interactions with intrinsic and external factors. However, the cellular-level factors influen…
View article: Impact of rare and common genetic variation on cell type-specific gene expression in human blood
Impact of rare and common genetic variation on cell type-specific gene expression in human blood Open
Understanding the genetic basis of gene expression can shed light on the regulatory mechanisms underlying complex traits and diseases. Single cell-resolved measures of RNA levels and single-cell expression quantitative trait loci (sc-eQTLs…
View article: Polymorphic tandem repeats influence cell type-specific gene expression across the human immune landscape
Polymorphic tandem repeats influence cell type-specific gene expression across the human immune landscape Open
Tandem repeats (TRs) - highly polymorphic, repetitive sequences dispersed across the human genome - are crucial regulators of gene expression and diverse biological processes, but have remained underexplored relative to other classes of ge…
View article: Deep Learning-Based Identification of Intraocular Pressure-Associated Genes Influencing Trabecular Meshwork Cell Morphology
Deep Learning-Based Identification of Intraocular Pressure-Associated Genes Influencing Trabecular Meshwork Cell Morphology Open
View article: High throughput functional profiling of genes at intraocular pressure loci reveals distinct networks for glaucoma
High throughput functional profiling of genes at intraocular pressure loci reveals distinct networks for glaucoma Open
Introduction Primary open angle glaucoma (POAG) is a leading cause of blindness globally. Characterized by progressive retinal ganglion cell degeneration, the precise pathogenesis remains unknown. Genome-wide association studies (GWAS) hav…
View article: High throughput functional profiling of genes at intraocular pressure loci reveals distinct networks for glaucoma
High throughput functional profiling of genes at intraocular pressure loci reveals distinct networks for glaucoma Open
INTRODUCTION Primary open angle glaucoma (POAG) is a leading cause of blindness globally. Characterised by progressive retinal ganglion cell degeneration, the precise pathogenesis remains unknown. Genome-wide association studies (GWAS) hav…
View article: Deep Learning-based Identification of Intraocular Pressure-Associated Genes Influencing Trabecular Meshwork Cell and Organelle Morphology
Deep Learning-based Identification of Intraocular Pressure-Associated Genes Influencing Trabecular Meshwork Cell and Organelle Morphology Open
PURPOSE The exact pathogenesis of primary open-angle glaucoma (POAG) is poorly understood. Genome-wide association studies (GWAS) have recently uncovered many loci associated with variation in intraocular pressure (IOP); a crucial risk fac…
View article: Comparison of CRISPR/Cas Endonucleases for in vivo Retinal Gene Editing
Comparison of CRISPR/Cas Endonucleases for in vivo Retinal Gene Editing Open
CRISPR/Cas has opened the prospect of direct gene correction therapy for some inherited retinal diseases. Previous work has demonstrated the utility of adeno-associated virus (AAV) mediated delivery to retinal cells in vivo; however…
View article: Comparison of CRISPR/Cas endonucleases for<i>in vivo</i>retinal gene editing
Comparison of CRISPR/Cas endonucleases for<i>in vivo</i>retinal gene editing Open
CRISPR/Cas has opened the prospect of direct gene correction therapy for some inherited retinal diseases. Previous work has demonstrated the utility of adeno-associated virus (AAV) mediated delivery to retinal cells in vivo ; however, with…
View article: Comparative performance of the BGI and Illumina sequencing technology for single-cell RNA-sequencing
Comparative performance of the BGI and Illumina sequencing technology for single-cell RNA-sequencing Open
The libraries generated by high-throughput single cell RNA-sequencing (scRNA-seq) platforms such as the Chromium from 10× Genomics require considerable amounts of sequencing, typically due to the large number of cells. The ability to use t…
View article: Comparison of CRISPR/Cas endonuclease gene editing efficiency of retinal cells in vivo
Comparison of CRISPR/Cas endonuclease gene editing efficiency of retinal cells in vivo Open
View article: Comparative performance of the BGI and Illumina sequencing technology for single-cell RNA-sequencing
Comparative performance of the BGI and Illumina sequencing technology for single-cell RNA-sequencing Open
The libraries generated by high-throughput single cell RNA-sequencing platforms such as the Chromium from 10X Genomics require considerable amounts of sequencing, typically due to the large number of cells. The ability to use this data to …
View article: Comparative performance of the BGI and Illumina sequencing technology for single-cell RNA-sequencing
Comparative performance of the BGI and Illumina sequencing technology for single-cell RNA-sequencing Open
The libraries generated by high-throughput single cell RNA-sequencing (scRNA-seq) platforms such as the Chromium from 10× Genomics require considerable amounts of sequencing, typically due to the large number of cells. The ability to use t…
View article: Building a national eye-care service in post-conflict Timor-Leste
Building a national eye-care service in post-conflict Timor-Leste Open
International organizations played a pivotal role in supporting the Timorese eye health system, in an initially vulnerable setting. We highlight how transition to domestic funding can be achieved through the creation of a domestic training…