Explanipedia

Genomic and Serologic Characterization of Enterovirus A71 Brainstem Encephalitis Open

Kristoffer E. Leon, Ryan Schubert, Dídac Casas‐Alba, Isobel A. Hawes, Prashanth Ramachandran , et al. · 2025

Etiological spectrum of non-compressive myelopathies in Uganda: a prospective, observational study using neuroimaging, autoantibodies, and next-generation sequencing Open

Abdu K Musubire, Kristoffer E. Leon, Eoin P. Flanagan, Prashanth Ramachandran, Chloe Gerungan , et al. · 2025

Background Non-compressive myelopathy can lead to severe disability and death. The diagnosis is often complex and resource-intensive, with regional variation in causes. Data on the epidemiology and etiology of non-compressive myelopathy in…

P-464. Implementation of Non-Mydriatic Fundus Imaging for HIV-Associated Meningitis Patients in Uganda Open

Spencer Yueh, Timothy Mugabi, Kristoffer E. Leon, Tu M. Tran, David B. Meya , et al. · 2025

Background Persons with HIV-associated meningitis are at increased risk of visual impairment. It is often unclear whether this is due to the underlying meningitis pathophysiology or whether a second etiology may be present, due to the diff…

Etiological Spectrum of Non-Compressive Myelopathies in Uganda: A Prospective, Observational Study Using Neuroimaging, Autoantibodies, and Next-Generation Sequencing Open

Abdu K Musubire, Kristoffer E. Leon, Eoin P. Flanagan, Prashanth Ramachandran, Chloe Gerungan , et al. · 2025

Utility of handheld non-mydriatic fundoscopy in a case of bilateral, reversible vision loss in an advanced HIV patient with cryptococcal meningitis in Sub-Saharan Africa Open

Kristoffer E. Leon, Timothy Mugabi, Tú-Anh Tran, Hawa Magembe, Caleb P Skipper · 2024

Cryptococcal meningitis is a fungal infection that is typically caused by Cryptococcus neoformans and most commonly seen in severely immunosuppressed patient. This disease causes severe neurologic disease due to elevated intracrania…

NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids Open

Camille R. Simoneau, Peiyi Chen, Galen Xing, Jennifer M. Hayashi, Irene P. Chen , et al. · 2024

As SARS-CoV-2 continues to spread worldwide, tractable primary airway cell models that recapitulate the cell-intrinsic response to arising viral variants are needed. Here we describe an adult stem cell-derived human airway organoid model o…

Replication Data for: Anti-schistosomal immunity to core xylose/fucose in N-glycans Open

Jamie Heimburg‐Molinaro, Nina Salinger Prasanphanich, Kristoffer E. Leon, W. Evan Secor, Charles B. Shoemaker , et al. · 2024

Raw data for paper Prasanphanich et al, Front. Mol. Biosci.

Advancing Diagnosis and Treatment in People Living with HIV and Tuberculosis Meningitis Open

Sarah Kimuda, Derrick Kasozi, Suzan Namombwe, Jane Gakuru, Timothy Mugabi , et al. · 2023

Anti-schistosomal immunity to core xylose/fucose in N-glycans Open

Nina Salinger Prasanphanich, Kristoffer E. Leon, W. Evan Secor, Charles B. Shoemaker, Jamie Heimburg‐Molinaro , et al. · 2023

Schistosomiasis is a globally prevalent, debilitating disease that is poorly controlled by chemotherapy and for which no vaccine exists. While partial resistance in people may develop over time with repeated infections and treatments, some…

Nuclear accumulation of host transcripts during Zika Virus Infection Open

Kristoffer E. Leon, Mir M. Khalid, Ryan A. Flynn, Krystal A. Fontaine, Thông Nguyen , et al. · 2023

Zika virus (ZIKV) infects fetal neural progenitor cells (NPCs) causing severe neurodevelopmental disorders in utero . Multiple pathways involved in normal brain development are dysfunctional in infected NPCs but how ZIKV centrally reprogra…

A covalent inhibitor targeting the papain-like protease from SARS-CoV-2 inhibits viral replication Open

Hesong Han, Albert Vallejo Gracia, Joachim Justad Røise, Lydia Boike, Kristoffer E. Leon , et al. · 2023

Compound 1 is a covalent inhibitor of SARS-CoV-2 PLpro that inhibits viral replication and has low non-specific reactivity with thiols.

NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids Open

Camille R. Simoneau, Peiyi Chen, Galen Xing, Mir M. Khalid, Nathan L. Meyers , et al. · 2022

As SARS-CoV-2 continues to spread worldwide, tractable primary airway cell models that accurately recapitulate the cell-intrinsic response to arising viral variants are needed. Here we describe an adult stem cell-derived human airway organ…

Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19 Open

Brian L. Le, Gaia Andreoletti, Tomiko Oskotsky, Albert Vallejo-Gracia, Romel Rosales , et al. · 2021

The novel SARS-CoV-2 virus emerged in December 2019 and has few effective treatments. We applied a computational drug repositioning pipeline to SARS-CoV-2 differential gene expression signatures derived from publicly available data. We uti…

Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19 Open

Brian L. Le, Gaia Andreoletti, Tomiko Oskotsky, Albert Vallejo-Gracia, Romel Rosales , et al. · 2021

The novel SARS-CoV-2 virus emerged in December 2019 and has few effective treatments. We applied a computational drug repositioning pipeline to SARS-CoV-2 differential gene expression signatures derived from publicly available data. We uti…

Zika Virus Infection Prevents Host mRNA Nuclear Export by Disrupting UPF1 Function Open

Kristoffer E. Leon, Ryan A. Flynn, Mir M. Khalid, Krystal A. Fontaine, Tom Nguyen , et al. · 2020

Zika virus (ZIKV) is a mosquito-borne RNA virus that can infect fetuses in utero causing characteristic neurodevelopmental disorders including microcephaly. We previously showed that ZIKV infection downregulates expression of up-frameshift…

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike Open

Michael Schoof, Bryan Faust, Reuben A. Saunders, Smriti Sangwan, Veronica V. Rezelj , et al. · 2020

Nanobodies that neutralize Monoclonal antibodies that bind to the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) show therapeutic promise but must be produced in mammalian cells and need to be delivered intra…

Rapid deployment of SARS-CoV-2 testing: The CLIAHUB Open

Emily Crawford, Irene Acosta, Vida Ahyong, Erika C. Anderson, Shaun Arevalo , et al. · 2020

Author(s): Crawford, Emily D; Acosta, Irene; Ahyong, Vida; Anderson, Erika C; Arevalo, Shaun; Asarnow, Daniel; Axelrod, Shannon; Ayscue, Patrick; Azimi, Camillia S; Azumaya, Caleigh M; Bachl, Stefanie; Bachmutsky, Iris; Bhaduri, Aparna; Br…

Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19 Open

Brian L. Le, Gaia Andreoletti, Tomiko Oskotsky, Albert Vallejo-Gracia, Romel Rosales , et al. · 2020

The novel SARS-CoV-2 virus emerged in December 2019 and has few effective treatments. We applied a computational drug repositioning pipeline to SARS-CoV-2 differential gene expression signatures derived from publicly available data. We uti…

An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation Open

Michael Schoof, Bryan Faust, Reuben A. Saunders, Smriti Sangwan, Veronica V. Rezelj , et al. · 2020

Without an effective prophylactic solution, infections from SARS-CoV-2 continue to rise worldwide with devastating health and economic costs. SARS-CoV-2 gains entry into host cells via an interaction between its Spike protein and the host …

An ‘Arms Race’ between the Nonsense-mediated mRNA Decay Pathway and Viral Infections Open

Kristoffer E. Leon, Mélanie Ott · 2020

Central Nervous System Virus Infection in African Children with Cerebral Malaria Open

Douglas G. Postels, Lawrence Osei‐Tutu, Karl B. Seydel, Qian Xu, Chenxi Li , et al. · 2020

We aimed to identify the contribution of central nervous system (CNS) viral coinfection to illness in African children with retinopathy-negative or retinopathy-positive cerebral malaria (CM). We collected cerebrospinal fluid (CSF) from 272…

Genomic and serologic characterization of enterovirus A71 brainstem encephalitis Open

Kristoffer E. Leon, Ryan Schubert, Dídac Casas‐Alba, Isobel A. Hawes, Prashanth Ramachandran , et al. · 2020

mNGS with VirScan significantly increased the CNS detection of EVs relative to qRT-PCR, and the latter generated an antigenic profile of the acute EV-A71 immune response. Genomic analysis confirmed the close relation of the outbreak EV-A71…

Zika Virus Disrupts the Nonsense-mediated mRNA Decay Pathway feat. A Clinical Application of Next Generation Sequencing Open

Kristoffer E. Leon · 2020

Zika virus (ZIKV) is a mosquito-borne illness responsible for an outbreak of microcephaly in Brazil in 2015. To better understand the molecular mechanisms behind the neurodevelopmental delay seen, we explored the pathways perturbed by ZIKV…

The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein Open

Krystal A. Fontaine, Kristoffer E. Leon, Mir M. Khalid, Sakshi Tomar, David Jimenez‐Morales , et al. · 2018

Zika virus (ZIKV) is a significant global health threat, as infection has been linked to serious neurological complications, including microcephaly. Using a human stem cell-derived neural progenitor model system, we find that a critical ce…

Pediatric Brainstem Encephalitis Outbreak Investigation with Metagenomic Next-Generation Sequencing Open

Kristoffer E. Leon, Dídac Casas‐Alba, Akshaya Ramesh, Lillian M. Khan, Cristian Launes , et al. · 2018

In 2016, Catalonia experienced a pediatric brainstem encephalitis outbreak caused by enterovirus A71 (EV-A71). Conventional testing identified EV in peripheral body sites, but EV was rarely identified in cerebrospinal fluid (CSF). RNA was …

Fatal Powassan Encephalitis (Deer Tick Virus, Lineage II) in a Patient With Fever and Orchitis Receiving Rituximab Open

Isaac H. Solomon, Kristyn M. Spera, Sophia L. Ryan, Jeffrey Helgager, Juliana Andrici , et al. · 2018

Owing to the rarity of Powassan encephalitis, a high degree of suspicion is required to make the diagnosis, particularly in an immunocompromised patient, in whom antibody-based assays may be falsely negative. Unbiased sequencing assays hav…

Identification of Plasmodium falciparum specific translation inhibitors from the MMV Malaria Box using a high throughput in vitro translation screen Open

Vida Ahyong, Christine Moore Sheridan, Kristoffer E. Leon, Jessica N. Witchley, Jonathan Diep , et al. · 2016

Delayed Diagnosis, Leprosy Reactions, and Nerve Injury Among Individuals With Hansen's Disease Seen at a United States Clinic Open

Kristoffer E. Leon, Jesse T. Jacob, Carlos Franco‐Paredes, Phyllis E. Kozarsky, Henry M. Wu , et al. · 2016

Background. Hansen's disease (HD), or leprosy, is uncommon in the United States. We sought to describe the characteristics of patients with HD in a US clinic, including an assessment of delays in diagnosis and HD reactions, which have both…

Complex Type 2 Reactions in Three Patients with Hansen's Disease from a Southern United States Clinic Open

Kristoffer E. Leon, Jorge Salinas, Robert W. McDonald, Anandi N. Sheth, Jessica K. Fairley · 2015

In non-endemic countries, leprosy, or Hansen's disease (HD), remains rare and is often underrecognized. Consequently, the literature is currently lacking in clinical descriptions of leprosy complications in the United States. Immune-mediat…

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