Kristopher Knott
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View article: 182 Role and clinical utility of cardiac magnetic resonance in the management of female cardio-oncology patients
182 Role and clinical utility of cardiac magnetic resonance in the management of female cardio-oncology patients Open
Background Advances in cancer treatment have revolutionized survival outcomes over the past decades but many anti-cancer treatments have cardiotoxic side effects. Furthermore, many cancer survivors go on to develop cardiovascular disease. …
View article: Accurate diagnosis of apical hypertrophic cardiomyopathy using explainable advanced electrocardiogram analysis
Accurate diagnosis of apical hypertrophic cardiomyopathy using explainable advanced electrocardiogram analysis Open
Aims Typical electrocardiogram (ECG) features of apical hypertrophic cardiomyopathy (ApHCM) include tall R waves and deep or giant T-wave inversion in the precordial leads, but these features are not always present. The ECG is used as the …
View article: Myocardial perfusion in cardiac amyloidosis
Myocardial perfusion in cardiac amyloidosis Open
Aims Cardiac involvement is the main driver of clinical outcomes in systemic amyloidosis and preliminary studies support the hypothesis that myocardial ischaemia contributes to cellular damage. The aims of this study were to assess the pre…
View article: S88 Can coronary artery calcium score calculated from CT thorax be used to predict the presence and severity of coronary artery disease in COPD?
S88 Can coronary artery calcium score calculated from CT thorax be used to predict the presence and severity of coronary artery disease in COPD? Open
Background Coronary artery disease (CAD) is often asymptomatic in patients with chronic obstructive pulmonary disease (COPD) and traditional screening methods may not be as useful in detecting it. A coronary artery calcium score (CACS) can…
View article: Accurate diagnosis of apical hypertrophic cardiomyopathy using explainable advanced ECG analysis
Accurate diagnosis of apical hypertrophic cardiomyopathy using explainable advanced ECG analysis Open
Background Typical electrocardiogram (ECG) features of apical hypertrophic cardiomyopathy (ApHCM) include tall R waves and deep or giant T-wave inversion in the precordial leads, but these features are not always present. We tested whether…
View article: 156 Left atrial dilatation on cardiovascular magnetic resonance imaging predicts adverse outcomes in acute heart failure
156 Left atrial dilatation on cardiovascular magnetic resonance imaging predicts adverse outcomes in acute heart failure Open
Introduction Acute hospital admissions due to heart failure account for significant morbidity and mortality. Identifying determinants of adverse outcomes in patients with acute heart failure is vital to ensuring patients are medically opti…
View article: Metformin associates with improved myocardial perfusion reserve and survival in patients with Type 2 Diabetes Mellitus
Metformin associates with improved myocardial perfusion reserve and survival in patients with Type 2 Diabetes Mellitus Open
Background Metformin is an antihyperglycemic agent frequently used in the treatment of Type 2 Diabetes Mellitus (T2DM). Patients with T2DM are at increased risk of cardiovascular diseases, including coronary artery disease (CAD), silent my…
View article: Surveillance of a large cardiac fibroma in a patient with Gorlin syndrome
Surveillance of a large cardiac fibroma in a patient with Gorlin syndrome Open
A male in his 80s was found incidentally to have a large mass in the right ventricle (RV) noted on CT imaging. This mass was further characterised with echocardiography, dedicated cardiac CT ([figure 1A][1]-B) and cardiovascular magnetic r…
View article: Apical Ischemia Is a Universal Feature of Apical Hypertrophic Cardiomyopathy
Apical Ischemia Is a Universal Feature of Apical Hypertrophic Cardiomyopathy Open
Background: Apical hypertrophic cardiomyopathy (ApHCM) accounts for ≈10% of hypertrophic cardiomyopathy cases and is characterized by apical hypertrophy, apical cavity obliteration, and tall ECG R waves with ischemic-looking deep T-wave in…
View article: Cardiac arrest in myocardial infarction with non-obstructive coronary artery (MINOCA) secondary to thyroid dysfunction
Cardiac arrest in myocardial infarction with non-obstructive coronary artery (MINOCA) secondary to thyroid dysfunction Open
A man in his 40s who was previously well had an out-of-hospital cardiac arrest. Postresuscitation ECG showed ST-elevation myocardial infarction (MI). Emergency coronary angiogram revealed MI with non-obstructive coronary arteries (MINOCA) …
View article: CMR is vital in the management of cardiology inpatients: a tertiary centre experience
CMR is vital in the management of cardiology inpatients: a tertiary centre experience Open
To review the utility of cardiovascular magnetic resonance (CMR) in the management of hospital inpatients, we performed a retrospective review of all inpatient CMR scans performed over a six-month period at a tertiary referral cardiology c…
View article: 12 Cardiovascular magnetic resonance has a significant role in the management of acute heart failure admissions: a tertiary referral service experience
12 Cardiovascular magnetic resonance has a significant role in the management of acute heart failure admissions: a tertiary referral service experience Open
Introduction Cardiac MRI is a vital tool in the assessment of heart failure. We investigated the utility of CMR on inpatients admitted to our dedicated heart failure unit (HFU, the first in the UK). Materials and Methods Patients admitted …
View article: 11 A review of the impact of cardiovascular magnetic resonance on the management of inpatients at a tertiary referral centre
11 A review of the impact of cardiovascular magnetic resonance on the management of inpatients at a tertiary referral centre Open
Introduction Cardiovascular Magnetic Resonance (CMR) is a highly versatile imaging modality, indicated in the assessment of most common cardiac presentations and is the gold standard for the assessment of cardiac chamber volume, tissue cha…
View article: Sex- and age-specific normal values for automated quantitative pixel-wise myocardial perfusion cardiovascular magnetic resonance
Sex- and age-specific normal values for automated quantitative pixel-wise myocardial perfusion cardiovascular magnetic resonance Open
Aims Recently developed in-line automated cardiovascular magnetic resonance (CMR) myocardial perfusion mapping has been shown to be reproducible and comparable with positron emission tomography (PET), and can be easily integrated into clin…
View article: Cardiovascular magnetic resonance phenotyping of heart failure with mildly reduced ejection fraction
Cardiovascular magnetic resonance phenotyping of heart failure with mildly reduced ejection fraction Open
Aims The 2016 European Society of Cardiology Heart Failure Guidelines defined a new category: heart failure with mid-range ejection fraction (HFmrEF) of 40–49%. This new category was highlighted as having limited evidence and research was …
View article: P29 Cardiovascular magnetic resonance is vital in the management of cardiology inpatients
P29 Cardiovascular magnetic resonance is vital in the management of cardiology inpatients Open
Objective Cardiovascular Magnetic Resonance (CMR) is a highly versatile imaging modality, indicated in the assessment of most common cardiac presentations. The EuroCMR registry showed that CMR impacts patient management in the majority of …
View article: Improving the diagnostic accuracy of apical hypertrophic cardiomyopathy using machine learning
Improving the diagnostic accuracy of apical hypertrophic cardiomyopathy using machine learning Open
Funding Acknowledgements Type of funding sources: Private grant(s) and/or Sponsorship. Main funding source(s): Dr Hughes is supported by the British Heart Foundation (grant number FS/17/82/33222). Introduction The imaging criteria for diag…
View article: Resolution of an intracardiac metastasis with targeted therapy in a patient with melanoma
Resolution of an intracardiac metastasis with targeted therapy in a patient with melanoma Open
A woman in her 30s with stage 4 B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutant melanoma with known pulmonary, intraorbital, brain and subcutaneous metastases was found to have a large mass in the right atrium (RA) on staging C…
View article: 138 Quantitative myocardial blood flow as a prognostic marker for cardiovascular outcomes in patients with type 2 diabetes mellitus: a multicentre study
138 Quantitative myocardial blood flow as a prognostic marker for cardiovascular outcomes in patients with type 2 diabetes mellitus: a multicentre study Open
Introduction Patients with Type 2 Diabetes Mellitus (T2DM) are at increased risk of cardiovascular disease, including epicardial coronary heart disease, silent myocardial infarction (MI), and coronary microvascular dysfunction (CMD). [1] A…
View article: Saturation-Pulse Prepared Heart-rate Independent Inversion-REcovery (SAPPHIRE) Biventricular T1 Mapping: Inter-Field Strength, Head-To-Head Comparison of Diastolic, Systolic and Dark-Blood Measurements
Saturation-Pulse Prepared Heart-rate Independent Inversion-REcovery (SAPPHIRE) Biventricular T1 Mapping: Inter-Field Strength, Head-To-Head Comparison of Diastolic, Systolic and Dark-Blood Measurements Open
Background To assess the feasibility of biventricular SAPPHIRE T 1 mapping in vivo across field strengths using diastolic, systolic and dark-blood (DB) approaches. Methods 10 healthy volunteers underwent same-day non-contrast cardiovascula…
View article: Improving cardiovascular magnetic resonance access in low- and middle-income countries for cardiomyopathy assessment: rapid cardiovascular magnetic resonance
Improving cardiovascular magnetic resonance access in low- and middle-income countries for cardiomyopathy assessment: rapid cardiovascular magnetic resonance Open
Aims To evaluate the impact of a simplified, rapid cardiovascular magnetic resonance (CMR) protocol embedded in care and supported by a partner education programme on the management of cardiomyopathy (CMP) in low- and middle-income countri…