Kristy L. Jackson
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View article: Novel formylpeptide receptor 1/2 agonist limits hypertension-induced cardiovascular damage
Novel formylpeptide receptor 1/2 agonist limits hypertension-induced cardiovascular damage Open
Aims Formylpeptide receptors (FPRs) play a critical role in the regulation of inflammation, an important driver of hypertension-induced end-organ damage. We have previously reported that the biased FPR small-molecule agonist, compound17b (…
View article: The <scp>pro‐resolving</scp> mediator, annexin <scp>A1</scp> regulates blood pressure, and <scp>age‐associated</scp> changes in cardiovascular function and remodeling
The <span>pro‐resolving</span> mediator, annexin <span>A1</span> regulates blood pressure, and <span>age‐associated</span> changes in cardiovascular function and remodeling Open
Aging is associated with chronic, low‐level inflammation which may contribute to cardiovascular pathologies such as hypertension and atherosclerosis. This chronic inflammation may be opposed by endogenous mechanisms to limit inflammation, …
View article: Endothelium-Dependent Relaxation is Impaired in Schlager Hypertensive (BPH/2J) Mice by Region-Specific Mechanisms in Conductance and Resistance Arteries
Endothelium-Dependent Relaxation is Impaired in Schlager Hypertensive (BPH/2J) Mice by Region-Specific Mechanisms in Conductance and Resistance Arteries Open
View article: Deficiency of MicroRNA-181a Results in Transcriptome-Wide Cell-Specific Changes in the Kidney and Increases Blood Pressure
Deficiency of MicroRNA-181a Results in Transcriptome-Wide Cell-Specific Changes in the Kidney and Increases Blood Pressure Open
MicroRNA miR-181a is downregulated in the kidneys of hypertensive patients and hypertensive mice. In vitro, miR-181a is a posttranslational inhibitor of renin expression, but pleiotropic mechanisms by which miR-181a may influence blood pre…
View article: Renal Deafferentation Prevents Progression of Hypertension and Changes to Sympathetic Reflexes in a Rabbit Model of Chronic Kidney Disease
Renal Deafferentation Prevents Progression of Hypertension and Changes to Sympathetic Reflexes in a Rabbit Model of Chronic Kidney Disease Open
There is increasing evidence that renal denervation is effective in alleviating hypertension associated with elevation of renal sympathetic nerve activity (RSNA) in chronic kidney disease (CKD), but whether this is due to reduction in rena…
View article: Deficiency of MicroRNA-181a Results in Transcriptome-Wide Cell Specific Changes in the Kidney that Lead to Elevated Blood Pressure and Salt Sensitivity
Deficiency of MicroRNA-181a Results in Transcriptome-Wide Cell Specific Changes in the Kidney that Lead to Elevated Blood Pressure and Salt Sensitivity Open
MicroRNA miR-181a is down-regulated in the kidneys of hypertensive patients and hypertensive mice. In vitro , miR-181a is a posttranslational inhibitor of renin expression, but pleiotropic mechanisms by which miR-181a may influence blood p…
View article: Role of Mineralocorticoid and Angiotensin Type 1 Receptors in the Paraventricular Nucleus in Angiotensin-Induced Hypertension
Role of Mineralocorticoid and Angiotensin Type 1 Receptors in the Paraventricular Nucleus in Angiotensin-Induced Hypertension Open
The hypothalamic paraventricular nucleus (PVN) is an important site where an interaction between circulating angiotensin (Ang) and mineralocorticoid receptor (MR) activity may modify sympathetic nerve activity (SNA) to influence long-term …
View article: Deletion of Orphan G Protein-Coupled Receptor GPR37L1 in Mice Alters Cardiovascular Homeostasis in a Sex-Specific Manner
Deletion of Orphan G Protein-Coupled Receptor GPR37L1 in Mice Alters Cardiovascular Homeostasis in a Sex-Specific Manner Open
GPR37L1 is a family A orphan G protein-coupled receptor (GPCR) with a putative role in blood pressure regulation and cardioprotection. In mice, genetic ablation of Gpr37l1 causes sex-dependent effects; female mice lacking Gpr37l1 (GPR37L1 …
View article: Contribution of the Renal Nerves to Hypertension in a Rabbit Model of Chronic Kidney Disease
Contribution of the Renal Nerves to Hypertension in a Rabbit Model of Chronic Kidney Disease Open
Overactivity of the sympathetic nervous system and high blood pressure are implicated in the development and progression of chronic kidney disease (CKD) and independently predict cardiovascular events in end-stage renal disease. To assess …
View article: Potential Therapeutic Use of Neurosteroids for Hypertension
Potential Therapeutic Use of Neurosteroids for Hypertension Open
The sympathetic nervous system (SNS) contribution to long-term setting of blood pressure (BP) and hence hypertension has been a continuing controversy over many decades. However, the contribution of increased sympathetic vasomotor tone to …
View article: Mechanisms Responsible for Genetic Hypertension in Schlager BPH/2 Mice
Mechanisms Responsible for Genetic Hypertension in Schlager BPH/2 Mice Open
It has been 45 years since Gunther Schlager used a cross breeding program in mice to develop inbred strains with high, normal, and low blood pressure (BPH/2, BPN/3, and BPL/1 respectively). Thus, it is timely to gather together the studies…
View article: Renal nerves contribute to hypertension in Schlager BPH/2J mice
Renal nerves contribute to hypertension in Schlager BPH/2J mice Open
View article: Chronic sympathetic driven hypertension promotes atherosclerosis by enhancing hematopoiesis
Chronic sympathetic driven hypertension promotes atherosclerosis by enhancing hematopoiesis Open
Hypertension is a major, independent risk factor for atherosclerotic cardiovascular disease. However, this pathology can arise through multiple pathways, which could influence vascular disease through distinct mechanisms. An overactive sym…
View article: [OP.5A.02] DYSREGULATION OF MICRORNA-181A CAUSED BY OVERACTIVE RENAL SYMPATHETIC NERVES CONTRIBUTES TO ELEVATED RENAL RENIN MRNA AND HYPERTENSION IN SCHLAGER BPH/2J MICE
[OP.5A.02] DYSREGULATION OF MICRORNA-181A CAUSED BY OVERACTIVE RENAL SYMPATHETIC NERVES CONTRIBUTES TO ELEVATED RENAL RENIN MRNA AND HYPERTENSION IN SCHLAGER BPH/2J MICE Open
Objective: BPH/2J mice are a genetic model of hypertension driven by greater activity of the sympathetic nervous system (SNS) and renin-angiotensin system (RAS). BPH/2J mice display high levels of renal renin mRNA accompanied by low levels…
View article: Acute Effect of Central Administration of Urotensin II on Baroreflex and Blood Pressure in Conscious Normotensive Rabbits
Acute Effect of Central Administration of Urotensin II on Baroreflex and Blood Pressure in Conscious Normotensive Rabbits Open
In the present study, we examined the effects of central administration of Urotensin II on blood pressure, heart rate, and baroreceptor heart rate reflexes in conscious normotensive rabbits. Preliminary operations were undertaken to implan…
View article: Factors contributing to neurogenic hypertension in genetically hypertensive mice
Factors contributing to neurogenic hypertension in genetically hypertensive mice Open
Hypertension affects approximately 1 in 4 people worldwide and whilst it is typically asymptomatic, it is an insidious disease contributing to life threatening conditions including heart failure, stroke and renal failure (Wolf et al., 1991…
View article: The Effects of Rilmenidine and Perindopril on Arousal Blood Pressure during 24 Hour Recordings in SHR
The Effects of Rilmenidine and Perindopril on Arousal Blood Pressure during 24 Hour Recordings in SHR Open
The surge in arterial pressure during arousal in the waking period is thought to be largely due to activation of the sympathetic nervous system. In this study we compared in SHR the effects of chronic administration of the centrally acting…
View article: Contribution of Orexin to the Neurogenic Hypertension in BPH/2J Mice
Contribution of Orexin to the Neurogenic Hypertension in BPH/2J Mice Open
BPH/2J mice are a genetic model of hypertension associated with an overactive sympathetic nervous system. Orexin is a neuropeptide which influences sympathetic activity and blood pressure. Orexin precursor mRNA expression is greater in hyp…