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View article: Rapid generation of ventral A9-like dopaminergic neurons from patterned iPSCs
Rapid generation of ventral A9-like dopaminergic neurons from patterned iPSCs Open
Summary In vitro modelling of highly vulnerable nigral dopaminergic (DA) neuronal subtypes in Parkinson’s disease (PD), is necessary for studying disease mechanisms. Here, we optimized a new approach by expressing the pioneer neurogenic tr…
View article: Sequestration of TDP-43 <sup>216-414</sup> Aggregates by Cytoplasmic Expression of the proSAAS Chaperone
Sequestration of TDP-43 <sup>216-414</sup> Aggregates by Cytoplasmic Expression of the proSAAS Chaperone Open
As neurons age, protein homeostasis becomes less efficient, resulting in misfolding and aggregation. Chaperone proteins perform vital functions in the maintenance of cellular proteostasis, and chaperone-based therapies that promote sequest…
View article: A protease protection assay for the detection of internalized alpha-synuclein pre-formed fibrils
A protease protection assay for the detection of internalized alpha-synuclein pre-formed fibrils Open
Alpha-synuclein pre-formed fibrils (PFFs) represent a promising model system for the study of cellular processes underlying cell-to-cell transmission of alpha-synuclein proteopathic aggregates. However, the ability to differentiate the fat…
View article: A protease protection assay for the detection of internalized alpha-synuclein pre-formed fibrils
A protease protection assay for the detection of internalized alpha-synuclein pre-formed fibrils Open
Alpha-synuclein pre-formed fibrils (PFFs) represent a promising model system for the study of cellular processes underlying cell-to-cell transmission of alpha-synuclein proteopathic aggregates. However, the ability to differentiate the fat…
View article: Secreted Chaperones in Neurodegeneration
Secreted Chaperones in Neurodegeneration Open
Protein homeostasis, or proteostasis, is a combination of cellular processes that govern protein quality control, namely, protein translation, folding, processing, and degradation. Disruptions in these processes can lead to protein misfold…
View article: Sequestration of TDP-43<sup>216-414</sup>aggregates by cytoplasmic expression of the proSAAS chaperone
Sequestration of TDP-43<sup>216-414</sup>aggregates by cytoplasmic expression of the proSAAS chaperone Open
As neurons age, protein homeostasis becomes less efficient, resulting in misfolding and aggregation. Chaperone proteins perform vital functions in the maintenance of cellular proteostasis, and chaperone-based therapies that promote sequest…
View article: SOD1 activity threshold and TOR signalling modulate VAP(P58S) aggregation via ROS-induced proteasomal degradation in a <i>Drosophila</i> model of Amyotrophic Lateral Sclerosis
SOD1 activity threshold and TOR signalling modulate VAP(P58S) aggregation via ROS-induced proteasomal degradation in a <i>Drosophila</i> model of Amyotrophic Lateral Sclerosis Open
Familial Amyotrophic Lateral Sclerosis (F-ALS) is an incurable, late onset motor neuron disease, linked strongly to various causative genetic loci. ALS8 codes for a missense mutation, P56S, in VAMP-associated Protein B (VAPB) that causes t…
View article: SOD1 activity thresholds and TOR signalling modulate VAP(P58S) aggregation via ROS-induced proteasomal degradation in a <i>Drosophila</i> model of Amyotrophic Lateral Sclerosis
SOD1 activity thresholds and TOR signalling modulate VAP(P58S) aggregation via ROS-induced proteasomal degradation in a <i>Drosophila</i> model of Amyotrophic Lateral Sclerosis Open
Familial Amyotrophic Lateral Sclerosis (F-ALS) is an incurable, late onset motor neuron disease, linked strongly to various causative genetic loci. ALS8 codes for a missense mutation, P56S, in VAMP-associated Protein B (VAPB) that causes t…