Krzysztof Irlik
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View article: Clinical risk phenotypes in diabetes and their associations with adverse cardiovascular events: A report from the Silesia Diabetes‐Heart Project
Clinical risk phenotypes in diabetes and their associations with adverse cardiovascular events: A report from the Silesia Diabetes‐Heart Project Open
Aims Diabetes is characterized by clinical heterogeneity. This study aimed to identify different clinical phenotypes of real‐world people with diabetes and to assess their associations with major adverse cardiovascular events (MACEs). Meth…
View article: Asystole Triggered by Swallowing: Insights From a Case of Infective Endocarditis in a 35-Year-Old HIV Patient
Asystole Triggered by Swallowing: Insights From a Case of Infective Endocarditis in a 35-Year-Old HIV Patient Open
BACKGROUND Asystole during swallowing is a rarely observed phenomenon attributable to several underlying factors. The present report documents a case of asystole during swallowing, caused by cardiac arrhythmias associated with infective en…
View article: Prognostic impact of peak oxygen consumption in heart failure: A systematic review and meta‐analysis
Prognostic impact of peak oxygen consumption in heart failure: A systematic review and meta‐analysis Open
Background and Aims Heart failure (HF) is a multifactorial disease for which peak oxygen uptake (VO 2 peak) may potentially be a prognostic marker of adverse clinical outcomes. This systematic review and meta‐analysis aimed to assess publi…
View article: Diabetic kidney disease phenotypes and the risk of cardiovascular events: The Silesia Diabetes-Heart Project
Diabetic kidney disease phenotypes and the risk of cardiovascular events: The Silesia Diabetes-Heart Project Open
People with DKD, with reduced eGFR or both reduced eGFR and elevated UACR, but not with elevated UACR alone, are at higher CV risk. Personalizing therapy based on clinic-based renal phenotyping can facilitate the initiation of CV disease m…
View article: Exercise capacity in heart failure: a systematic review and meta-analysis of HFrEF and HFpEF disparities in VO2peak and 6-minute walking distance
Exercise capacity in heart failure: a systematic review and meta-analysis of HFrEF and HFpEF disparities in VO2peak and 6-minute walking distance Open
Aims Heart failure (HF) with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF) exhibit unique physiological pathways, influencing exercise capacity and functional performance. This systematic review and meta…
View article: Prognostic Impact and Prevalence of Cachexia in Patients With Heart Failure: A Systematic Review and Meta‐Analysis
Prognostic Impact and Prevalence of Cachexia in Patients With Heart Failure: A Systematic Review and Meta‐Analysis Open
Background Cachexia, defined as the combination of weight loss, weakness, fatigue, anorexia and abnormal biochemical markers based on Evans' criteria, is known to exacerbate the prognosis of heart failure (HF) patients. This systematic rev…
View article: Adherence to the Atrial Fibrillation Better Care (ABC) pathway and outcomes in patients with chronic kidney disease: A report from the APHRS-AF registry
Adherence to the Atrial Fibrillation Better Care (ABC) pathway and outcomes in patients with chronic kidney disease: A report from the APHRS-AF registry Open
Background The Atrial Fibrillation Better Care (ABC) pathway is based on three pillars: "A" avoid stroke with oral anticoagulation, "B" better symptoms control, and "C" optimization of cardiovascular risk factors and lifestyles. This integ…
View article: Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: a systematic review and meta-analysis with meta-regression of observational studies
Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: a systematic review and meta-analysis with meta-regression of observational studies Open
Introduction Metformin is the most prescribed medication for type 2 diabetes mellitus (T2DM); there is a well-established link with the elevated incidence of gastrointestinal (GI) adverse events (AE) limiting its administration or intensif…
View article: Artificial intelligence-based classification of cardiac autonomic neuropathy from retinal fundus images in patients with diabetes: The Silesia Diabetes Heart Study
Artificial intelligence-based classification of cardiac autonomic neuropathy from retinal fundus images in patients with diabetes: The Silesia Diabetes Heart Study Open
Background Cardiac autonomic neuropathy (CAN) in diabetes mellitus (DM) is independently associated with cardiovascular (CV) events and CV death. Diagnosis of this complication of DM is time-consuming and not routinely performed in the cli…
View article: Natriuretic peptides and C‐reactive protein in in heart failure and malnutrition: a systematic review and meta‐analysis
Natriuretic peptides and C‐reactive protein in in heart failure and malnutrition: a systematic review and meta‐analysis Open
Background Heart failure (HF) and malnutrition exhibit overlapping risk factors, characterized by increased levels of natriuretic peptides and an inflammatory profile. The aim of this study was to compare the differences in plasma brain na…
View article: Metformin intolerance in type 2 diabetes mellitus – the possibility of using a multi-strain probiotic
Metformin intolerance in type 2 diabetes mellitus – the possibility of using a multi-strain probiotic Open
Metformin is a widely used drug in the management of type 2 diabetes (T2DM); however, its administration is linked with the elevated incidence of gastrointestinal (GI) adverse events (AEs) limiting its use or treatment intensification. The…
View article: Artificial intelligence‐enhanced electrocardiogram analysis for identifying cardiac autonomic neuropathy in patients with diabetes
Artificial intelligence‐enhanced electrocardiogram analysis for identifying cardiac autonomic neuropathy in patients with diabetes Open
Aim To develop and employ machine learning (ML) algorithms to analyse electrocardiograms (ECGs) for the diagnosis of cardiac autonomic neuropathy (CAN). Materials and Methods We used motif and discord extraction techniques, alongside long …
View article: Machine Learning Identifies Metabolic Dysfunction–Associated Steatotic Liver Disease in Patients With Diabetes Mellitus
Machine Learning Identifies Metabolic Dysfunction–Associated Steatotic Liver Disease in Patients With Diabetes Mellitus Open
Context The presence of metabolic dysfunction–associated steatotic liver disease (MASLD) in patients with diabetes mellitus (DM) is associated with a high risk of cardiovascular disease, but is often underdiagnosed. Objective To develop ma…
View article: Artificial intelligence-enhanced electrocardiogram analysis for identifying cardiac autonomic neuropathy in patients with diabetes
Artificial intelligence-enhanced electrocardiogram analysis for identifying cardiac autonomic neuropathy in patients with diabetes Open
Background Cardiac autonomic neuropathy (CAN) is an important yet often overlooked complication of diabetes, which significantly increases the risk of cardiovascular (CV) events and mortality. Traditional diagnostic methods like CV autonom…
View article: The influence of SGLT2 inhibitors on oxidative stress in heart failure and chronic kidney disease in patients with type 2 diabetes
The influence of SGLT2 inhibitors on oxidative stress in heart failure and chronic kidney disease in patients with type 2 diabetes Open
There is increasing interest in sodium-glucose cotransporter 2 inhibitors (SGLT2i) as not only a new oral glucose-lowering drug class but also one with cardio- and nephroprotective potential. Understanding the underlying mechanisms is ther…
View article: Machine Learning Predicts Cardiovascular Events in Patients With Diabetes: The Silesia Diabetes-Heart Project
Machine Learning Predicts Cardiovascular Events in Patients With Diabetes: The Silesia Diabetes-Heart Project Open
We aimed to develop a machine learning (ML) model for predicting cardiovascular (CV) events in patients with diabetes (DM). This was a prospective, observational study where clinical data of patients with diabetes hospitalized in the diabe…
View article: Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A systematic review, meta-analysis and meta-regression of randomized controlled trials
Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A systematic review, meta-analysis and meta-regression of randomized controlled trials Open
Introduction Metformin is the first choice drug in the treatment of type 2 diabetes mellitus but its administration may be linked to gastrointestinal adverse events limiting its use. Objectives The objective of this systematic review and m…
View article: Influence of SGLT2 Inhibitor Treatment on Urine Antioxidant Status in Type 2 Diabetic Patients: A Pilot Study
Influence of SGLT2 Inhibitor Treatment on Urine Antioxidant Status in Type 2 Diabetic Patients: A Pilot Study Open
Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) have been recognized as potent antioxidant agents. Since SGLT2i are nephroprotective drugs, we aimed to examine the urine antioxidant status in patients with type 2 diabetes mellitus (T2DM…