Kuan-Tsen Chen
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View article: Thrombospondin-1, CD47, and SIRPα display cell-specific molecular signatures in human islets and pancreata
Thrombospondin-1, CD47, and SIRPα display cell-specific molecular signatures in human islets and pancreata Open
CD47 is a cell surface receptor with two primary ligands, soluble thrombospondin-1 (TSP1) and cell surface signal regulatory protein alpha (SIRPα). Both interactions provide checkpoints for immune cell activity. We determined that fresh hu…
View article: Chronic marijuana usage by human pancreas donors is associated with impaired islet function
Chronic marijuana usage by human pancreas donors is associated with impaired islet function Open
We investigated the effect of chronic marijuana use, defined as 4 times weekly for more than 3 years, on human pancreatic islets. Pancreata from deceased donors who chronically used marijuana were compared to those from age, sex and ethnic…
View article: Evaluation of collagenase gold plus BP protease in isolating islets from human pancreata
Evaluation of collagenase gold plus BP protease in isolating islets from human pancreata Open
Selection of enzymes for optimal pancreas digestion is essential for successful human islet isolations. The aim of this study was to evaluate the efficacy and outcome of using Collagenase Gold plus BP protease (VitaCyte) (n = 8) by compari…