Kuixing Zhang
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View article: The global patent landscape of emerging infectious disease monkeypox
The global patent landscape of emerging infectious disease monkeypox Open
View article: Composite Classical Hodgkin Lymphoma and Mantle Cell Lymphoma: A Case Report
Composite Classical Hodgkin Lymphoma and Mantle Cell Lymphoma: A Case Report Open
View article: Machine learning-based evaluation of application value of pulse wave parameter model in the diagnosis of hypertensive disorder in pregnancy
Machine learning-based evaluation of application value of pulse wave parameter model in the diagnosis of hypertensive disorder in pregnancy Open
Hypertensive disorder in pregnancy (HDP) remains a major health burden, and it is associated with systemic cardiovascular adaptation. The pulse wave is an important basis for evaluating the status of the human cardiovascular system. This r…
View article: SAMS-Net: Fusion of attention mechanism and multi-scale features network for tumor infiltrating lymphocytes segmentation
SAMS-Net: Fusion of attention mechanism and multi-scale features network for tumor infiltrating lymphocytes segmentation Open
Automatic segmentation of tumor-infiltrating lymphocytes (TILs) from pathological images is essential for the prognosis and treatment of cancer. Deep learning technology has achieved great success in the segmentation task. It is still a c…
View article: Research on the classification of lymphoma pathological images based on deep residual neural network
Research on the classification of lymphoma pathological images based on deep residual neural network Open
BACKGROUND: Malignant lymphoma is a type of tumor that originated from the lymphohematopoietic system, with complex etiology, diverse pathological morphology, and classification. It takes a lot of time and energy for doctors to accurately …
View article: Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure
Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure Open
Cathepsin L (CTSL1) catalyzes the formation of peptides that influence blood pressure (BP). Naturally occurring genetic variation or targeted ablation of the Ctsl1 locus in mice yield cardiovascular pathology. Here, we searched for genetic…
View article: Heredity and cardiometabolic risk: naturally occurring polymorphisms in the human neuropeptide Y2 receptor promoter disrupt multiple transcriptional response motifs
Heredity and cardiometabolic risk: naturally occurring polymorphisms in the human neuropeptide Y2 receptor promoter disrupt multiple transcriptional response motifs Open
The neuropeptide Y2 G-protein-coupled receptor (NPY2R) relays signals from PYY or neuropeptide Y toward satiety and control of body mass. Targeted ablation of the NPY2R locus in mice yields obesity, and studies of NPY2R promoter genetic va…
View article: Role of Reactive Oxygen Species in Hyperadrenergic Hypertension: Biochemical, Physiological, and Pharmacological Evidence From Targeted Ablation of the Chromogranin A (Chga) Gene
Role of Reactive Oxygen Species in Hyperadrenergic Hypertension: Biochemical, Physiological, and Pharmacological Evidence From Targeted Ablation of the Chromogranin A (Chga) Gene Open
Oxidative stress, an excessive production of reactive oxygen species (ROS) outstripping antioxidant defense mechanisms, occurs in cardiovascular pathologies including hypertension. Here, we used biochemical, physiological, and pharmacologi…
View article: Author Correction: A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function
Author Correction: A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: A multi-feature image retrieval scheme for pulmonary nodule diagnosis
A multi-feature image retrieval scheme for pulmonary nodule diagnosis Open
Deep analysis of radiographic images can quantify the extent of intra-tumoral heterogeneity for personalized medicine. In this paper, we propose a novel content-based multi-feature image retrieval (CBMFIR) scheme to discriminate pulmonary …
View article: A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function
A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function Open
View article: Polymorphous Low-Grade Neuroepithelial tumor of the Young (PLNTY): Two Cases of the Recently Described Epileptogenic Neoplasm With Oligodendroglioma-Like Components and Heavy Calcification
Polymorphous Low-Grade Neuroepithelial tumor of the Young (PLNTY): Two Cases of the Recently Described Epileptogenic Neoplasm With Oligodendroglioma-Like Components and Heavy Calcification Open
Epileptogenic tumors affecting children and young adults are a diverse collection of neuroepithelial neoplasms. Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a recently described entity with a distinct morphologic, i…
View article: Elevated IGF2 mRNA Binding Protein 3 (IGF2BP3) Expression Is Associated With High-Grade Intraepithelial Lesion in Cervical Brushed Cells
Elevated IGF2 mRNA Binding Protein 3 (IGF2BP3) Expression Is Associated With High-Grade Intraepithelial Lesion in Cervical Brushed Cells Open
Conventional cervical cancer prevention program has prevented majority of cervical cancers in developed countries. The laboratory test to identify molecular markers for cervical precancerous lesion is a new direction with a lower cost, whi…
View article: Lymphoplasmacytic Lymphoma Transformation to B-cell Prolymphocytic Leukemias: An Extremely Unusual Event
Lymphoplasmacytic Lymphoma Transformation to B-cell Prolymphocytic Leukemias: An Extremely Unusual Event Open
B-cell prolymphocytic leukemia (B-PLL) is a rare disease, accounting for approximately 1% of lymphocytic leukemias. To our best knowledge, prolymphocytic transformation from lymphoplasmacytic lymphoma has not been previously reported. Here…
View article: Atypical Hemolytic Uremic Syndrome: A Brief Review
Atypical Hemolytic Uremic Syndrome: A Brief Review Open
Atypical hemolytic uremic syndrome (aHUS) is a disease characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury. The histopathologic lesions of aHUS include thrombotic microangiopathy involv…
View article: Study on Personnel Training Mode of Excellent Engineers in Biomedical Engineering
Study on Personnel Training Mode of Excellent Engineers in Biomedical Engineering Open
The Excellent Engineers Training Project" has put forward some new requirements for the cultivation of talents in our country.It is significant to study the talent training mode of excellent engineer training.According to the training stan…
View article: Identification of novel loci affecting circulating chromogranins and related peptides
Identification of novel loci affecting circulating chromogranins and related peptides Open
Chromogranins are pro-hormone secretory proteins released from neuroendocrine cells, with effects on control of blood pressure. We conducted a genome-wide association study for plasma catestatin, the catecholamine release inhibitory peptid…
View article: Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system
Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system Open
The functional variants of KLKB1 (rs3733402) and F12 (rs1801020) disrupted the cascade of enzymatic events, resulting in diminished formation of active renin. Using genetic, cellular and molecular approaches we found that conversion of zym…
View article: Analysis and validation of traits associated with a single nucleotide polymorphism Gly364Ser in catestatin using humanized chromogranin A mouse models
Analysis and validation of traits associated with a single nucleotide polymorphism Gly364Ser in catestatin using humanized chromogranin A mouse models Open
This functional genomics approach of creating humanized mouse models to study rs9658667 polymorphism recapitulated and validated many of the human trait associations. This approach can also be applied in the study of other human gene polym…