Gaurav Kumar Sharma
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View article: Evaluation of the regulatory effects of Laghu Guna on the pharmacological action of Guru Guna in albino Wistar rats: An experimental study
Evaluation of the regulatory effects of Laghu Guna on the pharmacological action of Guru Guna in albino Wistar rats: An experimental study Open
BACKGROUND: Ayurveda has enumerated 41 gunas (properties), of which 20 guna are named Gurvadi guna. These Gurvadi guna are expressed as 10 pairs of gunas. Based upon some observations according to Vagbhattta Ojavridhhi , attributed by Lang…
View article: SARS-CoV-2 infection in companion dogs: An analytical study
SARS-CoV-2 infection in companion dogs: An analytical study Open
View article: Molecular Mechanisms and Potential Therapeutic Targets of Ischemia–Reperfusion Injury in Kidney Transplantation
Molecular Mechanisms and Potential Therapeutic Targets of Ischemia–Reperfusion Injury in Kidney Transplantation Open
End-stage renal disease (ESRD) is a serious and lethal disease that carries with it a high morbidity and mortality rate if left untreated. Treating ESRD is conducted via renal replacement therapy and/or kidney transplantation, with the lat…
View article: Federated Learning for Predicting Mild Cognitive Impairment to Dementia Conversion
Federated Learning for Predicting Mild Cognitive Impairment to Dementia Conversion Open
Dementia is a progressive condition that impairs an individual's cognitive health and daily functioning, with mild cognitive impairment (MCI) often serving as its precursor. The prediction of MCI to dementia conversion has been well studie…
View article: Pollination compatibility studies between red and green colored cultivars of apple (Malus × domestica)
Pollination compatibility studies between red and green colored cultivars of apple (Malus × domestica) Open
View article: Differential expression of cytokine genes during natural course of lumpy skin disease virus infection in cattle with varied clinical presentation of the disease
Differential expression of cytokine genes during natural course of lumpy skin disease virus infection in cattle with varied clinical presentation of the disease Open
View article: SARS-CoV-2 infection in companion dogs: An analytical study
SARS-CoV-2 infection in companion dogs: An analytical study Open
View article: Expression of Immunodominant gI Protein of Duck Enteritis Virus and its Evaluation for ELISA
Expression of Immunodominant gI Protein of Duck Enteritis Virus and its Evaluation for ELISA Open
Background: Duck plague (DP), also known as duck viral enteritis (DVE) caused by Anatid alpha herpesvirus-1, is the major infectious viral disease reported in India very often with significant economic losses due to high morbidity and mort…
View article: Disruption of molecular interactions between G3BP1 stress granule host protein and nucleocapsid (NTD-N) protein impedes SARS-CoV-2 virus replication
Disruption of molecular interactions between G3BP1 stress granule host protein and nucleocapsid (NTD-N) protein impedes SARS-CoV-2 virus replication Open
The Ras GTPase-activating protein SH3-domain-binding protein 1 (G3BP1) serves as a formidable barrier to viral replication by generating stress granules (SGs) in response to viral infections. Interestingly, viruses, including SARS-CoV-2, h…
View article: Structural and mechanistic insights into Main protease (Mpro) dimer interface destabilization inhibitor: Unveiling new therapeutic avenues against SARS-CoV-2
Structural and mechanistic insights into Main protease (Mpro) dimer interface destabilization inhibitor: Unveiling new therapeutic avenues against SARS-CoV-2 Open
SARS-CoV-2 variants recurrence has emphasized the imperative prerequisite for effective antivirals. The main protease (Mpro) of SARS-CoV-2 is crucial for viral replication, making it one of the prime and promising antiviral target. Mpro fe…
View article: Efficacy of distal peripheral nerve blocks in lumbar radicular pain: A randomized placebo-controlled triple-blinded study
Efficacy of distal peripheral nerve blocks in lumbar radicular pain: A randomized placebo-controlled triple-blinded study Open
Context: Inflamed nerve root leads to mechano-sensitization and upregulation of sodium channels in nerve endings far distal to the site of inflammation, leading to tenderness of these nerve endings. Due to pseudounipolar nature, the blocka…
View article: Understanding the Pathogenesis of Endothelial Injury Induced by Bluetongue Virus in Experimentally Infected Sheep
Understanding the Pathogenesis of Endothelial Injury Induced by Bluetongue Virus in Experimentally Infected Sheep Open
Bluetongue (BT) is an economically important contagious viral disease transmitted by insect vectors of Culicoides species affecting both domestic and wild ruminants caused by Genus Orbivirus of Reoviridae family. Present in vivo study for …
View article: Genetic and antigenic characterization of bluetongue virus serotype-1 isolated from goat in India
Genetic and antigenic characterization of bluetongue virus serotype-1 isolated from goat in India Open
Bluetongue virus (BTV) affects domestic and wild ruminants and is transmitted by Culicoides spp. In the present study, genetic and antigenic characterization of the BTV-1 serotype (MKD20/08/Ind isolate) isolated from goat was carried out t…
View article: Development and evaluation of a chicken embryo fibroblast cell culture based live attenuated Indian strain duck plague vaccine
Development and evaluation of a chicken embryo fibroblast cell culture based live attenuated Indian strain duck plague vaccine Open
Duck plague (DP) is an acute, contagious and fatal disease, caused by duck enteritis virus (DEV), with worldwide distribution causing several outbreaks and posing severe economic losses. The present study was carried out with a goal of dev…
View article: Characterization of oil extracted from wild apricot seeds kernel using submerged alcoholic fermentation and its quality characteristics
Characterization of oil extracted from wild apricot seeds kernel using submerged alcoholic fermentation and its quality characteristics Open
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View article: The histidine kinase NahK regulates pyocyanin production through the PQS system
The histidine kinase NahK regulates pyocyanin production through the PQS system Open
Many bacterial histidine kinases work in two-component systems that combine into larger multi-kinase networks. NahK is one of the kinases in the GacS Multi-Kinase Network (MKN), which is the MKN that controls biofilm regulation in the oppo…
View article: Use of Multi-pass FSP treatment for improving mechanical properties and corrosion resistance of Mg-2Zn-HA composite
Use of Multi-pass FSP treatment for improving mechanical properties and corrosion resistance of Mg-2Zn-HA composite Open
Magnesium (Mg) alloys are very popular among the biomaterials for biodegradable bone implants due to their suitable properties matching with that of human cortical bone. However, their poor corrosion resistance in biological fluid is a maj…
View article: EVALUATION OF ANTIMICROBIAL ACTIVITY, GC-MS AND FT-IR PROFILE OF COW URINE DISTILLATES PREPARED FROM FRESH URINE OF INDIGENOUS COW BREEDS
EVALUATION OF ANTIMICROBIAL ACTIVITY, GC-MS AND FT-IR PROFILE OF COW URINE DISTILLATES PREPARED FROM FRESH URINE OF INDIGENOUS COW BREEDS Open
The present study was undertaken to explore the antimicrobial potential of cow urine distillate (gomutra ark) against pathogenic microorganisms of medical and veterinary significance. Cow urine distillates (CUDs) were prepared from fresh c…
View article: The histidine kinase NahK regulates pyocyanin production through the PQS system
The histidine kinase NahK regulates pyocyanin production through the PQS system Open
Many bacterial histidine kinases work in two-component systems that combine into larger multi-kinase networks. NahK is one of the kinases in the GacS Multi-Kinase Network (MKN), which is the MKN that controls biofilm regulation in the oppo…
View article: Genetic and antigenic characteristics of bluetongue virus serotype-1 from an apparently healthy goat in India
Genetic and antigenic characteristics of bluetongue virus serotype-1 from an apparently healthy goat in India Open
Bluetongue virus (BTV) affects domestic and wild ruminants and is transmitted by Culicoides spp. In the present study, genetic and antigenic characterization of the BTV-1 serotype (MKD20/08/Ind isolate) was carried out to understand the ph…
View article: Revealing and evaluation of antivirals targeting multiple druggable sites of RdRp complex in SARS-CoV-2
Revealing and evaluation of antivirals targeting multiple druggable sites of RdRp complex in SARS-CoV-2 Open
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) complex consisting of nsp12, nsp7, and nsp8 as the key enzyme for viral genome replication and is a proven antiviral drug target. In this study, molecular interactions of nsp7 and nsp8 with ns…
View article: Unraveling antiviral efficacy of multifunctional immunomodulatory triterpenoids against SARS-COV-2 targeting main protease and papain-like protease
Unraveling antiviral efficacy of multifunctional immunomodulatory triterpenoids against SARS-COV-2 targeting main protease and papain-like protease Open
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be over, but its variants continue to emerge, and patients with mild symptoms having long COVID is still under inv…
View article: A retrospective study showing a high rate of seropositivity against SARS-CoV-2 in wild felines in India
A retrospective study showing a high rate of seropositivity against SARS-CoV-2 in wild felines in India Open
View article: Successful Treatment of Perianal Warts with Intradermal Purified Protein Derivative
Successful Treatment of Perianal Warts with Intradermal Purified Protein Derivative Open
Perianal warts are among the most common sexually transmitted infections worldwide. The condition may be persistent, increase in size and number, and have a high recurrence rate. There are many therapeutic options of Perianal warts, but no…
View article: Dermatological Manifestations of Covid-19 in Pregnancy
Dermatological Manifestations of Covid-19 in Pregnancy Open
The number of COVID-19 cases, particularly those involving pregnancy, continues to be an issue in India and around the world. Fever (temperature>38°C), cough, and shortness of breath are the primary clinical signs. It can also be accompani…
View article: Oral Ranitidine in Molluscum Contagiosum- A Review
Oral Ranitidine in Molluscum Contagiosum- A Review Open
One of the most typical viral illnesses in children is molluscum contagiosum (MC). Even though it is typically benign and self-limiting, the danger of transmission and aesthetic problems necessitate treatment. There are numerous treatments…
View article: Role of Metformin Plus Myoinositol in Infertile Polycystic Ovarian Syndrome (PCOS) Women
Role of Metformin Plus Myoinositol in Infertile Polycystic Ovarian Syndrome (PCOS) Women Open
One of the most prevalent endocrine illnesses that affect women during their reproductive years is polycystic ovarian syndrome (PCOS). Hyperandrogenism, protracted anovulation, and irregular menstrual cycles are its hallmarks. About 50% of…
View article: Role of Vitamin C in Eczema
Role of Vitamin C in Eczema Open
Eczema is a skin problem that causes skin irritation, itchiness, roughness, and inflammation. There are different stages of eczema that are noticed in people from several age groups across the globe. Eczema is a common condition that’s est…
View article: Chimeric chikungunya virus-like particles with surface exposed SARS-CoV-2 RBD elicits potent immunogenic responses in mice
Chimeric chikungunya virus-like particles with surface exposed SARS-CoV-2 RBD elicits potent immunogenic responses in mice Open
The SARS-CoV-2 pandemic has reinforced efforts for developing effective vaccination strategy for existing and emerging viruses. Currently there are various vaccine technology available for treating viral diseases, however it is imperative …
View article: Enhanced Immune Responses and Protection Against Viral Challenge in Sheep with a Novel Nanoemulsion-Based Inactivated Bluetongue Virus Vaccine
Enhanced Immune Responses and Protection Against Viral Challenge in Sheep with a Novel Nanoemulsion-Based Inactivated Bluetongue Virus Vaccine Open