Kumar Sharp
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View article: Central Shunt as Palliation in a 30-Year-Old with Unrepaired Tetralogy of Fallot and Pulmonary Atresia: A Case Report
Central Shunt as Palliation in a 30-Year-Old with Unrepaired Tetralogy of Fallot and Pulmonary Atresia: A Case Report Open
Late presentation of complex congenital heart disease is uncommon in adults, particularly in regions with established paediatric cardiac services. We report a case of a 30-year-old male with unrepaired tetralogy of Fallot (TOF) and pulmona…
View article: Cardiac Surgical Intensive Care Unit admission and Monitoring methods.
Cardiac Surgical Intensive Care Unit admission and Monitoring methods. Open
View article: Alternatives to Remdesivir: Drug repurposing for inhibition of SARSCoV2 RNA dependent RNA polymerase
Alternatives to Remdesivir: Drug repurposing for inhibition of SARSCoV2 RNA dependent RNA polymerase Open
Even after more than a year of the beginning of COVID-19 pandemic, a specific treatment for the disease has not been discovered. Vaccination programmes are being rolled out as the fastest pace possible but achievement of herd immunity will…
View article: Multi-epitope peptide sequence in-silico construction from HGV genome
Multi-epitope peptide sequence in-silico construction from HGV genome Open
In this study I have approached through in-silico method or reverse vaccinology taking advantage of the genome sequence of hepatitis G virus. It serves its benefit of identifying antigens seen by both conventional as well as discovering an…
View article: D-dimer Levels in COVID-19 Patients and Its Correlation with Age and Gender: A Retrospective Analysis
D-dimer Levels in COVID-19 Patients and Its Correlation with Age and Gender: A Retrospective Analysis Open
Raised levels of coagulation parameters indicate thrombotic disorders which need to be managed as soon as possible. Radiological findings are confirmatory diagnosis in these cases however the increased load and risk of spread of COVID-19 i…
View article: Fatal Intestinal Perforation in a Tubal Ligation Procedure: A Rare Case
Fatal Intestinal Perforation in a Tubal Ligation Procedure: A Rare Case Open
Tubal sterilization is the second most commonly used procedure for family planning in the world. Tubal ligation is the most commonly used method for female sterilization in India. Among the most common complications in this procedure are b…
View article: Repurposing inhibitors for SARS-CoV2 main protease
Repurposing inhibitors for SARS-CoV2 main protease Open
SARS-CoV2 main protease is important for viral replication and one of the most potential targets for drug development in this current pandemic. Drug repurposing is a promising field to provide potential short-term acceptable therapy for ma…
View article: Folate and Tolazamide: Potential competitive inhibitors of barbiturate by in-silico molecular docking
Folate and Tolazamide: Potential competitive inhibitors of barbiturate by in-silico molecular docking Open
Barbiturates are the first line drugs for treatment of epilepsy for adults and children in the developing world because of its low cost and proven effectiveness. Due to their adverse effects, no effective management of toxicity and difficu…
View article: Application of In-Silico Reverse Vaccinology for Designing Multi-Epitope Vaccine Against Coronavirus
Application of In-Silico Reverse Vaccinology for Designing Multi-Epitope Vaccine Against Coronavirus Open
In absence of any specific medication or vaccine till now, experimentation has reached new heights. With lockdown imposed in almost every country and huge economic losses the search for a suitable vaccine has still been unsuccessful. In th…
View article: Application of In-Silico Reverse Vaccinology for Designing Multi-Epitope Vaccine Against Coronavirus
Application of In-Silico Reverse Vaccinology for Designing Multi-Epitope Vaccine Against Coronavirus Open
In absence of any specific medication or vaccine till now, experimentation has reached new heights. With lockdown imposed in almost every country and huge economic losses the search for a suitable vaccine has still been unsuccessful. In th…
View article: Comparative Analysis of SARS-CoV2 with Special Emphasis on Genome Sequences
Comparative Analysis of SARS-CoV2 with Special Emphasis on Genome Sequences Open
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus – 2 (SARS-CoV-2), was declared a global pandemic on 11th March, 2020 by World Health Organization. As of now,27th May,2020, there are about 54,88,…
View article: In-Silico FDA-Approved Drug Repurposing to Find the Possible Treatment of Coronavirus Disease-19 (COVID-19)
In-Silico FDA-Approved Drug Repurposing to Find the Possible Treatment of Coronavirus Disease-19 (COVID-19) Open
Identification of potential drug-target interaction for approved drugs serves as the basis of repurposing drugs. Studies have shown polypharmacology as common phenomenon. In-silico approaches help in screening large compound libraries at o…
View article: Computational Drug Simulation: A Step to the Possible Cure of COVID-19
Computational Drug Simulation: A Step to the Possible Cure of COVID-19 Open
World Health Organization declared COVID-19 as a pandemic on 11th March,2020. Without any exact cure or vaccine, this disease has certainly taken a toll of humanity. Computer-aided Drug Design (CADD) is the modern era simulator for aiding …
View article: Computational Drug Simulation: A Step to the Possible Cure of COVID-19
Computational Drug Simulation: A Step to the Possible Cure of COVID-19 Open
World Health Organization declared COVID-19 as a pandemic on 11th March,2020. Without any exact cure or vaccine, this disease has certainly taken a toll of humanity. Computer-aided Drug Design (CADD) is the modern era simulator for aiding …