Kumaraswamy Nanthakumar

High-density evaluation of the arrhythmogenic substrate in persistent atrial fibrillation Open

Haseeb Valli, Mahmoud Ehnesh, Sam Coveney, David G. Jones, Zhong Chen , et al. · 2025

Postsurgical Temporary Epicardial Pacing: Electrophysiological Implications of Contemporary Pacing Lead Designs Open

Intisar Ahmed, Chloe Netlefold, Robert D. Anderson, Stéphane Massé, M Burg , et al. · 2025

Epidemiology, clinical characteristics and potential mechanism of ibrutinib-induced ventricular arrhythmias Open

Yilin Pan, Yanan Zhao, Hongqi Ren, Xintong Wang, Caixia Liu , et al. · 2024

The Bruton’s Tyrosine Kinase Inhibitor, ibrutinib, has been widely employed due to its significant efficacy in B-cell lymphoma. However, the subsequent cardiac complications, notably atrial fibrillation (AF) and ventricular arrhythmias (VA…

Spontaneous termination of ventricular tachycardia in the human heart Open

Takahiro Hayashi, Nathan Denham, Chloe Nettlefold, Jayant Kakarla, Robert D. Anderson , et al. · 2024

Introduction Understanding the spatiotemporal location of the spontaneous termination of ventricular tachycardia (VT) may provide new insights for ablation. To test the hypothesis that spontaneous VT termination most frequently occurs at t…

Paced QRS Interval Duration and Pacing-Induced Cardiomyopathy - Time to Display Open

Arjun K. Aggarwal, Ayana Nanthakumar, Bonnie Daba, Arulalan Veluppillai, Kumaraswamy Nanthakumar , et al. · 2024

Arrhythmogenic Ventricular Remodeling by Next-Generation Bruton’s Tyrosine Kinase Inhibitor Acalabrutinib Open

Yanan Zhao, Praloy Chakraborty, Julianna Tomassetti, Tasnia Subha, Stéphane Massé , et al. · 2024

Cardiac arrhythmias remain a significant concern with Ibrutinib (IBR), a first-generation Bruton’s tyrosine kinase inhibitor (BTKi). Acalabrutinib (ABR), a next-generation BTKi, is associated with reduced atrial arrhythmia events. However,…

Primitive macrophages induce sarcomeric maturation and functional enhancement of developing human cardiac microtissues via efferocytic pathways Open

Homaira Hamidzada, Simon Pascual‐Gil, Qinghua Wu, G Kent, Stéphane Massé , et al. · 2024

The Accuracy of Cardiac Surface Conduction Velocity Measurements Open

Edward J. Vigmond, Caroline H. Roney, Jason D. Bayer, Kumaraswamy Nanthakumar · 2024

Background: Conduction velocity (CV) is a measure of the health of myocardial tissue. It can be measured by taking differences in activation times from intracardiac electrodes. Several factors introduce error into the measurement, amongst …

IL-6 and D-dimer Levels at Admission Predict Cardiac Injury and Early Mortality during SARS-CoV-2 Infection Open

Kexin Peng, Beibei Du, Daoyuan Si, Lina Jin, Bo Yang , et al. · 2024

Background: We previously described the mortality associated with cardiac injury in patients with coronavirus disease 2019 (COVID-19). The activation of immune and thrombotic biomarkers at admission, and their ability to predict cardiac in…

Atypical atrial flutter: Exploring the relationship between ibrutinib chemotherapy and atrial myopathy Open

Nathan Denham, Robert D. Anderson, Kumaraswamy Nanthakumar, Andrew C.T. Ha, Abhishek Bhaskaran · 2023

Key Teaching Points•The incidence of atrial arrhythmia is 5%–16% in patients taking Bruton's tyrosine kinase inhibitors, a class of chemotherapeutic agents that is used first line for many hematological malignancies. The main risk factors …

Uncoupling cytosolic calcium from membrane voltage by transient receptor potential melastatin 4 channel (TRPM4) modulation: A novel strategy to treat ventricular arrhythmias Open

Praloy Chakraborty, Mohammed Ali Azam, Stéphane Massé, Patrick F.H. Lai, Robert A. Rose , et al. · 2023

Pro-arrhythmic role of adrenergic spatial densities in the human atria: An in-silico study Open

Karl Magtibay, Stéphane Massé, Kumaraswamy Nanthakumar, Karthikeyan Umapathy · 2023

Chronic stress among young patients (≤ 45 years old) could result in autonomic dysfunction. Autonomic dysfunction could be exhibited via sympathetic hyperactivity, sympathetic nerve sprouting, and diffuse adrenergic stimulation in the atri…

Maturation of iPSC-derived cardiomyocytes in a heart-on-a-chip device enables modeling of dilated cardiomyopathy caused by R222Q-SCN5A mutation Open

Marianne Wauchop, Naimeh Rafatian, Yimu Zhao, Wenliang Chen, Mark Gagliardi , et al. · 2023

QRS Width: Easily Obtained but Overlooked Parameter in Monitoring Algorithms in Implantable Devices Open

Arjun K. Aggarwal, Ayana Nanthakumar, Bonnie Daba, Arulalan Veluppillai, Melanie Burg R , et al. · 2023

Introduction We describe the progressive increase in the QRS durations (QRSd) and the subsequent decrease in the left ventricular ejection fractions (LVEF) of two patients post pacemaker implantation. We aim to highlight the need for conte…

Orthogonal bipolar approach to detect cardiac repolarization changes related to activation direction Open

Stéphane Massé, Ahmed Niri, Mohd Asyadi Azam, Patrick F.H. Lai, J. Asta , et al. · 2023

Funding Acknowledgements Type of funding sources: None. Background In addition to wave propagation, tissue anisotropy is thought to determine repolarization (repol). This may explain PVC-induced vulnerability to re-entry, based on change o…

Clinical significance of conduction velocity orientation vectors on cardiac mapping surfaces Open

Jairo Rodríguez Padilla, Robert M. Anderson, Christian Joens, Stéphane Massé, Abhishek Bhaskaran , et al. · 2023

Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): This work was supported by the Lefoulon Delalande Foundation OBJECTIVE Electroanatomical maps using automated conduction velocity (CV) algorithms are now…

A method to identify which patients will have VT substrate ablation targets prior to ablation procedure Open

M Burg, R. David Anderson, Hanney Gonna, Abdullah Al-Shaheen, Ahmed Niri , et al. · 2023

Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Dr Nanthakumar is a recipient of the Mid-career Investigator Award from the Heart & Stroke Foundation of Ontario Background Recent trials in ventricular …

Multi-modal physiological parameter for mapping ablation lesions Open

Stéphane Massé, R. David Anderson, Hanney Gonna, Mohd Asyadi Azam, Patrick F.H. Lai , et al. · 2023

Funding Acknowledgements Type of funding sources: None. Background In addition to variety of force time indices, electrophysiologist use peak to peak voltage (Vpp) and or S wave on unipolar electrogram to assess RF lesions they deliver. Th…

Determining physiological VT ablation targets in the era of early VT ablation Open

M Burg, R. David Anderson, Hanney Gonna, Abdullah Al-Shaheen, E Shapira , et al. · 2023

Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Professor Nanthakumar is a recipient of the Mid-career Investigator Award from the Heart & Stroke Foundation of Ontario. Background Ablation targets in t…

Voltage-Guided Ablation for Atrial Fibrillation -- Current Insights and Future Directions Open

Haseeb Valli, Abhishek Deshmukh, Kumaraswamy Nanthakumar, Tom Wong, Shouvik Haldar · 2023

The prevalence of atrial fibrillation (AF) is forecasted to increase manifold, emphasizing the need for efficacious treatments. Pulmonary vein isolation (PVI) to eliminate ectopic triggers is now established as a fundamental component of t…

CE-452773-2 MICROVOLT INTRA-QRS ALTERNANS IDENTIFIES THE ENTRANCE SITES OF MONOMORPHIC VENTRICULAR TACHYCARDIA IN PATIENTS WITH ISCHEMIC CARDIOMYOPATHY: INSIGHTS FROM HIGH-RESOLUTION INTRAOPERATIVE MAPPING Open

Nathan Denham, Abhishek Bhaskaran, Adrian Suszko, Hanney Gonna, Stéphane Massé , et al. · 2023

Supraventricular tachycardia following slow pathway ablation: What is the mechanism? Open

Nathan Denham, Kumaraswamy Nanthakumar · 2023

The authors declare no conflict of interest. The data that support the findings of this study are available from the corresponding author upon reasonable request.

Orientation of conduction velocity vectors on cardiac mapping surfaces Open

Jairo Rodríguez Padilla, Robert D. Anderson, Christian Joens, Stéphane Massé, Abhishek Bhaskaran , et al. · 2023

Aims Electroanatomical maps using automated conduction velocity (CV) algorithms are now being calculated using two-dimensional (2D) mapping tools. We studied the accuracy of mapping surface 2D CV, compared to the three-dimensional (3D) vec…

Quantifying the impact of equity, diversity, and inclusion in electrophysiology: Training the first female electrophysiologists from Jamaica and Saint Lucia Open

Nordia Clare-Pascoe, Kurlene Cenac, Sunil Stephenson, R.O.H. Irvine, Romel Daniel , et al. · 2022

Training the first female electrophysiologists from Jamaica and Saint Lucia led to a quantifiable impact on EP care in both of these Caribbean countries. EDI strategies in EP training programs provide much needed benefits to developing nat…

Overdrive pacing in the acute management of osimertinib-induced ventricular arrhythmias: A case report and literature review Open

Yanyu Zhang, Xingtong Wang, Yilin Pan, Beibei Du, Kumaraswamy Nanthakumar , et al. · 2022

QT interval prolongation and ventricular arrhythmias (VAs) induced by osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, are life-threatening complications. However, no consensus has been achieved r…

Automated Identification of Ventricular Tachycardia Ablation Targets: Multicenter Validation and Workflow Characterization Open

Ahmed Niri, E Shapira, Stéphane Massé, Meir Bar‐Tal, Tal Bar‐on , et al. · 2022

Decrement evoked potentials (EPs) (DeEPs) constitute an accepted method to identify physiological ventricular tachycardia (VT) ablation targets without inducing VT. The feasibility of automated software (SW) in the detection of arrhythmoge…

Statins Protect Against Early Stages of Doxorubicin-induced Cardiotoxicity Through the Regulation of Akt Signaling and SERCA2 Open

Keith Dadson, Paaladinesh Thavendiranathan, Ludger Hauck, Daniela Grothe, Mohammed Ali Azam , et al. · 2022

Rosuvastatin counteracts the cardiotoxic effects of doxorubicin by directly targeting sarcoplasmic calcium cycling.

Synchronizing systolic calcium release with azumolene in an experimental model Open

Daoyuan Si, Praloy Chakraborty, Mohammed Ali Azam, Madhav Krishna Kumar Nair, Stéphane Massé , et al. · 2022

Treatment with azumolene is associated with improvement of systolic Ca²⁺ release synchrony and myocardial contractility following ischemic LDVF.

The validity of current implantable cardioverter-defibrillator guidelines in a real-world population of adults with congenital heart disease: A single-center experience Open

Satoshi Kawada, Praloy Chakraborty, Jared Nanthakumar, Lisa Albertini, Erwin Oechslin , et al. · 2022

Cardioprotective effects of dantrolene in doxorubicin-induced cardiomyopathy in mice Open

Mohammed Ali Azam, Praloy Chakraborty, Mahmoud Bokhari, Keith Dadson, Beibei Du , et al. · 2021

Dantrolene prevents cardiac contractile dysfunction following doxorubicin treatment by mitigating dysregulation of calcium dynamics.

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