Explanipedia

Electrochemical Bioimaging Using Bipolar Microelectrode Arrays Open

Koki Kubota, A. Endo, Kumi Y. Inoue · 2025

Detection of C‐Reactive Protein by Electrochemiluminescence‐Based Droplet‐Free Digital Immunoassay with Tyramide Signal Amplification Open

Hiroya Abe, Sho Nakamura, Kentaro Ito, Kosuke Ino, Zhengyi Liu , et al. · 2025

C‐reactive protein (CRP) is a widely used biomarker for monitoring inflammatory processes and assessing disease progression in various conditions, including cardiovascular diseases, infections, and autoimmune disorders. In this study, a si…

Bipolar electrochemical sensor with perylene diimide-based cathodic luminophore for dopamine detection and imaging Open

Tomoki Iwama, Mayo Komatsu, Kumi Y. Inoue, Koki Kubota, Takahiro Ito‐Sasaki , et al. · 2024

Bipolar electrochemical microscopy (BEM), which visualizes the concentration distribution of molecular species in biological systems by electrochemiluminescence (ECL), is expected to be applied to the high-spatiotemporal-resolution imaging…

ACCS 2023 Participation Report and ACCS 2024 Information from Japan Association of Chemical Sensors Open

Tomoyuki Yasukawa, Kumi Y. Inoue, Taro UEDA, Shinji TAMURA · 2024

Enhancement of Electrochemiluminescence by Au Paste Electrode for Bipolar Electroanalysis Open

A. Endo, Koki Kubota, Takahiro Ito‐Sasaki, Mayo Komatsu, Tomoki Iwama , et al. · 2023

Carbon paste electrodes (CPEs) are widely used because of their malleability and ease of modification of functional molecules. This study introduces the application of Au paste electrodes (AuPEs) as a method for amplifying electrochemilumi…

Relationship between Plasma Lipopolysaccharide Concentration and Health Status in Healthy Subjects and Patients with Abnormal Glucose Metabolism in Japan: A Preliminary Cross-Sectional Study Open

Nobuo Fuke, Shojiro Sawada, Takahiro Ito‐Sasaki, Kumi Y. Inoue, Yusuke Ushida , et al. · 2023

Lipopolysaccharides are components of Gram-negative bacteria. The relationship between blood lipopolysaccharide levels and health status has mainly been investigated in Europe, and there is a lack of information about Asia, particularly Ja…

C-reactive Protein Detection Using an Ion-sensitive Field-effect Transistor (ISFET)-based Aptasensor with a Chemically Modified Gate Surface for Improved Sensitivity Open

Siti Masturah binti Fakhruddin, Kumi Y. Inoue, Masayoshi Esashi, Hitoshi Shiku · 2023

Effect of Valinomycin on the Respiration Activity of Zebrafish Embryos Using a Large-Scale-Integration-based Multiple Amperometric Biosensor Open

Kazuki Terao, Masato Suzuki, Ryota Kunikata, Atsushi Suda, Kumi Y. Inoue , et al. · 2023

Intestinal and fecal pH in human health Open

Ryodai Yamamura, Kumi Y. Inoue, Kunihiko Nishino, Seiji Yamasaki · 2023

Gut microbiota has been reported to be closely related to host energy metabolism and immunity, and thus influence the development and progression of various human diseases. To date, the gut microbial metabolites such as short-chain fatty a…

Energy-harvesting and mass sensor performances of magnetostrictive cobalt ferrite-spattered Fe–Co alloy plate Open

Hiroki Kurita, Siti Masturah binti Fakhruddin, Kumi Y. Inoue, Takeru Nakaki, Shotaro Kuroda , et al. · 2023

Droplet-free digital immunoassay based on electrochemiluminescence Open

Kentaro Ito, Kumi Y. Inoue, Kosuke Ino, Hitoshi Shiku · 2023

Here, we report a droplet-free digital immunoassay for goat immunoglobulin G (IgG) based on electrochemiluminescence (ECL) for simplified digital immunoassay. Digital enzyme-linked immunosorbent assay (ELISA) enabled ultrasensitive detecti…

Highly Sensitive Electrochemical Endotoxin Sensor Based on Redox Cycling Using an Interdigitated Array Electrode Device Open

Kentaro Ito, Kumi Y. Inoue, Takahiro Ito‐Sasaki, Miho Ikegawa, Shinichiro Takano , et al. · 2023

The Limulus amebocyte lysate (LAL) reaction-based assay, the most commonly used endotoxin detection method, requires a skilled technician. In this study, to develop an easy-to-use and highly sensitive endotoxin sensor, we created an electr…

Bipolar Electrochemical Sensor with Perylene Diimide-Based Cathodic Luminophore for Dopamine Detection and Imaging Open

Kumi Y. Inoue, Tomoki Iwama, Mayo Komatsu, Koki Kubota, Takahiro Ito‐Sasaki , et al. · 2023

Batteryless wireless magnetostrictive Fe30Co70/Ni clad plate for human coronavirus 229E detection Open

Daiki Neyama, Siti Masturah binti Fakhruddin, Kumi Y. Inoue, Hiroki Kurita, Shion Osana , et al. · 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been garnered increasing for its rapid worldwide spread. Each country had implemented city-wide lockdowns and immigration regulations to prevent the spread of the infection, …

Electrochemiluminescence Imaging Based on Bipolar Electrochemistry Using Commercially Available Anisotropic Conductive Films Open

Rise Akasaka, Kosuke Ino, Tomoki Iwama, Kumi Y. Inoue, Yuji Nashimoto , et al. · 2022

Electrochemical Substrates and Systems for Enzyme-Based Bioassays Open

Yoshinobu Utagawa, Kentaro Ito, Kumi Y. Inoue, Yuji Nashimoto, Kosuke Ino , et al. · 2022

バイオ分析において基質が果たす役割は大きい.例えば,イムノアッセイでは酵素標識された抗体が用いられ,さらに酵素に特異的に反応する基質を添加して,酵素生成物を検出することで目的の測定物を定量できる.健康診断における検体サンプルや培養細胞における抗原の検出では,酵素を用いた免疫染色法が幅広く用いられており,基質からの酵素生成物の着色により可視化されている.多くの場合は,生成物の光学特性を生かし,着色したり,吸光度測定したりするが,装置の簡便さや優れた定量性を生かし,電気化学計測…

Droplet-Free Digital Immunoassay Based on Electrochemiluminescence Open

Kumi Y. Inoue, Kentaro Ito, Kosuke Ino, Hitoshi Shiku · 2022

Droplet-Free Digital Immunoassay Based on Electrochemiluminescence Open

Kumi Y. Inoue, Kentaro Ito, Kosuke Ino, Hitoshi Shiku · 2022

Droplet-Free Digital Immunoassay Based on Electrochemiluminescence Open

Kentaro Ito, Kumi Y. Inoue, Kosuke Ino, Hitoshi Shiku · 2022

Droplet-Free Digital Immunoassay Based on Electrochemiluminescence Open

Kumi Y. Inoue, Kentaro Ito, Kosuke Ino, Hitoshi Shiku · 2022

Thermally‐Drawn Multi‐Electrode Fibers for Bipolar Electrochemistry and Magnified Electrochemical Imaging Open

Tomoki Iwama, Yuanyuan Guo, Shoma Handa, Kumi Y. Inoue, Tatsuo Yoshinobu , et al. · 2021

Imaging systems using closed bipolar electrode (cBPE) arrays and electrochemiluminescence (ECL) have attracted great attention in recent years as a 2D imaging platform with high spatiotemporal resolution. However, the fabrication technique…

Simultaneous Monitoring of Oxygen Consumption and Movement of Zebrafish Embryos Based on an LSI-based Electrochemical Multiple-biosensor Open

Masato Suzuki, Yuka Iwaki, Kazuki Terao, Ryota Kunikata, Atsushi Suda , et al. · 2021

We have estimated the effect of a chemical reagent based on the oxygen consumption and the motion of zebrafish embryos by using an LSI-based amperometric sensor array device (Bio-LSI). Bio-LSI with 400 gold microelectrodes in a 6 mm × 6 mm…

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Osamu Shirai, Keisei Sowa, Yuki Kitazumi, Saki Ohta, Shunsuke Shiba , et al. · 2021

Detection and 2D Imaging of Dopamine Distribution Using a Closed Bipolar Electrode System by Applying a Cathodic Luminophore Open

Tomoki Iwama, Mayo Komatsu, Kumi Y. Inoue, Hitoshi Shiku · 2021

A 2D imaging system using closed bipolar electrodes (cBPEs) and electrochemiluminescence (ECL) is expected to realize high spatio‐temporal resolution imaging. However, imaging of the distributions of molecules that cause an oxidation react…

Bipolar Electrode‐based Electrochromic Devices for Analytical Applications – A Review Open

Siti Masturah binti Fakhruddin, Kosuke Ino, Kumi Y. Inoue, Yuji Nashimoto, Hitoshi Shiku · 2021

Bipolar electrode‐based (BPE‐based) electrochromic devices have garnered increasing attention in the past decade. These BPE‐based electrochromic devices have been used for analytical health monitoring, point‐of‐care (POC) diagnostics, and …

Electrochemical Sensor to Detect Proteinuria Using Peptidases and Glutamate Oxidase Jointly Immobilized on a Prussian Blue-modified Electrode Open

Kentaro Ito, Kumi Y. Inoue, Miura Tsubasa, Tomokazu Matsue, Hitoshi Shiku · 2021

In this work, we report a simple electrochemical sensor that detects proteinuria upon immersion into a sample. We immobilized peptidases in conjunction with glutamate oxidase (GluOx) on a Prussian blue-modified glassy carbon (PB-GC) electr…

Biosensors and biosensing in the era of digital health Open

Kumi Y. Inoue, Tetsuo Oishi · 2020

Current challenges and future perspectives on nanoscale analysis for electrochemistry Open

Katsuyoshi Ikeda, Kumi Y. Inoue · 2020

Recent Advances in Electrochemiluminescence-Based Systems for Mammalian Cell Analysis Open

Kaoru Hiramoto, Elena Villani, Tomoki Iwama, Keika Komatsu, Shinsuke Inagi , et al. · 2020

Mammalian cell analysis is essential in the context of both fundamental studies and clinical applications. Among the various techniques available for cell analysis, electrochemiluminescence (ECL) has attracted significant attention due to …

Electrochemical Detection of Kallikrein Using a <i>p</i>-Methoxyaniline-conjugated Tripeptide towards Simple Diagnosis of Primary Aldosteronism Open

Kousuke Ohyama, Sun Sixiang, Kumi Y. Inoue, Tomokazu Matsue, Takayuki Doi · 2019

Kallikrein is a serine protease which is involved in blood pressure regulation and is overexpressed in primary aldosteronism. We hypothesized that quick quantification of this enzyme could represen...

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