Explanipedia

Harnessing Seabuckthorn (Hippophae rhamnoides) Surfactants for Human Metapneumovirus (HMPV) Open

Tatenda Calshy Mapfumo, Mutaman Mohammed Alsamani Hago, Rajsekhar Adhikary, Poonam Verma, Kumud Pant · 2025

Human metapneumovirus (HMPV) is a highly mutating respiratory virus that ruses the immune system with frequent mutations, creating a major health challenge. Lacking approved vaccines or treatments, there is a pressing need for effective an…

Efficacy of <i>Garcinia indica</i> fractions on mast cell degranulation in experimental allergic conditions Open

L. Dayanand, Sachidananda Vijayakumar, Veeresh Prabhakar Veerapur, K S Nagashree, Sachin Kumar Singh , et al. · 2025

Objectives: Allergic reactions are classified into two categories: Early-phase response (EPR) and late-phase response (LPR). EPRs demonstrate a rapid onset of symptoms resulting from histamine release by mast cells (MCs). The introduction …

Computational drug discovery of phytochemical alkaloids targeting the NACHT/PYD domain in the NLRP3 inflammasome Open

Nilay Singh, Promila Sharma, Manoj K. Pal, Ragini Kahera, Himani Badoni , et al. · 2025

Current status of antimicrobial peptides databases and computational tools for optimization Open

Madhulika Jha, Akash Nautiyal, Kumud Pant, Navin Kumar · 2025

Antimicrobial resistance is projected as next pandemic with a propensity of around 10 million deaths per year by 2050. Alternatives of the antibiotic compounds are required to be explored on priority basis to treat viral, bacterial, and fu…

Neglected treasures in the wild: Glycine tomentella and Glycine tabacina: A mini review Open

Akansha Chauhan, Manu Pant, AK Gautam, Anju Rani, Kumud Pant , et al. · 2025

Wild species like Glycine tomentella and Glycine tabacina possess remarkable antioxidant and antidiabetic properties, largely attributed to their abundant sources of bioactive compounds, including flavonoids, isoflavones (genistein and dai…

Neural Network-Driven Discovery of RNA Structures Interacting with Protein Surfaces Open

Saish Naik, D. Komalavalli, Mohammed Ali Sohail, Saddam Husain, Kumud Pant , et al. · 2025

ANRIL's Epigenetic Regulation and Its Implications for Cardiovascular Disorders Open

Ehssan Moglad, Parjinder Kaur, Soumya V. Menon, Abida Khan, Haider Ali , et al. · 2024

Cardiovascular disorders (CVDs) are a major global health concern, but their underlying molecular mechanisms are not fully understood. Recent research highlights the role of long noncoding RNAs (lncRNAs), particularly ANRIL, in cardiovascu…

Evaluation of germination and growth pattern in Glycine max accessions from Garhwal region of Uttarakhand, India Open

Akansha Chauhan, Manu Pant, Arvind Singh Negi, Kumud Pant, Anju Rani · 2024

People in the hilly region are looking at soybean, a highly nutritious crop, as a solution to the problem of malnutrition. The inhabitants of hilly areas of Uttarakhand state in the Indian Himalayan region cultivate the soybean variety 'Bh…

Risk of cognitive decline among patients with dengue virus infection: a systematic review Open

Lakshmi Thangavelu, Siddig İbrahim Abdelwahab, Abdullah Farasani, Suhas Ballal, Pooja Bansal , et al. · 2024

Dengue fever, caused by the dengue virus and transmitted through Aedes mosquitoes, is a growing public health concern, particularly in tropical and subtropical regions. Traditionally associated with febrile and hemorrhagic symptoms, recent…

Exploring ethnic fermented drink ‘Pakhoi’ for its therapeutic properties: An in-silico perspective Open

Shikha Tomar, Shalini Kotnala, Riya, Kuldeep Chauhan, Anmol Sharma , et al. · 2024

The tribes of the Tons Valley in Uttarakhand, India, prepare Pakhoi, a traditional drink, as the subject of the current study. This drink is known to have therapeutic properties and has potential applications in anti-cancer research. The p…

Therapeutic approaches targeting aging and cellular senescence in Huntington's disease Open

Asif Ahmad Bhat, Ehssan Moglad, Muhammad Afzal, Riya Thapa, Waleed Hassan Almalki , et al. · 2024

Huntington's disease (HD) is a devastating neurodegenerative disease that is manifested by a gradual loss of physical, cognitive, and mental abilities. As the disease advances, age has a major impact on the pathogenic signature of mutant h…

Daidzein in traditional Chinese medicine: A deep dive into its Ethnomedicinal and therapeutic applications Open

Neelam Singla, Gaurav Gupta, Rashi Kulshrestha, Komal Sharma, Asif Ahmad Bhat , et al. · 2024

Introduction: Daidzein, a secondary metabolite found in Soybean (Glycine max L.) and Pueraria lobata (Willd.), plays a pivotal role in various therapeutic applications, including its potential as an anticancer agent, particularly in estrog…

Non-coding RNA: A key regulator in the Glutathione-GPX4 pathway of ferroptosis Open

Md Sadique Hussain, Gaurav Gupta, Moyad Shahwan, Pooja Bansal, Harpreet Kaur , et al. · 2024

Ferroptosis, a form of regulated cell death, has emerged as a crucial process in diverse pathophysiological states, encompassing cancer, neurodegenerative ailments, and ischemia-reperfusion injury. The glutathione (GSH)-dependent lipid per…

Autophagy‐associated non‐coding RNAs: Unraveling their impact on Parkinson's disease pathogenesis Open

Md Sadique Hussain, Ehssan Moglad, Muhammad Afzal, Shilpa Sharma, Gaurav Gupta , et al. · 2024

Background Parkinson's disease (PD) is a degenerative neurological condition marked by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta. The precise etiology of PD remains unclear, but emerging evidence sugges…

In silico Targeting of the NACHT/PYD Domain in NLRP3 Inflammasome Using Phytochemical Alkaloids: A Computational Drug Discovery Approach Open

NILAY SINGH, Promila Sharma, Manoj K. Pal, Ragini Kahera, Himani Badoni , et al. · 2024

Background The NLRP3 inflammasome plays a pivotal role in the innate immune system, orchestrating the activation of caspase-1 and the release of proinflammatory cytokines IL-1β and IL-18 in reaction to microbial infections and cellular dam…

Forkhead Box O (FOXO) signaling in NSCLC: pathways to targeted therapies Open

Lakshmi Thangavelu, Terezinha de Jesus Andreoli Pinto, Sachchidanand Pathak, Abhishek Tiwari, Abhishek Tiwari , et al. · 2024

Molecular Marker-Assisted Genetic Diversity Analysis in Soybean Cultivars from the Himalayan Region of Uttarakhand, India Open

Manu Pant, Kumud Pant, Akansha Chauhan, Arvind Negi, Pankaj Nainwal , et al. · 2024

In-Silico Studies Targeting the Drug-Resistant Outer Membrane Proteins of E. Coli with Possible Monoterpenes from Essential Oils Open

Nilay Singh, Promila Sharma, Manoj K. Pal, Ragini Kahera, Himani Badoni , et al. · 2024

Nutraceuticals Play an Emerging Role in SARS CoV2 and Neurological Dysfunction Open

A S Sriranjini, Ashish Thapliyal, Kumud Pant · 2023

The ApoE4 allele is a well-studied genetic risk factor for Alzheimer's disease, a condition with increasing prevalence and no cure. Precision nutrition, which targets metabolic pathways affected by ApoE4, offers a potential tool for diseas…

Development of yeast and microalgae consortium biofilm growth system for biofuel production Open

Bhawna Bisht, Monu Verma, Rohit Sharma, Pankaj Kumar Chauhan, Kumud Pant , et al. · 2023

Microplastic Pollution in Terrestrial Ecosystems and Its Interaction with Other Soil Pollutants: A Potential Threat to Soil Ecosystem Sustainability Open

Meera Rai, Gaurav Pant, Kumud Pant, Becky Nancy Aloo, Gaurav Kumar , et al. · 2023

The production and disposal of plastics have become significant concerns for the sustainability of the planet. During the past 75 years, around 80% of plastic waste has either ended up in landfills or been released into the environment. Pl…

Unravelling the hidden ethnic fermented treasure of the Himalayas - A review on the traditionally fermented beverages of the Northwest Indian Himalayan Region Open

Shikha Tomar, Kumud Pant, Promila Sharma, Somya Sinha, Debasis Mitra · 2023

Consumption of fermented foods has been an integral part of the human food resource since the beginning of civilization. For generations, the practice of preparing fermented food have remained the same with a very little alterations in the…

Identification of RNA Structure Over the Protein Surface Using Neural Network Open

Saish Naik, D. Komalavalli, Mohammed Ali Sohail, S.Syed Husain, Kumud Pant , et al. · 2023

In post-transcriptional control, protein-RNA interactions are crucial.Estimating the relationships from a protein sequence, on the other hand, is challenging.We demonstrate that localized physical properties of proteins sequence surfaces m…

Enabling Artificial Intelligence of Things (AIoT) Healthcare Architectures and Listing Security Issues Open

Anil Audumbar Pise, Khalid K. Almuzaini, Tariq Ahamed Ahanger, Ahmed Farouk, Kumud Pant , et al. · 2022

A significant study has been undertaken in the areas of health care and administration of cutting-edge artificial intelligence (AI) technologies throughout the previous decade. Healthcare professionals studied smart gadgets and other medic…

Deep Neural Networks for Optimal Selection of Features Related to Flu Open

Bingbing Rao, V. N. Lakshmana Kumar, D. Padmapriya, Kumud Pant, B Tejaswini , et al. · 2022

In recent times, humans who have been exposed to influenza A viruses (IAV) may not become hostile. Despite the fact that KLRD1 has been discovered as an influenza susceptibility biomarker, it remains to be seen if pre-exposure host gene ex…

Load balancing technique based on hybrid resource utilization in cloud computing Open

Vishal Awasthi, Ajay Tiwari, V. Jayaram, Surendra Kumar Shukla, Kumud Pant , et al. · 2022

Cloud computing uses the internet to supply dynamic services including memory, data, bandwidth and applications. Work schedules have an influence on cloud service reliability and performance. A proper provisioning method is required for a …

Synthesis, Characterization, and Remedial Action of Biogenic p-Ag Nanoparticles Open

Somya Sinha, Belay Zeleke Sibuh, Abhilasha Mishra, Kumud Pant, Shikha Tomar , et al. · 2022

In the present study, the silver (Ag) nanoparticles (NPs) were fabricated using pakhoi (p), a traditional alcoholic beverage popularly used in the Garhwal region of Uttarakhand that has been known to possess significant antimicrobial activ…

Molecular Docking and TLC Analysis of Candidate Compounds from Lesser used Medicinal Plants Against Diabetes Mellitus Targets Open

Bhavika Batra, Sukhvinder Singh Sudan, Manu Pant, Kumud Pant, Ankita Lal , et al. · 2022

The present work intends to investigate the potential of phytochemicals from less commonly used medicinal plants as possible candidates for Type 2 Diabetes (T2D) treatment using an in silico method.Plant ligands with T2D targets were studi…

Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review Open

Niraj Kumar Jha, Wei‐Chih Chen, Sanjay Kumar, Rajni Dubey, Lung‐Wen Tsai , et al. · 2022

Developmental signalling pathways such as Wnt/β-catenin, Notch and Sonic hedgehog play a central role in nearly all the stages of neuronal development. The term ‘embryonic’ might appear to be a misnomer to several people because these path…

FCN Network‐Based Weed and Crop Segmentation for IoT‐Aided Agriculture Applications Open

Shoaib Kamal, Vaishali Gajendra Shende, Korla Swaroopa, P. Madhavi, P. Saleem Akram , et al. · 2022

The main purpose of the work is to evaluate the deep machine learning algorithms used for the distinction between weeds and crop plants using the open database of images of the carrot garden. Precision farming methods are highly prevalent …

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