Jiankun Cui
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View article: Supplementation of aged garlic extract attenuates age-associated memory impairment and cognitive decline: Involvement of molecular pathways in the cortex and hippocampus
Supplementation of aged garlic extract attenuates age-associated memory impairment and cognitive decline: Involvement of molecular pathways in the cortex and hippocampus Open
The aging of the human population is associated with increases in comorbidities, including functional impairment and cognitive decline. With decreasing numbers of neurons and declining synaptic plasticity, the aging brain exhibits less per…
View article: Comparative Analysis of the Uterine Microbiome in Canine Pyometra: A 16S rRNA Sequencing Study
Comparative Analysis of the Uterine Microbiome in Canine Pyometra: A 16S rRNA Sequencing Study Open
Canine pyometra is a prevalent reproductive disorder predominantly affecting older, nulliparous bitches, with peak incidence during the diestrus phase. This condition is frequently complicated by systemic infections and carries high mortal…
View article: Effect of Maternal Dietary DHA and Prenatal Stress Mouse Model on Autistic-like Behaviors, Lipid Peroxidation Activity, and GABA Expression in Offspring Pups
Effect of Maternal Dietary DHA and Prenatal Stress Mouse Model on Autistic-like Behaviors, Lipid Peroxidation Activity, and GABA Expression in Offspring Pups Open
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restricted social communication and repetitive behaviors. Prenatal stress is critical in neurodevelopment and increases risk for ASD, particularly in those wi…
View article: Preparation of two kinds of immunocastration vaccines and their immune effects on male goats
Preparation of two kinds of immunocastration vaccines and their immune effects on male goats Open
Objective: Post-pubertal male goats exhibit undesirable behaviors (fighting, mounting) and reduced growth due to high testosterone, while traditional castration causes stress. Immunocastration offers a humane alternative. This study aimed …
View article: UTE MRI for assessing demyelination in an mTBI mouse model: An open-field low-intensity blast study
UTE MRI for assessing demyelination in an mTBI mouse model: An open-field low-intensity blast study Open
Mild traumatic brain injury (mTBI) is a leading cause of long-term disability. Following mTBI, secondary chemical cascades and neuroinflammation can result in myelin damage, significantly impairing cognitive function. This study aims to as…
View article: Transcriptome and DNA methylation analysis of the goat pineal gland during puberty
Transcriptome and DNA methylation analysis of the goat pineal gland during puberty Open
Previous studies have confirmed that methylation regulates gene transcription in the hypothalamus-pituitary-gonadal axis during puberty initiation, but little is known about the regulation of DNA methylation on gene expression in the pinea…
View article: Myelin Quantification Using Ultrashort Echo Time Magnetization Transfer Ratio in a Mouse Model of Traumatic Brain Injury
Myelin Quantification Using Ultrashort Echo Time Magnetization Transfer Ratio in a Mouse Model of Traumatic Brain Injury Open
Background and Purpose This study aims to assess the potential of ultrashort echo time imaging‐based magnetization transfer ratio (UTE‐MTR) in detecting demyelination in mice with mild traumatic brain injury (mTBI) caused by an open‐field …
View article: The effects of mild traumatic brain injury induced by a low‐intensity blast exposure on phosphoproteome networks and cognitive function influenced by mutant tau overexpression
The effects of mild traumatic brain injury induced by a low‐intensity blast exposure on phosphoproteome networks and cognitive function influenced by mutant tau overexpression Open
Background This study was to elucidate the impact of blast‐induced neurotrauma (BINT) on phosphoproteome networks and cognition in a genetically heterogeneous population of mice (rTg4510) with the human tau P301L mutation linked to Alzheim…
View article: Fecal microbiome transplantation from stroke donors promotes Alzheimer’s disease brain pathology and hypoperfusion in the 3xTg‐AD mice
Fecal microbiome transplantation from stroke donors promotes Alzheimer’s disease brain pathology and hypoperfusion in the 3xTg‐AD mice Open
Background The link between stroke and Alzheimer’s disease (AD) is recognized. However, the underlying mechanisms are not yet clear. This study seeks to determine if increased AD risk is linked to gut dysbiosis caused by acute ischemic str…
View article: Low-Intensity Blast Exposure Induces Multifaceted Long-Lasting Anxiety-Related Behaviors in Mice
Low-Intensity Blast Exposure Induces Multifaceted Long-Lasting Anxiety-Related Behaviors in Mice Open
Primary blast exposure is a predominant cause of mild traumatic brain injury (mTBI) among veterans and active-duty military personnel, and affected individuals may develop long-lasting behavioral disturbances that interfere with quality of…
View article: Transcriptome and DNA Methylation Analysis of the Goat Pineal Gland During Puberty
Transcriptome and DNA Methylation Analysis of the Goat Pineal Gland During Puberty Open
Epigenetic regulation of gene transcription may play a critical role in the onset of puberty. Previous studies have confirmed that methylation regulates gene transcription in the hypothalamus-pituitary-gonadal axis during puberty initiatio…
View article: Gut microbiota: a potential influencer of insomnia occurring after COVID-19 infection
Gut microbiota: a potential influencer of insomnia occurring after COVID-19 infection Open
The prevalence of insomnia has increased in recent years, significantly affecting the lives of many individuals. Coronavirus disease 2019 (COVID-19) infection has been found to have a substantial impact on the human gut microbiota (GM). Cl…
View article: Individualized high-resolution analysis to categorize diverse learning and memory deficits in tau rTg4510 mice exposed to low-intensity blast
Individualized high-resolution analysis to categorize diverse learning and memory deficits in tau rTg4510 mice exposed to low-intensity blast Open
Mild traumatic brain injury (mTBI) resulting from low-intensity blast (LIB) exposure in military and civilian individuals is linked to enduring behavioral and cognitive abnormalities. These injuries can serve as confounding risk factors fo…
View article: Full color control and patterned display device from cyan/magenta/yellow water-dispersed electrochromic polymer nanoparticles systems
Full color control and patterned display device from cyan/magenta/yellow water-dispersed electrochromic polymer nanoparticles systems Open
Electrochromic polymers (ECPs) have great application potential in flexible displays, and there is an increasing expectation of using green methods to form ECP films. Herein, we propose a modified microemulsion method to prepare cyan/magen…
View article: Effects of Vaccination against Recombinant FSH or LH Receptor Subunits on Gonadal Development and Functioning Male Rats
Effects of Vaccination against Recombinant FSH or LH Receptor Subunits on Gonadal Development and Functioning Male Rats Open
Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) play key roles in regulating testosterone secretion and spermatogenesis in male mammals, respectively, and they maintain the fertility of male animals by binding to their corr…
View article: The Chronic Effects of a Single Low-Intensity Blast Exposure on Phosphoproteome Networks and Cognitive Function Influenced by Mutant Tau Overexpression
The Chronic Effects of a Single Low-Intensity Blast Exposure on Phosphoproteome Networks and Cognitive Function Influenced by Mutant Tau Overexpression Open
Blast-induced neurotrauma (BINT) is a pressing concern for veterans and civilians exposed to explosive devices. Affected personnel may have increased risk for long-term cognitive decline and developing tauopathies including Alzheimer’s dis…
View article: Ezrin Thr567 phosphorylation participates in mouse oocyte maturation, fertilization, and early embryonic development
Ezrin Thr567 phosphorylation participates in mouse oocyte maturation, fertilization, and early embryonic development Open
Background Ezrin is a membrane-cytoskeleton linker, involved in cell polarization, cell migration, cell division, signal transduction and some other cellular activities that play an important role in oocyte maturation, fertilization and ea…
View article: Low-intensity open-field blast exposure effects on neurovascular unit ultrastructure in mice
Low-intensity open-field blast exposure effects on neurovascular unit ultrastructure in mice Open
View article: Gelatin Zymography Can Be Performed on Fixed Brain Tissue
Gelatin Zymography Can Be Performed on Fixed Brain Tissue Open
Gelatin zymography is widely used to detect gelatinase activity, which is performed on unfixed tissue because it is assumed that fixation inactivates enzymes. However, using fixed tissues has several advantages over using fresh tissues for…
View article: Hydrogen‐Bonding Induced Crosslinked Polymer Network for Highly Stable Electrochromic Device and a Construction Strategy for Black‐Bilayer Electrochromic Film
Hydrogen‐Bonding Induced Crosslinked Polymer Network for Highly Stable Electrochromic Device and a Construction Strategy for Black‐Bilayer Electrochromic Film Open
This work presents a new strategy to achieve highly stable electrochromic devices and bilayer film construction. A novel solution‐processable electrochromic polymer P1‐Boc with quinacridone as the conjugated backbone and t‐Boc as N‐substit…
View article: Ezrin Thr567 Phosphorylation Participates in Mouse Oocyte Maturation, Fertilization, and Early Embryonic Development
Ezrin Thr567 Phosphorylation Participates in Mouse Oocyte Maturation, Fertilization, and Early Embryonic Development Open
View article: Low-intensity blast induces acute glutamatergic hyperexcitability in mouse hippocampus leading to long-term learning deficits and altered expression of proteins involved in synaptic plasticity and serine protease inhibitors
Low-intensity blast induces acute glutamatergic hyperexcitability in mouse hippocampus leading to long-term learning deficits and altered expression of proteins involved in synaptic plasticity and serine protease inhibitors Open
Neurocognitive consequences of blast-induced traumatic brain injury (bTBI) pose significant concerns for military service members and veterans with the majority of "invisible injury." However, the underlying mechanism of such mild bTBI by …
View article: Perspectives on Primary Blast Injury of the Brain: Translational Insights Into Non-inertial Low-Intensity Blast Injury
Perspectives on Primary Blast Injury of the Brain: Translational Insights Into Non-inertial Low-Intensity Blast Injury Open
Most traumatic brain injuries (TBIs) during military deployment or training are clinically “mild” and frequently caused by non-impact blast exposures. Experimental models were developed to reproduce the biological consequences of high-inte…
View article: Long-Term Effects of Low-Intensity Blast Non-Inertial Brain Injury on Anxiety-Like Behaviors in Mice: Home-Cage Monitoring Assessments
Long-Term Effects of Low-Intensity Blast Non-Inertial Brain Injury on Anxiety-Like Behaviors in Mice: Home-Cage Monitoring Assessments Open
Mild traumatic brain injury induced by low-intensity blast (LIB) exposure poses concerns in military personnel. Using an open-field, non-inertial blast model and assessments by conventional behavioral tests, our previous studies revealed e…
View article: Laser shock composite microforming of Fe-based amorphous alloys
Laser shock composite microforming of Fe-based amorphous alloys Open
To address the shortcomings of Fe-based amorphous alloys that are difficult to plastically form at room temperature, this study used high strain rate laser instead of traditional loading methods to conduct composite microforming of drawing…
View article: Shock Wave Physics as Related to Primary Non-Impact Blast-Induced Traumatic Brain Injury
Shock Wave Physics as Related to Primary Non-Impact Blast-Induced Traumatic Brain Injury Open
Introduction Blast overpressure exposure, an important cause of traumatic brain injury (TBI), may occur during combat or military training. TBI, most commonly mild TBI, is considered a signature injury of recent combat in Iraq and Afghanis…
View article: Docosahexaenoic Acid (DHA) Supplementation Alters Phospholipid Species and Lipid Peroxidation Products in Adult Mouse Brain, Heart, and Plasma
Docosahexaenoic Acid (DHA) Supplementation Alters Phospholipid Species and Lipid Peroxidation Products in Adult Mouse Brain, Heart, and Plasma Open
View article: An Elastic Transmission Error Compensation Method for Rotary Vector Speed Reducers Based on Error Sensitivity Analysis
An Elastic Transmission Error Compensation Method for Rotary Vector Speed Reducers Based on Error Sensitivity Analysis Open
An elastic transmission error (TE) compensation method for a rotary vector (RV) speed reducer is proposed to improve its transmission accuracy based on error sensitivity analysis. Elastic and geometric TEs of the RV speed reducer can be co…
View article: Bioactive components from garlic on brain resiliency against neuroinflammation and neurodegeneration (Review)
Bioactive components from garlic on brain resiliency against neuroinflammation and neurodegeneration (Review) Open
Garlic (Allium sativum) has been widely used for culinary and medicinal purposes. Aged garlic extract (AGE) and sulfur-containing compounds, including S-allylcysteine (SAC) are well documented botanical active components of garlic. …
View article: Maternal Dietary Docosahexaenoic Acid Alters Lipid Peroxidation Products and (n-3)/(n-6) Fatty Acid Balance in Offspring Mice
Maternal Dietary Docosahexaenoic Acid Alters Lipid Peroxidation Products and (n-3)/(n-6) Fatty Acid Balance in Offspring Mice Open
The abundance of docosahexaenoic acid (DHA) in the mammalian brain has generated substantial interest in the search for its roles in regulating brain functions. Our recent study with a gene/stress mouse model provided evidence to support t…