Kunlun Huang
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View article: Longitudinal multi-omics decipher chlorinated paraffin 52 disruption of gut-brain axis homeostasis in HFD-fed mice
Longitudinal multi-omics decipher chlorinated paraffin 52 disruption of gut-brain axis homeostasis in HFD-fed mice Open
The global rise in metabolic diseases linked to high-fat diet (HFD) patterns has coincided with the emergence of chlorinated paraffins (CPs) as persistent, toxic environmental contaminants detected across food systems, raising dual concern…
View article: Thermal drying synthesized density-tunable and high stability nonthiolated spherical nucleic acids for split aptamer and lateral flow biosensors
Thermal drying synthesized density-tunable and high stability nonthiolated spherical nucleic acids for split aptamer and lateral flow biosensors Open
Spherical nucleic acids (SNAs) have attracted considerable interest in designing biosensors. Our group recently developed a thermal drying method to fabricate SNAs with an ultrahigh density of cost-effective nonthiolated DNA containing a p…
View article: Multi-target regulation by artemether in MAFLD through EGFR/HSP90 pathways
Multi-target regulation by artemether in MAFLD through EGFR/HSP90 pathways Open
These findings identify EGFR as a key target of Art, modulated directly or via HSP90, thereby offering new insights into Art's multi-target therapeutic mechanism in MAFLD.
View article: Regulation of Notch signaling by miR-79 in Drosophila eye development
Regulation of Notch signaling by miR-79 in Drosophila eye development Open
The Notch signaling pathway is crucial for cell fate determination and tissue morphogenesis. In Drosophila, Notch signaling regulates eye size, but the mechanisms that fine-tune its activity during eye development remain unclear. Here, we …
View article: Elucidating the ozone formation and transport mechanism in the Pearl River Delta against the backdrop of heatwave
Elucidating the ozone formation and transport mechanism in the Pearl River Delta against the backdrop of heatwave Open
Ozone plays a crucial role in shaping atmospheric environments, and understanding its vertical distribution is essential for deciphering its formation and transport mechanisms. This study integrates ozone lidar observations, WRF-Chem model…
View article: Streptococcus salivarius subsp. thermophilus ST-G30 Prevents Dexamethasone-Induced Muscle Atrophy in C2C12 Myotubes
Streptococcus salivarius subsp. thermophilus ST-G30 Prevents Dexamethasone-Induced Muscle Atrophy in C2C12 Myotubes Open
Background/Objectives: Sarcopenia is characterized by loss of muscle mass and strength and is associated with aging. Recently, its links with the gut–muscle axis have been reported, suggesting that probiotics could influence muscle health.…
View article: Pre-Administration of Saccharomyces boulardii-Derived Postbiotics Effectively Prevents Dextran Sulfate Sodium-Induced Colitis in Mice
Pre-Administration of Saccharomyces boulardii-Derived Postbiotics Effectively Prevents Dextran Sulfate Sodium-Induced Colitis in Mice Open
Ulcerative colitis (UC) is effectively alleviated by Saccharomyces boulardii (S. boulardii), an important probiotic. Postbiotics, defined as beneficial non-viable microorganisms and/or their components, can potentially improve gut health. …
View article: <i>Allobaculum</i> plays a predominant role in the activation of brown fat tissue by diallyl trisulfide
<i>Allobaculum</i> plays a predominant role in the activation of brown fat tissue by diallyl trisulfide Open
Diallyl trisulfide (DATS) is a bioactive compound in garlic. It has been reported to ameliorate obesity by preventing adipogenesis and lipogenesis in white adipose tissue. But we found DATS could also activate brown adipose tissue (BAT) in…
View article: Integrating 16S rRNA Gene Sequencing and Metabolomics Analysis to Reveal the Mechanism of L-Proline in Preventing Autism-like Behavior in Mice
Integrating 16S rRNA Gene Sequencing and Metabolomics Analysis to Reveal the Mechanism of L-Proline in Preventing Autism-like Behavior in Mice Open
Background/Objectives: Autism spectrum disorder (ASD) is characterized by impaired social interaction and repetitive stereotyped behavior. Effective interventions for the core autistic symptoms are currently limited. Methods: This study em…
View article: Effects and mechanisms of phytochemicals on skeletal muscle atrophy in glucolipid metabolic disorders: current evidence and future perspectives
Effects and mechanisms of phytochemicals on skeletal muscle atrophy in glucolipid metabolic disorders: current evidence and future perspectives Open
Skeletal muscle atrophy resulting from glucolipid metabolic disorders poses a serious challenge to human health with the rapidly increasing prevalence of diabetes and obesity. Clinical trials investigating treatment interventions against s…
View article: Zearalenone exacerbates lipid metabolism disorders by promoting liver lipid droplet formation and disrupting gut microbiota
Zearalenone exacerbates lipid metabolism disorders by promoting liver lipid droplet formation and disrupting gut microbiota Open
Zearalenone (ZEA), produced by Fusarium, is a fungal toxin commonly found in maize, wheat, and other cereals. ZEA has the ability to bind to estrogen receptors of humans and animals and is an environmental endocrine disruptor that may inte…
View article: Srgan-Sa: Super-Resolution Generative Adversarial Network with Integrated Attention Mechanisms
Srgan-Sa: Super-Resolution Generative Adversarial Network with Integrated Attention Mechanisms Open
With the development of the times, this paper proposes a dynamic spatial attention enhancement SRGAN-SA model to better solve the above problems, such as the loss of high-frequency details in traditional image super-resolution reconstructi…
View article: Targeting Odorant Receptors in Adipose Tissue with Food-Derived Odorants: A Novel Approach to Obesity Treatment
Targeting Odorant Receptors in Adipose Tissue with Food-Derived Odorants: A Novel Approach to Obesity Treatment Open
Odorant receptors (ORs) have long been thought to serve as chemosensors located on the cilia of olfactory sensory neurons (OSNs) in the olfactory epithelium, where they recognize odorant molecules and comprise the largest family of seven t…
View article: Functions of immunologically active peptides and their roles in intestinal inflammation
Functions of immunologically active peptides and their roles in intestinal inflammation Open
Immunologically active peptides are a class of peptides with immune functions such as enhancing body immunity, regulating cell growth and differentiation, migration, chemotaxis, neurotransmission, and inducing apoptosis of tumor cells. The…
View article: Single-Atom Ce-N-C Nanozyme Ameliorates Type 2 Diabetes Mellitus by Improving Glucose Metabolism Disorders and Reducing Oxidative Stress
Single-Atom Ce-N-C Nanozyme Ameliorates Type 2 Diabetes Mellitus by Improving Glucose Metabolism Disorders and Reducing Oxidative Stress Open
Type 2 diabetes mellitus (T2DM) as a chronic metabolic disease has become a global public health problem. Insulin resistance (IR) is the main pathogenesis of T2DM. Oxidative stress refers to an imbalance between free radical production and…
View article: Multi-omics analysis of Au@Pt nanozyme for the modulation of glucose and lipid metabolism
Multi-omics analysis of Au@Pt nanozyme for the modulation of glucose and lipid metabolism Open
Au@Pt nanozyme, a bimetallic core-shell structure Au and Pt nanoparticle, has attracted significant attention due to its excellent catalytic activity and stability. Here, we propose that Au@Pt improves glucose tolerance and reduces TG afte…
View article: Rapid Thermal Drying Synthesis of Nonthiolated Spherical Nucleic Acids with Stability Rivaling Thiolated DNA
Rapid Thermal Drying Synthesis of Nonthiolated Spherical Nucleic Acids with Stability Rivaling Thiolated DNA Open
Attaching DNA oligonucleotides to gold nanoparticles (AuNPs) to prepare spherical nucleic acids (SNAs) has offered tremendous insights into surface chemistry with resulting bioconjugates serving as critical reagents in biosensors and nanot…
View article: Rapid Thermal Drying Synthesis of Nonthiolated Spherical Nucleic Acids with Stability Rivaling Thiolated DNA
Rapid Thermal Drying Synthesis of Nonthiolated Spherical Nucleic Acids with Stability Rivaling Thiolated DNA Open
Attaching DNA oligonucleotides to gold nanoparticles (AuNPs) to prepare spherical nucleic acids (SNAs) has offered tremendous insights into surface chemistry with resulting bioconjugates serving as critical reagents in biosensors and nanot…
View article: Unveiling the Nutritional Veil of Sulforaphane: With a Major Focus on Glucose Homeostasis Modulation
Unveiling the Nutritional Veil of Sulforaphane: With a Major Focus on Glucose Homeostasis Modulation Open
Abnormal glucose homeostasis is associated with metabolic syndromes including cardiovascular diseases, hypertension, type 2 diabetes mellitus, and obesity, highlighting the significance of maintaining a balanced glucose level for optimal b…
View article: Exosomes as mediators of signal transmitters in biotoxins toxicity: a comprehensive review
Exosomes as mediators of signal transmitters in biotoxins toxicity: a comprehensive review Open
Small membranes known as exosomes surround them and are released by several cell types both in vitro and in vivo . These membranes are packed with a variety of biomolecules, including proteins, lipids, deoxyribonucleic acid (DNA), ribonucl…
View article: Oleuropein Supplementation Ameliorates Long-Course Diabetic Nephropathy and Diabetic Cardiomyopathy Induced by Advanced Stage of Type 2 Diabetes in db/db Mice
Oleuropein Supplementation Ameliorates Long-Course Diabetic Nephropathy and Diabetic Cardiomyopathy Induced by Advanced Stage of Type 2 Diabetes in db/db Mice Open
Previous studies have reported the therapeutic effects of oleuropein (OP) consumption on the early stage of diabetic nephropathy and diabetic cardiomyopathy. However, the efficacy of OP on the long-course of these diabetes complications ha…
View article: Coreopsis tinctoria improves energy metabolism in obese hyperglycemic mice
Coreopsis tinctoria improves energy metabolism in obese hyperglycemic mice Open
Coreopsis tinctoria (CT) improves energy metabolism. However, the role of CT in alleviating obesity-induced hyperglycemia by targeting the liver remains unknown. Therefore, this article aims to explore the mechanism by which CT improves en…