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View article: Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function
Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function Open
Polymer conjugation is applied to drugs, peptides, and proteins to enhance stability and impart functionalities. In the case of antibodies, polymers are often used as spacers or linkers in antibody‐drug conjugates to mitigate excessive hyd…
View article: Photoimmuno‐Lure Nanoplatform for Enhancing T Cell Expansion in Glioblastoma via Synergistic Treatment of Photodynamic Therapy and Immune Checkpoint Inhibition
Photoimmuno‐Lure Nanoplatform for Enhancing T Cell Expansion in Glioblastoma via Synergistic Treatment of Photodynamic Therapy and Immune Checkpoint Inhibition Open
The immunosuppressive tumor microenvironment (TME) of glioblastoma (GBM) limits the efficacy of immune checkpoint inhibitors (ICI), primarily due to the absence of cytotoxic T (T c ) cells. In this study, a photoimmuno‐lure nanoplatform is…
View article: Photo-responsive self-expanding catheter with photosensitizer-integrated silicone-covered membrane for minimally invasive local therapy in malignant esophageal cancer
Photo-responsive self-expanding catheter with photosensitizer-integrated silicone-covered membrane for minimally invasive local therapy in malignant esophageal cancer Open
Photodynamic therapy (PDT) using photosensitizer (PS)-integrated covered self-expandable metallic stents (SEMS) is proposed a new therapeutic approach for the treatment of palliative malignancies; however, the currently hydrophobic PS redu…
View article: Repeatable Photoactive Stent-Based Catheter to Enhance Therapeutic Efficacy for Esophageal Carcinoma
Repeatable Photoactive Stent-Based Catheter to Enhance Therapeutic Efficacy for Esophageal Carcinoma Open
Localized photodynamic therapy (PDT) using a photoactive stent-based catheter involves the direct delivery of reactive oxygen species to the mucosa in esophageal carcinoma; however, the damaged mucosa recovers within 2 to 4 weeks, which co…
View article: Endoluminal photodynamic therapy with a photoreactive stent‐based catheter system to treat malignant colorectal obstruction
Endoluminal photodynamic therapy with a photoreactive stent‐based catheter system to treat malignant colorectal obstruction Open
Photodynamic therapy (PDT) using photosensitizer (PS)‐embedded silicone membrane‐covered self‐expandable metallic stents (SEMSs) can function in palliative therapeutic option for malignant gastrointestinal tract obstruction. However, stent…
View article: Identification of hub modules and therapeutic targets associated with CD8+T-cells in HF and their pan-cancer analysis
Identification of hub modules and therapeutic targets associated with CD8+T-cells in HF and their pan-cancer analysis Open
Heart failure (HF) is a terminal condition of multiple cardiovascular disorders. Cancer is a deadly disease worldwide. The relationship between HF and cancer remains poorly understood. The Gene Expression Omnibus database was used to downl…
View article: Highly functional duodenal stent with photosensitizers enables photodynamic therapy for metabolic syndrome treatment: Feasibility and safety study in a porcine model
Highly functional duodenal stent with photosensitizers enables photodynamic therapy for metabolic syndrome treatment: Feasibility and safety study in a porcine model Open
Duodenal mucosal resurfacing (DMR) by thermal ablation of the duodenal mucosa is a minimally invasive endoscopic procedure for controlling metabolic syndrome (MS). However, thermal energy can cause adverse effects due to deep mucosal injur…
View article: Potential therapeutic targets for COVID-19 complicated with pulmonary hypertension: a bioinformatics and early validation study
Potential therapeutic targets for COVID-19 complicated with pulmonary hypertension: a bioinformatics and early validation study Open
Coronavirus disease (COVID-19) and pulmonary hypertension (PH) are closely correlated. However, the mechanism is still poorly understood. In this article, we analyzed the molecular action network driving the emergence of this event. Two da…
View article: Exploring the link between heart failure and cancer: insights into immune mechanisms and therapeutic targets for CD8 + T-cells
Exploring the link between heart failure and cancer: insights into immune mechanisms and therapeutic targets for CD8 + T-cells Open
Background Heart failure (HF) is a terminal condition of multiple cardiovascular disorders. Cancer is a highly prevalent and deadly disease worldwide. However, the relationship between HF and cancer remains poorly understood. Therefore, th…
View article: Human Adipose-Derived Stem Cells Genetically Programmed to Induce Necroptosis for Cancer Immunotherapy
Human Adipose-Derived Stem Cells Genetically Programmed to Induce Necroptosis for Cancer Immunotherapy Open
Herein, we present human adipose-derived stem cells (ADSCs) inserted with the receptor-interacting protein kinase-3 (RIP3) gene (RP@ADSCs), which induces cell necroptosis for tumor immunotherapy. Necroptosis has characteristics of both apo…
View article: Potential therapeutic targets for COVID-19 complicated with pulmonary hypertension: a bioinformatics and early validation study
Potential therapeutic targets for COVID-19 complicated with pulmonary hypertension: a bioinformatics and early validation study Open
coronavirus disease(COVID-19)and pulmonary hypertension(PH)are closely correlated. However, the mechanism is still poorly understood.In this article, we analyzed the molecular action network driving the emergence of this event.Two datasets…
View article: Synergistic Approach of Antibody‐Photosensitizer Conjugate Independent of KRAS‐Mutation and Its Downstream Blockade Pathway in Colorectal Cancer
Synergistic Approach of Antibody‐Photosensitizer Conjugate Independent of KRAS‐Mutation and Its Downstream Blockade Pathway in Colorectal Cancer Open
Here, a novel approach is presented to improve the efficacy of antibody‐drug conjugates (ADC) by integrating antibody‐mediated immunotherapy and photodynamic therapy (PDT) in a combination therapy system utilizing an antibody‐photosensitiz…
View article: Bioinformatics analyses of potentially common pathogenic networks for primary Sjogren’s syndrome complicated with acute myocardial infarction
Bioinformatics analyses of potentially common pathogenic networks for primary Sjogren’s syndrome complicated with acute myocardial infarction Open
Both primary Sjogren’s syndrome (pSS) and acute myocardial infarction (AMI) are intricately linked to one another. However, their common mechanism is not fully understood. Herein, we examined the underlying network of molecular action asso…
View article: Data from Photodynamic Therapy Using Photosensitizer-Encapsulated Polymeric Nanoparticle to Overcome ATP-Binding Cassette Transporter Subfamily G2 Function in Pancreatic Cancer
Data from Photodynamic Therapy Using Photosensitizer-Encapsulated Polymeric Nanoparticle to Overcome ATP-Binding Cassette Transporter Subfamily G2 Function in Pancreatic Cancer Open
Chlorin-based photosensitizers are commonly used in photodynamic therapy (PDT). These drugs are effluxed by cell membrane transporters, such as the ATP-binding cassette subfamily G member 2 (ABCG2). PDT efficacy is limited in tumor cells e…
View article: Supplementary Figure 1 from Photodynamic Therapy Using Photosensitizer-Encapsulated Polymeric Nanoparticle to Overcome ATP-Binding Cassette Transporter Subfamily G2 Function in Pancreatic Cancer
Supplementary Figure 1 from Photodynamic Therapy Using Photosensitizer-Encapsulated Polymeric Nanoparticle to Overcome ATP-Binding Cassette Transporter Subfamily G2 Function in Pancreatic Cancer Open
Structure of Chlorin e6 (A) and Photosensitizer-encapsulated Polymeric Nanoparticle (B).
View article: Data from Photodynamic Therapy Using Photosensitizer-Encapsulated Polymeric Nanoparticle to Overcome ATP-Binding Cassette Transporter Subfamily G2 Function in Pancreatic Cancer
Data from Photodynamic Therapy Using Photosensitizer-Encapsulated Polymeric Nanoparticle to Overcome ATP-Binding Cassette Transporter Subfamily G2 Function in Pancreatic Cancer Open
Chlorin-based photosensitizers are commonly used in photodynamic therapy (PDT). These drugs are effluxed by cell membrane transporters, such as the ATP-binding cassette subfamily G member 2 (ABCG2). PDT efficacy is limited in tumor cells e…
View article: Supplementary Figure Legends from Photodynamic Therapy Using Photosensitizer-Encapsulated Polymeric Nanoparticle to Overcome ATP-Binding Cassette Transporter Subfamily G2 Function in Pancreatic Cancer
Supplementary Figure Legends from Photodynamic Therapy Using Photosensitizer-Encapsulated Polymeric Nanoparticle to Overcome ATP-Binding Cassette Transporter Subfamily G2 Function in Pancreatic Cancer Open
Supplementary Figure Legends
View article: Supplementary Figure 2 from Photodynamic Therapy Using Photosensitizer-Encapsulated Polymeric Nanoparticle to Overcome ATP-Binding Cassette Transporter Subfamily G2 Function in Pancreatic Cancer
Supplementary Figure 2 from Photodynamic Therapy Using Photosensitizer-Encapsulated Polymeric Nanoparticle to Overcome ATP-Binding Cassette Transporter Subfamily G2 Function in Pancreatic Cancer Open
Characterization of the photosensitizers: A) The size distribution of PS-pNP was 40 nm and zeta-potential 35 mV. B) The fluorescence emission spectra of Ce6 and PS-pNP in DMSO (1µM). C) 1H-NMR analysis of mPEG3-bPEI1-Ce61 (PS-pNP) in DMSO…
View article: Supplementary Figure 2 from Photodynamic Therapy Using Photosensitizer-Encapsulated Polymeric Nanoparticle to Overcome ATP-Binding Cassette Transporter Subfamily G2 Function in Pancreatic Cancer
Supplementary Figure 2 from Photodynamic Therapy Using Photosensitizer-Encapsulated Polymeric Nanoparticle to Overcome ATP-Binding Cassette Transporter Subfamily G2 Function in Pancreatic Cancer Open
Characterization of the photosensitizers: A) The size distribution of PS-pNP was 40 nm and zeta-potential 35 mV. B) The fluorescence emission spectra of Ce6 and PS-pNP in DMSO (1µM). C) 1H-NMR analysis of mPEG3-bPEI1-Ce61 (PS-pNP) in DMSO…
View article: Supplementary Figure 1 from Photodynamic Therapy Using Photosensitizer-Encapsulated Polymeric Nanoparticle to Overcome ATP-Binding Cassette Transporter Subfamily G2 Function in Pancreatic Cancer
Supplementary Figure 1 from Photodynamic Therapy Using Photosensitizer-Encapsulated Polymeric Nanoparticle to Overcome ATP-Binding Cassette Transporter Subfamily G2 Function in Pancreatic Cancer Open
Structure of Chlorin e6 (A) and Photosensitizer-encapsulated Polymeric Nanoparticle (B).
View article: Supplementary Figure Legends from Photodynamic Therapy Using Photosensitizer-Encapsulated Polymeric Nanoparticle to Overcome ATP-Binding Cassette Transporter Subfamily G2 Function in Pancreatic Cancer
Supplementary Figure Legends from Photodynamic Therapy Using Photosensitizer-Encapsulated Polymeric Nanoparticle to Overcome ATP-Binding Cassette Transporter Subfamily G2 Function in Pancreatic Cancer Open
Supplementary Figure Legends
View article: Loranthus tanakae Franch. & Sav. Suppresses Inflammatory Response in Cigarette Smoke Condensate Exposed Bronchial Epithelial Cells and Mice
Loranthus tanakae Franch. & Sav. Suppresses Inflammatory Response in Cigarette Smoke Condensate Exposed Bronchial Epithelial Cells and Mice Open
Loranthus tanakae Franch. & Sav. found in China, Japan, and Korea is traditionally used for managing arthritis and respiratory diseases. In this study, we analyzed the components of L. tanakae 70% ethanol extract (LTE) and investigated the…
View article: Ovalbumin and Poly(i:c) Encapsulated Dendritic Cell‐Targeted Nanoparticles for Immune Activation in the Small Intestinal Lymphatic System
Ovalbumin and Poly(i:c) Encapsulated Dendritic Cell‐Targeted Nanoparticles for Immune Activation in the Small Intestinal Lymphatic System Open
Here, antigen and adjuvant encapsulated dendritic cell‐targeted nanoparticles for immune activation in the small intestinal lymphatic system to inhibit melanoma development are described. This strategy is demonstrated using chondroitin sul…
View article: Biocompatible carbonized iodine-doped dots for contrast-enhanced CT imaging
Biocompatible carbonized iodine-doped dots for contrast-enhanced CT imaging Open
Background Computed tomography (CT) imaging has been widely used for the diagnosis and surveillance of diseases. Although CT is attracting attention due to its reasonable price, short scan time, and excellent diagnostic ability, there are …
View article: Solubilized chlorin e6-layered double hydroxide complex for anticancer photodynamic therapy
Solubilized chlorin e6-layered double hydroxide complex for anticancer photodynamic therapy Open
Background Layered double hydroxides (LDHs) are one type of 2-dimensional material with unique structure and strongly positive surface charge. Particularly, LDHs can be exfoliated by mono-layered double hydroxides (MLHs) as a single layer,…
View article: Hemagglutinin Nanoparticulate Vaccine with Controlled Photochemical Immunomodulation for Pathogenic Influenza‐Specific Immunity
Hemagglutinin Nanoparticulate Vaccine with Controlled Photochemical Immunomodulation for Pathogenic Influenza‐Specific Immunity Open
Recently, viral infectious diseases, including COVID‐19 and Influenza, are the subjects of major concerns worldwide. One strategy for addressing these concerns focuses on nasal vaccines, which have great potential for achieving successful …
View article: ι-Carrageenan nanocomposites for enhanced stability and oral bioavailability of curcumin
ι-Carrageenan nanocomposites for enhanced stability and oral bioavailability of curcumin Open
Background Carrageenan (CRN), a polygalactan consisting of 15 to 40% ester sulfate, is used in oral controlled-release technology due to its viscosity and large molecular weight. Curcumin (Cur) is a highly potent antioxidant and anti-infla…