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View article: Study on Carboxymethylation Modification of Konjac Gum and Its Effect in Drilling Fluid and Fracturing Fluid
Study on Carboxymethylation Modification of Konjac Gum and Its Effect in Drilling Fluid and Fracturing Fluid Open
With the continuous progress and innovation of petroleum engineering technology, the development of new oilfield additives with superior environmental benefits has attracted widespread attention. Konjac glucomannan (KGM) is a natural resou…
View article: Spatial Transcriptomics of Human Decidua Identifies Molecular Signatures in Recurrent Pregnancy Loss
Spatial Transcriptomics of Human Decidua Identifies Molecular Signatures in Recurrent Pregnancy Loss Open
The human decidua establishes immune tolerance at the maternal–fetal interface and is essential for successful embryo implantation and development. Here, we conducted a spatial transcriptomic analysis of human decidua from early pregnancie…
View article: Landscape of extrachromosomal DNA characteristics in high-grade serous ovarian cancer via long-read sequencing
Landscape of extrachromosomal DNA characteristics in high-grade serous ovarian cancer via long-read sequencing Open
The non-Mendelian inheritance of extrachromosomal DNA (ecDNA) exacerbates tumor genomic heterogeneity and evolution. Due to short-read sequencing's reconstruction deficiencies, ecDNA abundance in clinical tumor tissues requires further est…
View article: High-Quality Cell Capture Reveals Transcriptomic Changes After Single-Axon Injury of Mauthner Cells
High-Quality Cell Capture Reveals Transcriptomic Changes After Single-Axon Injury of Mauthner Cells Open
In vivo single-cell capture methods based on micropipettes are essential for correlating morphological characteristics with transcriptomic profiling under physiological conditions. However, they often suffer from significant contamination …
View article: Comparative analysis of methodologies for detecting extrachromosomal circular DNA
Comparative analysis of methodologies for detecting extrachromosomal circular DNA Open
Extrachromosomal circular DNA (eccDNA) is crucial in oncogene amplification, gene transcription regulation, and intratumor heterogeneity. While various analysis pipelines and experimental methods have been developed for eccDNA identificati…
View article: Alternative mRNA splicing events and regulators in epidermal differentiation
Alternative mRNA splicing events and regulators in epidermal differentiation Open
Alternative splicing (AS) of messenger RNAs occurs in ∼95% of multi-exon human genes and generates diverse RNA and protein isoforms. We investigated AS events associated with human epidermal differentiation, a process crucial for skin func…
View article: eccDNA-pipe: an integrated pipeline for identification, analysis and visualization of extrachromosomal circular DNA from high-throughput sequencing data
eccDNA-pipe: an integrated pipeline for identification, analysis and visualization of extrachromosomal circular DNA from high-throughput sequencing data Open
Extrachromosomal circular DNA (eccDNA) is currently attracting considerable attention from researchers due to its significant impact on tumor biogenesis. High-throughput sequencing (HTS) methods for eccDNA identification are continually ev…
View article: Comparative analysis of methodologies for detecting extrachromosomal circular DNA
Comparative analysis of methodologies for detecting extrachromosomal circular DNA Open
Extrachromosomal circular DNA (eccDNA) is crucial in oncogene amplification, gene transcription regulation, and intratumor heterogeneity. While various analysis pipelines and experimental methods have been developed for eccDNA identificati…
View article: Heterochromatic silencing of immune‐related genes in glia is required for <scp>BBB</scp> integrity and normal lifespan in <i>drosophila</i>
Heterochromatic silencing of immune‐related genes in glia is required for <span>BBB</span> integrity and normal lifespan in <i>drosophila</i> Open
Glia and neurons face different challenges in aging and may engage different mechanisms to maintain their morphology and functionality. Here, we report that adult‐onset downregulation of a Drosophila gene CG32529/GLAD led to shortened life…
View article: Lsd1 safeguards T-cell development via suppressing endogenous retroelements and interferon responses
Lsd1 safeguards T-cell development via suppressing endogenous retroelements and interferon responses Open
The histone demethylase Lsd1 has been shown to play multiple essential roles in mammalian biology. However, its physiological functions in thymocyte development remain elusive. We observed that the specific deletion of Lsd1 in thymocytes c…
View article: Nickle-cobalt alloy nanocrystals inhibit activation of inflammasomes
Nickle-cobalt alloy nanocrystals inhibit activation of inflammasomes Open
Activation of inflammasomes—immune system receptor sensor complexes that selectively activate inflammatory responses—has been associated with diverse human diseases, and many nanomedicine studies have reported that structurally and chemica…
View article: POS0816 ALTERATIONS IN THE IMMUNE AND STROMAL CELL LANDSCAPE OF THE SALIVARY GLAND AND PERIPHERY IN PRIMARY SJÖGREN’S SYNDROME
POS0816 ALTERATIONS IN THE IMMUNE AND STROMAL CELL LANDSCAPE OF THE SALIVARY GLAND AND PERIPHERY IN PRIMARY SJÖGREN’S SYNDROME Open
Background Primary Sjögren's syndrome (pSS) is a heterogeneous, chronic, complex systemic autoimmune disease. Patients with pSS exhibit focal lymphocytic sialadenitis in the salivary gland (SG), supporting the SG as the pathogenic center a…
View article: Table S2 from Accumulation of Tumor-Infiltrating CD49a<sup>+</sup> NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma
Table S2 from Accumulation of Tumor-Infiltrating CD49a<sup>+</sup> NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma Open
The details and characteristics of each patient enrolled in Cohort 1
View article: Table S1 from Accumulation of Tumor-Infiltrating CD49a<sup>+</sup> NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma
Table S1 from Accumulation of Tumor-Infiltrating CD49a<sup>+</sup> NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma Open
Clinicopathological characteristics of patients in each cohort
View article: Data from Accumulation of Tumor-Infiltrating CD49a<sup>+</sup> NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma
Data from Accumulation of Tumor-Infiltrating CD49a<sup>+</sup> NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma Open
The discovery of CD49a+ liver-resident natural killer (NK) cells in mice alters our view of NK cells and provides another opportunity to study NK cells. Although evidence has suggested roles for NK cells in liver diseases, whether and how …
View article: Table S1 from Accumulation of Tumor-Infiltrating CD49a<sup>+</sup> NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma
Table S1 from Accumulation of Tumor-Infiltrating CD49a<sup>+</sup> NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma Open
Clinicopathological characteristics of patients in each cohort
View article: Table S2 from Accumulation of Tumor-Infiltrating CD49a<sup>+</sup> NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma
Table S2 from Accumulation of Tumor-Infiltrating CD49a<sup>+</sup> NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma Open
The details and characteristics of each patient enrolled in Cohort 1
View article: Figure S1 from Accumulation of Tumor-Infiltrating CD49a<sup>+</sup> NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma
Figure S1 from Accumulation of Tumor-Infiltrating CD49a<sup>+</sup> NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma Open
Total number of NK cells significantly reduces in the intratumoral region of HCC tissues.
View article: Figure S1 from Accumulation of Tumor-Infiltrating CD49a<sup>+</sup> NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma
Figure S1 from Accumulation of Tumor-Infiltrating CD49a<sup>+</sup> NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma Open
Total number of NK cells significantly reduces in the intratumoral region of HCC tissues.
View article: Data from Accumulation of Tumor-Infiltrating CD49a<sup>+</sup> NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma
Data from Accumulation of Tumor-Infiltrating CD49a<sup>+</sup> NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma Open
The discovery of CD49a+ liver-resident natural killer (NK) cells in mice alters our view of NK cells and provides another opportunity to study NK cells. Although evidence has suggested roles for NK cells in liver diseases, whether and how …
View article: Figure S2 from Accumulation of Tumor-Infiltrating CD49a<sup>+</sup> NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma
Figure S2 from Accumulation of Tumor-Infiltrating CD49a<sup>+</sup> NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma Open
Global transcriptomic analysis on primary CD49a+ and CD49a- NK cells.
View article: Figure S2 from Accumulation of Tumor-Infiltrating CD49a<sup>+</sup> NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma
Figure S2 from Accumulation of Tumor-Infiltrating CD49a<sup>+</sup> NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma Open
Global transcriptomic analysis on primary CD49a+ and CD49a- NK cells.
View article: Supplementary Methods, Figures 1-4, Movie Legend, Table Legends 1-5 from The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression
Supplementary Methods, Figures 1-4, Movie Legend, Table Legends 1-5 from The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression Open
PDF file - 2.4MB
View article: Supplementary Table 2 from The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression
Supplementary Table 2 from The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression Open
PDF file - 46K, Gene ontology for microarray gene sets. List of gene ontology (GO) terms from the microarray gene expression datasets of primary MECs � Znf217 using DAVID software
View article: Supplementary Table 4 from The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression
Supplementary Table 4 from The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression Open
PDF file - 29K, Overlapping adult stem cell signature genes. List of overlapping genes between our dataset (this study) and our adult stem cell signature, which is downregulated in many epithelial cancers relative to normal tissue. Primary…
View article: Supplementary Movie from The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression
Supplementary Movie from The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression Open
PDF file - 12MB, Movie of SCp2 cells infected with vector (left movie) or Znf217 (right movie) following a scratch with a pipette tip. This movie ran for 20.25 hours
View article: Supplementary Materials and Methods from The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression
Supplementary Materials and Methods from The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression Open
PDF file - 233K, This file contains supplemental materials and methods, including cell lines, antibodies and staining procedures used in this study